5-HT2B, 5-HT7, and DA2 Receptors Mediate the Effects of 5-HT and DA on Agonistic Behavior of the Chinese Mitten Crab (Eriocheir sinensis).

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) protects the embryo from endogenous and xenobiotic-enhanced oxidative DNA damage and embryopathies. Here we show in aged mice that G6PD similarly protects against endogenous reactive oxygen species (ROS)-mediated neurodegeneration. In G6PD-normal (G6PD(+/+)) and heterozygous (G...

journal_title：ACS chemical neuroscience

authors： Jeng W,Loniewska MM,Wells PG

更新日期：2013-07-17 00:00:00

abstract：:Phosphodiesterase 10 (PDE10) inhibitors have received much attention as promising therapeutic agents for central nervous system (CNS) disorders such as schizophrenia and Huntington's disease. Recently, a hit compound 1 with a novel chromone scaffold has shown moderate inhibitory activity against PDE10A (IC50 = 500 nM)...

journal_title：ACS chemical neuroscience

authors： Yu YF,Zhang C,Huang YY,Zhang S,Zhou Q,Li X,Lai Z,Li Z,Gao Y,Wu Y,Guo L,Wu D,Luo HB

更新日期：2020-04-01 00:00:00

abstract：:Serotonin (5-HT) is a key player in many physiological processes in both the adult organism and developing embryo. One of the mechanisms for 5-HT-mediated effects is covalent binding of 5-HT to the target proteins catalyzed by transglutaminases (serotonylation). Despite the implication in a variety of physiological pr...

journal_title：ACS chemical neuroscience

authors： Ivashkin E,Melnikova V,Kurtova A,Brun NR,Obukhova A,Khabarova MY,Yakusheff A,Adameyko I,Gribble KE,Voronezhskaya EE

更新日期：2019-08-21 00:00:00

abstract：:High levels of histamine H3 receptors (H3Rs) are found in the globus pallidus (GP), a neuronal nucleus in the basal ganglia involved in the control of motor behavior. By using rat GP isolated nerve terminals (synaptosomes), we studied whether H3R activation modified the previously reported enhancing action of adenosin...

journal_title：ACS chemical neuroscience

authors： Morales-Figueroa GE,Márquez-Gómez R,González-Pantoja R,Escamilla-Sánchez J,Arias-Montaño JA

更新日期：2014-08-20 00:00:00

abstract：:The distribution and density of neurons within the brain poses many challenges when making quantitative measurements of neurotransmission in the extracellular space. A volume neurotransmitter is released into the synapse during chemical communication and must diffuse through the extracellular space to an implanted sen...

journal_title：ACS chemical neuroscience

authors： Atcherley CW,Laude ND,Monroe EB,Wood KM,Hashemi P,Heien ML

更新日期：2015-09-16 00:00:00

abstract：:Development of pharmacological tools for the ionotropic glutamate receptors (iGluRs) is imperative for the study and understanding of the role and function of these receptors in the central nervous system. We report the synthesis of 18 analogues of (2 S,3 R)-2-carboxy-3-pyrrolidine acetic acid (3a), which explores the...

journal_title：ACS chemical neuroscience

authors： Poulie CBM,Alcaide A,Krell-Jørgensen M,Larsen Y,Astier E,Bjørn-Yoshimoto WE,Yi F,Syrenne JT,Storgaard M,Nielsen B,Frydenvang KA,Jensen AA,Hansen KB,Pickering DS,Bunch L

更新日期：2019-06-19 00:00:00

abstract：:Ionic zinc is found at a high concentration in some glutamatergic vesicles of the mammalian brain. Ionic zinc is also found chelated to macromolecules in the extracellular space, constituting what has been called the "zinc veneer". In this communication we show that the zinc ionophore, pyrithione, can be used to demon...

journal_title：ACS chemical neuroscience

authors： Nydegger I,Rumschik SM,Zhao J,Kay AR

更新日期：2012-10-17 00:00:00

abstract：:Carboranes have been extensively investigated as potential drugs for the treatment of malignant human brain tumors by boron neutron capture therapy (BNCT). This noninvasive treatment modality utilizes compounds containing the nonradioactive isotope 10B which has a high propensity to capture slow neutrons. In response,...

journal_title：ACS chemical neuroscience

authors： He T,Chittur SV,Musah RA

更新日期：2019-03-20 00:00:00

abstract：:Aminorex (5-phenyl-4,5-dihydro-1,3-oxazol-2-amine) and 4-methylaminorex (4-methyl-5-phenyl-4,5-dihydro-1,3-oxazol-2-amine) are psychostimulants that have long been listed in Schedules IV and I of the UN Convention on Psychotropic Substances of 1971. However, a range of psychoactive analogues exist that are not interna...

journal_title：ACS chemical neuroscience

authors： Maier J,Mayer FP,Brandt SD,Sitte HH

更新日期：2018-10-17 00:00:00

abstract：:Autoantibodies to Parkinson's disease (PD) amyloidogenic protein, α-synuclein, were recognized as a prospective biomarker for early disease diagnostics, yet there is inconsistency in previous reports, potentially related to PD status. Therefore, plasma and cerebrospinal fluid (CSF) of the cross-sectional cohort of 60 ...

