Interleukin-1 Receptor Antagonist Protects Newborn Mice Against Pulmonary Hypertension.

abstract：:Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children. Stx-mediated endothelial injury initiates the cascade leading to thrombotic microangiopathy (TMA), still the exact pathogenesis remains elusive. Interestingly, there is...

journal_title：Frontiers in immunology

authors： Wijnsma KL,Veissi ST,de Wijs S,van der Velden T,Volokhina EB,Wagener FADTG,van de Kar NCAJ,van den Heuvel LP

更新日期：2020-12-22 00:00:00

abstract：:Adverse life circumstances evoke a common "conserved transcriptional response to adversity" (CTRA) in mammalian leukocytes. To investigate whether this pattern is preserved in lower vertebrates, maraena whitefish (Coregonus maraena) were exposed for 9 days to different stocking densities: ~10 kg/m3 (low density), ~33 ...

journal_title：Frontiers in immunology

authors： Korytář T,Nipkow M,Altmann S,Goldammer T,Köllner B,Rebl A

更新日期：2016-12-23 00:00:00

abstract：:Viral defense at mucosal sites depends on interferons (IFN) and IFN stimulated genes (ISGs), either of which may be constitutively expressed to maintain an "antiviral state" (AVS). However, the mechanisms that govern the AVS are poorly defined. Using a BEAS-2B respiratory epithelial cell line deficient in IRF1, we dem...

journal_title：Frontiers in immunology

authors： Panda D,Gjinaj E,Bachu M,Squire E,Novatt H,Ozato K,Rabin RL

更新日期：2019-05-15 00:00:00

abstract：:HIV-1 controllers (HIC) are extremely rare patients with the ability to control viral replication, maintain unchanging CD4 T-cell count, and evade disease progression for extensive periods of time, in the absence of antiretroviral therapy. In order to establish the representation of key genetic correlates of atypical ...

journal_title：Frontiers in immunology

authors： Westrop SJ,Cocker ATH,Boasso A,Sullivan AK,Nelson MR,Imami N

更新日期：2017-06-27 00:00:00

abstract：:Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized the treatment of melanoma and several other cancers, but in the process, a new class of drug side effect has emerged-immune related adverse events. The observation that therapeutic blockade of these inhibitory receptors is sufficie...

journal_title：Frontiers in immunology

authors： Paluch C,Santos AM,Anzilotti C,Cornall RJ,Davis SJ

更新日期：2018-10-08 00:00:00

abstract：:Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in th...

journal_title：Frontiers in immunology

authors： Goronzy JJ,Li G,Yang Z,Weyand CM

更新日期：2013-06-04 00:00:00

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:B cells in fish were recently proven to have potent innate immune activities like macrophages. This inspired us to further explore the innate nature of B cells in fish. Moreover, antimicrobial peptides (AMPs) are representative molecules of innate immunity, and they can modulate the functions of macrophages. These mak...

journal_title：Frontiers in immunology

authors： Zhang XJ,Wang P,Zhang N,Chen DD,Nie P,Li JL,Zhang YA

更新日期：2017-04-04 00:00:00

abstract：:Sialic acids, a group of acidic sugars abundantly expressed in the tissues of deuterostome animals but rarely found in microbes, serve as a "signature of self" for these animals. Cognate sensors for sialic acids include Siglecs, a family of transmembrane lectins of vertebrate immune systems that recognize glycans cont...

journal_title：Frontiers in immunology

authors： Angata T

更新日期：2018-12-04 00:00:00

abstract：:The host's ability to discriminate friend and foe and to establish a precise homeostasis with its associated microbiota is crucial for its survival and fitness. Among the mediators of intestinal host-microbe interactions, NOD-like receptor (NLR) proteins take center stage. They are present in the epithelial lining and...

journal_title：Frontiers in immunology

authors： Lipinski S,Rosenstiel P

更新日期：2013-12-27 00:00:00

abstract：:Cooperation between the innate and adaptive immune responses is critical for enabling protective immunity against various invading microbes. Distinct types of effector T cells have different functions in adaptive immune responses. Th1 cells play important roles in the control of intracellular bacteria by producing IFN...

journal_title：Frontiers in immunology

authors： Koyasu S,Moro K

更新日期：2012-05-07 00:00:00

abstract：:The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in vascular development and autoimmune diseases. Recent studies indicate...

