Arid1a regulates insulin sensitivity and lipid metabolism.


BACKGROUND:Although significant progress has been made in understanding the mechanisms of steatosis and insulin resistance, the physiological functions of the epigenetic regulators in these processes remain largely elusive. METHODS:Hepatocyte-specific Arid1a knockout mice were administrated with high-fat diet (HFD) for 12 weeks, then insulin sensitivity was assessed by glucose tolerance test (GTT) and insulin tolerance test (ITT). The metabolism-related indicators were determined by employing a variety of biological methods, including histology, real-time PCR, enzyme-linked immunosorbent assay (ELISA), Western blotting assay, Chromatin immunoprecipitation (ChIP), RNA-seq and assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq). FINDINGS:Hepatocyte-specific Arid1a deletion significantly increases susceptibility to develop hepatic steatosis, insulin resistance and inflammation in mice fed a HFD. In vitro, Arid1a deletion in isolated hepatocytes directly leads to free fatty acid-induced lipid accumulation and insulin resistance. Mechanically, Arid1a deficiency impairs fatty acid oxidation by downregulating PPARα and altering the epigenetic landscape of some metabolism genes. INTERPRETATION:These findings reveal that targeting Arid1a might be a promising therapeutic strategy for liver steatosis and insulin resistance. FUND: This work was supported by National Natural Science Foundation of China (81672772 and 81472621), China National Science and Technology Major Project for Prevention and Treatment of Infectious Diseases (No.2017ZX 10203207) and National Program on Key Research Project of China (grant no. 2016YFC0902701).






Qu YL,Deng CH,Luo Q,Shang XY,Wu JX,Shi Y,Wang L,Han ZG




Has Abstract


2019-04-01 00:00:00










  • The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p.

    abstract:BACKGROUND:Non-small cell lung carcinomas (NSCLC) are prevalent, lethal cancers with especially grim prospects due to late-stage detection and chemoresistance. Circular RNAs (circRNAs) are non-coding RNAs that participate in tumor development. However, the role of circRNAs in NSCLC is not well known. This study investi...


    pub_type: 杂志文章


    authors: Wei S,Zheng Y,Jiang Y,Li X,Geng J,Shen Y,Li Q,Wang X,Zhao C,Chen Y,Qian Z,Zhou J,Li W

    更新日期:2019-06-01 00:00:00

  • EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure.

    abstract:BACKGROUND:Recurrent implantation failure (RIF) remains a critical and challenging problem in assisted reproductive technology mainly due to impaired decidualization. The endocytic and transcytotic activity in the endometrium are crucial for decidualization. The most representative endocytic gene is the C-terminal Eps1...


    pub_type: 杂志文章


    authors: Zhou Q,Yan G,Ding L,Liu J,Yu X,Kong S,Zhang M,Wang Z,Liu Y,Jiang Y,Kong N,Sun J,Sun H

    更新日期:2019-12-01 00:00:00

  • Nutritional Psychiatry: Where to Next?

    abstract::The nascent field of 'Nutritional Psychiatry' offers much promise for addressing the large disease burden associated with mental disorders. A consistent evidence base from the observational literature confirms that the quality of individuals' diets is related to their risk for common mental disorders, such as depressi...


    pub_type: 杂志文章,评审


    authors: Jacka FN

    更新日期:2017-03-01 00:00:00

  • Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide.

    abstract:BACKGROUND:Suicide is a major issue for global public health. Suicidality describes a broad spectrum of thoughts and behaviours, some of which are common in the general population. Although suicide results from a complex interaction of multiple social and psychological factors, predisposition to suicidality is at least...


    pub_type: 杂志文章


    authors: Strawbridge RJ,Ward J,Ferguson A,Graham N,Shaw RJ,Cullen B,Pearsall R,Lyall LM,Johnston KJA,Niedzwiedz CL,Pell JP,Mackay D,Martin JL,Lyall DM,Bailey MES,Smith DJ

