Corticotectal Projections From the Premotor or Primary Motor Cortex After Cortical Lesion or Parkinsonian Symptoms in Adult Macaque Monkeys: A Pilot Tracing Study.

Abstract:

:The corticotectal projections, together with the corticobulbar (corticoreticular) projections, work in parallel with the corticospinal tract (CST) to influence motoneurons in the spinal cord both directly and indirectly via the brainstem descending pathways. The tectospinal tract (TST) originates in the deep layers of the superior colliculus. In the present study, we analyzed the corticotectal projections from two motor cortical areas, namely the premotor cortex (PM) and the primary motor cortex (M1) in eight macaque monkeys subjected to either a cortical lesion of the hand area in M1 (n = 4) or Parkinson's disease-like symptoms PD (n = 4). A subgroup of monkeys with cortical lesion was subjected to anti-Nogo-A antibody treatment whereas all PD monkeys were transplanted with Autologous Neural Cell Ecosystems (ANCEs). The anterograde tracer BDA was used to label the axonal boutons both en passant and terminaux in the ipsilateral superior colliculus. Individual axonal boutons were charted in the different layers of the superior colliculus. In intact animals, we previously observed that corticotectal projections were denser when originating from PM than from M1. In the present M1 lesioned monkeys, as compared to intact ones the corticotectal projection originating from PM was decreased when treated with anti-Nogo-A antibody but not in untreated monkeys. In PD-like symptoms' monkeys, on the other hand, there was no consistent change affecting the corticotectal projection as compared to intact monkeys. The present pilot study overall suggests that the corticotectal projection is less affected by M1 lesion or PD symptoms than the corticoreticular projection previously reported in the same animals.

journal_name

Front Neuroanat

authors

Fregosi M,Contestabile A,Badoud S,Borgognon S,Cottet J,Brunet JF,Bloch J,Schwab ME,Rouiller EM

doi

10.3389/fnana.2019.00050

subject

Has Abstract

pub_date

2019-05-22 00:00:00

pages

50

issn

1662-5129

journal_volume

13

pub_type

杂志文章
  • A stereological study of synapse number in the epileptic human hippocampus.

    abstract::Hippocampal sclerosis is the most frequent pathology encountered in resected mesial temporal structures from patients with intractable temporal lobe epilepsy (TLE). Here, we have used stereological methods to compare the overall density of synapses and neurons between non-sclerotic and sclerotic hippocampal tissue obt...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2011.00008

    authors: Alonso-Nanclares L,Kastanauskaite A,Rodriguez JR,Gonzalez-Soriano J,Defelipe J

    更新日期:2011-02-24 00:00:00

  • Alterations in dendrite and spine morphology of cortical pyramidal neurons in DISC1-binding zinc finger protein (DBZ) knockout mice.

    abstract::Dendrite and dendritic spine formation are crucial for proper brain function. DISC1-binding zinc finger protein (DBZ) was first identified as a Disrupted-In-Schizophrenia1 (DISC1) binding partner. DBZ is highly expressed in the cerebral cortex of developing and adult rodents and is involved in neurite formation, cell ...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00052

    authors: Koyama Y,Hattori T,Nishida T,Hori O,Tohyama M

    更新日期:2015-04-30 00:00:00

  • The Representation of White Matter in the Central Nervous System.

    abstract::The white matter of the central nervous system (CNS) is difficult to represent in anatomy because it is located predominantly "between" other anatomical entities. In a classic presentation, like a cross section of a brain segment, white matter is present and can be labeled adequately. Several appearances of the same e...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2018.00102

    authors: Baud R,Sprumont P,Ten Donkelaar HJ

    更新日期:2018-12-13 00:00:00

  • Barriers in the brain: resolving dendritic spine morphology and compartmentalization.

    abstract::Dendritic spines are micron-sized protrusions that harbor the majority of excitatory synapses in the central nervous system. The head of the spine is connected to the dendritic shaft by a 50-400 nm thin membrane tube, called the spine neck, which has been hypothesized to confine biochemical and electric signals within...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2014.00142

    authors: Adrian M,Kusters R,Wierenga CJ,Storm C,Hoogenraad CC,Kapitein LC

    更新日期:2014-12-04 00:00:00

  • Feed-forward and feedback projections of midbrain reticular formation neurons in the cat.

    abstract::Gaze changes involving the eyes and head are orchestrated by brainstem gaze centers found within the superior colliculus (SC), paramedian pontine reticular formation (PPRF), and medullary reticular formation (MdRF). The mesencephalic reticular formation (MRF) also plays a role in gaze. It receives a major input from t...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2013.00055

    authors: Perkins E,May PJ,Warren S

    更新日期:2014-01-10 00:00:00

  • Prepatterning and patterning of the thalamus along embryonic development of Xenopus laevis.

