The Contribution of Fluoride to the Pathogenesis of Eye Diseases: Molecular Mechanisms and Implications for Public Health.

Abstract:

:This study provides diverse lines of evidence demonstrating that fluoride (F) exposure contributes to degenerative eye diseases by stimulating or inhibiting biological pathways associated with the pathogenesis of cataract, age-related macular degeneration and glaucoma. As elucidated in this study, F exerts this effect by inhibiting enolase, τ-crystallin, Hsp40, Na⁺, K⁺-ATPase, Nrf2, γ -GCS, HO-1 Bcl-2, FoxO1, SOD, PON-1 and glutathione activity, and upregulating NF-κB, IL-6, AGEs, HsP27 and Hsp70 expression. Moreover, F exposure leads to enhanced oxidative stress and impaired antioxidant activity. Based on the evidence presented in this study, it can be concluded that F exposure may be added to the list of identifiable risk factors associated with pathogenesis of degenerative eye diseases. The broader impact of these findings suggests that reducing F intake may lead to an overall reduction in the modifiable risk factors associated with degenerative eye diseases. Further studies are required to examine this association and determine differences in prevalence rates amongst fluoridated and non-fluoridated communities, taking into consideration other dietary sources of F such as tea. Finally, the findings of this study elucidate molecular pathways associated with F exposure that may suggest a possible association between F exposure and other inflammatory diseases. Further studies are also warranted to examine these associations.

authors

Waugh DT

doi

10.3390/ijerph16050856

subject

Has Abstract

pub_date

2019-03-08 00:00:00

issue

5

eissn

1661-7827

issn

1660-4601

pii

ijerph16050856

journal_volume

16

pub_type

杂志文章,评审
  • Impact of Gender Inequalities in the Causes of Mortality on the Competitiveness of OECD Countries.

    abstract::The aim of the present study is to quantify the relations between gender inequalities in mortality by selected causes of mortality and between competitiveness of Organisation for Economic Co-operation and Development (OECD) countries. Data for the analyses were obtained from OECD databases and the World Economic Forum...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17103698

    authors: Gavurova B,Ivankova V,Rigelsky M,Suhanyi L

    更新日期:2020-05-24 00:00:00

  • Position Statement on Active Outdoor Play.

    abstract::A diverse, cross-sectorial group of partners, stakeholders and researchers, collaborated to develop an evidence-informed Position Statement on active outdoor play for children aged 3-12 years. The Position Statement was created in response to practitioner, academic, legal, insurance and public debate, dialogue and dis...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章,评审

    doi:10.3390/ijerph120606475

    authors: Tremblay MS,Gray C,Babcock S,Barnes J,Bradstreet CC,Carr D,Chabot G,Choquette L,Chorney D,Collyer C,Herrington S,Janson K,Janssen I,Larouche R,Pickett W,Power M,Sandseter EB,Simon B,Brussoni M

    更新日期:2015-06-08 00:00:00

  • Nurses' Attitudes Toward Psychiatric Help for Depression: The Serial Mediation Effect of Self-Stigma and Depression on Public Stigma and Attitudes Toward Psychiatric Help.

    abstract::This study aimed to examine the mediating effects of self-stigma and depression on the public stigma and nurses' attitudes toward psychiatric help. A cross-sectional study with 184 nurses at one general hospital in South Korea was conducted employing a self-administered survey, using the Attitudes toward Seeking Psych...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17145073

    authors: Lee E,Jeong YM,Yi SJ

    更新日期:2020-07-14 00:00:00

  • Comments on: Chari, R.; Burke, T.A.; White, R.H.; Fox, M.A. Integrating Susceptibility into environmental policy: an analysis of the national ambient air quality standard for lead. Int. J. Environ. Res. Public Health 2012, 9, 1077-1096.

    abstract::In their recent article [1], Chari et al. call attention to the important subject of setting National Ambient Air Quality Standards (NAAQS) to provide requisite protection for public health, including the health of sensitive groups, as specified under the Clean Air Act (73 FR 66965) [2]. The authors focus on considera...

    journal_title:International journal of environmental research and public health

    pub_type: 评论,杂志文章

    doi:10.3390/ijerph10020712

    authors: Murphy DL,Patel M,Kirrane E,Vinikoor-Imler L

    更新日期:2013-02-08 00:00:00

  • Analysis of Risk Factors Associated with the Development of Hepatocellular Carcinoma in Chronic HBV-Infected Chinese: A Meta-Analysis.

