The Epigenomics of Pituitary Adenoma.

Abstract:

:Background: The vast majority of pituitary tumors are benign and behave accordingly; however, a fraction are invasive and are more aggressive, with a very small fraction being frankly malignant. The cellular pathways that drive transformation in pituitary neoplasms are poorly characterized, and current classification methods are not reliable correlates of clinical behavior. Novel techniques in epigenetics, the study of alterations in gene expression without changes to the genetic code, provide a new dimension to characterize tumors, and may hold implications for prognostication and management. Methods: We conducted a review of primary epigenetic studies of pituitary tumors with a focus on histone modification, DNA methylation, and transcript modification. Results: High levels of methylation have been identified in invasive and large pituitary tumors. DNA methyltransferase overexpression has been detected in pituitary tumors, especially in macroadenomas. Methylation differences at CpG sites in promoter regions may distinguish several types of tumors from normal pituitary tissue. Histone modifications have been linked to increased p53 expression and longer progression-free survival in pituitary tumors; sirtuins are expressed at higher values in GH-expressing compared to nonfunctional adenomas and correlate inversely with size in somatotrophs. Upregulation in citrullinating enzymes may be an early pathogenic marker of prolactinomas. Numerous genes involved with cell growth and signaling show altered methylation status for pituitary tumors, including cell cycle regulators, components of signal transduction pathways, apoptotic regulators, and pituitary developmental signals. Conclusions: The limited clinical predictive capacity of the current pituitary tumor classification system suggests that tumor subclasses likely remain to be discovered. Ongoing epigenetic studies could provide a basis for adding methylation and/or acetylation screening to standard pituitary tumor workups. Identifying robust correlations between tumor epigenetics and corresponding histological, radiographic, and clinical course information could ultimately inform clinical decision-making.

authors

Hauser BM,Lau A,Gupta S,Bi WL,Dunn IF

doi

10.3389/fendo.2019.00290

subject

Has Abstract

pub_date

2019-05-14 00:00:00

pages

290

issn

1664-2392

journal_volume

10

pub_type

杂志文章,评审
  • NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons.

    abstract::Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the development of obesity, in part, by targeting the hypothalamus. Palmitate, the most abun...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00351

    authors: Tran A,He W,Jiang N,Chen JTC,Belsham DD

    更新日期:2020-06-12 00:00:00

  • Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton.

    abstract::Estetrol (E4) is a natural human estrogen present at high concentrations during pregnancy. Due to its high oral bioavailability and long plasma half-life, E4 is particularly suitable for therapeutic applications. E4 acts as a selective estrogen receptor (ER) modulator, exerting estrogenic actions on the endometrium or...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2014.00080

    authors: Giretti MS,Montt Guevara MM,Cecchi E,Mannella P,Palla G,Spina S,Bernacchi G,Di Bello S,Genazzani AR,Genazzani AD,Simoncini T

    更新日期:2014-05-26 00:00:00

  • Protease-Activated Receptors in the Intestine: Focus on Inflammation and Cancer.

    abstract::Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR) family. Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically soluble ligands able to induce their activation. Indeed, PARs are physiologically activated after proteolytic cleavage of their N-terminal...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00717

    authors: Sébert M,Sola-Tapias N,Mas E,Barreau F,Ferrand A

    更新日期:2019-10-24 00:00:00

  • The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women.

    abstract::Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action. Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3',5'-tri-iodothyronine; rT3) in two studies ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00698

    authors: Sathyapalan T,Köhrle J,Rijntjes E,Rigby AS,Dargham SR,Kilpatrick ES,Atkin SL

    更新日期:2018-11-22 00:00:00

  • Behavioral Abnormalities in Knockout and Humanized Tau Mice.

    abstract::Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervou...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00124

    authors: Gonçalves RA,Wijesekara N,Fraser PE,De Felice FG

    更新日期:2020-03-12 00:00:00

  • Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From in vitro and in vivo Studies.

    abstract::Spinal cord injuries (SCIs) represent a variety of conditions related to the damage of the spinal cord with consequent musculoskeletal repercussions. The bone and muscle tissues share several catabolic pathways that lead to variable degrees of disability in SCI patients. In this review article, we provide a comprehens...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00204

    authors: Invernizzi M,de Sire A,Renò F,Cisari C,Runza L,Baricich A,Carda S,Fusco N

