A polyvalent coral snake antivenom with broad neutralization capacity.

abstract：:Adenosine-5'-triphosphate (ATP) is an important phosphate metabolite abundantly found in Mycobacterium leprae bacilli. This pathogen does not derive ATP from its host but has its own mechanism for the generation of ATP. Interestingly, this molecule as well as several antigenic proteins act as bio-markers for the detec...

journal_title：PLoS neglected tropical diseases

authors： Nandi SK,Chakraborty A,Panda AK,Ray SS,Kar RK,Bhunia A,Biswas A

更新日期：2015-03-26 00:00:00

abstract：:The Global Programme to Eliminate Lymphatic Filariasis has made significant progress toward interrupting transmission of lymphatic filariasis (LF) through mass drug administration (MDA). Operational challenges in defining endpoints of elimination programs include the need to determine appropriate post-MDA surveillance...

journal_title：PLoS neglected tropical diseases

authors： Lau CL,Won KY,Lammie PJ,Graves PM

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:In 2012 the WHO formally recognised that infants and preschool children are at significant risk of schistosomiasis and qualify for treatment with praziquantel (PZQ). Targeted surveys determining both the performance and safety of this drug are now needed in endemic areas. We have formally assessed parasitolo...

journal_title：PLoS neglected tropical diseases

authors： Sousa-Figueiredo JC,Betson M,Atuhaire A,Arinaitwe M,Navaratnam AM,Kabatereine NB,Bickle Q,Stothard JR

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The range of the Asian tiger mosquito Aedes albopictus is expanding globally, raising the threat of emerging and re-emerging arbovirus transmission risks including dengue and chikungunya. Its detection in Papua New Guinea's (PNG) southern Fly River coastal region in 1988 and 1992 placed it 150 km from mainla...

journal_title：PLoS neglected tropical diseases

authors： Beebe NW,Ambrose L,Hill LA,Davis JB,Hapgood G,Cooper RD,Russell RC,Ritchie SA,Reimer LJ,Lobo NF,Syafruddin D,van den Hurk AF

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:Viral hemorrhagic fevers (VHF) are acute diseases associated with bleeding, organ failure, and shock. VHF may hardly be distinguished clinically from other diseases in the African hospital, including viral hepatitis. This study was conducted to determine if VHF and viral hepatitis contribute to hospital morb...

journal_title：PLoS neglected tropical diseases

authors： Bonney JH,Osei-Kwasi M,Adiku TK,Barnor JS,Amesiya R,Kubio C,Ahadzie L,Olschläger S,Lelke M,Becker-Ziaja B,Pahlmann M,Günther S

更新日期：2013-09-19 00:00:00

abstract：IMPORTANCE:Trichiasis surgery programs globally have faced high rates of poor surgical outcomes. Identifying correctable risk factors for improving long-term outcomes is essential for countries targeting elimination of trachoma as a public health problem. OBJECTIVE:To determine whether the location of trichiatic eyela...

journal_title：PLoS neglected tropical diseases

authors： Gower EW,Munoz B,Rajak S,Habtamu E,West SK,Merbs SL,Harding JC,Alemayehu W,Callahan EK,Emerson PM,Gebre T,Burton MJ

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management. Here, we quantify heterogeneities in Leishmania infantum parasite numbers in reservoir and non-reservoir host populations, and relate this ...

journal_title：PLoS neglected tropical diseases

authors： Courtenay O,Carson C,Calvo-Bado L,Garcez LM,Quinnell RJ

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:The World Health Organization identified Uganda as one of the 10 highly endemic countries for schistosomiasis. Annual mass drug administration (MDA) with praziquantel has led to a decline in intensity of Schistosoma mansoni infections in several areas. However, as hotspots with high (re)infection rates remai...

journal_title：PLoS neglected tropical diseases

authors： Trienekens SCM,Faust CL,Meginnis K,Pickering L,Ericsson O,Nankasi A,Moses A,Tukahebwa EM,Lamberton PHL

更新日期：2020-05-13 00:00:00

abstract：:Most statistical and mechanistic models used to predict mosquito-borne disease transmission incorporate climate drivers of disease transmission by utilizing environmental data collected at geographic scales that are potentially coarser than what mosquito populations may actually experience. Temperature and relative hu...

journal_title：PLoS neglected tropical diseases

authors： Murdock CC,Evans MV,McClanahan TD,Miazgowicz KL,Tesla B

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:In the late twentieth century, emergence of high rates of treatment failure with antimonial compounds (SSG) for visceral leishmaniasis (VL) caused a public health crisis in Bihar, India. We hypothesize that exposure to arsenic through drinking contaminated groundwater may be associated with SSG treatment fai...

