Abstract：
:This study provides diverse lines of evidence demonstrating that fluoride (F) exposure contributes to degenerative eye diseases by stimulating or inhibiting biological pathways associated with the pathogenesis of cataract, age-related macular degeneration and glaucoma. As elucidated in this study, F exerts this effect by inhibiting enolase, τ-crystallin, Hsp40, Na⁺, K⁺-ATPase, Nrf2, γ -GCS, HO-1 Bcl-2, FoxO1, SOD, PON-1 and glutathione activity, and upregulating NF-κB, IL-6, AGEs, HsP27 and Hsp70 expression. Moreover, F exposure leads to enhanced oxidative stress and impaired antioxidant activity. Based on the evidence presented in this study, it can be concluded that F exposure may be added to the list of identifiable risk factors associated with pathogenesis of degenerative eye diseases. The broader impact of these findings suggests that reducing F intake may lead to an overall reduction in the modifiable risk factors associated with degenerative eye diseases. Further studies are required to examine this association and determine differences in prevalence rates amongst fluoridated and non-fluoridated communities, taking into consideration other dietary sources of F such as tea. Finally, the findings of this study elucidate molecular pathways associated with F exposure that may suggest a possible association between F exposure and other inflammatory diseases. Further studies are also warranted to examine these associations.
journal_name
Int J Environ Res Public Healthauthors
Waugh DTdoi
10.3390/ijerph16050856subject
Has Abstractpub_date
2019-03-08 00:00:00issue
5eissn
1661-7827issn
1660-4601pii
ijerph16050856journal_volume
16pub_type
杂志文章,评审abstract：:Tracking physical activity and sleep patterns using wearable trackers has become a current trend. However, little information exists about the comparability of wearable trackers measuring sleep. This study examined the comparability of wearable trackers for estimating sleep measurement with a sleep diary (SD) for thre...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,随机对照试验
doi：10.3390/ijerph15061265
更新日期：2018-06-15 00:00:00
abstract：:The quality of family relationships is important for individual and family well-being. Improving family relationships is also an important goal in methadone maintenance treatment (MMT). Little is known about factors associated with the improvement of family relationships among MMT clients. This study aimed to identify...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17010119
更新日期：2019-12-23 00:00:00
abstract：:In this review, the career of a pediatric exercise physiologist (HCGK) is given over a period of almost 50 years. His research was concentrated on the relationship of physical activity (physical education, sport, and daily physical activity) with health and fitness in teenagers in secondary schools. (1) His first expe...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph17082888
更新日期：2020-04-22 00:00:00
abstract：:Globalization and environmental change, social and demographic determinants and health system capacity are significant drivers of infectious diseases which can also act as epidemic precursors. Thus, monitoring changes in these drivers can help anticipate, or even forecast, an upsurge of infectious diseases. The Europe...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph120606333
更新日期：2015-06-02 00:00:00
abstract：:The importance of setting a policy focus on promoting cycling and walking as sustainable and healthy modes of transport is increasingly recognized. However, to date a science-driven scoring system to assess the policy environment for cycling and walking is lacking. In this study, spreadsheet-based scoring systems for ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph18030986
更新日期：2021-01-22 00:00:00
abstract：:In this article we provide an overview of the newest data concerning the effect of non-alcoholic constituents of alcoholic beverages, especially of beer, on pancreatic secretion, and their possible role in alcoholic pancreatitis and pancreatic carcinoma. The data indicate that non-alcoholic constituents of beer stimul...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph7031093
更新日期：2010-03-01 00:00:00
abstract：:Pollution emissions impose serious social negative externalities, especially in terms of public health. To reduce pollution emissions cost-effectively, the marginal abatement costs (MACs) of pollution emissions must be determined. Since the industrial sectors are the essential pillars of China's economic growth, as we...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph14121509
更新日期：2017-12-05 00:00:00
abstract：:Home processing can reduce pesticide residues in agricultural products, and the common forms of treatment include washing, peeling, blanching, and cooking. In this study, the removal effects of tap water, micron calcium solution, alkaline electrolyzed water (AlEW), ozone water, active oxygen, and sodium bicarbonate on...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16030472
更新日期：2019-02-06 00:00:00
abstract：:Perceived social discrimination in China has significant effects on drinking behavior. This finding was reached through multivariate logistic regression analysis of a sample of 22,566 adults in the 2016 China Family Panel Studies (CFPS). This was a cross-sectional study conducted with computer-assisted face-to-face in...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17176043
更新日期：2020-08-20 00:00:00
abstract：:We describe the different length (DL) qPCR method for quantification of UV induced DNA damage in cell killing. The principle of DL qPCR is that DNA damage inhibits PCR. Applications with different lengths can therefore be used to detect different levels of UV-induced DNA damage. The assay was evaluated on three strain...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph7093376
更新日期：2010-09-01 00:00:00
abstract：:The pupillary responses to light in patients with depression and normal controls were evaluated among Chinese females. Four parameters related to the pupil were assessed using a video-based pupillometer. The results showed that there were significant differences in the pupil area in the darkness and the pupil area at ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph110202236
更新日期：2014-02-21 00:00:00
abstract：:This paper aims to present life years at risk (LYAR), a new measure of population health needs for primary, secondary and tertiary prevention, which classifies health outcomes by care type and distinguishes between positive and negative outcomes. It is determined by the probability of ill-health event, population size...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph6092387
更新日期：2009-09-01 00:00:00
abstract：:The Zero Valent Iron (ZVI) is the material most commonly used for permeable reactive barriers (PRB). For technical and economic reasons, hoter reactive substances usable in alternative to ZVI are investigated. The present study takes into account a vegetable fibers, the cabuya, investigating its capacity to retain hea...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph14070684
