Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing.

Abstract:

Background:Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigated whether glutamate concentration in the dACC modulates brain response during salience processing. Methods:Twenty-seven healthy subjects (12♀, 15♁) provided both STEAM MRS at 7T measuring glutamate concentrations in the dACC as well as a functional magnetic resonance imaging (fMRI) task to study the influence on content-related salience processing and expectedness. Salience was modulated for both sexual and non-sexual emotional photos in either expected or unexpected situations. Correlation between MRS and task fMRI was investigated by performing regression analyses controlling for age, gender, and gray matter partial volume. Results/Conclusion:During picture processing, the extent of deactivation in the Posterior Cingulate Cortex (PCC) was attenuated by two different salience attributions: sexual content and unexpectedness of emotional content. Our results indicate that stimulus inherent salience induces an attenuation of the deactivation in PCC, which is in turn balanced by higher level of glutamate in the dACC.

journal_name

Front Behav Neurosci

authors

von Düring F,Ristow I,Li M,Denzel D,Colic L,Demenescu LR,Li S,Borchardt V,Liebe T,Vogel M,Walter M

doi

10.3389/fnbeh.2019.00232

subject

Has Abstract

pub_date

2019-10-02 00:00:00

pages

232

issn

1662-5153

journal_volume

13

pub_type

杂志文章
  • Distinctive Roles of 5-aza-2'-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats.

    abstract::5-aza-2'-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases (DNMTs), has been implicated in aversive memory and the function of brain region involved in processing emotion. However, little is known about the role of 5-aza in the reconsolidation of opiate withdrawal memory. In the present study, using the mo...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00050

    authors: Liu P,Zhang J,Li M,Sui N

    更新日期:2016-03-15 00:00:00

  • In silico Interrogation of Insect Central Complex Suggests Computational Roles for the Ellipsoid Body in Spatial Navigation.

    abstract::The central complex in the insect brain is a composite of midline neuropils involved in processing sensory cues and mediating behavioral outputs to orchestrate spatial navigation. Despite recent advances, however, the neural mechanisms underlying sensory integration and motor action selections have remained largely el...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00142

    authors: Fiore VG,Kottler B,Gu X,Hirth F

    更新日期:2017-08-03 00:00:00

  • Validating Rat Model of Empathy for Pain: Effects of Pain Expressions in Social Partners.

    abstract::Pain can be socially transferred between familiar rats due to empathic responses. To validate rat model of empathy for pain, effects of pain expressions in a cagemate demonstrator (CD) in pain on empathic pain responses in a naïve cagemate observer (CO) after 30 min priming dyadic social interactions (PDSI) were evalu...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00242

    authors: Li CL,Yu Y,He T,Wang RR,Geng KW,Du R,Luo WJ,Wei N,Wang XL,Wang Y,Yang Y,Yu YQ,Chen J

    更新日期:2018-10-17 00:00:00

  • The Interplay of Achievement Motive-Goal Incongruence and State and Trait Self-Control: A Pilot Study Considering Cortical Correlates of Self-Control.

    abstract::Objective: This study utilized different theoretical perspectives to better understand motor performance. We refered to concepts of achievement motive-goal incongruence and assessed cortical correlates of self-control. We assumed that more self-control is required when people act in conformance with an incongruent goa...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00235

    authors: Schüler J,Hofstetter J,Wolff W

    更新日期:2019-10-04 00:00:00

  • Contextual Modulation of Vocal Behavior in Mouse: Newly Identified 12 kHz "Mid-Frequency" Vocalization Emitted during Restraint.

    abstract::While several studies have investigated mouse ultrasonic vocalizations (USVs) emitted by isolated pups or by males in mating contexts, studies of behavioral contexts other than mating and vocalization categories other than USVs have been limited. By improving our understanding of the vocalizations emitted by mice acro...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00038

    authors: Grimsley JM,Sheth S,Vallabh N,Grimsley CA,Bhattal J,Latsko M,Jasnow A,Wenstrup JJ

    更新日期:2016-03-09 00:00:00

  • Chronic Stress Alters Behavior in the Forced Swim Test and Underlying Neural Activity in Animals Exposed to Alcohol Prenatally: Sex- and Time-Dependent Effects.