    更新日期:2020-04-15 00:00:00

  • Oxidative Phosphorylation Impairment by DDT and DDE.

    abstract::There is increasing evidence supporting the characterization of the pesticide DDT and its metabolite, DDE, as obesogens and metabolic disruptors. Elucidating the mechanism is critical to understanding whether the association of DDT and DDE with obesity and diabetes is in fact causal. One area of research investigating...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00122

    authors: Elmore SE,La Merrill MA

    更新日期:2019-03-12 00:00:00

  • Anti-Obesity Effect of Dictyophora indusiata Mushroom Polysaccharide (DIP) in High Fat Diet-Induced Obesity via Regulating Inflammatory Cascades and Intestinal Microbiome.

    abstract::Obesity is a multifactorial metabolic disorder characterized by low-grade chronic inflammation, hyper-permeability of the gut epithelium, and perturbation of the intestinal microbiome. Despite the numerous therapeutic efficacies of Dictyophora indusiata mushroom, its biological activity in alleviating obesity through ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.558874

    authors: Kanwal S,Aliya S,Xin Y

    更新日期:2020-11-19 00:00:00

  • Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7.

    abstract::SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, such as ribosome biogenesis, gene expression, cellular metabolism and c...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00652

    authors: Wu D,Li Y,Zhu KS,Wang H,Zhu WG

    更新日期:2018-11-19 00:00:00

  • The Effects of Soy Protein and Cocoa With or Without Isoflavones on Glycemic Control in Type 2 Diabetes. A Double-Blind, Randomized, Placebo-Controlled Study.

    abstract::Objective: Soy and cocoa have been suggested to be beneficial for diabetes. The aim of this study was to identify the effects of soy protein, isoflavones, and cocoa on glycemic control parameters. Research design and methods: The study was a parallel, double-blind, placebo-controlled study where patients with diet or ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00296

    authors: Konya J,Sathyapalan T,Kilpatrick ES,Atkin SL

    更新日期:2019-05-09 00:00:00

  • A Short-Day Photoperiod Delays the Timing of Puberty in Female Mice via Changes in the Kisspeptin System.

    abstract::The reproduction of seasonal breeders is modulated by exposure to light in an interval of 24 h defined as photoperiod. The interruption of reproductive functions in seasonally breeding rodents is accompanied by the suppression of the Kiss1 gene expression, which is known to be essential for reproduction. In non-season...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00044

    authors: Bohlen TM,Silveira MA,Buonfiglio DDC,Ferreira-Neto HC,Cipolla-Neto J,Donato J Jr,Frazao R

    更新日期:2018-02-20 00:00:00

  • Corrigendum: The Gambian Bone and Muscle Ageing Study: Baseline Data From a Prospective Observational African Sub-Saharan Study.

    abstract::[This corrects the article on p. 219 in vol. 8, PMID: 28912754.]. ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fendo.2018.00160

    authors: Zengin A,Fulford AJ,Sawo Y,Jarjou LM,Schoenmakers I,Goldberg G,Prentice A,Ward KA

    更新日期:2018-04-16 00:00:00

  • Small Ubiquitin-Like Modifier 4 (SUMO4) Gene M55V Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis Including 6,823 Subjects.

    abstract:Background:Many studies suggest that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter. Objective and methods:A meta-analysis co...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2017.00303

    authors: Li YY,Wang H,Yang XX,Geng HY,Gong G,Kim HJ,Zhou YH,Wu JJ

    更新日期:2017-11-02 00:00:00

  • Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.

    abstract::This review focuses on the biologic importance of the vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. Nearly all DBP is produced in the liver, where its regulation is influenced by estrogen, glucocorticoids and inflammatory c...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00317

    authors: Bikle DD,Schwartz J

    更新日期:2019-05-28 00:00:00

  • Evaluation of the Possibility to Detect Circulating Tumor DNA From Pituitary Adenoma.

    abstract::Objective: Circulating free DNA (cfDNA) in general and circulating tumor DNA (ctDNA) in particular is becoming an increasingly used form of liquid biopsy biomarkers. In this study, we are investigating the ability to detect ctDNA from the plasma of pituitary adenoma (PA) patients. Design: Tumor tissue samples were obt...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00615

    authors: Megnis K,Peculis R,Rovite V,Laksa P,Niedra H,Balcere I,Caune O,Breiksa A,Nazarovs J,Stukens J,Konrade I,Pirags V,Klovins J