    abstract::Hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC) in China. At present, there still are 9.3 million chronic HBV-infected Chinese. Numerous studies have explored the association between possible factors and hepatocellular carcinoma risk, however, the results ...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章,meta分析,评审

    doi:10.3390/ijerph13060604

    authors: Lyu X,Liu K,Chen Y,Wang Z,Yao J,Cai G,Jiang Z,Wang Z,Jiang J,Gu H

    更新日期:2016-06-17 00:00:00

  • Resistance markers and genetic diversity in Acinetobacter baumannii strains recovered from nosocomial bloodstream infections.

    abstract::In this study, phenotypic and genotypic methods were used to detect metallo-β-lactamases, cephalosporinases and oxacillinases and to assess genetic diversity among 64 multiresistant Acinetobacter baumannii strains recovered from blood cultures in five different hospitals in Brazil from December 2008 to June 2009. High...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph110201465

    authors: Martins HS,Bomfim MR,França RO,Farias LM,Carvalho MA,Serufo JC,Santos SG

    更新日期:2014-01-28 00:00:00

  • Dissipation Behavior of Three Pesticides in Prickly Pear (Opuntia ficus-indica (L.) Mill.) Pads in Morelos, Mexico.

    abstract::The dissipation of three field-applied pesticides (chlorothalonil, chlorpyrifos, and malathion), on cultivated prickly pear (Opuntia ficus-indica (L.) Mill.) pads was studied. The extraction of pesticides was carried out using the European quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction technique...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16162922

    authors: Ramírez-Bustos II,Saldarriaga-Noreña H,Fernández-Herrera E,Juárez-López P,Alia-Tejacal I,Guillén-Sánchez D,Rivera-León I,López-Martínez V

    更新日期:2019-08-15 00:00:00

  • Facilitators and barriers to effective smoking cessation: counselling services for inpatients from nurse-counsellors' perspectives--a qualitative study.

    abstract::Tobacco use has reached epidemic levels around the World, resulting in a world-wide increase in tobacco-related deaths and disabilities. Hospitalization presents an opportunity for nurses to encourage inpatients to quit smoking. This qualitative descriptive study was aimed to explore nurse-counsellors' perspectives of...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph110504782

    authors: Li IC,Lee SY,Chen CY,Jeng YQ,Chen YC

    更新日期:2014-05-06 00:00:00

  • A Survey of Snakebite Knowledge among Field Forces in China.

    abstract:BACKGROUND:A snakebite is a neglected extrinsic injury associated with high morbidity and global mortality. Members of Chinese field forces are at high risk of snakebites, and their perception and knowledge of snakebites are unknown. The aim of this study is to assess perception and knowledge of snakebites in field for...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph14010015

    authors: Chen C,Gui L,Kan T,Li S,Qiu C

    更新日期:2016-12-26 00:00:00

  • Impacts of Climate Change on Vector Borne Diseases in the Mediterranean Basin - Implications for Preparedness and Adaptation Policy.

    abstract::The Mediterranean region is vulnerable to climatic changes. A warming trend exists in the basin with changes in rainfall patterns. It is expected that vector-borne diseases (VBD) in the region will be influenced by climate change since weather conditions influence their emergence. For some diseases (i.e., West Nile vi...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph120606745

    authors: Negev M,Paz S,Clermont A,Pri-Or NG,Shalom U,Yeger T,Green MS

    更新日期:2015-06-15 00:00:00

  • Designing and Facilitating Collaborative Research Design and Data Analysis Workshops: Lessons Learned in the Healthy Neighborhoods Study.

    abstract::One impediment to expanding the prevalence and quality of community-engaged research is a shortage of instructive resources for collaboratively designing research instruments and analyzing data with community members. This article describes how a consortium of community residents, grassroots community organizations, a...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16030324

    authors: Binet A,Gavin V,Carroll L,Arcaya M

    更新日期:2019-01-24 00:00:00

  • Diurnal Profiles of Locomotive and Household Activities Using an Accelerometer in Community-Dwelling Older Adults with Musculoskeletal Disorders: A Cross-Sectional Survey.

    abstract::The present study investigates the diurnal profiles of locomotive and household activities in older adults with musculoskeletal disorders (MSDs) using an accelerometer. Furthermore, we examined the effect of chronic pain on their diurnal profiles in both activities. Seventy-one older adults with MSDs (73-89 years) wer...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17155337

    authors: Sakakima H,Takada S,Norimatsu K,Otsuka S,Nakanishi K,Tani A

    更新日期:2020-07-24 00:00:00

  • Adsorption Behavior and Mechanism for the Uptake of Fluoride Ions by Reed Residues.

    abstract::The adsorption behavior and mechanism for the uptake of fluoride ions by untreated and desugared reed residues (roots, stems and leaves) were studied through adsorption experiments, elemental analysis, infrared spectroscopy and surface area analysis. The results showed that the adsorption capacity of untreated and des...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph15010101

    authors: Song R,Yang S,Xu H,Wang Z,Chen Y,Wang Y

    更新日期:2018-01-09 00:00:00

  • Menopausal Age and Chronic Diseases in Elderly Women: A Cross-Sectional Study in Northeast China.

