Abstract：
:This study provides diverse lines of evidence demonstrating that fluoride (F) exposure contributes to degenerative eye diseases by stimulating or inhibiting biological pathways associated with the pathogenesis of cataract, age-related macular degeneration and glaucoma. As elucidated in this study, F exerts this effect by inhibiting enolase, τ-crystallin, Hsp40, Na⁺, K⁺-ATPase, Nrf2, γ -GCS, HO-1 Bcl-2, FoxO1, SOD, PON-1 and glutathione activity, and upregulating NF-κB, IL-6, AGEs, HsP27 and Hsp70 expression. Moreover, F exposure leads to enhanced oxidative stress and impaired antioxidant activity. Based on the evidence presented in this study, it can be concluded that F exposure may be added to the list of identifiable risk factors associated with pathogenesis of degenerative eye diseases. The broader impact of these findings suggests that reducing F intake may lead to an overall reduction in the modifiable risk factors associated with degenerative eye diseases. Further studies are required to examine this association and determine differences in prevalence rates amongst fluoridated and non-fluoridated communities, taking into consideration other dietary sources of F such as tea. Finally, the findings of this study elucidate molecular pathways associated with F exposure that may suggest a possible association between F exposure and other inflammatory diseases. Further studies are also warranted to examine these associations.
journal_name
Int J Environ Res Public Healthauthors
Waugh DTdoi
10.3390/ijerph16050856subject
Has Abstractpub_date
2019-03-08 00:00:00issue
5eissn
1661-7827issn
1660-4601pii
ijerph16050856journal_volume
16pub_type
杂志文章,评审abstract：:The aim of the present study is to quantify the relations between gender inequalities in mortality by selected causes of mortality and between competitiveness of Organisation for Economic Co-operation and Development (OECD) countries. Data for the analyses were obtained from OECD databases and the World Economic Forum...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17103698
更新日期：2020-05-24 00:00:00
abstract：:A diverse, cross-sectorial group of partners, stakeholders and researchers, collaborated to develop an evidence-informed Position Statement on active outdoor play for children aged 3-12 years. The Position Statement was created in response to practitioner, academic, legal, insurance and public debate, dialogue and dis...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph120606475
更新日期：2015-06-08 00:00:00
abstract：:This study aimed to examine the mediating effects of self-stigma and depression on the public stigma and nurses' attitudes toward psychiatric help. A cross-sectional study with 184 nurses at one general hospital in South Korea was conducted employing a self-administered survey, using the Attitudes toward Seeking Psych...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17145073
更新日期：2020-07-14 00:00:00
abstract：:In their recent article [1], Chari et al. call attention to the important subject of setting National Ambient Air Quality Standards (NAAQS) to provide requisite protection for public health, including the health of sensitive groups, as specified under the Clean Air Act (73 FR 66965) [2]. The authors focus on considera...
journal_title：International journal of environmental research and public health
pub_type： 评论,杂志文章
doi：10.3390/ijerph10020712
更新日期：2013-02-08 00:00:00
abstract：:Hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC) in China. At present, there still are 9.3 million chronic HBV-infected Chinese. Numerous studies have explored the association between possible factors and hepatocellular carcinoma risk, however, the results ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,meta分析,评审
doi：10.3390/ijerph13060604
更新日期：2016-06-17 00:00:00
abstract：:In this study, phenotypic and genotypic methods were used to detect metallo-β-lactamases, cephalosporinases and oxacillinases and to assess genetic diversity among 64 multiresistant Acinetobacter baumannii strains recovered from blood cultures in five different hospitals in Brazil from December 2008 to June 2009. High...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph110201465
更新日期：2014-01-28 00:00:00
abstract：:The dissipation of three field-applied pesticides (chlorothalonil, chlorpyrifos, and malathion), on cultivated prickly pear (Opuntia ficus-indica (L.) Mill.) pads was studied. The extraction of pesticides was carried out using the European quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction technique...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16162922
更新日期：2019-08-15 00:00:00
abstract：:Tobacco use has reached epidemic levels around the World, resulting in a world-wide increase in tobacco-related deaths and disabilities. Hospitalization presents an opportunity for nurses to encourage inpatients to quit smoking. This qualitative descriptive study was aimed to explore nurse-counsellors' perspectives of...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph110504782
更新日期：2014-05-06 00:00:00
abstract：BACKGROUND:A snakebite is a neglected extrinsic injury associated with high morbidity and global mortality. Members of Chinese field forces are at high risk of snakebites, and their perception and knowledge of snakebites are unknown. The aim of this study is to assess perception and knowledge of snakebites in field for...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph14010015
更新日期：2016-12-26 00:00:00
abstract：:The Mediterranean region is vulnerable to climatic changes. A warming trend exists in the basin with changes in rainfall patterns. It is expected that vector-borne diseases (VBD) in the region will be influenced by climate change since weather conditions influence their emergence. For some diseases (i.e., West Nile vi...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph120606745
更新日期：2015-06-15 00:00:00
abstract：:One impediment to expanding the prevalence and quality of community-engaged research is a shortage of instructive resources for collaboratively designing research instruments and analyzing data with community members. This article describes how a consortium of community residents, grassroots community organizations, a...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16030324
更新日期：2019-01-24 00:00:00
abstract：:The present study investigates the diurnal profiles of locomotive and household activities in older adults with musculoskeletal disorders (MSDs) using an accelerometer. Furthermore, we examined the effect of chronic pain on their diurnal profiles in both activities. Seventy-one older adults with MSDs (73-89 years) wer...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17155337
更新日期：2020-07-24 00:00:00
abstract：:The adsorption behavior and mechanism for the uptake of fluoride ions by untreated and desugared reed residues (roots, stems and leaves) were studied through adsorption experiments, elemental analysis, infrared spectroscopy and surface area analysis. The results showed that the adsorption capacity of untreated and des...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15010101
