Abstract:
:We aimed to evaluate the status and barriers related to hepatitis C virus (HCV) treatment among Chinese methadone maintenance treatment (MMT) clients, and the willingness and barriers of patients to accept directly observed treatment (DOT) service and oral direct-acting antivirals (DAAs). We conducted a cross-sectional survey from July to October 2017 in Guangdong Province, China, involving 678 HCV antibody-positive MMT patients. If they reported being infected with HCV, then their HCV treatment experience, willingness to use DOT and DAAs, along with any barriers, were collected. Logistic regression analysis was used to identify the correlates of initiating HCV treatment. Among those reporting HCV infection (54%, 366/678), 39% (144/366) initiated treatment; however, 38% (55/144) interrupted and 55% (79/135) delayed treatment for 15 months. Seventy-five percent (273/366) and 53% (195/366) were willing to use DOT and DAAs, respectively. Unaffordable medical costs and insignificant symptoms were the major barriers to HCV treatment and accepting DOT or DAAs. The lack of a stable residence, being a woman, and having ever injected drugs were all associated with a low probability of initiating treatment (p < 0.05). This study highlights a limited uptake of HCV treatment among MMT patients, and a need to strengthen the popularity of DOT and DAAs and integrate them into Chinese MMT clinics.
journal_name
Int J Environ Res Public Healthauthors
Liu Y,Zou X,Chen W,Gong C,Ling Ldoi
10.3390/ijerph16224436subject
Has Abstractpub_date
2019-11-12 00:00:00issue
22eissn
1661-7827issn
1660-4601pii
ijerph16224436journal_volume
16pub_type
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更新日期:2019-12-30 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-30 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2020-11-16 00:00:00
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doi:10.3390/ijerph17144968
更新日期:2020-07-10 00:00:00
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doi:10.3390/ijerph17176321
更新日期:2020-08-31 00:00:00
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doi:10.3390/ijerph17030860
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更新日期:2018-03-23 00:00:00
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journal_title:International journal of environmental research and public health
pub_type: 杂志文章,多中心研究
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journal_title:International journal of environmental research and public health
pub_type: 杂志文章,随机对照试验
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更新日期:2019-12-23 00:00:00
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更新日期:2019-05-26 00:00:00
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journal_title:International journal of environmental research and public health
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更新日期:2019-11-08 00:00:00
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journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
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更新日期:2021-01-04 00:00:00
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journal_title:International journal of environmental research and public health
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更新日期:2020-09-19 00:00:00
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pub_type: 杂志文章
doi:10.3390/ijerph17238999
更新日期:2020-12-03 00:00:00