    更新日期:2019-03-01 00:00:00

  • Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.

    abstract::Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in 20% to 60% of individuals with virological failure (VF) on a WHO-recommended TDF-containing first-line regimen. However, the full spectrum of reverse transcriptase (RT) mutations selected in individuals with VF on such...


    pub_type: 杂志文章


    authors: Rhee SY,Varghese V,Holmes SP,Van Zyl GU,Steegen K,Boyd MA,Cooper DA,Nsanzimana S,Saravanan S,Charpentier C,de Oliveira T,Etiebet MA,Garcia F,Goedhals D,Gomes P,Günthard HF,Hamers RL,Hoffmann CJ,Hunt G,Jiamsakul A,

    更新日期:2017-04-01 00:00:00

  • Proteins mimicking epitope of HIV-1 virus neutralizing antibody induce virus-neutralizing sera in mice.

    abstract:BACKGROUND:The development of an effective vaccine preventing HIV-1 infection is hindered by the enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutralizing antibody. Functional studies of rare elite neutralizers led to t...


    pub_type: 杂志文章


    authors: Kosztyu P,Kuchar M,Cerny J,Barkocziova L,Maly M,Petrokova H,Czernekova L,Liskova V,Raskova Kafkova L,Knotigova P,Masek J,Turanek J,Maly P,Raska M

    更新日期:2019-09-01 00:00:00

  • Transcriptional and clonal characterization of B cell plasmablast diversity following primary and secondary natural DENV infection.

    abstract::Antibody-mediated humoral immunity is thought to play a central role in mediating the immunopathogenesis of acute DENV infection, but limited data are available on the diversity, specificity, and functionality of the antibody response at the molecular level elicited by primary or secondary DENV infection. In order to ...


    pub_type: 杂志文章


    authors: Waickman AT,Gromowski GD,Rutvisuttinunt W,Li T,Siegfried H,Victor K,Kuklis C,Gomootsukavadee M,McCracken MK,Gabriel B,Mathew A,Grinyo I Escuer A,Fouch ME,Liang J,Fernandez S,Davidson E,Doranz BJ,Srikiatkhachorn A,Endy

    更新日期:2020-04-01 00:00:00

  • Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort.

    abstract:BACKGROUND:Paracetamol is the first choice for antipyretic or analgesic treatment throughout pregnancy. Products with Paracetamol are readily available over the counter and therefore easily accessible for self-medication. Epidemiological data on Paracetamol intake pattern during pregnancy and its potential immunologica...


    pub_type: 杂志文章


    authors: Bremer L,Goletzke J,Wiessner C,Pagenkemper M,Gehbauer C,Becher H,Tolosa E,Hecher K,Arck PC,Diemert A,Tiegs G

    更新日期:2017-12-01 00:00:00

  • Reduced Intellectual Ability in Offspring of Ovarian Hyperstimulation Syndrome: A Cohort Study.

    abstract:BACKGROUND:Ovarian hyperstimulation syndrome (OHSS), a complication of ovarian stimulation, has various adverse effects on both pregnant women and their offspring. However, whether OHSS will affect intellectual ability in offspring is still unknown. METHODS:We recruited 86 Chinese children born to OHSS women and 172 c...


    pub_type: 杂志文章


    authors: Xu GF,Zhou CL,Xiong YM,Li JY,Yu TT,Tian S,Lin XH,Liao Y,Lv Y,Zhang FH,Liu ZW,Shi YY,Shen Y,Sha J,Zhang D,Zhu YM,Sheng JZ,Huang HF

    更新日期:2017-06-01 00:00:00

  • miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.

    abstract:BACKGROUND:Pleural fibrosis is defined as excessive depositions of matrix components that result in pleural tissue architecture destruction and dysfunction. In severe cases, the progression of pleural fibrosis leads to lung entrapment, resulting in dyspnea and respiratory failure. However, the mechanism of pleural fibr...