journal_title：PLoS neglected tropical diseases

authors： Perry MR,Prajapati VK,Menten J,Raab A,Feldmann J,Chakraborti D,Sundar S,Fairlamb AH,Boelaert M,Picado A

更新日期：2015-03-02 00:00:00

abstract：BACKGROUND:Human brucellosis (HB) is a bacterial zoonosis that is more frequent in low income and middle-income countries; it is sometimes associated with outbreaks. The aim of this study was to describe the largest outbreak of HB in Brazil. METHODS:A retrospective cohort study of patients suspected of having contract...

journal_title：PLoS neglected tropical diseases

authors： Lemos TS,Cequinel JC,Costa TP,Navarro AB,Sprada A,Shibata FK,Gondolfo R,Tuon FF

更新日期：2018-09-18 00:00:00

abstract：:Between March 2014 and July 2015 at least 10,500 Ebola cases including more than 4,800 deaths occurred in Liberia, the majority in Monrovia. However, official numbers may have underestimated the size of the outbreak. Closure of health facilities and mistrust in existing structures may have additionally impacted on all...

journal_title：PLoS neglected tropical diseases

authors： Kuehne A,Lynch E,Marshall E,Tiffany A,Alley I,Bawo L,Massaquoi M,Lodesani C,Le Vaillant P,Porten K,Gignoux E

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:Epidemiological studies carried out using culture or microscopy in most of the amoebiasis endemic developing countries, yielded confusing results since none of these could differentiate the pathogenic Entamoeba histolytica from the non-pathogenic Entamoeba dispar and Entamoeba moshkovskii. The Northeastern p...

journal_title：PLoS neglected tropical diseases

authors： Nath J,Ghosh SK,Singha B,Paul J

更新日期：2015-12-03 00:00:00

abstract：BACKGROUND:The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2], a low mole...

journal_title：PLoS neglected tropical diseases

authors： Benítez D,Medeiros A,Fiestas L,Panozzo-Zenere EA,Maiwald F,Prousis KC,Roussaki M,Calogeropoulou T,Detsi A,Jaeger T,Šarlauskas J,Peterlin Mašič L,Kunick C,Labadie GR,Flohé L,Comini MA

更新日期：2016-04-12 00:00:00

abstract：:Burkholderia pseudomallei causes the tropical infection melioidosis. Pneumonia is a common manifestation of melioidosis and is associated with high mortality. Understanding the key elements of host defense is essential to developing new therapeutics for melioidosis. As a flagellated bacterium encoding type III secreti...

journal_title：PLoS neglected tropical diseases

authors： West TE,Myers ND,Chantratita N,Chierakul W,Limmathurotsakul D,Wuthiekanun V,Miao EA,Hajjar AM,Peacock SJ,Liggitt HD,Skerrett SJ

更新日期：2014-09-18 00:00:00

abstract：:Soil-transmitted helminths (STH) are a major cause of morbidity in tropical developing countries with a global infection prevalence of more than one billion people and disease burden of around 3.4 million disability adjusted life years. Infection prevalence directly correlates to inadequate sanitation, impoverished co...

journal_title：PLoS neglected tropical diseases

authors： Stracke K,Clarke N,Awburn CV,Vaz Nery S,Khieu V,Traub RJ,Jex AR

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:Hantaan virus (HTNV; family Hantaviridae, order Bunyavirales) causes hemorrhagic fever with renal syndrome (HFRS), which has raised serious concerns in Eurasia, especially in China, Russia, and South Korea. Previous studies reported genetic diversity and phylogenetic features of HTNV in different parts of Ch...

journal_title：PLoS neglected tropical diseases

authors： Li N,Li A,Liu Y,Wu W,Li C,Yu D,Zhu Y,Li J,Li D,Wang S,Liang M

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Antibody-detecting rapid diagnostic tests (RDTs) against rK39 are available to aid in the diagnosis of visceral leishmaniasis (VL). Although these rK39 RDTs have been developed, validated and approved for use with serum, they are universally performed using whole blood. It was therefore necessary to determin...

journal_title：PLoS neglected tropical diseases

authors： Matlashewski G,Das VN,Pandey K,Singh D,Das S,Ghosh AK,Pandey RN,Das P

更新日期：2013-05-23 00:00:00

abstract：:In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, the epidemiological trend in Chin...

journal_title：PLoS neglected tropical diseases

authors： Liang H,Zheng L,Xia H,Tang J

更新日期：2020-08-06 00:00:00

abstract：:P. vivax and P. falciparum parasites display different tropism for host cells and induce very different clinical symptoms and pathology, suggesting that the immune responses required for protection may differ between these two species. However, no study has qualitatively compared the immune responses to P. falciparum ...

