WITHDRAWN: Maternal iodine supplements in areas of deficiency.

Abstract:

BACKGROUND:Iodine deficiency is the leading preventable cause of intellectual impairment in the world. Although iodine supplementation is generally considered to be safe, there is a possibility of high doses of iodine suppressing maternal thyroid function. OBJECTIVES:The objective of this review was to assess the effects of iodine supplementation before or during pregnancy in areas of iodine deficiency. SEARCH STRATEGY:We searched the Cochrane Pregnancy and Childbirth Group trials register. SELECTION CRITERIA:All acceptably controlled trials of maternal iodine supplementation during pregnancy with clinical outcomes. DATA COLLECTION AND ANALYSIS:Eligibility and trial quality were assessed by two reviewers. MAIN RESULTS:Three trials involving 1551 women were included. In two trials, iodine supplementation was associated with a statistically significant reduction in deaths during infancy and early childhood (relative risk 0.71, 95% confidence interval 0.56 to 0.90). Iodine supplementation was associated with decreased prevalence of endemic cretinism at the age of four years (relative risk 0.27, 95% confidence interval 0.12 to 0.60) and better psychomotor development scores between four to 25 months of age. AUTHORS' CONCLUSIONS:Iodine supplementation in a population with high levels of endemic cretinism results in an important reduction in the incidence of the condition with no apparent adverse effects.

authors

Mahomed K,Gülmezoglu AM

doi

10.1002/14651858.CD000135.pub2

subject

Has Abstract

pub_date

2007-07-18 00:00:00

pages

CD000135

issue

3

issn

1469-493X

pub_type

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