    pub_type: 杂志文章


    authors: Wang M,Xiong L,Jiang LJ,Lu YZ,Liu F,Song LJ,Xiang F,He XL,Yu F,Shuai SY,Ma WL,Ye H

    更新日期:2019-03-01 00:00:00

  • The path toward using microbial metabolites as therapies.

    abstract::Metabolites have emerged as the quintessential effectors mediating the impact of the commensal microbiome on human physiology, both locally at the sites of microbial colonization and systemically. The endocrine activity of the microbiome and its involvement in a multitude of complex diseases has made microbiome-modula...


    pub_type: 杂志文章,评审


    authors: Descamps HC,Herrmann B,Wiredu D,Thaiss CA

    更新日期:2019-06-01 00:00:00

  • Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma.

    abstract::Clear cell renal cell carcinoma (ccRCC) is the most lethal neoplasm of the urologic system. Clinical therapeutic effect varies greatly between individual ccRCC patients, so there is an urgent need to develop prognostic molecular biomarkers to help clinicians identify patients in need of early aggressive management. In...


    pub_type: 杂志文章


    authors: Zheng J,Wang L,Peng Z,Yang Y,Feng D,He J

    更新日期:2017-02-01 00:00:00

  • A novel imaging based Nomogram for predicting post-surgical biochemical recurrence and adverse pathology of prostate cancer from pre-operative bi-parametric MRI.

    abstract:BACKGROUND:We developed and validated an integrated radiomic-clinicopathologic nomogram (RadClip) for post-surgical biochemical recurrence free survival (bRFS) and adverse pathology (AP) prediction in men with prostate cancer (PCa). RadClip was further compared against extant prognostics tools like CAPRA and Decipher. ...


    pub_type: 杂志文章


    authors: Li L,Shiradkar R,Leo P,Algohary A,Fu P,Tirumani SH,Mahran A,Buzzy C,Obmann VC,Mansoori B,El-Fahmawi A,Shahait M,Tewari A,Magi-Galluzzi C,Lee D,Lal P,Ponsky L,Klein E,Purysko AS,Madabhushi A

    更新日期:2021-01-01 00:00:00

  • Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review.

    abstract:BACKGROUND:The Early Cancer Detection Consortium is developing a blood-test to screen the general population for early identification of cancer, and has therefore conducted a systematic mapping review to identify blood-based biomarkers that could be used for early identification of cancer. METHODS:A mapping review wit...


    pub_type: 杂志文章,meta分析,评审


    authors: Uttley L,Whiteman BL,Woods HB,Harnan S,Philips ST,Cree IA,Early Cancer Detection Consortium.

    更新日期:2016-08-01 00:00:00

  • Incidentalome from Genomic Sequencing: A Barrier to Personalized Medicine?

    abstract:BACKGROUND:In Western cohorts, the prevalence of incidental findings (IFs) or incidentalome, referring to variants in genes that are unrelated to the patient's primary condition, is between 0.86% and 8.8%. However, data on prevalence and type of IFs in Asian population is lacking. METHODS:In 2 cohorts of individuals w...


    pub_type: 杂志文章


    authors: Jamuar SS,Kuan JL,Brett M,Tiang Z,Tan WL,Lim JY,Liew WK,Javed A,Liew WK,Law HY,Tan ES,Lai A,Ng I,Teo YY,Venkatesh B,Reversade B,Tan EC,Foo R

    更新日期:2016-02-04 00:00:00

  • Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells.

    abstract::Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by the lack of individualized infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid (LO) that inherite...


    pub_type: 杂志文章


    authors: Nie YZ,Zheng YW,Miyakawa K,Murata S,Zhang RR,Sekine K,Ueno Y,Takebe T,Wakita T,Ryo A,Taniguchi H

    更新日期:2018-09-01 00:00:00

  • A New Metastatic Lymph Node Classification-based Survival Predicting Model in Patients With Small Bowel Adenocarcinoma: A Derivation and Validation Study.