    更新日期:2019-09-18 00:00:00

  • Zebrafish for Personalized Regenerative Medicine; A More Predictive Humanized Model of Endocrine Disease.

    abstract::Regenerative medicine is a multidisciplinary field that aims to determine different factors and develop various methods to regenerate impaired tissues, organs, and cells in the disease and impairment conditions. When treatment procedures are specified according to the individual's information, the leading role of pers...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00396

    authors: Arjmand B,Tayanloo-Beik A,Foroughi Heravani N,Alaei S,Payab M,Alavi-Moghadam S,Goodarzi P,Gholami M,Larijani B

    更新日期:2020-07-17 00:00:00

  • Mini Nutritional Assessment Scores Indicate Higher Risk for Prospective Mortality and Contrasting Correlation With Age-Related Epigenetic Biomarkers.

    abstract::The plasticity of the individual epigenetic landscape that goes to countless rearrangements throughout life is closely the reflection of environmental factors such as chemical exposure, socio-economic status and nutrient intakes both early and late in life. The Mini Nutritional Assessment (MNA) is a well-validated too...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00672

    authors: Montesanto A,D'Aquila P,Rossano V,Passarino G,Bellizzi D

    更新日期:2019-10-01 00:00:00

  • Endothelin Type A Receptor Genotype is a Determinant of Quantitative Traits of Metabolic Syndrome in Asian Hypertensive Families: A SAPPHIRe Study.

    abstract::Co-heritability of hypertension and insulin resistance (IR) within families not only implies genetic susceptibility may be responsible for these complex traits but also suggests a rational that biological candidate genes for hypertension may serve as markers for features of the metabolic syndrome (MetS). Thus we deter...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2013.00172

    authors: Ho LT,Hsu YP,Hsiao CF,Ting CT,Shih KC,Chuang LM,Masaki K,Grove J,Quertermous T,Juan CC,Lin MW,Chiang SC,Chen YD

    更新日期:2013-11-28 00:00:00

  • Differentiated Thyroid Carcinoma in Pediatric Age: Genetic and Clinical Scenario.

    abstract::Introduction: Follicular-derived differentiated thyroid carcinoma (DTC) is the most common endocrine and epithelial malignancy in children. The differences in the clinical and pathological features of pediatric vs. adult DTC could relate to a different genetic profile. Few studies are currently available in this issue...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00552

    authors: Galuppini F,Vianello F,Censi S,Barollo S,Bertazza L,Carducci S,Colato C,Manso J,Rugge M,Iacobone M,Watutantrige Fernando S,Pennelli G,Mian C

    更新日期:2019-08-07 00:00:00

  • Incretin hormones as immunomodulators of atherosclerosis.

    abstract::Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00112

    authors: Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

    更新日期:2012-09-07 00:00:00

  • Therapeutic Irradiation: Consequences for Bone and Bone Marrow Adipose Tissue.

    abstract::Radiotherapy continues to be one of the most accepted medical treatments for cancer. Localized irradiation is the most common treatment for prostate, pancreatic, rectal, cervical and endometrial malignancies. Conventional localized fractions are total doses of 30-62Gy at 1.8-2Gy per fraction, with administration of ~6...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00587

    authors: Costa S,Reagan MR

    更新日期:2019-08-29 00:00:00

  • Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland-Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist C

    abstract:Introduction:Vitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professi...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00246

    authors: Rusińska A,Płudowski P,Walczak M,Borszewska-Kornacka MK,Bossowski A,Chlebna-Sokół D,Czech-Kowalska J,Dobrzańska A,Franek E,Helwich E,Jackowska T,Kalina MA,Konstantynowicz J,Książyk J,Lewiński A,Łukaszkiewicz J,Marcinowska

    更新日期:2018-05-31 00:00:00

  • Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency.

    abstract:Objective:The aim of this study is to evaluate the effect of growth hormone therapy (rGH) on mitochondrial function on peripheral muscle and to correlate with exercise capacity in subjects with severe adult growth hormone deficiency (GHD). Design:Six months, double-blind, randomized, crossover, placebo-controlled tria...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00056

    authors: Gonzalez S,Sathyapalan T,Javed Z,Atkin SL

    更新日期:2018-02-23 00:00:00

  • Effects of physiological levels of the green tea extract epigallocatechin-3-gallate on breast cancer cells.