    abstract::Previous developmental studies of the thalamus (alar part of the diencephalic prosomere p2) have defined the molecular basis for the acquisition of the thalamic competence (preparttening), the subsequent formation of the secondary organizer in the zona limitans intrathalamica, and the early specification of two antero...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00107

    authors: Bandín S,Morona R,González A

    更新日期:2015-08-10 00:00:00

  • An In vivo Multi-Modal Structural Template for Neonatal Piglets Using High Angular Resolution and Population-Based Whole-Brain Tractography.

    abstract::An increasing number of applications use the postnatal piglet model in neuroimaging studies, however, these are based primarily on T1 weighted image templates. There is a growing need for a multimodal structural brain template for a comprehensive depiction of the piglet brain, particularly given the growing applicatio...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2016.00092

    authors: Zhong J,Chen DQ,Walker M,Waspe A,Looi T,Piorkowska K,Drake JM,Hodaie M

    更新日期:2016-09-27 00:00:00

  • Structural and Synaptic Organization of the Adult Reeler Mouse Somatosensory Neocortex: A Comparative Fine-Scale Electron Microscopic Study of Reeler With Wild Type Mice.

    abstract::The reeler mouse has been widely used to study various aspects of cortico- and synaptogenesis, but also as a model for several neurological and neurodegenerative disorders. In contrast to development, comparably little is known about the neuronal composition and synaptic organization of the adult reeler mouse neocorte...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2018.00080

    authors: Prume M,Rollenhagen A,Lübke JHR

    更新日期:2018-10-05 00:00:00

  • Pyramidal Neurons Are Not Generalizable Building Blocks of Cortical Networks.

    abstract::A key challenge in cortical neuroscience is to gain a comprehensive understanding of how pyramidal neuron heterogeneity across different areas and species underlies the functional specialization of individual neurons, networks, and areas. Comparative studies have been important in this endeavor, providing data relevan...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2017.00011

    authors: Luebke JI

    更新日期:2017-03-07 00:00:00

  • Dual transneuronal tracing in the rat entorhinal-hippocampal circuit by intracerebral injection of recombinant rabies virus vectors.

    abstract::Dual transneuronal tracing is a novel viral tracing methodology which employs two recombinant viruses, each expressing a different reporter protein. Peripheral injection of recombinant pseudorabies viruses has been used as a powerful method to define neurons that coordinate outputs to various peripheral targets of mot...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/neuro.05.001.2009

    authors: Ohara S,Inoue K,Yamada M,Yamawaki T,Koganezawa N,Tsutsui K,Witter MP,Iijima T

    更新日期:2009-01-19 00:00:00

  • Flexible Multi-Beam Light-Sheet Fluorescence Microscope for Live Imaging Without Striping Artifacts.

    abstract::The development of light-sheet fluorescence microscopy (LSFM) has greatly expanded the experimental capabilities in many biological and biomedical research fields, enabling for example live studies of murine and zebrafish neural activity or of cell growth and division. The key feature of the method is the selective il...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2019.00007

    authors: Sancataldo G,Gavryusev V,de Vito G,Turrini L,Locatelli M,Fornetto C,Tiso N,Vanzi F,Silvestri L,Pavone FS

    更新日期:2019-02-08 00:00:00

  • Spinogenesis and Pruning in the Anterior Ventral Inferotemporal Cortex of the Macaque Monkey: An Intracellular Injection Study of Layer III Pyramidal Cells.

    abstract::Pyramidal cells grow and mature at different rates among different cortical areas in the macaque monkey. In particular, differences across the areas have been reported in both the timing and magnitude of growth, branching, spinogenesis, and pruning in the basal dendritic trees of cells in layer III. Presently availabl...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2011.00042

    authors: Elston GN,Oga T,Okamoto T,Fujita I

    更新日期:2011-07-21 00:00:00

  • Cerebellum: links between development, developmental disorders and motor learning.

    abstract::The study of the links and interactions between development and motor learning has noticeable implications for the understanding and management of neurodevelopmental disorders. This is particularly relevant for the cerebellum which is critical for sensorimotor learning. The olivocerebellar pathway is a key pathway con...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2012.00001

    authors: Manto MU,Jissendi P

    更新日期:2012-01-23 00:00:00

  • Flexible and Stable Value Coding Areas in Caudate Head and Tail Receive Anatomically Distinct Cortical and Subcortical Inputs.

