Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza.


:Salvia miltiorrhiza Bunge, a member of the Lamiaceae family, is valued in traditional Chinese Medicine. Its dried root (named Danshen) has been used for hundreds of years, primarily for the treatment of cardiovascular and cerebrovascular diseases. Tanshinones are the main active ingredients in S. miltiorrhiza and exhibit significant pharmacological activities, such as antioxidant activity, anti-inflammatory activity, cardiovascular effects, and antitumor activity. Danshen dripping pill of Tianshili is an effective drug widely used in the clinical treatment of cardiovascular diseases. With the increasing demand for clinical drugs, the traditional method for extracting and separating tanshinones from medicinal plants is insufficient. Therefore, in combination with synthetic biological methods and strategies, it is necessary to analyze the biosynthetic pathway of tanshinones and construct high-yield functional bacteria to obtain tanshinones. Moreover, the biosynthesis of tanshinones has been studied for more than two decades but remains to be completely elucidated. This review will systematically present the composition, extraction and separation, pharmacological activities and biosynthesis of tanshinones from S. miltiorrhiza, with the intent to provide references for studies on other terpenoid bioactive components of traditional Chinese medicines and to provide new research strategies for the sustainable development of traditional Chinese medicine resources.


Front Pharmacol


Jiang Z,Gao W,Huang L




Has Abstract


2019-03-14 00:00:00








  • Periplaneta americana Extracts Accelerate Liver Regeneration via a Complex Network of Pathways.

    abstract::Successful recovery from hepatectomy is partially contingent upon the rate of residual liver regeneration. The traditional Chinese medicines known as Periplaneta americana extracts (PAEs) positively influence wound healing by promoting tissue repair. However, the effect of PAEs on liver regeneration is unknown. We use...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zou Y,Zhang M,Zeng D,Ruan Y,Shen L,Mu Z,Zou J,Xie C,Yang Z,Qian Z,Xu R,Li S,Kang Q,Zou H,Zhao S,Liu L,Wang K,Wang X,Zhang X

    更新日期:2020-07-31 00:00:00

  • Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology.

    abstract::In this paper we discuss the consensus view on the use of qualifying biomarkers in drug safety, raised within the frame of the XXIV meeting of the Spanish Society of Clinical Pharmacology held in Málaga (Spain) in October, 2011. The widespread use of biomarkers as surrogate endpoints is a goal that scientists have lon...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Agúndez JA,Del Barrio J,Padró T,Stephens C,Farré M,Andrade RJ,Badimon L,García-Martín E,Vilahur G,Lucena MI

    更新日期:2012-01-19 00:00:00

  • The Lipid Mediator Resolvin D1 Reduces the Skin Inflammation and Oxidative Stress Induced by UV Irradiation in Hairless Mice.

    abstract::UV irradiation-induced oxidative stress and inflammation contribute to the development of skin diseases. Therefore, targeting oxidative stress and inflammation might contribute to reduce skin diseases. Resolvin D1 (RvD1) is a bioactive metabolite generated during inflammation to actively orchestrate the resolution of ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Saito P,Melo CPB,Martinez RM,Fattori V,Cezar TLC,Pinto IC,Bussmann AJC,Vignoli JA,Georgetti SR,Baracat MM,Verri WA Jr,Casagrande R

    更新日期:2018-10-31 00:00:00

  • Vitamin d and susceptibility of chronic lung diseases: role of epigenetics.

    abstract::Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environment...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Sundar IK,Rahman I

    更新日期:2011-08-30 00:00:00

  • Anaplastic Lymphoma Kinase Is a Regulator of Alcohol Consumption and Excitatory Synaptic Plasticity in the Nucleus Accumbens Shell.

    abstract::Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nu...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Mangieri RA,Maier EY,Buske TR,Lasek AW,Morrisett RA

    更新日期:2017-08-15 00:00:00

  • Mechanistic Study of Bakuchiol-Induced Anti-breast Cancer Stem Cell and in Vivo Anti-metastasis Effects.