更新日期：2018-01-09 00:00:00
abstract：:Many factors affect menopausal age, and early or late onset of menopause may be associated with many chronic health problems. However, limited data are available regarding this phenomenon in the Northeast China population. For this study, 2011 elderly women were selected as a sample from participants in a cross-sectio...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph13100936
更新日期：2016-09-22 00:00:00
abstract：:Bullying and cyberbullying have severe psychological and legal consequences for those involved. However, it is unclear how or even if previous experience of bullying and cyberbullying is considered in mental health assessments. Furthermore, the relevance and effectiveness of current legal solutions has been debated ex...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph14121449
更新日期：2017-11-24 00:00:00
abstract：:This article describes a collaboration among a group of university faculty, undergraduate students, local governments, local residents, and U.S. Army staff to address long-standing concerns about the environmental health effects of an Army ammunition plant. The authors describe community-responsive scientific pilot st...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17051695
更新日期：2020-03-05 00:00:00
abstract：:Sub-Saharan African (SSA) countries face a growing burden of cardiovascular disease (CVD), attributed to economic, nutritional, demographic, and epidemiological transitions. These factors increase the prevalence of CVD risk factors, and the CVD burden overlaps with a high prevalence of infectious diseases. This review...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph16030419
更新日期：2019-02-01 00:00:00
abstract：:A health scare can be described as a campaign that attempts to alert the public of a particular substance or activity that can lead to a negative effect on health. A recent health scare to emerge relates to the health hazards associated with the use of e-cigarettes, which has caused widespread debate, which peaked tow...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17072236
更新日期：2020-03-26 00:00:00
abstract：BACKGROUND:While greenness has been associated with lower depression, the generalizability of this association in arid landscapes remains undetermined. We assessed the association between depression and residential greenness, but also brownness and grayness among nursing students living in El Paso, Texas (the Chihuahua...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17218146
更新日期：2020-11-04 00:00:00
abstract：:Seaports' energy strategy should rely on the use of renewable energy. Presently, the share of renewable energy used by many of the ports worldwide is negligible. Some initiatives are in the process of implementation to produce some of the energy used by the Port of Valencia, one the largest ports in the Mediterranean ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17228473
更新日期：2020-11-16 00:00:00
abstract：:Smoking tobacco can impair proper vascular endothelial functioning. This is exhibited through reduced nitric oxide synthesis as well as activity due to accompanying oxidative stress. We examined the relationship between nitric oxide and markers of oxidative stress/antioxidant defense in serum of smoking and non-smokin...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15122719
更新日期：2018-12-03 00:00:00
abstract：:The improper stacking of chromium (Cr) slag poses a great threat to the environment and human health. The toxicity of Cr in soil is not only related to its total amount, but also to its fractions. A simulated experiment was conducted in laboratory to assess the environmental risk of Cr fractions migration and distribu...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17082835
更新日期：2020-04-20 00:00:00
abstract：:Diurnal fluctuations in power output have been well established with power loss typically occurring in morning (AM) times. Beetroot juice (BRJ) is a source of dietary nitrate that possess ergogenic properties, but it is unknown if ingestion can mitigate performance decrements in the morning. The purpose of this study ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph18020412
更新日期：2021-01-07 00:00:00
abstract：:Conventional regulatory air quality monitoring sites tend to be sparsely located. The availability of lower-cost air pollution sensors, however, allows for their use in spatially dense community monitoring networks, which can be operated by various stakeholders, including concerned residents, organizations, academics,...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16183268
更新日期：2019-09-05 00:00:00
abstract：:This research aimed to uncover how the nutrition literacy domains (functional, interactive, critical) influence the dietary decisions of young adults in college. For this qualitative study, undergraduate college students aged 18-24 years old (n = 24) were recruited to participate in focus groups. The focus group trans...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph18031124
更新日期：2021-01-27 00:00:00
abstract：:Although many developing countries use harvested rainwater (HRW) for drinking and other household purposes, its quality is seldom monitored. Continuous assessment of the microbial quality of HRW would ensure the safety of users of such water. The current study investigated the prevalence of pathogenic Escherichia coli...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15050892
更新日期：2018-05-01 00:00:00
abstract：:People typically choose to live in quiet areas in order to safeguard their health and wellbeing. However, the benefits of living in quiet areas are relatively understudied compared to the burdens associated with living in noisy areas. Additionally, research is increasingly focusing on the relationship between the huma...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph10041284
更新日期：2013-03-27 00:00:00
abstract：:Poultry manure is the main source of agricultural and rural non-point source pollution, and its effective disposal through anaerobic digestion (AD) is of great significance; meanwhile, the high nitrogen content of chicken manure makes it a typical feedstock for anaerobic digestion. The performance of chicken-manure-ba...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16122239
更新日期：2019-06-25 00:00:00
abstract：:UV/H₂O₂, which is an advanced treatment technology used to reduce multiple contaminants, is effective in potable water treatment. Simultaneous degradation effects and kinetics of three types of coexisting micropollutant estrogens (steroid estrogens, SEs), including estrone (E1), 17β-estradiol (E2) and 17α-ethinyl estr...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph121012016
更新日期：2015-09-25 00:00:00
abstract：:The United States spends more on health care than any other OECD country, yet the nation's health is declining. Recent research has identified multiple sources for this decline, including one's position in social and economic structures, environmental quality, and individual and collective social capital. This paper a...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph18020620
更新日期：2021-01-13 00:00:00
