Longitudinal 18F-FDG PET and MRI Reveal Evolving Imaging Pathology That Corresponds to Disease Progression in a Patient With ALS-FTD.

abstract：:There is currently no therapeutic drug treatment for traumatic brain injury (TBI) despite decades of experimental clinical trials. This may be because the mechanistic pathways for improving TBI outcomes have yet to be identified and exploited. As such, there remains a need to seek out new molecular targets and their d...

journal_title：Frontiers in neurology

authors： Hook G,Jacobsen JS,Grabstein K,Kindy M,Hook V

更新日期：2015-09-02 00:00:00

abstract：:Introduction: Parkinson's disease (PD) is a neurodegenerative disorder affecting a substantial proportion of the elderly Cypriot population. The objective of this study was to evaluate PD risk variants that have been identified previously in Genome Wide Association Studies (GWAS) and to find environmental factors that...

journal_title：Frontiers in neurology

authors： Georgiou A,Demetriou CA,Christou YP,Heraclides A,Leonidou E,Loukaides P,Yiasoumi E,Pantziaris M,Kleopa KA,Papacostas SS,Loizidou MA,Hadjisavvas A,Zamba-Papanicolaou E

更新日期：2019-10-17 00:00:00

abstract：:Extracellular vesicles (EVs) are involved in the development and progression of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. Moreover, EVs have the capacity to modify the physiology of neuronal circuits by transferring proteins, RNA, lipids, and metabolites. The proteomic characterization...

journal_title：Frontiers in neurology

authors： Quiroz-Baez R,Hernández-Ortega K,Martínez-Martínez E

更新日期：2020-12-11 00:00:00

abstract：:Background: Discharge planning of stroke patients during inpatient neurorehabilitation is often difficult since it depends both on the patient's ability to perform activities of daily living (ADL) and the social context. The aim of this study was to define ADL cut-off scores using the Lucerne ICF-based multidisciplina...

journal_title：Frontiers in neurology

authors： Ottiger B,Lehnick D,Pflugshaupt T,Vanbellingen T,Nyffeler T

更新日期：2020-11-25 00:00:00

abstract：:Background: Measuring cognitive functioning is common in traumatic brain injury (TBI) research, but no universally accepted method for combining several neuropsychological test scores into composite, or summary, scores exists. This study examined several possible composite scores for the test battery used in the large...

journal_title：Frontiers in neurology

authors： Stenberg J,Karr JE,Terry DP,Saksvik SB,Vik A,Skandsen T,Silverberg ND,Iverson GL

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND:An estimated 30-50% of essential tremor (ET) diagnoses are incorrect, and the true diagnosis in those patients is often Parkinson's disease (PD) or other tremor disorders. There are general statements about the tremor in these ET and PD, but published data on the more subtle characteristics of tremor are sur...

journal_title：Frontiers in neurology

authors： Sternberg EJ,Alcalay RN,Levy OA,Louis ED

更新日期：2013-05-10 00:00:00

abstract：:Objective: Hemorrhagic transformation (HT) in ischemic moyamoya disease (MMD), reasonably defined as hemorrhage events in patients with ischemic onset manifestation, leads to a poor outcome. This study aims to reveal factors associated with HT in patients with ischemic onset manifestation and to assess the outcome of ...

journal_title：Frontiers in neurology

authors： Lu J,Li Z,Zhao Y,Chen X,Shi G,Zhao J

更新日期：2020-06-25 00:00:00

abstract：:The combination of phasic and tonic neuromuscular processes are involved in the maintenance of normal upright posture. The latter is of particular importance in some pathologies, such as Parkinson's Disease (PD), which is known by one of its cardinal symptoms-tonic dysfunction (i.e., rigidity). Changes in tonic functi...

journal_title：Frontiers in neurology

authors： Wright WG

更新日期：2019-01-21 00:00:00

abstract：:Traumatic brain injury is the leading cause of death in children. Children with severe TBI are in need of neurointensive care where the goal is to prevent secondary brain injury by avoiding secondary insults. Monitoring of cerebral blood flow (CBF) and autoregulation in the injured brain is crucial. However, there are...

journal_title：Frontiers in neurology

authors： Rostami E,Nilsson P,Enblad P

更新日期：2020-04-16 00:00:00

abstract：:While the spread of some neurodegenerative disease-associated proteinopathies, such as tau and α-synuclein, is well studied and clearly implicates transsynaptic pathology transmission, research into the progressive spread of amyloid-β pathology has been less clear. In fact, prior analyses of transregional amyloid-β pa...

journal_title：Frontiers in neurology

authors： Mezias C,Raj A

更新日期：2017-12-18 00:00:00

abstract：:Cerebral stroke is a leading cause of death and persistent disability of elderly in the world. Although stroke prevention by targeting several risk factors such as diabetes and hypertension has decreased the stroke incidence, the total number of strokes is increasing due to the population aging and new preventive ther...

