Is the HPA Axis as Target for Depression Outdated, or Is There a New Hope?

abstract：:This study explored how different forms of reward-based decision-making are associated with pathological gambling (PG) among abstinent individuals with prior dependence on different classes of drugs. Participants had lifetime histories of either "pure" heroin dependence (n = 64), "pure" amphetamine dependence (n = 51)...

journal_title：Frontiers in psychiatry

authors： Wilson MJ,Vassileva J

更新日期：2018-06-05 00:00:00

abstract：BACKGROUND:Evidence indicates that early life stress (ELS) can induce persistent changes in the hypothalamic-pituitary-adrenal (HPA) axis to respond to stress in the adult life that leads to depression. These appear to be related to the impairment of HPA hormones through binding to glucocorticoid (GR) and mineralocorti...

journal_title：Frontiers in psychiatry

authors： Baes Cv,Martins CM,Tofoli SM,Juruena MF

更新日期：2014-01-24 00:00:00

abstract：:Background: The personality trait neuroticism has been implicated in a poor response to stress, may relate to increased concentrations of cytokines and the development of depression. Inflammatory mechanisms may also be associated with the onset, severity and symptoms of depression. Both are related to poor antidepress...

journal_title：Frontiers in psychiatry

authors： Schmidt FM,Sander C,Minkwitz J,Mergl R,Dalton B,Holdt LM,Teupser D,Hegerl U,Himmerich H

更新日期：2018-11-20 00:00:00

abstract：:Cogmed Working Memory Training (CWMT), an online cognitive training program developed for children, is an increasingly popular non-pharmacological intervention for ADHD amongst all ages, despite limited supporting evidence. The initial objective of the present work was to examine the short- and long-term impacts of CW...

journal_title：Frontiers in psychiatry

authors： Marcelle ET,Ho EJ,Kaplan MS,Adler LA,Castellanos FX,Milham MP

更新日期：2018-08-28 00:00:00

abstract：Background:Disorganization of semantic memory in patients with schizophrenia has been studied by referring to their category fluency performance. Recently, data-mining techniques such as singular value decomposition (SVD) analysis have been reported to be effective in elucidating the latent semantic memory structure in...

journal_title：Frontiers in psychiatry

authors： Sumiyoshi C,Fujino H,Sumiyoshi T,Yasuda Y,Yamamori H,Fujimoto M,Hashimoto R

更新日期：2018-03-21 00:00:00

abstract：STUDY OBJECTIVE:Animal data suggest that Δ(9)-TetraHydroCannabinol (Δ(9)THC) stabilizes autonomic output during sleep, reduces spontaneous sleep-disordered breathing, and blocks serotonin-induced exacerbation of sleep apnea. On this basis, we examined the safety, tolerability, and efficacy of dronabinol (Δ(9)THC), an e...

journal_title：Frontiers in psychiatry

authors： Prasad B,Radulovacki MG,Carley DW

更新日期：2013-01-22 00:00:00

abstract：:Due to advances over the last several decades, many fields of medicine are moving toward a precision medicine approach where treatments are tailored to nuanced patient factors. While in some disciplines these innovations are commonplace leading to unique biomarker-guided experimental medicine trials, there are no such...

journal_title：Frontiers in psychiatry

authors： Joshi YB,Light GA

更新日期：2018-11-19 00:00:00

abstract：Objective:Employment was associated with recovery in individuals with schizophrenia. Our study aimed to delineate the vocational profile and investigate factors associated with likelihood of employment in individuals with schizophrenia. Materials and Methods:276 community dwelling outpatients with schizophrenia were r...

journal_title：Frontiers in psychiatry

authors： Ang MS,Rekhi G,Lee J

更新日期：2020-08-27 00:00:00

abstract：:Introduction: Previous studies on internet gaming disorder (IGD) have reported an association between personality traits and impulsive or problematic use of the internet or internet games, but the results obtained were inconsistent. Our study's hypothesis was that personality traits are associated with the individual'...

journal_title：Frontiers in psychiatry

authors： Seong W,Hong JS,Kim S,Kim SM,Han DH

更新日期：2019-08-28 00:00:00

abstract：:Cognitive performance at illness onset may predict outcomes in first-episode psychosis (FEP), and the change in cognition may associate with clinical changes. Cognitive testing was administered to 54 FEP participants 2 months after entering treatment and to 39 participants after 1 year. We investigated whether baselin...

journal_title：Frontiers in psychiatry

authors： Lindgren M,Holm M,Kieseppä T,Suvisaari J

更新日期：2020-12-04 00:00:00

abstract：:Over the past years, there has been a growing interest in the association between lifestyle psychosocial interventions, severe mental illness, and suicide risk. Patients with severe mental disorders have higher mortality rates, poor health states, and higher suicide risk compared to the general population. Lifestyle b...