    abstract::Anatomically distinct areas within the basal ganglia encode flexible- and stable-value memories for visual objects (Hikosaka et al., 2014), but an important question remains: do they receive inputs from the same or different brain areas or neurons? To answer this question, we first located flexible and stable value-co...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2017.00106

    authors: Griggs WS,Kim HF,Ghazizadeh A,Costello MG,Wall KM,Hikosaka O

    更新日期:2017-11-24 00:00:00

  • Neuronal Organization of Deep Brain Opsin Photoreceptors in Adult Teleosts.

    abstract::Biological impacts of light beyond vision, i.e., non-visual functions of light, signify the need to better understand light detection (or photoreception) systems in vertebrates. Photopigments, which comprise light-absorbing chromophores bound to a variety of G-protein coupled receptor opsins, are responsible for visua...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2016.00048

    authors: Hang CY,Kitahashi T,Parhar IS

    更新日期:2016-04-27 00:00:00

  • Origin and Migration of Olfactory Cajal-Retzius Cells.

    abstract::Early telencephalic development involves the migration of diverse cell types that can be identified by specific molecular markers. Most prominent among them are Cajal-Retzius (CR) cells that emanate mainly from the cortical hem and to a lesser extent from rostrolateral, septal and caudo-medial regions. One additional ...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2017.00097

    authors: Frade-Pérez MD,Miquelajáuregui A,Varela-Echavarría A

    更新日期:2017-11-01 00:00:00

  • Distribution of vasotocin- and vasoactive intestinal peptide-like immunoreactivity in the brain of blue tit (Cyanistes coeruleus).

    abstract::Blue tits (Cyanistes coeruleus) are songbirds, used as model animals in numerous studies covering a wide field of research. Nevertheless, the distribution of neuropeptides in the brain of this avian species remains largely unknown. Here we present some of the first results on distribution of Vasotocine (AVT) and Vasoa...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00090

    authors: Montagnese CM,Székely T,Csillag A,Zachar G

    更新日期:2015-07-14 00:00:00

  • Expansion Light Sheet Microscopy Resolves Subcellular Structures in Large Portions of the Songbird Brain.

    abstract::Expansion microscopy and light sheet imaging (ExLSM) provide a viable alternative to existing tissue clearing and large volume imaging approaches. The analysis of intact volumes of brain tissue presents a distinct challenge in neuroscience. Recent advances in tissue clearing and light sheet microscopy have re-addresse...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2019.00002

    authors: Düring DN,Rocha MD,Dittrich F,Gahr M,Hahnloser RHR

    更新日期:2019-01-31 00:00:00

  • Hypothesis on the dual origin of the Mammalian subplate.

    abstract::The development of the mammalian neocortex relies heavily on subplate. The proportion of this cell population varies considerably in different mammalian species. Subplate is almost undetectable in marsupials, forms a thin, but distinct layer in mouse and rat, a larger layer in carnivores and big-brained mammals as pig...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2011.00025

    authors: Montiel JF,Wang WZ,Oeschger FM,Hoerder-Suabedissen A,Tung WL,García-Moreno F,Holm IE,Villalón A,Molnár Z

    更新日期:2011-04-07 00:00:00

  • Dogs Have the Most Neurons, Though Not the Largest Brain: Trade-Off between Body Mass and Number of Neurons in the Cerebral Cortex of Large Carnivoran Species.

    abstract::Carnivorans are a diverse group of mammals that includes carnivorous, omnivorous and herbivorous, domesticated and wild species, with a large range of brain sizes. Carnivory is one of several factors expected to be cognitively demanding for carnivorans due to a requirement to outsmart larger prey. On the other hand, l...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2017.00118

    authors: Jardim-Messeder D,Lambert K,Noctor S,Pestana FM,de Castro Leal ME,Bertelsen MF,Alagaili AN,Mohammad OB,Manger PR,Herculano-Houzel S

    更新日期:2017-12-12 00:00:00

  • Nonapeptides and the evolution of social group sizes in birds.

    abstract::Species-typical patterns of grouping have profound impacts on many aspects of physiology and behavior. However, prior to our recent studies in estrildid finches, neural mechanisms that titrate species-typical group-size preferences, independent of other aspects of social organization (e.g., mating system and parental ...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2011.00013

    authors: Goodson JL,Kingsbury MA

    更新日期:2011-03-02 00:00:00

  • Automatic Mitochondria Segmentation for EM Data Using a 3D Supervised Convolutional Network.

