Abstract:
Background:The diagnosis of cellulitis is made clinically without a gold standard diagnostic test, and cellulitis has many disease mimics. There is currently no consensus for optimal antimicrobial treatment duration or method of antimicrobial delivery. Methods:This was a randomized controlled open-label multicenter trial to determine the safety and efficacy of 24 hours of intravenous (IV) therapy compared with ≥72 hours of IV therapy, both followed by oral therapy to a maximum of 7-10 days' duration for the treatment of lower limb cellulitis. Results:Over 40 months, 80 patients were recruited. Thirty-nine patients were assigned to 24 hours of IV antibiotics and 41 to ≥72 hours of IV antibiotics. The mean duration (range) of IV antibiotics in the 24-hour group was 25.5 (17-40) hours, and in the ≥72-hour group it was 78 (41.5-210) hours. Three patients in the 24-hour arm and 4 patients in the ≥72-hour arm were excluded from the analysis due to withdrawal from the trial. Analysis of the remaining patients revealed that 6 patients (4 in the intervention arm and 2 in the control arm) did not achieve an adequate response to therapy. Only 1 patient experienced self-limiting adverse effects of treatment. Conclusions:The noninferiority of short-course IV therapy cannot be determined from this trial. Challenges included resource limitations for recruitment, misdiagnosis, participant withdrawal, and subjective responses to therapy based on visual assessment by treating clinicians. Further studies are needed to determine if short-course IV therapy is a suitable treatment option. Australia Council of Clinical Trials Registry No:ACTRN12613001366741.
journal_name
Open Forum Infect Disjournal_title
Open forum infectious diseasesauthors
Clarke MC,Cheng AC,Pollard JG,Birch M,Cowan RU,Linke JA,Walton AL,Friedman NDdoi
10.1093/ofid/ofz335subject
Has Abstractpub_date
2019-07-20 00:00:00pages
ofz335issue
9issn
2328-8957pii
ofz335journal_volume
6pub_type
杂志文章abstract:Background:The Short Physical Performance Battery (SPPB) is a well regarded physical functioning assessment including balance, gait speed, and chair-stand tests. Its use has not been widely assessed in human immunodeficiency virus (HIV) care. We evaluated the feasibility of integrating the SPPB into care of aging peopl...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz038
更新日期:2019-03-11 00:00:00
abstract:Background:Staphylococcus aureus is the most common cause of native septic arthritis. Few studies have characterized this disease during the US opioid epidemic. The role of methicillin-resistant Staphylococcus aureus (MRSA) nasal screening in this disease has not been elucidated. We sought to identify risk factors and ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofaa593
更新日期:2020-12-18 00:00:00
abstract::Background. Sepsis is a serious and common condition with high mortality and morbidity. The public awareness, knowledge, and perception of sepsis in Sweden are unknown. Methods. A survey was performed using an online interview distributed to adults, aged 18-74, between March 6 and 9, 2015. Results. A total of 1001 ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofv161
更新日期:2015-10-26 00:00:00
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abstract:Background:Few studies have investigated predictors of serological response to syphilis treatment in people living with HIV (PLWH). Methods:This was a retrospective, longitudinal study on PLWH who were diagnosed with and treated for syphilis who had an assessable serological response between January 2004 and June 2016...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy324
更新日期:2018-11-30 00:00:00
abstract:Background:Hepatitis C virus (HCV), a major cause of morbidity and mortality, is common and rising among young persons who inject drugs (PWID). Reducing the level of viremia may be an intervention, yet the impact of viremia on HCV transmission is unknown. Methods:We conducted a prospective study of injecting partnersh...
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-02-19 00:00:00
abstract::We implemented a real-time report to distribute respiratory pathogen data for our 8-hospital system to anyone with an Internet connection and a web browser. Real-time access to accurate regional laboratory observation data during an epidemic influenza season can guide diagnostic and therapeutic strategies. ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
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更新日期:2018-11-30 00:00:00
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journal_title:Open forum infectious diseases
pub_type: 杂志文章
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更新日期:2014-07-02 00:00:00
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journal_title:Open forum infectious diseases
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journal_title:Open forum infectious diseases
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-08-29 00:00:00
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pub_type: 杂志文章
doi:10.1093/ofid/ofaa192
更新日期:2020-05-27 00:00:00
abstract::[This corrects the article DOI: 10.1093/ofid/ofy251.]. ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章,已发布勘误
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更新日期:2019-04-03 00:00:00
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更新日期:2019-10-04 00:00:00
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pub_type: 杂志文章
doi:10.1093/ofid/ofy137
更新日期:2018-06-16 00:00:00
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更新日期:2020-02-18 00:00:00
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更新日期:2019-10-11 00:00:00
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doi:10.1093/ofid/ofx042
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更新日期:2017-01-13 00:00:00
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更新日期:2019-04-25 00:00:00
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doi:10.1093/ofid/ofy068
更新日期:2018-04-23 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-02 00:00:00
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abstract::[This corrects the article DOI: 10.1093/ofid/ofx156.][This corrects the article DOI: 10.1093/ofid/ofx156.]. ...
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pub_type: 杂志文章,已发布勘误
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更新日期:2018-01-30 00:00:00