    abstract::Dysregulation of the hypothalamic-pituitary-adrenal (HPA) stress response has been suggested to play a role in vulnerability to stress-related disorders, such as depression. Prenatal alcohol exposure (PAE) may result in HPA dysregulation, which in turn may predispose individuals to the effects of stress exposure throu...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00042

    authors: Lam VYY,Raineki C,Takeuchi LE,Ellis L,Woodward TS,Weinberg J

    更新日期:2018-03-09 00:00:00

  • Learning about Time within the Spinal Cord II: Evidence that Temporal Regularity Is Encoded by a Spinal Oscillator.

    abstract::How a stimulus impacts spinal cord function depends upon temporal relations. When intermittent noxious stimulation (shock) is applied and the interval between shock pulses is varied (unpredictable), it induces a lasting alteration that inhibits adaptive learning. If the same stimulus is applied in a temporally regular...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00014

    authors: Lee KH,Huang YJ,Grau JW

    更新日期:2016-02-11 00:00:00

  • Adult mouse basal forebrain harbors two distinct cholinergic populations defined by their electrophysiology.

    abstract::We performed whole-cell recordings from basal forebrain (BF) cholinergic neurons in transgenic mice expressing enhanced green fluorescent protein (eGFP) under the control of the choline acetyltransferase promoter. BF cholinergic neurons can be differentiated into two electrophysiologically identifiable subtypes: early...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00021

    authors: Unal CT,Golowasch JP,Zaborszky L

    更新日期:2012-05-08 00:00:00

  • Learning about time within the spinal cord: evidence that spinal neurons can abstract and store an index of regularity.

    abstract::Prior studies have shown that intermittent noxious stimulation has divergent effects on spinal cord plasticity depending upon whether it occurs in a regular (fixed time, FT) or irregular (variable time, VT) manner: In spinally transected animals, VT stimulation to the tail or hind leg impaired spinal learning whereas ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00274

    authors: Lee KH,Turtle JD,Huang YJ,Strain MM,Baumbauer KM,Grau JW

    更新日期:2015-10-21 00:00:00

  • Lingering Effects of Prenatal Alcohol Exposure on Basal and Ethanol-Evoked Expression of Inflammatory-Related Genes in the CNS of Adolescent and Adult Rats.

    abstract::Emerging data suggest that alcohol's effects on central inflammatory factors are not uniform across the lifespan. In particular, prenatal alcohol exposure (PAE) significantly alters steady-state levels of neuroimmune factors, as well as subsequent reactivity to later immune challenge. Thus, the current experiment inve...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00082

    authors: Doremus-Fitzwater TL,Youngentob SL,Youngentob L,Gano A,Vore AS,Deak T

    更新日期:2020-06-29 00:00:00

  • Evidence for a functional subdivision of Premotor Ear-Eye Field (Area 8B).

    abstract::The Supplementary Eye Field (SEF) and the Frontal Eye Field (FEF) have been described as participating in gaze shift control. Recent evidence suggests, however, that other areas of the dorsomedial prefrontal cortex also influence gaze shift. Herein, we have investigated electrically evoked ear- and eye movements from ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00454

    authors: Lanzilotto M,Perciavalle V,Lucchetti C

    更新日期:2015-01-30 00:00:00

  • The bio-distribution of the antidepressant clomipramine is modulated by chronic stress in mice: effects on behavior.

    abstract::Major depression (MD) is one of the most common psychiatric disorders, severely affecting the quality of life of millions of people worldwide. Despite the availability of several classes of antidepressants, treatment efficacy is still very variable and many patients do not respond to the treatment. Clomipramine (CMI),...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00445

    authors: Balsevich G,Namendorf C,Gerlach T,Uhr M,Schmidt MV

    更新日期:2015-01-06 00:00:00

  • Executive function and endocrinological responses to acute resistance exercise.

    abstract:THIS STUDY HAD THE FOLLOWING TWO AIMS:First, to explore the effects of acute resistance exercise (RE, i.e., using exercise machines to contract and stretch muscles) on behavioral and electrophysiological performance when performing a cognitive task involving executive functioning in young male adults; Second, to invest...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00262

    authors: Tsai CL,Wang CH,Pan CY,Chen FC,Huang TH,Chou FY

    更新日期:2014-08-01 00:00:00

  • Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.

