Genome Wide Association Study and Next Generation Sequencing: A Glimmer of Light Toward New Possible Horizons in Frontotemporal Dementia Research.

abstract：:The value of an object acquired by a particular action often determines the motivation to produce that action. Previous studies found neural signals related to the values of different objects or goods in the orbitofrontal cortex, while the values of outcomes expected from different actions are broadly represented in m...

journal_title：Frontiers in neuroscience

authors： Kim S,Cai X,Hwang J,Lee D

更新日期：2012-07-17 00:00:00

abstract：:Silver nano-particles (Ag-NPs) are becoming increasingly prevalent in consumer products as antibacterial agents. The increased use of Ag NP-enhanced products will almost certainly increase environmental silver levels, resulting in increased exposures and the potential for increased adverse reactions including neurotox...

journal_title：Frontiers in neuroscience

authors： Liu F,Mahmood M,Xu Y,Watanabe F,Biris AS,Hansen DK,Inselman A,Casciano D,Patterson TA,Paule MG,Slikker W Jr,Wang C

更新日期：2015-04-08 00:00:00

abstract：:Emerging evidence suggest an impaired endocannabinoid activity in the pathophysiology of binge eating disorder (BED). Herein, we investigated whether endocannabinoid tone could be modified as a consequence of dietary-induced binge eating in female rats. For this purpose, brain levels of the endocannabinoids anandamide...

journal_title：Frontiers in neuroscience

authors： Satta V,Scherma M,Piscitelli F,Usai P,Castelli MP,Bisogno T,Fratta W,Fadda P

更新日期：2018-02-02 00:00:00

abstract：:Cochlear implantation constitutes a successful therapy of inner ear deafness, with the majority of patients showing good outcomes. There is, however, still some unexplained variability in outcomes with a number of cochlear-implant (CI) users, showing major limitations in speech comprehension. The current study used a ...

journal_title：Frontiers in neuroscience

authors： Kessler M,Schierholz I,Mamach M,Wilke F,Hahne A,Büchner A,Geworski L,Bengel FM,Sandmann P,Berding G

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND:Some drugs of abuse down regulate the expression of cystine/glutamate (xCT) antiporter in the nucleus accumbens (Acb) after extinction or withdrawal. The altered level of xCT exchanger in Acb, a structure involved in ethanol reinforcement, may contribute to the pathological glutamatergic signaling, linked to...

journal_title：Frontiers in neuroscience

authors： Peana AT,Muggironi G,Bennardini F

更新日期：2014-10-06 00:00:00

abstract：:Background: Stress-induced cellular changes in limbic brain structures contribute to the development of various psychopathologies. In vivo detection of these microstructural changes may help us to develop objective biomarkers for psychiatric disorders. Diffusion tensor imaging (DTI) is an advanced neuroimaging techniq...

journal_title：Frontiers in neuroscience

authors： Nagy SA,Vranesics A,Varga Z,Csabai D,Bruszt N,Bali ZK,Perlaki G,Hernádi I,Berente Z,Miseta A,Dóczi T,Czéh B

更新日期：2020-06-03 00:00:00

abstract：:It was evidenced that impairment of calcium homeostasis is a potential mechanism in the development of Alzheimer's disease (AD). It remains, however, unclear how the calcium signaling are associated with in AD progression. Here we review recent studies to discuss the relationship among the signaling of intracellular c...

journal_title：Frontiers in neuroscience

authors： Wang JM,Sun C

更新日期：2010-12-02 00:00:00

abstract：:A new paradigm in neuroscience has recently emerged - the brain-gut axis (BGA). The contemporary focus in this paradigm has been gut → brain ("bottom-up"), in which the gut-microbiome, and its perturbations, affects one's psychological state-of-mind and behavior, and is pivotal in neurodegenerative disorders. The emer...

journal_title：Frontiers in neuroscience

authors： Isaiah S,Loots DT,Solomons R,van der Kuip M,Tutu Van Furth AM,Mason S

更新日期：2020-04-21 00:00:00

abstract：OBJECTIVES:The thickness of the brain's cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic a...

journal_title：Frontiers in neuroscience

authors： Kochunov P,Glahn DC,Nichols TE,Winkler AM,Hong EL,Holcomb HH,Stein JL,Thompson PM,Curran JE,Carless MA,Olvera RL,Johnson MP,Cole SA,Kochunov V,Kent J,Blangero J

更新日期：2011-10-19 00:00:00

abstract：:Gene editing is an attractive potential treatment of inherited retinopathies. However, it often relies on endogenous DNA repair. Retinal DNA repair is incompletely characterized in humans and animal models. We investigated recruitment of the double stranded break (DSB) repair complex of γH2AX and 53bp1 in both develop...