journal_title：ACS chemical neuroscience

authors： Horvath I,Iashchishyn IA,Forsgren L,Morozova-Roche LA

更新日期：2017-06-21 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disease, and its main hallmark is the deposition of amyloid beta (Aβ) peptides. However, several clinical trials focusing on Aβ-targeting agents have failed recently, and thus new therapeutic leads are focusing on alternate targets such as tau protein patho...

journal_title：ACS chemical neuroscience

authors： Cho HJ,Sharma AK,Zhang Y,Gross ML,Mirica LM

更新日期：2020-05-20 00:00:00

abstract：:Inflammation is a potential factor in the pathophysiology of depression. A traditional Chinese herbal medicine, arctiin, and its aglycone, arctigenin, are the major bioactive components in Fructus arctii and exhibit neuroprotective and anti-inflammatory activities. Arctigenin has been reported to have antidepressant-l...

journal_title：ACS chemical neuroscience

authors： Xu X,Zeng XY,Cui YX,Li YB,Cheng JH,Zhao XD,Xu GH,Ma J,Piao HN,Jin X,Piao LX

更新日期：2020-08-05 00:00:00

abstract：:Accumulating evidence suggested that soluble oligomeric β-amyloid protein (Aβ) exerts diverse roles in neuronal cell death, neuroinflammation, oxidative stress, and the eventual dementia associated with Alzheimer's disease (AD). Developing an agent with multiple properties may be a reasonable strategy for the treatmen...

journal_title：ACS chemical neuroscience

authors： Yang S,Liu W,Lu S,Tian YZ,Wang WY,Ling TJ,Liu RT

更新日期：2016-04-20 00:00:00

abstract：:Penitrem A, PA, is an indole diterpene alkaloid produced by several fungal species. PA acts as a selective Ca2+-dependent K-channels (Maxi-K, BK) antagonist in brain, causing motor system dysfunctions including tremors and seizures. However, its molecular mechanism at the peripheral nervous system (PNS) is still ambig...

journal_title：ACS chemical neuroscience

authors： Qusa MH,Abdelwahed KS,Meyer SA,El Sayed KA

更新日期：2020-11-04 00:00:00

abstract：:Bipolar disorder is a complex neuropsychiatric disorder, characterized by intermittent episodes of mania and depression. Recent studies have indicated argyrophilic grains, composed of hyperphosphorylated tau, are observable in postmortem brains of bipolar patients. It remains uncertain how tau hyperphosphorylation res...

journal_title：ACS chemical neuroscience

authors： Naserkhaki R,Zamanzadeh S,Baharvand H,Nabavi SM,Pakdaman H,Shahbazi S,Vosough M,Ghaedi G,Barzegar A,Mirtorabi D,Hedayatshodeh M,Ehsani E,Falahati M,Hajipour MJ,Shahpasand K

更新日期：2019-03-20 00:00:00

abstract：:As the major psychoactive agent in opium and direct precursor for heroin, morphine is a historically critical molecule in chemical neuroscience. A structurally complex phenanthrene alkaloid produced by Papaver somniferum, morphine has fascinated chemists seeking to disentangle pharmacologically beneficial analgesic ef...

journal_title：ACS chemical neuroscience

authors： Devereaux AL,Mercer SL,Cunningham CW

更新日期：2018-10-17 00:00:00

abstract：:Humanin (HN), a 24-amino acid bioactive peptide, has been shown to increase cell survival of neurons after exposure to Aβ and NMDA-induced toxicity and thus could be beneficial in the treatment of Alzheimer's disease (AD). The neuroprotection by HN is reported to be primarily through its agonist binding properties to ...

journal_title：ACS chemical neuroscience

authors： Alam MP,Bilousova T,Spilman P,Vadivel K,Bai D,Elias CJ,Evseenko D,John V

更新日期：2018-03-21 00:00:00

abstract：:Selective potentiators of glutamate response at metabotropic glutamate receptor subtype 5 (mGluR5) have exciting potential for the development of novel treatment strategies for schizophrenia. A total of 1,382 compounds with positive allosteric modulation (PAM) of the mGluR5 glutamate response were identified through h...

journal_title：ACS chemical neuroscience

authors： Mueller R,Rodriguez AL,Dawson ES,Butkiewicz M,Nguyen TT,Oleszkiewicz S,Bleckmann A,Weaver CD,Lindsley CW,Conn PJ,Meiler J

更新日期：2010-04-21 00:00:00

abstract：:The nicotinic acetylcholine receptor (nAChR) family, the archetype member of the pentameric ligand-gated ion channels, is ubiquitously distributed in the central and peripheral nervous systems, and its members are the targets for both genetic and acquired forms of neurological disorders. In the central nervous system,...

journal_title：ACS chemical neuroscience

authors： Paz ML,Barrantes FJ

更新日期：2019-05-15 00:00:00

abstract：:Natural environments contain numerous volatile compounds emanating from a large number of sources, and the survival of many animals depends on their ability to segregate odors of interest within complex odorous scenes. In a recent paper, we described how the ability of mice to detect odors within mixtures depends on t...