    abstract::Physiological concentrations of the green tea extract epigallocatechin-3-gallate (EGCG) caused growth inhibition in estrogen receptor α (ERα)-positive MCF7 cells that was associated with down-regulation of the ERα and reduced insulin-like growth factor binding protein-2 abundance and increased protein abundance of the...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2014.00061

    authors: Zeng L,Holly JM,Perks CM

    更新日期:2014-05-07 00:00:00

  • Steroids and Brain, a Rising Bio-Medical Domain: a Perspective.

    abstract::Some newly described steroid-related compounds, also found in the rest of the body, are formed and active in the central nervous system, particularly in the brain. Some are of pharmacological and physiopathological interest. We specifically report on two compounds, "MAP4343," a new neurosteroid very efficient antidepr...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00316

    authors: Baulieu EE

    更新日期:2018-06-15 00:00:00

  • A Novel Multimodal Therapy for Anaplastic Thyroid Carcinoma: 125 I Seed Implantation Plus Apatinib After Surgery.

    abstract::Anaplastic thyroid cancer is known to be the most lethal malignancy among endocrine tumors for its extremely limited survival rate after diagnosis. As a result of this poor survival prognosis, multimodal therapy is currently under investigation to address this global concern. In this reported case, the 125I seed impla...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2020.00207

    authors: Niu Y,Ding Z,Deng X,Guo B,Kang J,Wu B,Fan Y

    更新日期:2020-04-22 00:00:00

  • The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of Carotid Intima-Media Thickness in Patients With Type 2 Diabetes.

    abstract::Background: Chronic inflammatory disorders and dyslipidemia in type 2 diabetes mellitus (T2DM) are essential contributors to the development of atherosclerotic cardiovascular disease. Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel and simple measure associated positively with the body ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00191

    authors: Chen JW,Li C,Liu ZH,Shen Y,Ding FH,Shu XY,Zhang RY,Shen WF,Lu L,Wang XQ

    更新日期:2019-04-04 00:00:00

  • Adiponectin, Leptin and Visfatin in Hypoxia and its Effect for Weight Loss in Obesity.

    abstract::Rationale: Hypoxia induces leptin gene expression in human adipocytes via hypoxia-inducible factors (HIF-α/β). Under ambient moderate hypoxia, leptin in adipocytes is elevated for at least 14 days. Leptin is supposedly involved in the reduced food intake, increased utilization of fatty acids for energy production and ...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2018.00615

    authors: Rausch LK,Hofer M,Pramsohler S,Kaser S,Ebenbichler C,Haacke S,Gatterer H,Netzer NC

    更新日期:2018-10-18 00:00:00

  • Re-Evaluation of the PBAN Receptor Molecule: Characterization of PBANR Variants Expressed in the Pheromone Glands of Moths.

    abstract::Sex pheromone production in most moths is initiated following pheromone biosynthesis activating neuropeptide receptor (PBANR) activation. PBANR was initially cloned from pheromone glands (PGs) of Helicoverpa zea and Bombyx mori. The B. mori PBANR is characterized by a relatively long C-terminus that is essential for l...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00006

    authors: Lee JM,Hull JJ,Kawai T,Goto C,Kurihara M,Tanokura M,Nagata K,Nagasawa H,Matsumoto S

    更新日期:2012-01-24 00:00:00

  • High-Intensity Interval Training Is Equivalent to Moderate-Intensity Continuous Training for Short- and Medium-Term Outcomes of Glucose Control, Cardiometabolic Risk, and Microvascular Complication Markers in Men With Type 2 Diabetes.

    abstract::We sought to determine the efficacy of 12 weeks high-intensity interval training (HIIT), compared to moderate-intensity continuous training (MICT) on glucose control, cardiometabolic risk and microvascular complication markers in men living with type 2 diabetes (T2D). Both modalities were combined with resistance trai...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00475

    authors: Wormgoor SG,Dalleck LC,Zinn C,Borotkanics R,Harris NK

    更新日期:2018-08-28 00:00:00