journal_title：Frontiers in neurology

authors： Darsalia V,Johansen OE,Lietzau G,Nyström T,Klein T,Patrone C

更新日期：2019-05-08 00:00:00

abstract：:Microglia are activated during pathological events in the brain and are capable of releasing various types of inflammatory cytokines. Here, we demonstrate that the addition of 5% microglia activated by 1 μg/ml lipopolysaccharides (LPS) to hippocampal cultures upregulates Na(+) current densities (INavD) of bipolar as w...

journal_title：Frontiers in neurology

authors： Klapal L,Igelhorst BA,Dietzel-Meyer ID

更新日期：2016-03-30 00:00:00

abstract：:Background: In people with multiple sclerosis (MS), optic neuritis (ON) results in inner retinal layer thinning, and reduced density of the retinal microvasculature. Objective: To compare inter-eye differences (IEDs) in macular optical coherence tomography (OCT) and OCT angiography (OCTA) measures in MS patients with ...

journal_title：Frontiers in neurology

authors： Murphy OC,Kalaitzidis G,Vasileiou E,Filippatou AG,Lambe J,Ehrhardt H,Pellegrini N,Sotirchos ES,Luciano NJ,Liu Y,Fitzgerald KC,Prince JL,Calabresi PA,Saidha S

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Unlike many other central nervous system (CNS) tumors, the surgical management of primary central nervous system lymphomas (PCNSL) is traditionally limited by diagnostic biopsy. Studies that predate the use of modern neurosurgical techniques have reported a prohibitive operative morbidity for this surgery. T...

journal_title：Frontiers in neurology

authors： Yun J,Yang J,Cloney M,Mehta A,Singh S,Iwamoto FM,Neugut AI,Sonabend AM

更新日期：2017-09-12 00:00:00

abstract：:Chronic subdural hematoma (cSDH) is a common disease process associated with significant morbidity that occurs most often in elderly patients. Asymptomatic patients are typically treated conservatively, with surgical intervention reserved for patients with symptomatic and/or large hematomas that cause brain compressio...

journal_title：Frontiers in neurology

authors： Catapano JS,Nguyen CL,Wakim AA,Albuquerque FC,Ducruet AF

更新日期：2020-10-20 00:00:00

abstract：:Background: Mild traumatic brain injuries (mTBIs) are a significant social, sport, and military health issue. In spite of advances in the clinical management of these injuries, the underlying pathophysiology is not well-understood. There is a critical need to advance objective biomarkers, allowing the identification a...

journal_title：Frontiers in neurology

authors： Raikes AC,Bajaj S,Dailey NS,Smith RS,Alkozei A,Satterfield BC,Killgore WDS

更新日期：2018-06-20 00:00:00

abstract：:This study reports the case of an acoustic shock injury (ASI), which did not result in a significant hearing loss, but was followed by manifold chronic symptoms both within (tinnitus, otalgia, tingling in the ear, tension in the ear, and red tympanum) and outside the ears (blocked nose, pain in the neck/temporal regio...

journal_title：Frontiers in neurology

authors： Londero A,Charpentier N,Ponsot D,Fournier P,Pezard L,Noreña AJ

更新日期：2017-08-16 00:00:00

abstract：:Manual dexterity measures can be useful for early detection of age-related functional decline and for prediction of cognitive decline. However, what aspects of sensorimotor function to assess remains unclear. Manual dexterity markers should be able to separate impairments related to cognitive decline from those relate...

journal_title：Frontiers in neurology

authors： Carment L,Abdellatif A,Lafuente-Lafuente C,Pariel S,Maier MA,Belmin J,Lindberg PG

更新日期：2018-10-29 00:00:00

abstract：:α-synuclein is involved in the pathogenesis of multiple system atrophy (MSA) and can be regulated by peripheral immune activation (PIA). We aimed to clarify the correlations between PIA and the prevalence of MSA and to analyze the role of PIA in the progression of the disease. A total of 321 patients with probable MSA...

journal_title：Frontiers in neurology

authors： Cao B,Chen X,Zhang L,Wei Q,Liu H,Feng W,Chen Y,Shang H

更新日期：2020-07-07 00:00:00

abstract：Introduction:Transcranial high-resolution ultrasonography reliably allows diagnosis and monitoring of intracerebral hemorrhage in adults. Sonographic monitoring of subdural hematoma (SDH) has not been evaluated in adults so far. This study investigates the reliability of transcranial gray-scale sonography (TGS) in moni...