    abstract::Cancer stem cells are involved in cancer establishment, progression, and resistance to current treatments. We demonstrated the in vitro and in vivo anti-breast cancer effect of bakuchiol in a previous study. However, the ability of bakuchiol to target breast cancer stem cells (BCSCs) and inhibit breast cancer metastas...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Li L,Liu CC,Chen X,Xu S,Hernandez Cortes-Manno S,Cheng SH

    更新日期:2017-10-18 00:00:00

  • Validation of a Case-Finding Algorithm for Identifying Patients with Non-small Cell Lung Cancer (NSCLC) in Administrative Claims Databases.

    abstract::Objective: To assess the validity of a treatments- and tests-based Case-Finding Algorithm for identifying patients with non-small cell lung cancer (NSCLC) from claims databases. Data sources: Primary data from the HealthCore Integrated Research Environment (HIRE)-Oncology database and the HealthCore Integrated Researc...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Turner RM,Chen YW,Fernandes AW

    更新日期:2017-11-30 00:00:00

  • Hydrogen Sulfide Inhibits Cigarette Smoke-Induced Endoplasmic Reticulum Stress and Apoptosis in Bronchial Epithelial Cells.

    abstract::Background: Apoptosis of lung structural cells contributes to the process of lung damage and remodeling in chronic obstructive pulmonary disease (COPD). Our previous studies demonstrated that exogenous hydrogen sulfide (H2S) can reduce the lung tissue pathology score, anti-inflammation and anti-oxidation effects in CO...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lin F,Liao C,Sun Y,Zhang J,Lu W,Bai Y,Liao Y,Li M,Ni X,Hou Y,Qi Y,Chen Y

    更新日期:2017-09-28 00:00:00

  • Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators.

    abstract::The psoralen-related compound, 4,6,4'-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. We recently demonstrated that TMA, like lumacaftor (VX-809), stab...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Laselva O,Marzaro G,Vaccarin C,Lampronti I,Tamanini A,Lippi G,Gambari R,Cabrini G,Bear CE,Chilin A,Dechecchi MC

    更新日期:2018-07-04 00:00:00

  • A New Framework to Implement Model-Informed Dosing in Clinical Guidelines: Piperacillin and Amikacin as Proof of Concept.

    abstract::Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guidelines based on these do...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Hartman SJF,Swaving JGE,van Beek SW,van Groen BD,de Hoop M,van der Zanden TM,Ter Heine R,de Wildt SN

    更新日期:2020-12-16 00:00:00

  • Sequential Treatment with Pazopanib and Everolimus in Metastatic Renal Cell Carcinoma.

    abstract::In metastatic renal cell carcinoma, complete response to first-line antiangiogenic agents is rare and resistance to therapy often develops. Protocols for sequential treatment with angiogenesis and mTOR inhibitors are under evaluation to improve outcomes. In this observational, real-world study, patients received a fir...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Rossetti S,D'Aniello C,Iovane G,Scagliarini S,Laterza MM,De Vita F,Savastano C,Cartenì G,Porricelli MA,Berretta M,Pisconti S,Facchini G,Cavaliere C

    更新日期:2017-07-20 00:00:00

  • Myricetin Attenuated Diabetes-Associated Kidney Injuries and Dysfunction via Regulating Nuclear Factor (Erythroid Derived 2)-Like 2 and Nuclear Factor-κB Signaling.

    abstract::Background/Aims: Previous studies have suggested that myricetin (Myr) could promote the expression and nuclear translocation of nuclear factor (erythroid-derived 2)-like (Nrf2). This study aimed to investigate whether Myr could attenuate diabetes-associated kidney injuries and dysfunction in wild-type (WT) and Nrf2 kn...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yang ZJ,Wang HR,Wang YI,Zhai ZH,Wang LW,Li L,Zhang C,Tang L

    更新日期:2019-06-11 00:00:00

  • Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer Therapy.

    abstract::With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set o...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Belizário JE,Sangiuliano BA,Perez-Sosa M,Neyra JM,Moreira DF

    更新日期:2016-09-29 00:00:00

  • The Ultrasmall Biocompatible CuS@BSA Nanoparticle and Its Photothermal Effects.