    abstract::The increased understanding that neuropathology begins decades before symptom onset, has led to the conceptualization and widespread utilization of Mild Cognitive Impairment (MCI) as an important transitional state between healthy aging and dementia. Further subcategorization to MCI subtype has led to more distinct pr...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00259

    authors: Broadhouse KM,Mowszowski L,Duffy S,Leung I,Cross N,Valenzuela MJ,Naismith SL

    更新日期:2019-11-21 00:00:00

  • Boldness in Male and Female Zebrafish (Danio rerio) Is Dependent on Strain and Test.

    abstract::Differences in selection pressure in nature and labs have profound effects on zebrafish strains. The widely used AB strain of zebrafish has been domesticated over several decades. Recently, there has been an upsurge in the availability of genetically modified lines, e.g., the spiegeldanio (spd), which has a mutation i...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00248

    authors: Mustafa A,Roman E,Winberg S

    更新日期:2019-11-19 00:00:00

  • Audiovisual Temporal Processing and Synchrony Perception in the Rat.

    abstract::Extensive research on humans has improved our understanding of how the brain integrates information from our different senses, and has begun to uncover the brain regions and large-scale neural activity that contributes to an observer's ability to perceive the relative timing of auditory and visual stimuli. In the pres...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00246

    authors: Schormans AL,Scott KE,Vo AM,Tyker A,Typlt M,Stolzberg D,Allman BL

    更新日期:2017-01-10 00:00:00

  • Embodying an outgroup: the role of racial bias and the effect of multisensory processing in somatosensory remapping.

    abstract::We come to understand other people's physical and mental states by re-mapping their bodily states onto our sensorimotor system. This process, also called somatosensory resonance, is an essential ability for social cognition and is stronger when observing ingroup than outgroup members. Here we investigated, first, whet...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00165

    authors: Fini C,Cardini F,Tajadura-Jiménez A,Serino A,Tsakiris M

    更新日期:2013-11-18 00:00:00

  • Multilevel control of run orientation in Drosophila larval chemotaxis.

    abstract::Chemotaxis is a powerful paradigm to study how orientation behavior is driven by sensory stimulation. Drosophila larvae navigate odor gradients by controlling the duration of their runs and the direction of their turns. Straight runs and wide-amplitude turns represent two extremes of a behavioral continuum. Here we es...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00038

    authors: Gomez-Marin A,Louis M

    更新日期:2014-02-13 00:00:00

  • Emotion and cognition in high and low stress sensitive mouse strains: a combined neuroendocrine and behavioral study in BALB/c and C57BL/6J mice.

    abstract::Emotionally arousing experiences and stress influence cognitive processes and vice versa. Understanding the relations and interactions between these three systems forms the core of this study. We tested two inbred mouse strains (BALB/c, C57BL/6J; male; 3-month-old) for glucocorticoid stress system markers (expression ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.08.008.2007

    authors: Brinks V,van der Mark M,de Kloet R,Oitzl M

    更新日期:2007-12-30 00:00:00

  • A Window on the Study of Aversive Instrumental Learning: Strains, Performance, Neuroendocrine, and Immunologic Systems.

    abstract::The avoidance response is present in pathological anxiety and interferes with normal daily functions. The aim of this article is to shed light on performance markers of active avoidance (AA) using two different rat strains, Sprague-Dawley (SD) and Wistar. Specifically, good and poor performers were evaluated regarding...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00162

    authors: de Oliveira CC,Gouveia FV,de Castro MC,Kuroki MA,Dos Santos LC,Fonoff ET,Teixeira MJ,Otoch JP,Martinez RC

    更新日期:2016-08-24 00:00:00

  • Cross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol.

    abstract::Identifying the biological substrates of complex neurobehavioral traits such as alcohol dependency pose a tremendous challenge given the diverse model systems and phenotypic assessments used. To address this problem we have developed a platform for integrated analysis of high-throughput or genome-wide functional genom...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00001

    authors: Bubier JA,Wilcox TD,Jay JJ,Langston MA,Baker EJ,Chesler EJ

    更新日期:2016-01-21 00:00:00

  • Slips of Action and Sequential Decisions: A Cross-Validation Study of Tasks Assessing Habitual and Goal-Directed Action Control.

    abstract::Instrumental learning and decision-making rely on two parallel systems: a goal-directed and a habitual system. In the past decade, several paradigms have been developed to study these systems in animals and humans by means of e.g., overtraining, devaluation procedures and sequential decision-making. These different pa...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00234

    authors: Sjoerds Z,Dietrich A,Deserno L,de Wit S,Villringer A,Heinze HJ,Schlagenhauf F,Horstmann A