journal_title：PLoS neglected tropical diseases

authors： Burel JG,Apte SH,McCarthy JS,Doolan DL

更新日期：2016-12-08 00:00:00

abstract：:A 51-year-old man with 3-month unhealing cat bite wound was diagnosed with sporotrichosis, a subacute-to-chronic infection caused by the worldwide endemic, dimorphic fungus Sporothrix globosa. The case would help clinicians to raise awareness of human sporotrichosis due to cat bites, which remains rare and is likely t...

journal_title：PLoS neglected tropical diseases

authors： Liu Y,Liu L,Kang M,Zong Z

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Leprosy is a condition that has long been associated with stigma and discrimination, even when infected persons have been cured. This paper describes stigma and discrimination as viewed by caregivers who are associated with people affected by leprosy in Ghana. METHODS:A qualitative interview with semi-struc...

journal_title：PLoS neglected tropical diseases

authors： Asampong E,Dako-Gyeke M,Oduro R

更新日期：2018-01-29 00:00:00

abstract：BACKGROUND:MPT64 rapid speciation tests are increasingly being used in diagnosis of tuberculosis (TB). Mycobacterium africanum West Africa 2 (Maf 2) remains an important cause of TB in West Africa and causes one third of disease in The Gambia. Since the introduction of MPT64 antigen tests, a higher than expected rate o...

journal_title：PLoS neglected tropical diseases

authors： Ofori-Anyinam B,Kanuteh F,Agbla SC,Adetifa I,Okoi C,Dolganov G,Schoolnik G,Secka O,Antonio M,de Jong BC,Gehre F

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:Cryptosporidium is a protozoan parasite that causes mild to severe diarrhoeal disease in humans. To date, several commercial companies have developed rapid immunoassays for the detection of Cryptosporidium infection. However, the challenge is to identify an accurate, simple and rapid diagnostic tool for the ...

journal_title：PLoS neglected tropical diseases

authors： Manouana GP,Lorenz E,Mbong Ngwese M,Nguema Moure PA,Maiga Ascofaré O,Akenten CW,Amuasi J,Rakotozandrindrainy N,Rakotozandrindrainy R,Mbwana J,Lusingu J,Byrne N,Melhem S,Zinsou JF,Adegbite RB,Hogan B,Winter D,May J,Kre

更新日期：2020-07-13 00:00:00

abstract：:Zika virus (ZIKV) has emerged since 2013 as a significant global human health threat following outbreaks in the Pacific Islands and rapid spread throughout South and Central America. Severe congenital and neurological sequelae have been linked to ZIKV infections. Assessing the ability of common mosquito species to tra...

journal_title：PLoS neglected tropical diseases

authors： Main BJ,Nicholson J,Winokur OC,Steiner C,Riemersma KK,Stuart J,Takeshita R,Krasnec M,Barker CM,Coffey LL

更新日期：2018-06-21 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0007140.]. ...

journal_title：PLoS neglected tropical diseases

authors： PLOS Neglected Tropical Diseases Staff.

更新日期：2019-06-28 00:00:00

abstract：BACKGROUND:Despite the known burden of neglected tropical diseases (NTDs) on child health, there is limited information on current efforts to increase pediatric therapeutic options. Our objective was to quantify and characterize research activity and treatment availability for NTDs in children in order to inform the pr...

journal_title：PLoS neglected tropical diseases

authors： Rees CA,Hotez PJ,Monuteaux MC,Niescierenko M,Bourgeois FT

更新日期：2019-01-29 00:00:00

abstract：:Rhinoscleroma is a chronic granulomatous infection of the upper airways caused by the bacterium Klebsiella pneumoniae subsp. rhinoscleromatis. The disease is endemic in tropical and subtropical areas, but its diagnosis remains difficult. As a consequence, and despite available antibiotherapy, some patients evolve adva...

journal_title：PLoS neglected tropical diseases

authors： Fevre C,Passet V,Deletoile A,Barbe V,Frangeul L,Almeida AS,Sansonetti P,Tournebize R,Brisse S

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited. METHODOLOGY/PRINCIPAL FINDINGS:Four hundred and seventy nine acutely febrile...

journal_title：PLoS neglected tropical diseases

authors： Stubbs SCB,Johar E,Yudhaputri FA,Yohan B,Santoso MS,Hayati RF,Denis D,Blacklaws BA,Powers AM,Sasmono RT,Myint KSA,Frost SDW

更新日期：2020-12-21 00:00:00

abstract：BACKGROUND:Trachoma is a major cause of blindness in Southern Sudan. Its distribution has only been partially established and many communities in need of intervention have therefore not been identified or targeted. The present study aimed to develop a tool to improve targeting of survey and control activities. METHODS...

journal_title：PLoS neglected tropical diseases

authors： Clements AC,Kur LW,Gatpan G,Ngondi JM,Emerson PM,Lado M,Sabasio A,Kolaczinski JH

更新日期：2010-08-17 00:00:00