    abstract::Nanomaterials with localized surface plasmon resonance (LSPR) have exquisite optical properties, which allow a wide range of applications. Non-stoichiometric copper sulfides with active LSPR have drawn great attention, because its LSPR peak falls in the NIR region that is suitable for deep bioimaging and photothermal ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wan X,Liu M,Ma M,Chen D,Wu N,Li L,Li Z,Lin G,Wang X,Xu G

    更新日期:2019-02-26 00:00:00

  • Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions.

    abstract::Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), are idiosyncratic and unpredictable drug-hypersensitivity reactions with a high-mortality rate ranging from 10% to over 30%, thus causing a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Chang CJ,Chen CB,Hung SI,Ji C,Chung WH

    更新日期:2020-07-02 00:00:00

  • The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients.

    abstract::Cancer is a common malignant disease worldwide with an increasing mortality in recent years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the treatment of cardiovascular and cerebrovascular diseases for thousands of years. The liposoluble tanshinones in S. miltiorrhiza are importan...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Fu L,Han B,Zhou Y,Ren J,Cao W,Patel G,Kai G,Zhang J

    更新日期:2020-03-19 00:00:00

  • Pulmonary Rehabilitation and Asthma.

    abstract::Asthma is a chronic inflammatory disease characterized by airflow limitation and variable respiratory symptoms. It is characterized by variable symptoms such as cough, wheeze, chest tightness, and shortness of breath which vary in intensity and time. In order to reach a comprehensive approach of disease management, th...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Zampogna E,Zappa M,Spanevello A,Visca D

    更新日期:2020-05-06 00:00:00

  • Medicinal Plants as Sources of Active Molecules Against COVID-19.

    abstract::The Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) or novel coronavirus (COVID-19) infection has been declared world pandemic causing a worrisome number of deaths, especially among vulnerable citizens, in 209 countries around the world. Although several therapeutic molecules are being tested, no ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Benarba B,Pandiella A

    更新日期:2020-08-07 00:00:00

  • Rosmarinic Acid Protects against Inflammation and Cardiomyocyte Apoptosis during Myocardial Ischemia/Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma.

    abstract::The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new therapeutic opportunity to design drugs with a specific target for improving the efficacy. In this study, we first forecasted that Rosmarinic acid (R...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Han J,Wang D,Ye L,Li P,Hao W,Chen X,Ma J,Wang B,Shang J,Li D,Zheng Q

    更新日期:2017-07-11 00:00:00

  • Proanthocyanidin Polymer-Rich Fraction of Stryphnodendron adstringens Promotes in Vitro and in Vivo Cancer Cell Death via Oxidative Stress.

    abstract::Cervical cancer is the fourth most common cancer that affects women, mainly through human papilloma virus (HPV) infection with high-risk HPV16 and HPV18. The present study investigated the in vitro anticancer activity and mechanism of action of a proanthocyanidin polymer-rich fraction of Stryphnodendron adstringens (F...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Kaplum V,Ramos AC,Consolaro MEL,Fernandez MA,Ueda-Nakamura T,Dias-Filho BP,Silva SO,de Mello JCP,Nakamura CV

    更新日期:2018-07-03 00:00:00

  • The Bone Extracellular Matrix in Bone Formation and Regeneration.

    abstract::Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties. In bone, ECMs are involved in regulating cell adhesion, prolifer...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Lin X,Patil S,Gao YG,Qian A

    更新日期:2020-05-26 00:00:00

  • Metabolomics Reveals Effect of Zishen Jiangtang Pill, a Chinese Herbal Product on High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice.

    abstract::A Chinese herbal decoction, Zishen Jiangtang Pill (ZJP), has been clinically prescribed to diabetic patients to prevent excessive blood sugar levels for decades. However, the potential mechanisms of this action have not been well investigated. The purpose of this study was to explore the metabolic variations in respon...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Chen J,Zheng L,Hu Z,Wang F,Huang S,Li Z,Zheng P,Zhang S,Yi T,Li H

    更新日期:2019-03-19 00:00:00

  • Eupalinolide J Suppresses the Growth of Triple-Negative Breast Cancer Cells via Targeting STAT3 Signaling Pathway.