    abstract::Many factors affect menopausal age, and early or late onset of menopause may be associated with many chronic health problems. However, limited data are available regarding this phenomenon in the Northeast China population. For this study, 2011 elderly women were selected as a sample from participants in a cross-sectio...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph13100936

    authors: Fu Y,Yu Y,Wang S,Kanu JS,You Y,Liu Y,Zhang Y,Liu Y,Li B,Tao Y,Kou C

    更新日期:2016-09-22 00:00:00

  • Bullying and Cyberbullying: Their Legal Status and Use in Psychological Assessment.

    abstract::Bullying and cyberbullying have severe psychological and legal consequences for those involved. However, it is unclear how or even if previous experience of bullying and cyberbullying is considered in mental health assessments. Furthermore, the relevance and effectiveness of current legal solutions has been debated ex...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph14121449

    authors: Samara M,Burbidge V,El Asam A,Foody M,Smith PK,Morsi H

    更新日期:2017-11-24 00:00:00

  • Building Interdisciplinary Partnerships for Community-Engaged Environmental Health Research in Appalachian Virginia.

    abstract::This article describes a collaboration among a group of university faculty, undergraduate students, local governments, local residents, and U.S. Army staff to address long-standing concerns about the environmental health effects of an Army ammunition plant. The authors describe community-responsive scientific pilot st...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17051695

    authors: Satterwhite E,Bell SE,Marr LC,Thompson CK,Prussin AJ 2nd,Buttling L,Pan J,Gohlke JM

    更新日期:2020-03-05 00:00:00

  • Cardiovascular Disease Healthcare Utilization in Sub-Saharan Africa: A Scoping Review.

    abstract::Sub-Saharan African (SSA) countries face a growing burden of cardiovascular disease (CVD), attributed to economic, nutritional, demographic, and epidemiological transitions. These factors increase the prevalence of CVD risk factors, and the CVD burden overlaps with a high prevalence of infectious diseases. This review...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章,评审

    doi:10.3390/ijerph16030419

    authors: Chikafu H,Chimbari MJ

    更新日期:2019-02-01 00:00:00

  • Contextualising the 2019 E-Cigarette Health Scare: Insights from Twitter.

    abstract::A health scare can be described as a campaign that attempts to alert the public of a particular substance or activity that can lead to a negative effect on health. A recent health scare to emerge relates to the health hazards associated with the use of e-cigarettes, which has caused widespread debate, which peaked tow...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17072236

    authors: Ahmed W,Marin-Gomez X,Vidal-Alaball J

    更新日期:2020-03-26 00:00:00

  • Green, Brown, and Gray: Associations between Different Measurements of Land Patterns and Depression among Nursing Students in El Paso, Texas.

    abstract:BACKGROUND:While greenness has been associated with lower depression, the generalizability of this association in arid landscapes remains undetermined. We assessed the association between depression and residential greenness, but also brownness and grayness among nursing students living in El Paso, Texas (the Chihuahua...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17218146

    authors: Nazif-Munoz JI,Cedeno Laurent JG,Browning M,Spengler J,Olvera Álvarez HA

    更新日期:2020-11-04 00:00:00

  • Wave Energy Assessment at Valencia Gulf and Comparison of Energy Production of Most Suitable Wave Energy Converters.

    abstract::Seaports' energy strategy should rely on the use of renewable energy. Presently, the share of renewable energy used by many of the ports worldwide is negligible. Some initiatives are in the process of implementation to produce some of the energy used by the Port of Valencia, one the largest ports in the Mediterranean ...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17228473

    authors: Cascajo R,García E,Quiles E,Morant F,Correcher A

    更新日期:2020-11-16 00:00:00

  • Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women.

    abstract::Smoking tobacco can impair proper vascular endothelial functioning. This is exhibited through reduced nitric oxide synthesis as well as activity due to accompanying oxidative stress. We examined the relationship between nitric oxide and markers of oxidative stress/antioxidant defense in serum of smoking and non-smokin...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph15122719

    authors: Chełchowska M,Ambroszkiewicz J,Gajewska J,Mazur J,Lewandowski L,Reśko-Zachara M,Maciejewski TM

    更新日期:2018-12-03 00:00:00

  • Assessing Chromium Contamination in Red Soil: Monitoring the Migration of Fractions and the Change of Related Microorganisms.

