Eupalinolide J Suppresses the Growth of Triple-Negative Breast Cancer Cells via Targeting STAT3 Signaling Pathway.

abstract：:Nonmuscle myosin ⅡA, a kind of ATP-dependent molecular motor, binds actin to form the molecular motors of the cell. We found that interfering with nonmuscle myosin heavy chain (NMMHC) ⅡA could affect the exosome release from microglial cells stimulated by LPS. LPS could enhance exosome release from microglial cells by...

journal_title：Frontiers in pharmacology

authors： Lv Y,Chen J,Hu J,Qian Y,Kong Y,Fu L

更新日期：2020-12-08 00:00:00

abstract：:Objective: Clinical trials are the source of evidence. ClinicalTrials.gov is valuable for analyzing current conditions. Until now, the state of drug interventions for heart infections is unknown. The purpose of this study was to comprehensively assess the characteristics of trials on cardiac-related infections and the...

journal_title：Frontiers in pharmacology

authors： Ma LL,Qiu Y,Song MN,Chen Y,Qu JX,Li BH,Zhao MJ,Liu XC

更新日期：2019-07-05 00:00:00

abstract：:Vascular calcification is a major complication of cardiovascular disease and chronic renal failure. Autophagy help to maintain a stable internal and external environment that is important for modulating arteriosclerosis, but its pathogenic mechanism is far from clear. Here, we aimed to identify the bioactive compounds...

journal_title：Frontiers in pharmacology

authors： He HQ,Law BYK,Zhang N,Qiu CL,Qu YQ,Wu AG,Han Y,Song Q,Zheng WL,Liu Y,He YZ,Wong VKW

更新日期：2019-12-19 00:00:00

abstract：:Impetigo is the most common childhood skin infection in the world. There are two patterns of impetigo: nonbullous (or impetigo contagiosa) and bullous. The nonbullous type is due to Staphylococcus aureus and group A beta-haemolytic Streptococcus and occurs in 70% of impetigo cases. Impetigo is often a self-limited dis...

journal_title：Frontiers in pharmacology

authors： Davino G,D'Alvano T,Esposito S

更新日期：2020-11-18 00:00:00

abstract：:Cystic Fibrosis (CF) is a recessive genetic disease due to mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene encoding the CFTR chloride channel. The ion transport abnormalities related to CFTR mutation generate a dehydrated airway surface liquid (ASL) layer, which is responsible for an a...

journal_title：Frontiers in pharmacology

authors： Briottet M,Shum M,Urbach V

更新日期：2020-09-02 00:00:00

abstract：:Acute lung injury (ALI) is a complex syndrome with sepsis occurring in critical patients, who usually lack effective therapy. Nuciferine is a primary bioactive component extracted from the lotus leaf, and it displays extensive pharmacological functions, including anti-cancer, anti-inflammatory, and antioxidant propert...

journal_title：Frontiers in pharmacology

authors： Wu H,Yang Y,Guo S,Yang J,Jiang K,Zhao G,Qiu C,Deng G

更新日期：2017-12-21 00:00:00

abstract：:Osteoporosis is a common health problem worldwide caused by an imbalance of bone formation vs. bone resorption. However, current therapeutic approaches aimed at enhancing bone formation or suppressing bone resorption still have some limitations. In this study, we demonstrated for the first time that cepharanthine (CEP...

journal_title：Frontiers in pharmacology

authors： Zhou CH,Meng JH,Yang YT,Hu B,Hong JQ,Lv ZT,Chen K,Heng BC,Jiang GY,Zhu J,Cheng ZH,Zhang W,Cao L,Wang W,Shen WL,Yan SG,Wu HB

更新日期：2018-03-27 00:00:00

abstract：:Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic disulfide-rich peptide...

journal_title：Frontiers in pharmacology

authors： Huang YH,Chaousis S,Cheneval O,Craik DJ,Henriques ST

更新日期：2015-02-09 00:00:00

abstract：:Biopeptides derived from marine species have garnered significant research interest owing to their anti-inflammatory, antibacterial, and anticancer activities. In our previous study, Hydrostatin-SN1, a bioactive peptide extracted from the Hydrophis cyanocinctus venom gland T7 phage display library, demonstrated anti-i...

journal_title：Frontiers in pharmacology

authors： Zhang C,Guo S,Wang J,Li A,Sun K,Qiu L,Li J,Wang S,Ma X,Lu Y

更新日期：2020-06-19 00:00:00

abstract：:Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare the in vitro antimicrobial activity against Staphylococcus aureus biofilms. Methods: Large unilamellar vesicles of conventional (LUV VAN), fusogenic (LUVfuso VAN), and cationic (LUVcat VAN) liposomes e...