journal_title：Frontiers in immunology

authors： Iragavarapu-Charyulu V,Wojcikiewicz E,Urdaneta A

更新日期：2020-03-05 00:00:00

abstract：:Multiple sclerosis (MS) is the most common neurological immune-mediated disease leading to disability in young adults. The outcome of the disease is unpredictable, and over time, neurological disabilities accumulate. Interferon beta-1b was the first drug to be approved in the 1990s for relapsing-remitting MS to modula...

journal_title：Frontiers in immunology

authors： Rommer PS,Milo R,Han MH,Satyanarayan S,Sellner J,Hauer L,Illes Z,Warnke C,Laurent S,Weber MS,Zhang Y,Stuve O

更新日期：2019-07-11 00:00:00

abstract：:There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed in human lung fibroblasts following the induction of inflammation us...

journal_title：Frontiers in immunology

authors： Hadjicharalambous MR,Roux BT,Feghali-Bostwick CA,Murray LA,Clarke DL,Lindsay MA

更新日期：2018-12-11 00:00:00

abstract：:Heat-shock protein 70 (Hsp70) is frequently found on the plasma membrane of a large number of malignant tumors including non-small cell lung cancer (NSCLC) and gets released into the blood circulation in lipid vesicles. On the one hand, a membrane (m)Hsp70-positive phenotype correlates with a high aggressiveness of th...

journal_title：Frontiers in immunology

authors： Gunther S,Ostheimer C,Stangl S,Specht HM,Mozes P,Jesinghaus M,Vordermark D,Combs SE,Peltz F,Jung MP,Multhoff G

更新日期：2015-11-02 00:00:00

abstract：:Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC), represent a major global health burden. A large population of microorganisms residing in the GI tract regulate physiological processes, such as the immune response, metabolic balance, and homeostasis. Accumulating evidence has reveal...

journal_title：Frontiers in immunology

authors： Peng C,Ouyang Y,Lu N,Li N

更新日期：2020-06-30 00:00:00

abstract：:S100A12 is a calcium-binding protein of the S100 subfamily of myeloid-related proteins that acts as an alarmin to induce a pro-inflammatory innate immune response. It has been linked to several chronic inflammatory diseases, however its role in the common oral immunopathology periodontitis is largely unknown. Previous...

journal_title：Frontiers in immunology

authors： Lira-Junior R,Holmström SB,Clark R,Zwicker S,Majster M,Johannsen G,Axtelius B,Åkerman S,Svensson M,Klinge B,Boström EA

更新日期：2020-01-31 00:00:00

abstract：:Viral hemorrhagic fever (VHF) as a disease entity was first codified in the 1930s by soviet scientists investigating patients suffering from hantavirus infection. The group of hemorrhagic fever viruses (HFVs) has since expanded to include members from at least four different virus families: Arenaviridae, Bunyaviridae,...

journal_title：Frontiers in immunology

authors： Schönrich G,Raftery MJ

更新日期：2017-09-26 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1) elite controllers (ELCs) represent a unique population that control viral replication in the absence of antiretroviral therapy (cART). It is well established that expression of multiple inhibitory receptors on CD8+ T cells is associated with HIV-1 disease progression. Howeve...

journal_title：Frontiers in immunology

authors： Noyan K,Nguyen S,Betts MR,Sönnerborg A,Buggert M

更新日期：2018-01-22 00:00:00

abstract：:Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed...

journal_title：Frontiers in immunology

authors： Fu B,Wang D,Shen X,Guo C,Liu Y,Ye Y,Sun R,Li J,Tian Z,Wei H

更新日期：2020-12-23 00:00:00

abstract：:In the current quest for a complete cure for HIV/AIDS, highly sensitive HIV-1 latency detection methods are critical to verify full viral eradication. Until now, the in vitro quantitative viral outgrowth assays (qVOA) have been the gold standard for assessing latent HIV-1 viral burden. However, these assays have been ...

journal_title：Frontiers in immunology

authors： Schmitt K,Akkina R

更新日期：2018-03-05 00:00:00

abstract：:In response to the global burden of liver disease there has been a commensurate increase in the demand for liver transplantation. However, due to a paucity of donor organs many centers have moved toward the routine use of marginal allografts, which can be associated with a greater risk of complications and poorer clin...