journal_title：Frontiers in neurology

authors： Niesen WD,Rosenkranz M,Weiller C

更新日期：2018-05-28 00:00:00

abstract：:Introduction: Safe driving requires integration of higher-order cognitive and motor functions, which are commonly compromised in patients with antibody-mediated encephalitis (AME) associated with N-methyl-D-aspartate receptors or leucine-rich glioma-inactivated 1 autoantibodies. How these deficits influence the return...

journal_title：Frontiers in neurology

authors： Day GS,Babulal GM,Rajasekar G,Stout S,Roe CM

更新日期：2020-07-28 00:00:00

abstract：:Autoimmune encephalitis often causes acute psychiatric symptoms and epileptic seizures. However, it is becoming increasingly clear that depending on the target antigen both symptoms and disease severity may vary. Furthermore, the identification and characterization of antibody subtypes are highly relevant for personal...

journal_title：Frontiers in neurology

authors： Edwin Thanarajah S,Prüss H,Warnke C,Barbe MT,Schroeter M,Fink GR,Onur OA

更新日期：2019-03-05 00:00:00

abstract：:Background and Objective: Parkinson disease (PD) with rapid eye movement (REM) sleep behavior disorder (PD-RBD) tend to be a distinct phenotype with more severe clinical characteristics and pathological lesion when compared with PD without RBD (PD-nRBD). However, the pathological mechanism underlying PD-RBD remains un...

journal_title：Frontiers in neurology

authors： Li J,Zeng Q,Zhou W,Zhai X,Lai C,Zhu J,Dong S,Lin Z,Cheng G

更新日期：2020-10-27 00:00:00

abstract：:Traumatic brain injury (TBI) and the activation of secondary injury mechanisms have been linked to impaired cognitive function, which, as observed in TBI patients and animal models, can persist for months and years following the initial injury. Impairments in neurotransmission have been well documented in experimental...

journal_title：Frontiers in neurology

authors： Carlson SW,Henchir J,Dixon CE

更新日期：2017-10-10 00:00:00

abstract：:Background and objective: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited systemic arteriopathy, the classic feature of which is small vessel lesions. Studies on intracranial large arteries in CADASIL are not common. We aim to evaluate intracranial l...

journal_title：Frontiers in neurology

authors： Zhang C,Li W,Li S,Niu S,Wang X,Yu X,Zhang Z

更新日期：2020-08-18 00:00:00

abstract：:Background: We hypothesized that right and left temporal lobe epilepsy (RTLE and LTLE, respectively) have distinctive spatial patterns of white matter (WM) changes that can be differentiated and interpreted with the use of multiple diffusion parameters. We compared the global microstructure of fiber bundles with regar...

journal_title：Frontiers in neurology

authors： Buksakowska I,Szabó N,Martinkovič L,Faragó P,Király A,Vrána J,Kincses ZT,Meluzín J,Šulc V,Kynčl M,Roček M,Tichý M,Charvát F,Hořínek D,Marusič P

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Neurological complications are common after orthotopic liver transplantation (OLT). We aimed to characterize the risk factors associated with neurological complications and mortality among patients who underwent OLT in the post-model for end-stage liver disease (MELD) era. METHODS:In a retrospective review,...

journal_title：Frontiers in neurology

authors： Fu KA,DiNorcia J,Sher L,Velani SA,Akhtar S,Kalayjian LA,Sanossian N

更新日期：2014-12-17 00:00:00

abstract：:Introduction: Although patients with Parkinson's disease (PD) often suffer from oropharyngeal dysphagia, knowledge about the underlying pathophysiological mechanisms is limited. Substance P (SP) is a localization-independent neurotransmitter of the entire nervous system. Reduced levels of SP were found in saliva of pa...

journal_title：Frontiers in neurology

authors： Schröder JB,Marian T,Claus I,Muhle P,Pawlowski M,Wiendl H,Suntrup-Krueger S,Meuth SG,Dziewas R,Ruck T,Warnecke T

更新日期：2019-04-16 00:00:00

abstract：:Objective: The platelet-to-lymphocyte ratio (PLR) is a new marker of atherosclerotic inflammation and has been identified as a predictive factor in cardiovascular diseases, but its significance in patients with acute ischaemic stroke (AIS) who have undergone intravenous thrombolysis (IVT) is still unknown. Methods: Co...

journal_title：Frontiers in neurology

authors： Xu JH,He XW,Li Q,Liu JR,Zhuang MT,Huang FF,Bao GS

更新日期：2019-11-13 00:00:00

abstract：:Objective: We conducted this study to analyze the clinical characteristics of the psychiatric symptoms of patients with anti-NMDAR encephalitis. Methods: A retrospective study of anti-NMDAR encephalitis in China was performed. The clinical characteristics of the psychiatric symptoms, the relationship between the antib...

journal_title：Frontiers in neurology

authors： Wang W,Zhang L,Chi XS,He L,Zhou D,Li JM

更新日期：2020-01-24 00:00:00