journal_title：Frontiers in neuroscience

authors： Müller B,Ellinwood NM,Lorenz B,Stieger K

更新日期：2018-05-01 00:00:00

abstract：:Psychiatric disorders represent a great medical and social challenge and people suffering from these conditions face many impairments regarding personal and professional life. In addition, a mental disorder will manifest itself in approximately one quarter of the world's population at some period of their life. Dysfun...

journal_title：Frontiers in neuroscience

authors： Zuccoli GS,Saia-Cereda VM,Nascimento JM,Martins-de-Souza D

更新日期：2017-09-07 00:00:00

abstract：:The diagnosis of multiple sclerosis (MS) is usually based on clinical symptoms and signs of damage to the central nervous system, which is assessed using magnetic resonance imaging. The correct interpretation of these data requires excellent clinical expertise and experience. Deep neural networks aim to assist clinici...

journal_title：Frontiers in neuroscience

authors： Lopatina A,Ropele S,Sibgatulin R,Reichenbach JR,Güllmar D

更新日期：2020-12-18 00:00:00

abstract：Background:The mechanism of post-stroke cognitive impairment (PSCI) has not been explained. We aimed to investigate whether miR-let-7i participates in the PSCI and illuminates its underlying role in oxygen-glucose deprivation (OGD)-induced cell apoptosis. Methods:Blood samples from 36 subjects with PSCI and 38 with po...

journal_title：Frontiers in neuroscience

authors： Wang ZQ,Li K,Huang J,Huo TT,Lv PY

更新日期：2020-03-24 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) has been shown to affect motor and cognitive task performance and learning when applied to brain areas involved in the task. Targeted stimulation has also been found to alter connectivity within the stimulated hemisphere during rest. However, the connectivity effect of th...

journal_title：Frontiers in neuroscience

authors： Baxter BS,Edelman BJ,Sohrabpour A,He B

更新日期：2017-12-07 00:00:00

abstract：:Intermittent theta burst stimulation (iTBS), a patterned repetitive transcranial magnetic stimulation, was applied over the posterior superior temporal sulcus (pSTS) or dorsolateral prefrontal cortex (DLPFC) to explore its impact in adults with autism spectrum disorder (ASD). Among 25 adults with ASD, 19 (mean age: 20...

journal_title：Frontiers in neuroscience

authors： Ni HC,Hung J,Wu CT,Wu YY,Chang CJ,Chen RS,Huang YZ

更新日期：2017-05-09 00:00:00

abstract：:There is a need for reliable and objective measures of early and mild symptomology in multiple sclerosis (MS), as deficits can be subtle and difficult to quantify objectively in patients without overt physical deficits. We hypothesized that a speech-in-noise (SiN) task would be sensitive to demyelinating effects on pr...

journal_title：Frontiers in neuroscience

authors： Iva P,Fielding J,Clough M,White O,Godic B,Martin R,Rajan R

更新日期：2020-12-23 00:00:00

abstract：:It is known that olfaction is essential for the occurrence of sexual behavior in male goldfish. Sex pheromones from ovulatory females elicit male sexual behavior, chasing, and sperm releasing act. In female goldfish, ovarian prostaglandin F2α (PGF) elicits female sexual behavior, egg releasing act. It has been conside...

journal_title：Frontiers in neuroscience

authors： Kawaguchi Y,Nagaoka A,Kitami A,Mitsuhashi T,Hayakawa Y,Kobayashi M

更新日期：2014-04-30 00:00:00

abstract：:Resting-state functional magnetic resonance imaging (rsfMRI) is being widely used for charting brain connectivity and dynamics in healthy and diseased brains. However, the resting state paradigm allows an unconstrained fluctuation of brain arousal, which may have profound effects on resting-state fMRI signals and asso...

journal_title：Frontiers in neuroscience

authors： Gu Y,Han F,Liu X

更新日期：2019-11-05 00:00:00

abstract：:There is increasing evidence of associations between the presence of temporomandibular joint (TMJ) disorders and tinnitus. It has been recently proposed that tinnitus patients with TMJ complaints could constitute a subtype, meaning a subgroup of tinnitus patients responsive to specific treatments. Tinnitus patients wi...

journal_title：Frontiers in neuroscience

authors： Edvall NK,Gunan E,Genitsaridi E,Lazar A,Mehraei G,Billing M,Tullberg M,Bulla J,Whitton J,Canlon B,Hall DA,Cederroth CR