journal_title：Frontiers in immunology

authors： Owen A,Newsome PN

更新日期：2020-06-19 00:00:00

abstract：:Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

journal_title：Frontiers in immunology

authors： Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

更新日期：2019-06-04 00:00:00

abstract：:Studying the evolutionary diversification of mammalian antiviral defenses is of main importance to better understand our innate immune repertoire. The small HERC proteins are part of a multigene family, including HERC5 and HERC6, which have probably diversified through complex evolutionary history in mammals. Here, we...

journal_title：Frontiers in immunology

authors： Jacquet S,Pontier D,Etienne L

更新日期：2020-12-18 00:00:00

abstract：:Immunoglobulin G (IgG), a glycoprotein secreted by plasma B-cells, plays a major role in the human adaptive immune response and are associated with a wide range of diseases. Glycosylation of the Fc binding region of IgGs, responsible for the antibody's effector function, is essential for prompting a proper immune resp...

journal_title：Frontiers in immunology

authors： Wahl A,van den Akker E,Klaric L,Štambuk J,Benedetti E,Plomp R,Razdorov G,Trbojević-Akmačić I,Deelen J,van Heemst D,Slagboom PE,Vučković F,Grallert H,Krumsiek J,Strauch K,Peters A,Meitinger T,Hayward C,Wuhrer M,Beekm

更新日期：2018-02-26 00:00:00

abstract：:The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functio...

journal_title：Frontiers in immunology

authors： Wosen JE,Ilstad-Minnihan A,Co JY,Jiang W,Mukhopadhyay D,Fernandez-Becker NQ,Kuo CJ,Amieva MR,Mellins ED

更新日期：2019-08-20 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment option for hematologic malignancies but relapse remains the most common cause of death. Infusion of donor lymphocytes (DLIs) can induce remission and prolong survival by exerting graft-vs.-leukemia (GVL) effects. However, sufficient tumor...

journal_title：Frontiers in immunology

authors： Jahnke S,Schmid H,Secker KA,Einhaus J,Duerr-Stoerzer S,Keppeler H,Schober-Melms I,Baur R,Schumm M,Handgretinger R,Bethge W,Kanz L,Schneidawind C,Schneidawind D

更新日期：2019-07-09 00:00:00

abstract：:We recently identified a new human subset of NK-like [KIR/NKG2A(+)] CD8(+) T cells with a marked/memory phenotype, high Eomesodermin expression, potent antigen-independent cytotoxic activity, and the capacity to generate IFN-γ rapidly after exposure to pro-inflammatory cytokines. These features support the hypothesis ...

journal_title：Frontiers in immunology

authors： Jacomet F,Cayssials E,Barbarin A,Desmier D,Basbous S,Lefèvre L,Levescot A,Robin A,Piccirilli N,Giraud C,Guilhot F,Roy L,Herbelin A,Gombert JM

更新日期：2017-01-16 00:00:00

abstract：Background:Chagas disease caused by Trypanosoma cruzi (T. cruzi) affects approximately six million individuals worldwide. Clinical manifestations are expected to occur due to the parasite persistence and host immune response. Herein we investigated potential associations between IL1B, IL6, IL17A, or IL18 polymorphism p...

journal_title：Frontiers in immunology

authors： Gomes Dos Santos A,Watanabe EH,Ferreira DT,Oliveira J,Nakanishi ÉS,Oliveira CS,Bocchi E,Novaes CTG,Cruz F,Carvalho NB,Sato PK,Yamashiro-Kanashiro EH,Pontillo A,de Freitas VLT,Onuchic LF,Shikanai-Yasuda MA

更新日期：2020-10-22 00:00:00

abstract：:Chimeric Antigen Receptor (CAR) T cells expressing the fusion of the NKG2D protein with CD3ζ (NKG2D-CAR T Cells) acquire a specificity for stress-induced ligands expressed on hematological and solid cancers. However, these stress ligands are also transiently expressed by activated T cells implying that NKG2D-based T c...

journal_title：Frontiers in immunology

authors： Breman E,Demoulin B,Agaugué S,Mauën S,Michaux A,Springuel L,Houssa J,Huberty F,Jacques-Hespel C,Marchand C,Marijsse J,Nguyen T,Ramelot N,Violle B,Daro D,De Waele P,Gilham DE,Steenwinckel V

更新日期：2018-12-12 00:00:00