    abstract:BACKGROUND:Current methods of lymph node (LN) staging are controversial in predicting the survival of SBA. We aimed to develop an alternative LN-classification-based nomogram to individualize SBA prognosis. METHODS:Based on the data from the Surveillance, Epidemiology, and End Results (SEER) database of patients diagn...


    pub_type: 杂志文章


    authors: Wu S,Chen JN,Zhang QW,Tang CT,Zhang XT,Tang MY,Li XB,Ge ZZ

    更新日期:2018-06-01 00:00:00

  • Pathophysiologic Response to Burns in the Elderly.

    abstract::Over the last decades advancements have improved survival and outcomes of severely burned patients except one population, elderly. The Lethal Dose 50 (LD50) burn size in elderly has remained the same over the past three decades, and so has morbidity and mortality, despite the increased demand for elderly burn care. Th...


    pub_type: 杂志文章


    authors: Jeschke MG,Patsouris D,Stanojcic M,Abdullahi A,Rehou S,Pinto R,Chen P,Burnett M,Amini-Nik S

    更新日期:2015-07-31 00:00:00

  • Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis.

    abstract::Pericardial tuberculosis (TB) is associated with high therapy failure and high mortality rates. Antibiotics have to penetrate to site of infection at sufficient non-protein bound concentrations, and then enter bacteria to inhibit intracellular biochemical processes. The antibiotic concentrations achieved in pericardia...


    pub_type: 杂志文章


    authors: Shenje J,Ifeoma Adimora-Nweke F,Ross IL,Ntsekhe M,Wiesner L,Deffur A,McIlleron HM,Pasipanodya J,Gumbo T,Mayosi BM

    更新日期:2015-09-16 00:00:00

  • Extracellular Vesicles Secreted by Human Adipose-derived Stem Cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19.

    abstract::It has previously been reported that human adipose-derived stem cells (hASCs) can promote the regeneration of damaged tissues in rats with liver failure through a 'paracrine effect'. Here we demonstrate a therapeutic effect of hASCs derived Extracellular Vesicles (EVs) on rat models with acute liver failure, as shown ...


    pub_type: 杂志文章


    authors: Jin Y,Wang J,Li H,Gao S,Shi R,Yang D,Wang X,Wang X,Zhu L,Wang X,Chen C,Ning K,Gao Z,Xu J,Fu Q

    更新日期:2018-08-01 00:00:00


    abstract::The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. Here we report that induction of the SYK gene expression in human cells causes a significant down-regulation of evolutionarily conserved genes a...


    pub_type: 杂志文章


    authors: Uckun FM,Ma H,Ozer Z,Goodman P,Zhang J,Qazi S

    更新日期:2014-11-01 00:00:00

  • Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer.

    abstract:BACKGROUND:Citizen science, scientific research conducted by non-specialists, has the potential to facilitate biomedical research using available large-scale data, however validating the results is challenging. The Cell Slider is a citizen science project that intends to share images from tumors with the general public...


    pub_type: 杂志文章


    authors: Candido Dos Reis FJ,Lynn S,Ali HR,Eccles D,Hanby A,Provenzano E,Caldas C,Howat WJ,McDuffus LA,Liu B,Daley F,Coulson P,Vyas RJ,Harris LM,Owens JM,Carton AF,McQuillan JP,Paterson AM,Hirji Z,Christie SK,Holmes AR,S

    更新日期:2015-05-09 00:00:00

  • Identification of Associations Between Prescribed Medications and Cancer: A Nationwide Screening Study.

    abstract:PURPOSE:We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. METHODS:We identified all patients (cases) with incident cancer in Denmark during 2000-2012 (n=278,485) and matched each case to 10 controls. Compl...


    pub_type: 杂志文章


    authors: Pottegård A,Friis S,Christensen Rd,Habel LA,Gagne JJ,Hallas J

    更新日期:2016-05-01 00:00:00

  • A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy.

