Abstract:
:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role of antinuclear antibodies and autoreactive T cells in SLE, extensive efforts have been made to demonstrate how B cells act as antibody-producing or as antigen-presenting cells that can prime autoreactive T cell activation. With the discovery of new innate immune cells and inflammatory mediators, innate immunity is emerging as a key player in disease pathologies. Recent work over the last decade has highlighted the importance of innate immune cells and molecules in promoting and potentiating SLE. In this review, we discuss recent evidence of the involvement of different innate immune cells and pathways in the pathogenesis of SLE. We also discuss new therapeutics targets directed against innate immune components as potential novel therapies in SLE.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Herrada AA,Escobedo N,Iruretagoyena M,Valenzuela RA,Burgos PI,Cuitino L,Llanos Cdoi
10.3389/fimmu.2019.00772subject
Has Abstractpub_date
2019-04-15 00:00:00pages
772issn
1664-3224journal_volume
10pub_type
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