Abstract:
:Pinocembrin (PIN) is a natural flavonoid widely found in bee propolis with potent gastrointestinal protective effects. In consequence, PIN has great potential in preventing inflammatory bowel diseases (IBDs) while scant information is available. In this study, a dextran sulfate sodium (DSS)-induced rats ulcerative colitis model (3.5% DSS in drinking water for 7 days) was applied to explore the protective effects of PIN on macroscopic colitis symptoms, inflammation, intestinal epithelial barrier function, and gut microbiota homeostasis. While DSS-treated rats showed severe colitis clinical symptoms and histological changes (colonic pathological damages and intestinal goblet cells loss), pre-administration of PIN (5 and 10 mg/kg, p.o.) for a week alleviated these symptoms. Pre-administration of PIN also suppressed the pro-inflammatory gene expressions and improved tight junction functions of colonic epithelial cells. Additionally, PIN administration reversed DSS-induced short chain fatty acid loss, and improved the gut microbial diversity assessed by 16S rRNA phylogenetic sequencing. Overall, our results suggest a wide spectrum of protective effects of PIN in preventing IBDs.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Hu L,Wu C,Zhang Z,Liu M,Maruthi Prasad E,Chen Y,Wang Kdoi
10.3389/fphys.2019.00908subject
Has Abstractpub_date
2019-07-19 00:00:00pages
908issn
1664-042Xjournal_volume
10pub_type
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journal_title:Frontiers in physiology
pub_type: 杂志文章
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journal_title:Frontiers in physiology
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pub_type: 杂志文章
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abstract::Pesticide resistance is a serious problem that poses a major challenge to pest control. One of the most potent resistance mechanisms is the overexpression of genes coding for detoxification enzymes. The expression of detoxification genes is regulated by a series of transcription factors. Previous studies have revealed...
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pub_type: 杂志文章
doi:10.3389/fphys.2018.01478
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pub_type: 杂志文章,评审
doi:10.3389/fphys.2014.00052
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doi:10.3389/fphys.2020.00879
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2015.00199
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pub_type: 杂志文章
doi:10.3389/fphys.2020.00249
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pub_type: 杂志文章
doi:10.3389/fphys.2020.00312
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abstract:BACKGROUND:Recent findings strongly promoted the hypothesis that common pelvic gynecological diseases including endometriosis and ovarian neoplasia may develop de novo from ectopic endometrial-like glands and/or embryonic epithelial remnants. To verify the frequency, the anatomical localization and the phenotype of mis...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2012.00444
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2013.00033
更新日期:2013-03-01 00:00:00
abstract::Dentin dysplasia (DD) and dentinogenesis imperfecta (DGI) patients have abnormal structure, morphology, and function of dentin. DD-II, DGI-II, and DGI-III are caused by heterozygous mutations in the dentin sialophosphoprotein (DSPP) gene in humans. Evidences have shown that loss of function of DSPP in Dspp knockout mi...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.593626
更新日期:2020-11-09 00:00:00
abstract::Directed cell migration is essential all along an individual's life, from embryogenesis to tissue repair and cancer metastasis. Thus, due to its biomedical relevance, directed cell migration is currently under intense research. Directed cell migration has been shown to be driven by an assortment of external biasing cu...
journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2020.586432
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abstract::New therapeutic agents are needed in digestive tract tumors. Co-029/tspan8 is a tetraspanin frequently expressed on human colorectal tumors, In this work, we report the effects of the monoclonal antibody Ts29.2, targeting Co-029/tspan8, on colorectal tumor cells in vitro and after implantation in nude mice. HT29, Isre...
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doi:10.3389/fphys.2014.00364
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journal_title:Frontiers in physiology
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doi:10.3389/fphys.2012.00463
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journal_title:Frontiers in physiology
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doi:10.3389/fphys.2013.00272
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journal_title:Frontiers in physiology
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journal_title:Frontiers in physiology
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