更新日期：2019-08-22 00:00:00

abstract：:This paper presents a unique approach for wavelet-based MRI brain image de-noising. Adaptive soft and hard threshold functions are first proposed to improve the results of standard soft and hard threshold functions for image de-noising in the wavelet domain. Then, we applied the newly emerged improved adaptive general...

journal_title：Frontiers in neuroscience

authors： Amiri Golilarz N,Gao H,Kumar R,Ali L,Fu Y,Li C

更新日期：2020-07-22 00:00:00

abstract：:Recent studies have shown that synaptic unreliability is a robust and sufficient mechanism for inducing the stochasticity observed in cortex. Here, we introduce Synaptic Sampling Machines (S2Ms), a class of neural network models that uses synaptic stochasticity as a means to Monte Carlo sampling and unsupervised learn...

journal_title：Frontiers in neuroscience

authors： Neftci EO,Pedroni BU,Joshi S,Al-Shedivat M,Cauwenberghs G

更新日期：2016-06-29 00:00:00

abstract：:Introduction: The presence of a temporomandibular disorder is one of the most frequent causes of orofacial pain (OFP). When pain continues beyond tissue healing time, it becomes chronic and may be caused, among other factors, by the sensitization of higher-order neurons. The aim of this study is to describe psychologi...

journal_title：Frontiers in neuroscience

authors： Baroni A,Severini G,Straudi S,Buja S,Borsato S,Basaglia N

更新日期：2020-11-12 00:00:00

abstract：:Stimulation of the pineal gland via its sympathetic innervation pathway results in the production of N-acetylserotonin and melatonin. Melatonin has many therapeutic roles and is heavily implicated in the regulation of the sleep-wake cycle. In addition, N-acetylserotonin has recently been reported to promote neurogenes...

journal_title：Frontiers in neuroscience

authors： Lumsden SC,Clarkson AN,Cakmak YO

更新日期：2020-04-02 00:00:00

abstract：:Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient Intensive Language-Action Therapy (ILAT, previously CIAT or CI...

journal_title：Frontiers in neuroscience

authors： Heikkinen PH,Pulvermüller F,Mäkelä JP,Ilmoniemi RJ,Lioumis P,Kujala T,Manninen RL,Ahvenainen A,Klippi A

更新日期：2019-02-04 00:00:00

abstract：:Experiment was carried out to study the proprioception accuracy of elderly (61-83 years old) and young (22-36 years old) subjects during contralateral elbow matching in sagittal plane. The subjects performed the task under ordinary condition and under experimental condition (matching forearm attached to the rocking cy...

journal_title：Frontiers in neuroscience

authors： Talis VL,Levik YS

更新日期：2016-11-16 00:00:00

abstract：:We review the role of oscillations in the brain and in the auditory system showing that the ability of humans to distinguish changes in pitch can be explained as a precise analysis of temporal information in auditory signals by neural oscillations. The connections between auditory brain stem chopper neurons construct ...

journal_title：Frontiers in neuroscience

authors： Bahmer A,Gupta DS

更新日期：2018-10-31 00:00:00

abstract：:Chronic exposure to alcohol produces adaptations within the basolateral amygdala (BLA) that are associated with the development of anxiety-like behaviors during withdrawal. In part, these adaptations are mediated by plasticity in glutamatergic synapses occurring through an AMPA receptor mediated form of post-synaptic ...

journal_title：Frontiers in neuroscience

authors： Gioia DA,Alexander N,McCool BA

更新日期：2017-07-21 00:00:00

abstract：:Brain state classification for communication and control has been well established in the area of brain-computer interfaces over the last decades. Recently, the passive and automatic extraction of additional information regarding the psychological state of users from neurophysiological signals has gained increased att...

journal_title：Frontiers in neuroscience

authors： Hettich DT,Bolinger E,Matuz T,Birbaumer N,Rosenstiel W,Spüler M

更新日期：2016-06-10 00:00:00

abstract：:We performed this study to investigate the possibility of a definitive pattern of Galectin-3 (Gal-3) expression in the cerebrospinal fluid (CSF) and serum of Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS) patients. In our study, we collected the CSF and serum samples of 31 AD patients, 19 ALS patient...

journal_title：Frontiers in neuroscience

authors： Ashraf GM,Baeesa SS

更新日期：2018-06-29 00:00:00

abstract：:Numerous observational studies have shown that depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have a higher rate of progress to dementia. However, it is still uncertain whether there are any differences between MCI patients with and without depression symptom in their brain func...

journal_title：Frontiers in neuroscience

authors： Yu Y,Li Z,Lin Y,Yu J,Peng G,Zhang K,Jia X,Luo B

更新日期：2019-12-17 00:00:00