    abstract::Recent studies have supported the relation between mitochondrial functions and degenerative disorders related to ageing, such as Alzheimer's and Parkinson's diseases. Since these studies have exposed the need for detailed and high-resolution analysis of physical alterations in mitochondria, it is necessary to be able ...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2018.00092

    authors: Xiao C,Chen X,Li W,Li L,Wang L,Xie Q,Han H

    更新日期:2018-11-02 00:00:00

  • A comparison of manual neuronal reconstruction from biocytin histology or 2-photon imaging: morphometry and computer modeling.

    abstract::Accurate 3D reconstruction of neurons is vital for applications linking anatomy and physiology. Reconstructions are typically created using Neurolucida after biocytin histology (BH). An alternative inexpensive and fast method is to use freeware such as Neuromantic to reconstruct from fluorescence imaging (FI) stacks a...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2014.00065

    authors: Blackman AV,Grabuschnig S,Legenstein R,Sjöström PJ

    更新日期:2014-07-11 00:00:00

  • Some predictions of Rafael Lorente de Nó 80 years later.

    abstract::Rafael Lorente de Nó, the youngest of Santiago Ramón y Cajal disciples, was one of the last Century's more influential researches in neuroscience. This assay highlights two fundamental contributions of Rafael Lorente de Nó to neurobiology: the intrinsic organization of the mammalian cerebral cortex and the basic physi...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2014.00147

    authors: Larriva-Sahd JA

    更新日期:2014-12-03 00:00:00

  • Striatal spine plasticity in Parkinson's disease.

    abstract::Striatal dopamine (DA) denervation results in a significant loss of dendritic spines on medium spiny projection neurons in Parkinson's disease. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated parkinsonian monkeys, spines contacted either by cortical or thalamic glutamatergic terminals are severely affected on ...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2010.00133

    authors: Villalba RM,Smith Y

    更新日期:2010-12-10 00:00:00

  • Development of a highly sensitive immunohistochemical method to detect neurochemical molecules in formalin-fixed and paraffin-embedded tissues from autopsied human brains.

    abstract::Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase). We have developed an immunostaining method that is highly sensitive in detection of neurochemical antigens. Ou...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00022

    authors: Goto S,Morigaki R,Okita S,Nagahiro S,Kaji R

    更新日期:2015-03-03 00:00:00

  • Perinatal asphyxia results in altered expression of the hippocampal acylethanolamide/endocannabinoid signaling system associated to memory impairments in postweaned rats.

    abstract::Perinatal asphyxia (PA) is an obstetric complication that strongly affects the CNS. The endocannabinoid system (ECS) is a lipid transmitter system involved in several physiological processes including synaptic plasticity, neurogenesis, memory, and mood. Endocannabinoids, and other acylethanolamides (AEs) without endoc...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00141

    authors: Blanco E,Galeano P,Holubiec MI,Romero JI,Logica T,Rivera P,Pavón FJ,Suarez J,Capani F,Rodríguez de Fonseca F

    更新日期:2015-11-03 00:00:00

  • Parkinson's disease: animal models and dopaminergic cell vulnerability.

    abstract::Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the global population over 65 years of age. A hallmark feature of PD is the degeneration of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and the consequent striatal DA deficiency. Yet, the pathogenesis of PD re...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2014.00155

    authors: Blesa J,Przedborski S

    更新日期:2014-12-15 00:00:00

  • SAT1, A Glutamine Transporter, is Preferentially Expressed in GABAergic Neurons.

    abstract::Subsets of GABAergic neurons are able to maintain high frequency discharge patterns, which requires efficient replenishment of the releasable pool of GABA. Although glutamine is considered a preferred precursor of GABA, the identity of transporters involved in glutamine uptake by GABAergic neurons remains elusive. Mol...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/neuro.05.001.2010

    authors: Solbu TT,Bjørkmo M,Berghuis P,Harkany T,Chaudhry FA

    更新日期:2010-02-08 00:00:00

  • Neurons in the white matter of the adult human neocortex.

    abstract::The white matter (WM) of the adult human neocortex contains the so-called "interstitial neurons". They are most numerous in the superficial WM underlying the cortical gyri, and decrease in density toward the deep WM. They are morphologically heterogeneous. A subgroup of interstitial neurons display pyramidal-cell like...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/neuro.05.007.2009

    authors: Suárez-Solá ML,González-Delgado FJ,Pueyo-Morlans M,Medina-Bolívar OC,Hernández-Acosta NC,González-Gómez M,Meyer G

    更新日期:2009-06-09 00:00:00