journal_title：Frontiers in pharmacology

authors： Scriboni AB,Couto VM,Ribeiro LNM,Freires IA,Groppo FC,de Paula E,Franz-Montan M,Cogo-Müller K

更新日期：2019-11-29 00:00:00

abstract：:In studies comparing regular versus on-demand treatment for patients with mild persistent asthma, on-demand treatment seems to have a similar efficacy on clinical and functional outcomes, but it does not suppress chronic airway inflammation or airway hyper-responsiveness (AHR) associated with asthma. Data on the effic...

journal_title：Frontiers in pharmacology

authors： Montuschi P

更新日期：2011-07-14 00:00:00

abstract：:Tumor-targeting nanomaterial-based chemotherapeutic drug delivery systems have been shown to represent an efficacious approach for the treatment of cancer because of their stability in blood circulation and predictable delivery patterns, enhanced tumor-selective drug accumulation, and decreased toxicity to normal tiss...

journal_title：Frontiers in pharmacology

authors： Yu T,Li Y,Gu X,Li Q

更新日期：2020-08-28 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown etiology typically characterized by episodes of spiking fever, evanescent rash, arthralgia, leukocytosis, and hyperferritinemia. The pivotal role of interleukin (IL)-1 and other pro-inflammatory cytokines gives rise to the development of new ...

journal_title：Frontiers in pharmacology

authors： Galozzi P,Baggio C,Bindoli S,Oliviero F,Sfriso P

更新日期：2018-09-21 00:00:00

abstract：:Objective: Prevalence of osteoporosis in Chinese postmenopausal women has significantly increased over the past decade and oral bisphosphonates are the most potent antiresorptive drugs. The purpose of the present research was to evaluate the cost-effectiveness of oral alendronate for individuals with osteoporosis. We ...

journal_title：Frontiers in pharmacology

authors： You R,Liu Z

更新日期：2020-11-16 00:00:00

abstract：Background:Erectile dysfunction (ED) occurs more frequently and causes a worse response to the first-line therapies in diabetics compared with nondiabetic men. Corpus cavernosum vascular dysfunction plays a pivotal role in the occurrence of diabetes mellitus ED (DMED). The aim of this study was to investigate the prote...

journal_title：Frontiers in pharmacology

authors： Yuan P,Ma D,Gao X,Wang J,Li R,Liu Z,Wang T,Wang S,Liu J,Liu X

更新日期：2020-08-12 00:00:00

abstract：:Natural products (NPs) are an important source for new drug discovery over the past decades, which have been demonstrated to be effectively used in cancer prevention, treatment, and adjuvant therapy. Many methods, such as the genomic and metabolomic approaches, immunochemistry, mass spectrometry, and chromatography, h...

journal_title：Frontiers in pharmacology

authors： Yan T,Zeng Q,Wang L,Wang N,Cao H,Xu X,Chen X

更新日期：2019-11-28 00:00:00

abstract：:Background: Currently, although non-steroidal anti-inflammatory drugs (NSAIDs) were recommended for acute renal colic in the 2018 European Association of Urology guidelines, there are no specific NSAIDs and no specific routes of administration in this guideline. The clinical practice of advocating intravenous opioids ...

journal_title：Frontiers in pharmacology

authors： Gu HY,Luo J,Wu JY,Yao QS,Niu YM,Zhang C

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) bo...

journal_title：Frontiers in pharmacology

authors： de Bruijn W,Ibáñez C,Frisk P,Bak Pedersen H,Alkan A,Vella Bonanno P,Brkičić LS,Bucsics A,Dedet G,Eriksen J,Fadare JO,Fürst J,Gallego G,Godói IP,Guerra Júnior AA,Gürsöz H,Jan S,Jones J,Joppi R,Kerman S,Laius O,Ma

更新日期：2016-07-22 00:00:00

abstract：:Fingolimod is used for the treatment of multiple sclerosis (MS) and targets receptors for the bioactive sphingolipid sphingosine-1-phosphate (S1P). Whether fingolimod or other MS therapies conversely affect plasma concentrations of sphingolipids has, however, not yet been analyzed. Herein, we quantified 15 representat...

journal_title：Frontiers in pharmacology

authors： Ottenlinger FM,Mayer CA,Ferreirós N,Schreiber Y,Schwiebs A,Schmidt KG,Ackermann H,Pfeilschifter JM,Radeke HH

