Abstract:
:Natural killer (NK) cells are the major innate effectors primed to eliminate virus-infected and tumor or neoplastic cells. Recent studies also suggest nuances in phenotypic and functional characteristics among NK cell subsets may further permit execution of regulatory and adaptive roles. Animal models, particularly non-human primate (NHP) models, are critical for characterizing NK cell biology in disease and under homeostatic conditions. In HIV infection, NK cells mediate multiple antiviral functions via upregulation of activating receptors, inflammatory cytokine secretion, and antibody dependent cell cytotoxicity through antibody Fc-FcR interaction and others. However, HIV infection can also reciprocally modulate NK cells directly or indirectly, leading to impaired/ineffective NK cell responses. In this review, we will describe multiple aspects of NK cell biology in HIV/SIV infections and their association with viral control and disease progression, and how NHP models were critical in detailing each finding. Further, we will discuss the effect of NK cell depletion in SIV-infected NHP and the characteristics of newly described memory NK cells in NHP models and different mouse strains. Overall, we propose that the role of NK cells in controlling viral infections remains incompletely understood and that NHP models are indispensable in order to efficiently address these deficits.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Manickam C,Shah SV,Nohara J,Ferrari G,Reeves RKdoi
10.3389/fimmu.2019.01124subject
Has Abstractpub_date
2019-05-22 00:00:00pages
1124issn
1664-3224journal_volume
10pub_type
杂志文章,评审abstract::Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in supernatants of in v...
journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2017.01946
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abstract::Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1), Th17, and regulatory T-cell (Treg) responses, throughout life. Although known to be the major cause of peptic ulcer disease and gastric cancer, disease occurs in a minority of thos...
journal_title:Frontiers in immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Frontiers in immunology
pub_type: 杂志文章
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2019.00746
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abstract::We previously reported that adiponectin (AD) promotes naïve T cell differentiation into Th17 cells and participates in synovial inflammation and the bone erosion process in patients with rheumatoid arthritis. Here, we use a T cell lineage adiponectin receptor 1 (AdipoR1) conditional knockout model to investigate the r...
journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2020.02040
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2015.00614
更新日期:2015-12-07 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2019.01532
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2019.00264
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2017.00081
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abstract::Bovine neonatal pancytopenia (BNP) was a vaccine-induced alloimmune disease observed in young calves and characterized by hemorrhages, pancytopenia, and severe destruction of the hematopoietic tissues. BNP was induced by alloreactive maternal antibodies present in the colostrum of certain cows vaccinated with a highly...
journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.01902
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2019.02327
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.00728
更新日期:2018-04-10 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2018.02467
更新日期:2018-10-24 00:00:00
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journal_title:Frontiers in immunology
pub_type: 临床试验,杂志文章
doi:10.3389/fimmu.2019.01405
更新日期:2019-06-26 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.01939
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.00890
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2014.00242
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2013.00304
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journal_title:Frontiers in immunology
pub_type:
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更新日期:2020-07-03 00:00:00
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pub_type: 杂志文章
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更新日期:2020-06-18 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2016.00583
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2016-11-23 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2019.01726
更新日期:2019-07-23 00:00:00