Abstract:
BACKGROUND:Although many thromboembolism risk factors are well defined, formation of thrombus or dense spontaneous contrast (sludge) in the left atrium remains enigmatic and confounding. Exclusion of the thrombus is extremely important with respect to planned reversal of sinus rhythm. Data regarding the routine transesophagal echocardiography (TEE) before cardioversion are inconclusive. The authors focused on analyzing the usefulness of TEE before cardioversion by assessment of factors influencing the risk of thrombus and/or dense spontaneous echo contrast with the intention of extendingindications for TEE in the group with a high risk of thrombus or to forgo TEE in the low risk group. METHODS:Two hundred sixty-nine consecutive patients with persistent (> 48 h) atrial fibrillation or atrial flutter, in whom a direct current cardioversion was planned, were undergoing TEE for the detection of the left atrial thrombus or dense spontaneous echocontrast. Additional clinical and echocardiographic data were collected. The relationship between both thrombus and dense spontaneous echocontrast and covariates was analyzed with the use of binary logistic regression. RESULTS:Left atrium (LA) appendage (LAA) thrombus and/or sludge were detected in 79 (29%) patients. Signs of dementia in mini mental state examination (hazard ratio: 1.16; p = 0.005), low velocities in LAA (hazard ratio [HR]: 3.38; p = 0.032); presence of spontaneous echo contrast in LA (HR: 3.38; p = 0,003) consecutive episode of AF (HR: 2.27; p = 0,046); longer duration of atrial fibrillation (HR: 1.009; p = 0.022); were significant predictors of thrombus and/or dense spontaneous echo contrast. None of the patients with a CHA₂DS₂VASc score ≤ 1 had thrombus or sludge in the LAA. Among patients with a CHA₂DS₂VASc score > 1, the prevalence of thrombus or sludge in LAA was independent of the CHA₂DS₂VASc score value. CONCLUSIONS:Amongst many factors, including an established as risk for thromboembolism only a few of them increased the risk for the presence of thrombus in LAA: low velocities in LAA, presence of spontaneous echocontrast, longer duration of arrhythmia, consecutive (not first) arrhythmia episode and signs of dementia from a mini-mental state examination questionnaire. It was believed that there could be a need for an extension of indications of TEE in vast majority of the patients with atrial arrhythmias, due most often to an unpredictable occurrence of thrombus and potentially disastrous thromboembolism. The only exception could have been the group of the patients with a CHA₂DS₂VASc score ≤ 1.
journal_name
Cardiol Jjournal_title
Cardiology journalauthors
Kosmalska K,Rzyman M,Miękus P,Gilis-Malinowska N,Nowak R,Fijałkowski Mdoi
10.5603/CJ.a2019.0056subject
Has Abstractpub_date
2019-06-21 00:00:00issn
1897-5593pii
VM/OJS/J/62824pub_type
杂志文章abstract:BACKGROUND:The relationship between right ventricle (RV), extracellular matrix (ECM) fibrosis and fibrosis-linked, circulating microRNAs in dilated cardiomyopathy (DCM) is unknown. AIM:The aim of the study was to uncover the associations between serum markers of ECM metabolism and circulating microRNAs with RV morphol...
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abstract::Takotsubo syndrome (TTS) is still a relatively understudied and often undetected disease. It is usually preceded by emotional or physical triggers. We here report a case of TTS following a car accident. Typical apical ballooning with moderate reduction of left ventricular ejection fraction (LVEF) and increased level o...
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doi:
更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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