    abstract::Cancer cells frequently up-regulate DNA replication and repair proteins such as the multifunctional DNA2 nuclease/helicase, counteracting DNA damage due to replication stress and promoting survival. Therefore, we hypothesized that blocking both DNA replication and repair by inhibiting the bifunctional DNA2 could be a ...


    pub_type: 杂志文章


    authors: Liu W,Zhou M,Li Z,Li H,Polaczek P,Dai H,Wu Q,Liu C,Karanja KK,Popuri V,Shan SO,Schlacher K,Zheng L,Campbell JL,Shen B

    更新日期:2016-04-01 00:00:00

  • Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.

    abstract:BACKGROUND:Tyrosine kinase inhibitors (TKIs) are clinically effective in non-small cell lung cancer (NSCLC) patients harbouring epidermal growth factor receptor (EGFR) oncogene mutations. Genetic factors, other than EGFR sensitive mutations, that allow prognosis of TKI treatment remain undefined. METHODS:We retrospect...


    pub_type: 杂志文章


    authors: Chen M,Xu Y,Zhao J,Zhong W,Zhang L,Bi Y,Wang M

    更新日期:2019-04-01 00:00:00

  • A prognostic gene expression signature for oropharyngeal squamous cell carcinoma.

    abstract:BACKGROUND:Robust prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) is important for developing individualized treatment plans. This study was conducted to develop and validate a clinically feasible prognostic classifier based on transcriptome-wide gene expression profiles. METHO...


    pub_type: 杂志文章


    authors: Liu X,Liu P,Chernock RD,Kuhs KAL,Lewis JS Jr,Luo J,Gay HA,Thorstad WL,Wang X

    更新日期:2020-11-01 00:00:00

  • Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism.

    abstract:BACKGROUND:Intake of ω-3 PUFAs have been demonstrated to have positive effects on pregnancy outcome, whose receptor, GPR120, regulates several cellular functions including differentiation, metabolism and immune reaction. However, whether GPR120 is involved in decidualization and pregnancy remains unknown. METHODS:Deci...


    pub_type: 杂志文章


    authors: Huang J,Xue M,Zhang J,Yu H,Gu Y,Du M,Ye W,Wan B,Jin M,Zhang Y

    更新日期:2019-01-01 00:00:00

  • Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link.

    abstract::Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological disorders, whose complex relationship is not completely understood. Cerebrovascular pathology, a key element in both conditions, could represent a mechanistic link between Aβ/tau deposition after TBI and the development of post conc...


    pub_type: 杂志文章,评审


    authors: Ramos-Cejudo J,Wisniewski T,Marmar C,Zetterberg H,Blennow K,de Leon MJ,Fossati S

    更新日期:2018-02-01 00:00:00

  • OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling.

    abstract:BACKGROUND:Activation of autocrine VEGF-VEGFR2 signalling in tumour cells activates cell proliferation, survival, and angiogenesis, all of which are crucial for tumour progression. Ovarian cancer-associated antigen 66 (OVA66) is now known to be overexpressed in multiple tumours and plays a role in tumour development, b...


    pub_type: 杂志文章


    authors: Song F,Chen Q,Rao W,Zhang R,Wang Y,Ge H,Wei Q

    更新日期:2019-03-01 00:00:00

  • Childhood growth and neurocognition are associated with distinct sets of metabolites.

    abstract:BACKGROUND:Undernutrition is a serious global problem that contributes to increased child morbidity and mortality, impaired neurocognitive development, and decreased educational and economic attainment. Current interventions are only marginally effective, and identification of associated metabolic pathways can offer ne...


    pub_type: 杂志文章


    authors: Moreau GB,Ramakrishnan G,Cook HL,Fox TE,Nayak U,Ma JZ,Colgate ER,Kirkpatrick BD,Haque R,Petri WA Jr

    更新日期:2019-06-01 00:00:00