更新日期：2017-06-24 00:00:00
abstract：:Highly variable changes in cognitive functions occur as people get older, and socio-economically disadvantaged older adults are more likely to suffer from cognitive decline. This study aims to identify the longitudinal trend in cognitive functions among different socio-economic groups of older adults. The Chinese Long...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17072418
更新日期：2020-04-02 00:00:00
abstract：:This study examines the relationships between alcohol taxation, drinking during pregnancy, and infant health. Merged data from the US Natality Detailed Files, as well as the Behavioral Risk Factor Surveillance System (1985-2002), data regarding state taxes on beer, wine, and liquor, a state- and year-fixed-effect redu...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph7051901
更新日期：2010-05-01 00:00:00
abstract：:The assessment of work-related functioning is a key process in vocational rehabilitation to identify specific domains of disability that can be considered within return to work strategies. The Work Rehabilitation Questionnaire (WORQ) was developed to evaluate work-related functioning based on the International Classif...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16152795
更新日期：2019-08-05 00:00:00
abstract：BACKGROUND:Most patients with thyroid cancer suffer from salivary gland (SG) dysfunctions after radioiodine (RI) therapy. We investigated the effects of keratinocyte growth factor (KGF)-1 on RI-induced SG dysfunction in an animal model. METHODS:Six C57BL/6 mice were assigned to each of the following groups: treatment ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17176322
更新日期：2020-08-31 00:00:00
abstract：:(1) Background: This article adopts an interdisciplinary perspective to analyse, examine, and reflect upon prominent health literacy (HL) understandings in childhood and youth. (2) Method: The conceptual analysis combined Rodgers' and Jabareen's approaches to conceptual analysis in eight phases. (3) Results: First, we...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16183417
更新日期：2019-09-14 00:00:00
abstract：:During physical exercise, the absorbed dose of air pollutants increases. Acute effects of exposure to air pollutants during exercise in healthy young adults remain poorly documented. The aim of this study was to assess the acute responses in fractionated exhaled nitric oxide (FeNO) and blood pressure to air pollution ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17239012
更新日期：2020-12-03 00:00:00
abstract：:Supermarkets are natural and important settings for implementing environmental interventions to improve healthy eating, and governmental policies could help improve the nutritional quality of purchases in this setting. This review aimed to: (1) identify governmental policies in the United States (U.S.), including regu...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph17207493
更新日期：2020-10-15 00:00:00
abstract：:This study examined the associations between eating or skipping breakfast and the quality of breakfast eaten on health-related quality of life (HRQOL), perceived stress and depression in 527 Spanish adolescents. Results showed differences in stress and two domains of HRQOL; Moods and Emotions and Parent Relations and ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15081781
更新日期：2018-08-19 00:00:00
abstract：:Studying the driving factors of environmental pollution is of great importance for China. Previous literature mainly focused on the cause of national aggregate emission changes. However, research about the effect of fiscal expenditures on science and technology (FESTs) on environmental pollution is rare. Considering t...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17238761
更新日期：2020-11-25 00:00:00
abstract：:This scoping review explores the state of science regarding women's toileting behaviors, gaps in knowledge, and areas for future research. Online databases were searched to identify papers published in English between January 2010 through July 2019; the search identified 25 articles. The Toileting Behaviors-Women's El...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16204000
更新日期：2019-10-19 00:00:00
abstract：:Individuals with diabetes are twice as likely to struggle from depressive symptoms than individuals without diabetes. However, this joint condition is undertreated in nearly two-thirds of patients. Failure to monitor the comorbidity may lead to suboptimal therapy. This study evaluated the association of antidepressant...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15091904
更新日期：2018-09-01 00:00:00
abstract：:COVID-19 infection has a broad spectrum of severity ranging from an asymptomatic form to a severe acute respiratory syndrome that requires mechanical ventilation. Starting with the description of our case series, we evaluated the clinical presentation and evolution of COVID-19. This article is addressed particularly t...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph17145062
更新日期：2020-07-14 00:00:00
abstract：:The study explored experiences of stress in children aged 10-12. An inductive qualitative design was used. Ten focus group interviews were conducted with Swedish schoolchildren (n = 42) aged 10-12. The interviews were audio-recorded, transcribed verbatim, and analyzed using qualitative content analysis. The study iden...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17114021
更新日期：2020-06-05 00:00:00
abstract：:Freezing of Gait (FOG) is a common condition in people with Parkinson's disease (PD). FOG entails suddenly experiencing difficulties moving or feeling that one's feet are as glued to the ground. It is triggered, e.g., when passing through doorways. Earlier studies suggest that being in natural environments affects FOG...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph120707274
更新日期：2015-06-29 00:00:00
abstract：:The fastest aging society with the lowest fertility rate can be buffered by support for healthy pregnancies using sociocultural approaches. We aimed to address adult perceptions of a healthy pregnancy and explored their needs and concerns about childbirth across the lifespan. We conducted a qualitative study using con...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17072460
更新日期：2020-04-03 00:00:00
abstract：:Stakeholder input into the decision-making process when developing public health programs and policies is crucial. This article presents an innovative approach, involving online participation with a wide group of stakeholders located in different geographic locations for policy consensus. The results of the project ha...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17207657
更新日期：2020-10-20 00:00:00
abstract：:The aim of this study was two-fold: (1) to analyze the within-week variations of heart rate, session-rated of perceived exertion (sRPE), total distance, distance in 8.0-11.99 km/h-1, recovery distance in 12.0-17.99 km/h-1, distance in >18.0 km/h-1, maximum speed, number of sprints, heart rate variability, delayed onse...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17061843
更新日期：2020-03-12 00:00:00