journal_title：ACS chemical neuroscience

authors： Rokni D,Murthy VN

更新日期：2014-10-15 00:00:00

abstract：:As the first drug to see widespread use for the treatment of attention deficit hyperactivity disorder (ADHD), methylphenidate was the forerunner and catalyst to the modern era of rapidly increasing diagnosis, treatment, and medication development for this condition. During its often controversial history, it has vario...

journal_title：ACS chemical neuroscience

authors： Wenthur CJ

更新日期：2016-08-17 00:00:00

abstract：:No selective drugs exist, and we have been designing, synthesizing, and evaluating multitarget-directed ligands since the beginning of modern medicinal chemistry, without knowing it, most possibly. The challenge to discover the efficient Multi-Target Small Molecules (MTSMs) for Alzheimer's disease (AD) therapy implies...

journal_title：ACS chemical neuroscience

authors： Oset-Gasque MJ,Marco-Contelles J

更新日期：2018-03-21 00:00:00

abstract：:The intramembrane aspartyl protease γ-secretase (GSEC) cleaves single-span transmembrane helices including the C-terminal fragment of the amyloid precursor protein (APP). This substrate is initially cleaved at the ϵ-site followed by successive processing (trimming) events mostly in steps of three amino acids. GSEC is ...

journal_title：ACS chemical neuroscience

authors： Hitzenberger M,Zacharias M

更新日期：2019-03-20 00:00:00

abstract：:The efficacy of positive allosteric modulators (PAMs) of the metabotropic glutamate receptor 4 (mGlu4) in preclinical rodent models of Parkinson's disease has been established by a number of groups. Here, we report an advanced preclinically characterized mGlu4 PAM, N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin...

journal_title：ACS chemical neuroscience

authors： Engers DW,Blobaum AL,Gogliotti RD,Cheung YY,Salovich JM,Garcia-Barrantes PM,Daniels JS,Morrison R,Jones CK,Soars MG,Zhuo X,Hurley J,Macor JE,Bronson JJ,Conn PJ,Lindsley CW,Niswender CM,Hopkins CR

更新日期：2016-09-21 00:00:00

abstract：:Exposure to di-(2-ethylhexyl) phthalate (DEHP), a widely used kind of plasticizer, can result in neurodevelopment impairments and learning and memory disorders. We studied the effects and possible mechanisms of maternal DEHP treatment on hippocampal synaptic plasticity in offspring. Pregnant Wistar rats were randomly ...

journal_title：ACS chemical neuroscience

authors： Dong J,Fu H,Fu Y,You M,Li X,Wang C,Leng K,Wang Y,Chen J

更新日期：2021-01-20 00:00:00

abstract：:Neurotensin (NT) exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2. This opioid-independent antinociception represents a potential alternative for pain management. While activation of NTS1 also induces a drop in blood pressure and body temperature, NTS2 appears to be an a...

journal_title：ACS chemical neuroscience

authors： Eiselt E,Gonzalez S,Martin C,Chartier M,Betti C,Longpré JM,Cavelier F,Tourwé D,Gendron L,Ballet S,Sarret P

更新日期：2019-11-20 00:00:00

abstract：:The dorsal raphe nucleus contains one of the largest groups of serotonergic neurons in the mammalian brain and is the main site of origin of the serotonergic projection to the cerebral cortex. Early electrophysiological studies suggested that serotonergic neurons in this cell group formed a homogeneous cell class. Mor...

journal_title：ACS chemical neuroscience

authors： Andrade R,Haj-Dahmane S

更新日期：2013-01-16 00:00:00

abstract：:Botulinum neurotoxin (BoNT), the etiological agent that causes the neuroparalytic disease botulism, has become a highly studied drug target in light of the potential abuse of this toxin as a weapon of bioterrorism. In particular, small molecule inhibitors of the light chain metalloprotease of BoNT serotype A have rece...

journal_title：ACS chemical neuroscience

authors： Capek P,Zhang Y,Barlow DJ,Houseknecht KL,Smith GR,Dickerson TJ

更新日期：2011-06-15 00:00:00

abstract：:Several chemotherapeutic agents used for cancer treatment induce dose-limiting peripheral neuropathy that compromises patients' quality of life and limits cancer treatment. Recently, mitochondrial dysfunction has been shown to be involved in the mechanism of chemotherapy-induced peripheral neuropathy. SS-20 is a mitoc...

journal_title：ACS chemical neuroscience

authors： Toyama S,Shimoyama N,Szeto HH,Schiller PW,Shimoyama M

更新日期：2018-07-18 00:00:00

abstract：:N-Methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in numerous neurological disorders. NMDARs typically comprise two GluN1 and two GluN2 subunits. The four GluN2 subtypes (GluN2A-GluN2D) have distinct functional properties a...

journal_title：ACS chemical neuroscience

authors： Swanger SA,Vance KM,Acker TM,Zimmerman SS,DiRaddo JO,Myers SJ,Bundgaard C,Mosley CA,Summer SL,Menaldino DS,Jensen HS,Liotta DC,Traynelis SF

更新日期：2018-02-21 00:00:00