journal_title：Frontiers in psychiatry

authors： Berardelli I,Corigliano V,Hawkins M,Comparelli A,Erbuto D,Pompili M

更新日期：2018-11-06 00:00:00

abstract：:According to the glutamate hypothesis of schizophrenia, the abnormality of glutamate transmission induced by hypofunction of NMDA receptors (NMDARs) is causally associated with the positive and negative symptoms of schizophrenia. However, the underlying mechanisms responsible for the changes in glutamate transmission ...

journal_title：Frontiers in psychiatry

authors： Mei YY,Wu DC,Zhou N

更新日期：2018-11-06 00:00:00

abstract：:A small number of severely and persistently mentally ill in-patients awaiting residential or long-stay facilities represent an obstacle to the efficient utilization of acute care beds. These facilities are costly and currently reputed to be contrary to recovery principles. In 2013, all acute psychiatric care wards in ...

journal_title：Frontiers in psychiatry

authors： Rapisarda F,Felx A,Gagnon S,De Benedictis L,Luyet A,Boutin M,Corbière M,Lesage A

更新日期：2020-04-07 00:00:00

abstract：:Objective: To analyze sex differences in demographic and clinical characteristics of individuals who died by suicide in Mexico City. Method: Statistical analysis of residents of Mexico City whose cause of death was suicide, during two years period from January 2014 to December 2015, with a coroner's report. Suicide mo...

journal_title：Frontiers in psychiatry

authors： Romero-Pimentel AL,Mendoza-Morales RC,Fresan A,Garcia-Dolores F,Gonzalez-Saenz EE,Morales-Marin ME,Nicolini H,Borges G

更新日期：2018-09-07 00:00:00

abstract：:Background: Opiates, cannabis, and stimulants are highly abused and are prevalent disorders. Psychological interventions are crucial given that they help individuals maintain abstinence following a lapse or relapse into substance use. The dual-process theory has posited that while the repeated use of a substance leads...

journal_title：Frontiers in psychiatry

authors： Zhang MWB,Ying J,Wing T,Song G,Fung DSS,Smith HE

更新日期：2018-08-15 00:00:00

abstract：:This study compares the impact of repeated injections of baclofen (an agonist of GABAB receptors) or diazepam (a benzodiazepine having an agonist action on GABAA receptors) given during the alcohol-withdrawal period on the stress-induced restoration of alcohol-seeking behavior and hypothalamic-pituitary-adrenal (HPA) ...

journal_title：Frontiers in psychiatry

authors： Rabat Y,Henkous N,Corio M,Nogues X,Beracochea D

更新日期：2019-04-16 00:00:00

abstract：:Background: The issue of treatment resistance in eating disorder care is controversial. Prior research has identified multiple failed treatment attempts as a common criterion for severe and enduring anorexia nervosa, but little is known about patients who have multiple failed treatment attempts. This study was designe...

journal_title：Frontiers in psychiatry

authors： Smith S,Woodside DB

更新日期：2021-01-08 00:00:00

abstract：:Major depression is a high-prevalence mental disease with major socio-economic impact, for both the direct and the indirect costs. Major depression symptoms can be faked or exaggerated in order to obtain economic compensation from insurance companies. Critically, depression is potentially easily malingered, as the sym...

journal_title：Frontiers in psychiatry

authors： Monaro M,Toncini A,Ferracuti S,Tessari G,Vaccaro MG,De Fazio P,Pigato G,Meneghel T,Scarpazza C,Sartori G

更新日期：2018-06-08 00:00:00

abstract：:The nucleus accumbens (NAc) plays an important role in the reward circuit, and abnormal regional activities of the reward circuit have been reported in various psychiatric disorders including somatization disorder (SD). However, few researches are designed to analyze the NAc connectivity in SD. This study was designed...

journal_title：Frontiers in psychiatry

authors： Ou Y,Su Q,Liu F,Ding Y,Chen J,Zhang Z,Zhao J,Guo W

更新日期：2019-08-16 00:00:00

abstract：:Japan recently ordered a string of death sentences for offenders with mental illness. Based on the verdicts, we describe cases where one or more psychiatrists conducted psychiatric evaluations for several months and testified in lay judge courts. We compared these cases with those in which the death penalty was avoide...

journal_title：Frontiers in psychiatry

authors： Kashiwagi H,Hirabayashi N

更新日期：2018-11-02 00:00:00

abstract：:Suicide is a serious public health issue worldwide, yet current clinical methods for assessing a person's risk of taking their own life remain unreliable and new methods for assessing suicide risk are being explored. The widespread adoption of electronic health records (EHRs) has opened up new possibilities for epidem...