    更新日期:2016-12-20 00:00:00

  • Whisking Kinematics Enables Object Localization in Head-Centered Coordinates Based on Tactile Information from a Single Vibrissa.

    abstract::During active tactile exploration with their whiskers (vibrissae), rodents can rapidly orient to an object even though there are very few proprioceptors in the whisker muscles. Thus a long-standing question in the study of the vibrissal system is how the rat can localize an object in head-centered coordinates without ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00145

    authors: Yang AE,Hartmann MJ

    更新日期:2016-07-19 00:00:00

  • Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission.

    abstract::Problematic alcohol drinking and alcohol dependence are an increasing health problem worldwide. Alcohol abuse is responsible for approximately 5% of the total deaths in the world, but addictive consumption of it has a substantial impact on neurological and memory disabilities throughout the population. One of the bett...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2019.00288

    authors: Mira RG,Lira M,Tapia-Rojas C,Rebolledo DL,Quintanilla RA,Cerpa W

    更新日期:2020-01-24 00:00:00

  • Early adversity disrupts the adult use of aversive prediction errors to reduce fear in uncertainty.

    abstract::Early life adversity increases anxiety in adult rodents and primates, and increases the risk for developing post-traumatic disorder (PTSD) in humans. We hypothesized that early adversity impairs the use of learning signals -negative, aversive prediction errors-to reduce fear in uncertainty. To test this hypothesis, we...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00227

    authors: Wright KM,DiLeo A,McDannald MA

    更新日期:2015-08-27 00:00:00

  • Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy.

    abstract::Major advances in the past decade have led a better understanding of the pathophysiology of narcolepsy with cataplexy (NC) caused by the early loss of hypothalamic hypocretin neurons. Although a role for hypocretin in the regulation of sleep/wakefulness state is widely recognized, other functions, not necessarily rela...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00050

    authors: Bayard S,Dauvilliers YA

    更新日期:2013-05-23 00:00:00

  • Distinct patterns of outcome valuation and amygdala-prefrontal cortex synaptic remodeling in adolescence and adulthood.

    abstract::Adolescent behavior is typified by increased risk-taking, reward- and novelty-seeking, as well as an augmented need for social and environmental stimulation. This behavioral phenotype may result from alterations in outcome valuation or reward learning. In the present set of experiments, we directly compared adult and ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00115

    authors: Stolyarova A,Izquierdo A

    更新日期:2015-05-07 00:00:00

  • A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats.

    abstract::A role of the gut microbiota in psychiatric disorders is supported by a growing body of literature. The effects of a probiotic mixture of four bacterial strains were studied in two models of anxiety and depression, naturally stress-sensitive Fischer rats and Long Evans rats subjected to maternal deprivation. Rats chro...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.581296

    authors: Daugé V,Philippe C,Mariadassou M,Rué O,Martin JC,Rossignol MN,Dourmap N,Svilar L,Tourniaire F,Monnoye M,Jardet D,Bangratz M,Holowacz S,Rabot S,Naudon L

    更新日期:2020-11-12 00:00:00

  • Goal Achievement Failure Drives Corticospinal Modulation in Promotion and Prevention Contexts.

    abstract::When making decisions, people are typically differently sensitive to gains and losses according to the motivational context in which the choice is performed. As hypothesized by Regulatory Focus Theory (RFT), indeed, goals are supposed to change in relation to the set of possible outcomes. In particular, in a promotion...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00071

    authors: Lo Gerfo E,Pisoni A,Ottone S,Ponzano F,Zarri L,Vergallito A,Varoli E,Fedeli D,Romero Lauro LJ

    更新日期:2018-04-24 00:00:00

  • Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability.

    abstract::The role of Y chromosome in sex determination and male fertility is well established. It is also known that infertile men are prone to psychological disturbances. Earlier studies in the laboratory identified genes expressed in testes that are putatively regulated by Y chromosome in man and mouse. With the availability...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00215

    authors: Dey SK,Kamle A,Dereddi RR,Thomas SM,Thummala SR,Kumar A,Chakravarty S,Jesudasan RA

    更新日期:2018-09-21 00:00:00