    abstract::The improper stacking of chromium (Cr) slag poses a great threat to the environment and human health. The toxicity of Cr in soil is not only related to its total amount, but also to its fractions. A simulated experiment was conducted in laboratory to assess the environmental risk of Cr fractions migration and distribu...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17082835

    authors: Zhang S,Hao X,Tang J,Hu J,Deng Y,Xu M,Zhu P,Tao J,Liang Y,Yin H,Jiang L,Liu X,Liu H

    更新日期:2020-04-20 00:00:00

  • Acute Beetroot Juice Supplementation Attenuates Morning-Associated Decrements in Supramaximal Exercise Performance in Trained Sprinters.

    abstract::Diurnal fluctuations in power output have been well established with power loss typically occurring in morning (AM) times. Beetroot juice (BRJ) is a source of dietary nitrate that possess ergogenic properties, but it is unknown if ingestion can mitigate performance decrements in the morning. The purpose of this study ...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph18020412

    authors: Dumar AM,Huntington AF,Rogers RR,Kopec TJ,Williams TD,Ballmann CG

    更新日期:2021-01-07 00:00:00

  • Next-Generation Community Air Quality Sensors for Identifying Air Pollution Episodes.

    abstract::Conventional regulatory air quality monitoring sites tend to be sparsely located. The availability of lower-cost air pollution sensors, however, allows for their use in spatially dense community monitoring networks, which can be operated by various stakeholders, including concerned residents, organizations, academics,...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16183268

    authors: Seto E,Carvlin G,Austin E,Shirai J,Bejarano E,Lugo H,Olmedo L,Calderas A,Jerrett M,King G,Meltzer D,Wilkie A,Wong M,English P

    更新日期:2019-09-05 00:00:00

  • College Students' Views on Functional, Interactive and Critical Nutrition Literacy: A Qualitative Study.

    abstract::This research aimed to uncover how the nutrition literacy domains (functional, interactive, critical) influence the dietary decisions of young adults in college. For this qualitative study, undergraduate college students aged 18-24 years old (n = 24) were recruited to participate in focus groups. The focus group trans...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph18031124

    authors: McNamara J,Mena NZ,Neptune L,Parsons K

    更新日期:2021-01-27 00:00:00

  • Antibiotic-Resistant Pathogenic Escherichia Coli Isolated from Rooftop Rainwater-Harvesting Tanks in the Eastern Cape, South Africa.

    abstract::Although many developing countries use harvested rainwater (HRW) for drinking and other household purposes, its quality is seldom monitored. Continuous assessment of the microbial quality of HRW would ensure the safety of users of such water. The current study investigated the prevalence of pathogenic Escherichia coli...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph15050892

    authors: Malema MS,Abia ALK,Tandlich R,Zuma B,Mwenge Kahinda JM,Ubomba-Jaswa E

    更新日期:2018-05-01 00:00:00

  • Do quiet areas afford greater health-related quality of life than noisy areas?

    abstract::People typically choose to live in quiet areas in order to safeguard their health and wellbeing. However, the benefits of living in quiet areas are relatively understudied compared to the burdens associated with living in noisy areas. Additionally, research is increasingly focusing on the relationship between the huma...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph10041284

    authors: Shepherd D,Welch D,Dirks KN,McBride D

    更新日期:2013-03-27 00:00:00

  • Performance of Anaerobic Digestion of Chicken Manure Under Gradually Elevated Organic Loading Rates.

    abstract::Poultry manure is the main source of agricultural and rural non-point source pollution, and its effective disposal through anaerobic digestion (AD) is of great significance; meanwhile, the high nitrogen content of chicken manure makes it a typical feedstock for anaerobic digestion. The performance of chicken-manure-ba...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16122239

    authors: Zhang C,Wang F,Pei M,Qiu L,Qiang H,Yao Y

    更新日期:2019-06-25 00:00:00

  • Simultaneous Degradation of Estrone, 17β-Estradiol and 17α-Ethinyl Estradiol in an Aqueous UV/H₂O₂ System.

    abstract::UV/H₂O₂, which is an advanced treatment technology used to reduce multiple contaminants, is effective in potable water treatment. Simultaneous degradation effects and kinetics of three types of coexisting micropollutant estrogens (steroid estrogens, SEs), including estrone (E1), 17β-estradiol (E2) and 17α-ethinyl estr...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph121012016

    authors: Ma X,Zhang C,Deng J,Song Y,Li Q,Guo Y,Li C

    更新日期:2015-09-25 00:00:00

  • Exploring the Nexus of Energy Burden, Social Capital, and Environmental Quality in Shaping Health in US Counties.

    abstract::The United States spends more on health care than any other OECD country, yet the nation's health is declining. Recent research has identified multiple sources for this decline, including one's position in social and economic structures, environmental quality, and individual and collective social capital. This paper a...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph18020620

    authors: Reames TG,Daley DM,Pierce JC

    更新日期:2021-01-13 00:00:00