journal_title：Frontiers in psychiatry

authors： Bittar A,Velupillai S,Downs J,Sedgwick R,Dutta R

更新日期：2020-11-27 00:00:00

abstract：:Marijuana is the most commonly used drug of abuse among adolescents. Considerable clinical evidence supports the hypothesis that adolescent neurodevelopmental exposure to high levels of the principal psychoactive component in marijuana, -delta-9-tetrahydrocanabinol (THC), is associated with a high risk of developing p...

journal_title：Frontiers in psychiatry

authors： Renard J,Rushlow WJ,Laviolette SR

更新日期：2018-07-02 00:00:00

abstract：Introduction:Although research over the past decade has resulted in significantly increased knowledge about distal risk factors for non-suicidal self-injury (NSSI), little is known about short-term (proximal) factors that predict NSSI thoughts and behaviors. Drawing on contemporaneous theories of NSSI, as well as the c...

journal_title：Frontiers in psychiatry

authors： Kiekens G,Hasking P,Nock MK,Boyes M,Kirtley O,Bruffaerts R,Myin-Germeys I,Claes L

更新日期：2020-03-20 00:00:00

abstract：:Despite being a commonly used protocol to treat major depressive disorder (MDD), the underlying mechanism of repetitive transcranial magnetic stimulation (rTMS) on dorsolateral prefrontal cortex (DLPFC) remains unclear. In the current study, we investigated the resting-state fMRI data of 100 healthy subjects by explor...

journal_title：Frontiers in psychiatry

authors： Ishida T,Dierks T,Strik W,Morishima Y

更新日期：2020-08-20 00:00:00

abstract：Objectives:The modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) was designed to assess food addiction using a shorter version than the YFAS 2.0. We lack data about the psychometric properties of the mYFAS 2.0 in patients with obesity, as well as studies comparing the psychometric properties of the mYFAS 2.0 versus th...

journal_title：Frontiers in psychiatry

authors： Brunault P,Berthoz S,Gearhardt AN,Gierski F,Kaladjian A,Bertin E,Tchernof A,Biertho L,de Luca A,Hankard R,Courtois R,Ballon N,Benzerouk F,Bégin C

更新日期：2020-09-08 00:00:00

abstract：:Background: A growing body of research underlines that interpersonal trauma in childhood leads to heightened susceptibility for substance use disorders (SUDs) in later life. Little research has been conducted on parenting experiences of mothers in recovery from substance use, taking into account their own upbringing a...

journal_title：Frontiers in psychiatry

authors： Meulewaeter F,De Pauw SSW,Vanderplasschen W

更新日期：2019-10-18 00:00:00

abstract：:Objective: To establish the prevalence of Type D personality in patients with somatic symptoms and related disorders and to evaluate the association of Type D personality with treatment outcomes. This study explores the effect of Type D personality and its two traits, negative affectivity (NA) and social inhibition (S...

journal_title：Frontiers in psychiatry

authors： de Vroege L,de Heer EW,van der Thiel E,van den Broek KC,van Eck van der Sluijs JF,van der Feltz-Cornelis CM

更新日期：2019-06-19 00:00:00

abstract：Background:Accumulating evidence has shown that valproate has the greatest teratogenic potential for increasing the risk of major congenital malformations, such as neural tube defects, cleft palate, and neurodevelopmental disability. Although valproate is a pharmacological option for acute mania and is used as a stabil...

journal_title：Frontiers in psychiatry

authors： Tachibana M,Hashimoto T,Tanaka M,Watanabe H,Sato Y,Takeuchi T,Terao T,Kimura S,Koyama A,Ebisawa S,Shizu Y,Nagase T,Hirakawa J,Hatta K,Nakazato M,Iyo M

更新日期：2020-04-15 00:00:00

abstract：:Incarceration affects the lives of many African American men and often leads to poverty, ill health, violence, and a decreased quality of life. There has been an unprecedented increase in incarceration among African American males since 1970. In 2009, the incarceration rate among black males was 6.7 times that of whit...

journal_title：Frontiers in psychiatry

authors： Mukku VK,Benson TG,Alam F,Richie WD,Bailey RK

更新日期：2012-11-12 00:00:00

abstract：:Despite many studies documenting the prevalence of various co-occurring psychiatric symptoms in children and adults with ASD, less is known about how these symptoms relate to subtypes defined by particular phenotypic features within the ASD population. We examined the severity and prevalence of comorbid symptoms of ps...

journal_title：Frontiers in psychiatry

authors： Plesa Skwerer D,Joseph RM,Eggleston B,Meyer SR,Tager-Flusberg H

更新日期：2019-02-18 00:00:00