更新日期：2016-11-03 00:00:00

abstract：:Investigation of the effects of serotonin on memory formation in the chick revealed an action on at least two 5-HT receptors. Serotonin injected intracerebrally produced a biphasic effect on memory consolidation with enhancement at low doses and inhibition at higher doses. The non-selective 5-HT receptor antagonist me...

journal_title：Frontiers in pharmacology

authors： Gibbs ME,Hertz L

更新日期：2014-04-01 00:00:00

abstract：:High-throughput techniques allow for massive screening of drug combinations. To find combinations that exhibit an interaction effect, one filters for promising compound combinations by comparing to a response without interaction. A common principle for no interaction is Loewe Additivity which is based on the assumptio...

journal_title：Frontiers in pharmacology

authors： Lederer S,Dijkstra TMH,Heskes T

更新日期：2018-02-06 00:00:00

abstract：Background and Aim:Platycodon grandiflorum (PG) has been widely used for treating chronic bronchitis (CB). However, the material basis and underlying mechanism of action of PG against CB have not yet been elucidated. Methods:To analyze the ingredients in PG, ultraperformance liquid chromatography-quadrupole-time-of-fl...

journal_title：Frontiers in pharmacology

authors： Deng Y,Ren H,Ye X,Xia L,Liu M,Liu Y,Yang M,Yang S,Ye X,Zhang J

更新日期：2020-09-08 00:00:00

abstract：:Background: No risk model for predicting thrombocytopenia associated with periprocedural tirofiban exposure is available. The purpose of this study was to develop a simple clinical pre-procedure risk model based on pre-procedural characteristics for early prediction of thrombocytopenia before patients were exposed to ...

journal_title：Frontiers in pharmacology

authors： Yi YH,Yin WJ,Gu ZC,Fang WJ,Li DY,Hu C,Liu K,Ma RR,Zhou LY

更新日期：2018-12-10 00:00:00

abstract：:It is currently thought that the dementia of Alzheimer's disease is due to the neurotoxicity of the deposits or aggregates of amyloid-β (Aβ) in the extracellular space of the cerebral cortex. This model has been widely criticized because there is a poor correlation between deposits and dementia. Others have questioned...

journal_title：Frontiers in pharmacology

authors： Holtzman JL

更新日期：2013-05-13 00:00:00

abstract：:Ginsenoside is a major active component of ginseng, which exhibits various pharmacological properties such as hepatoprotection, tumor suppression and diabetes resistance. In this study, the anti-diabetic effects of protopanaxadiol (PPD) and protopanaxatriol (PPT)-type saponins were explored and compared in high-fat di...

journal_title：Frontiers in pharmacology

authors： Deng J,Liu Y,Duan Z,Zhu C,Hui J,Mi Y,Ma P,Ma X,Fan D,Yang H

更新日期：2017-08-02 00:00:00

abstract：:There is urgent need for the development of mechanistically different and less side-effect prone antipsychotic compounds. The endocannabinoid system has been suggested to represent a potential new target in this indication. While the chronic use of cannabis itself has been considered a risk factor contributing to the ...

journal_title：Frontiers in pharmacology

authors： Rohleder C,Müller JK,Lange B,Leweke FM

更新日期：2016-11-08 00:00:00

abstract：:The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effe...

journal_title：Frontiers in pharmacology

authors： Sakhnevych SS,Yasinska IM,Fasler-Kan E,Sumbayev VV

更新日期：2019-04-05 00:00:00

abstract：:Wound management is a significant and growing issue worldwide. Knowledge of dressing products and clinical expertise in dressing selection are two major components in holistic wound management to ensure evidence-based wound care. With expanding global market of dressing products, there is need to update clinician know...

journal_title：Frontiers in pharmacology

authors： Weller CD,Team V,Sussman G

更新日期：2020-02-28 00:00:00

abstract：:We prepared hybrids consisting of Angelica gigas Nakai (AGN) root or flower extract and layered double hydroxide (LDH) for potential anticancer nanomedicine, as decursin species (DS) in AGN are known to have anticancer activity. Dimethylsulfoxide solvent was determined hybridization reaction media, as it has affinity ...

journal_title：Frontiers in pharmacology

authors： Kim HJ,Lee GJ,Choi AJ,Kim TH,Kim TI,Oh JM

更新日期：2018-07-09 00:00:00

abstract：:A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic exposure to cortisol is associated with risk factors related to metabolic syndrome like weight ...

journal_title：Frontiers in pharmacology

authors： Díaz-Castro F,Monsalves-Álvarez M,Rojo LE,Del Campo A,Troncoso R

更新日期：2020-04-24 00:00:00