    abstract::Persistent activation of STAT3 plays an important role in the development of triple-negative breast cancer (TNBC), and suppression of STAT3 is considered as a novel approach for cancer therapy. In this project, we aimed to examine the anticancer activity and molecular mechanism of eupalinolide J (EJ) in TNBC cells. Th...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lou C,Chen Y,Zhang J,Yang B,Zhao H

    更新日期:2019-09-19 00:00:00

  • Parecoxib Shortens the Duration of Acute Postoperative Pain After Laparoscopic-Assisted Vaginal Hysterectomy.

    abstract::The effect of parecoxib sodium on the duration and severity of acute postoperative pain after laparoscopic-assisted vaginal hysterectomy has been inadequately studied. This randomized, controlled trial compared the effects of parecoxib, methylprednisolone, and placebo on the duration of acute postoperative pain after ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yang S,Xiao W,Wang S,Meng L,Zhou L,Wan A,Liu Y,Feng S,Wang T

    更新日期:2019-06-18 00:00:00

  • Administration of Δ9-Tetrahydrocannabinol (THC) Post-Staphylococcal Enterotoxin B Exposure Protects Mice From Acute Respiratory Distress Syndrome and Toxicity.

    abstract::Acute Respiratory Distress Syndrome (ARDS) is a life-threatening complication that can ensue following Staphylococcus aureus infection. The enterotoxin produced by these bacteria (SEB) acts as a superantigen thereby activating a large proportion of T cells leading to cytokine storm and severe lung injury. Δ9Tetrahydro...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Mohammed A,Alghetaa H,Sultan M,Singh NP,Nagarkatti P,Nagarkatti M

    更新日期:2020-06-16 00:00:00

  • Effect of a New Synergistic Combination of Low Doses of Acetylsalicylic Acid, Caffeine, Acetaminophen, and Chlorpheniramine in Acute Low Back Pain.

    abstract::The present paper continues a more complex research related to the increased synergism in terms of both anti-inflammatory and analgesic effect obtained by the addition of chlorpheniramine (CLF) to the common acetylsalicylic acid (ASA), acetaminophen (PAR), and caffeine (CAF) combination. This synergistic effect was pr...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Voicu VA,Mircioiu C,Plesa C,Jinga M,Balaban V,Sandulovici R,Costache AM,Anuta V,Mircioiu I

    更新日期:2019-06-20 00:00:00

  • In Vivo Cannabidiol Treatment Improves Endothelium-Dependent Vasorelaxation in Mesenteric Arteries of Zucker Diabetic Fatty Rats.

    abstract::Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism. The aim of the present study was to determine whether treatment with CBD in vivo would also...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wheal AJ,Jadoon K,Randall MD,O'Sullivan SE

    更新日期:2017-05-18 00:00:00

  • Gleditsia Saponin C Induces A549 Cell Apoptosis via Caspase-Dependent Cascade and Suppresses Tumor Growth on Xenografts Tumor Animal Model.

    abstract::Saponins are natural compounds and possess the most promising anti-cancer function. Here, a saponin gleditsia saponin C (GSC), extracted from gleditsiae fructus abnormalis, could induce apoptosis of lung tumor cell line A549 via caspase dependent cascade and this effect could be prevented by the caspase inhibitors. In...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Cheng Y,He W,He Y

    更新日期:2018-01-15 00:00:00

  • How the Toxin got its Toxicity.

    abstract::Venom systems are functional and ecological traits, typically used by one organism to subdue or deter another. A predominant subset of their constituent molecules-"toxins"-share this ecological function and are therefore molecules that mediate interactions between organisms. Such molecules have been referred to as "ex...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Jackson TNW,Koludarov I

    更新日期:2020-12-14 00:00:00

  • Methylene Blue Inhibits the SARS-CoV-2 Spike-ACE2 Protein-Protein Interaction-a Mechanism that can Contribute to its Antiviral Activity Against COVID-19.

    abstract::Due to our interest in the chemical space of organic dyes to identify potential small-molecule inhibitors (SMIs) for protein-protein interactions (PPIs), we initiated a screen of such compounds to assess their inhibitory activity against the interaction between SARS-CoV-2 spike protein and its cognate receptor ACE2, w...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Bojadzic D,Alcazar O,Buchwald P

    更新日期:2021-01-13 00:00:00