Congenital Hypogonadotrophic Hypogonadism: Minipuberty and the Case for Neonatal Diagnosis.

abstract：:GPER-1 is a novel membrane sited G protein-coupled estrogen receptor. Clinical studies have shown that patients suffering an estrogen receptor α (ERα)/GPER-1 positive, breast cancer have a lower survival rate than those who have developed ERα-positive/GPER-1 negative tumors. Moreover, absence of GPER-1 improves the pr...

journal_title：Frontiers in endocrinology

authors： Molina L,Bustamante F,Ortloff A,Ramos I,Ehrenfeld P,Figueroa CD

更新日期：2020-09-30 00:00:00

abstract：:Gonadotropin-inhibitory hormone (GnIH) was first identified in Japanese quail to be an inhibitor of gonadotropin synthesis and release. GnIH peptides have since been identified in all vertebrates, and all share an LPXRFamide (X = L or Q) motif at their C-termini. The receptor for GnIH is the G protein-coupled receptor...

journal_title：Frontiers in endocrinology

authors： Ubuka T,Son YL,Tobari Y,Narihiro M,Bentley GE,Kriegsfeld LJ,Tsutsui K

更新日期：2014-01-27 00:00:00

abstract：:Interferon gamma (IFNγ) is a Th1 cytokine that is critical for innate and adaptive immunity. Toll-like receptors (TLRs) signaling pathways are critical in early host defense against invading pathogens. miR-146a has been reported to participate in the regulation of host immunity. The known mechanisms of integrations be...

journal_title：Frontiers in endocrinology

authors： Peng W,Sun Y,Li GF,He LG,Li RZ,Liang YS,Ding X,Yu X,Zhang Y,Lin HR,Lu DQ

更新日期：2018-02-26 00:00:00

abstract：:Catecholamine (CA) secretion from the adrenal medullary tissue is a key step of the adaptive response triggered by an organism to cope with stress. Whereas molecular and cellular secretory processes have been extensively studied at the single chromaffin cell level, data available for the whole gland level are much sca...

journal_title：Frontiers in endocrinology

authors： De Nardi F,Lefort C,Bréard D,Richomme P,Legros C,Guérineau NC

更新日期：2017-09-25 00:00:00

abstract：:Amphibian post-embryonic development and Thyroid Hormones (TH) signaling are deeply and intimately connected. In anuran amphibians, TH induce the spectacular and complex process known as metamorphosis. In paedomorphic salamanders, at similar development time, raising levels of TH fail to induce proper metamorphosis, a...

journal_title：Frontiers in endocrinology

authors： Kerdivel G,Blugeon C,Fund C,Rigolet M,Sachs LM,Buisine N

更新日期：2019-04-02 00:00:00

abstract：:Background: Myostatin (Mstn), a member of the TGF-β superfamily, is a negative regulator of skeletal muscle mass in mammals. Precise regulation of Mstn expression is important for somite growth in fish. MicroRNA (miRNA), a type of small non-coding RNA, regulates gene expression at the post-transcriptional level and pa...

journal_title：Frontiers in endocrinology

authors： Zhao Z,Yu X,Jia J,Yang G,Sun C,Li W

更新日期：2019-12-03 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV)/AIDS pandemic represents the most significant global health challenge in modern history. This infection leads toward an inflammatory state associated with chronic immune dysregulation activation that tilts the immune-skeletal interface and its deep integration between cell...

journal_title：Frontiers in endocrinology

authors： Delpino MV,Quarleri J

更新日期：2020-09-02 00:00:00

abstract：Background:Left ventricular (LV) diastolic dysfunction has been demonstrated to be an independent predictor of the future heart failure. Heart failure is one of the severe complications caused by overt hyperthyroidism. However, the effects of overt hyperthyroidism on diastolic dysfunction are conflicting, and little is...

journal_title：Frontiers in endocrinology

authors： Li H,Zeng R,Liao Y,Fu M,Zhang H,Wang L,Li Y

更新日期：2021-01-08 00:00:00

abstract：Objective:Individuals with diabetic peripheral neuropathy (DPN) have functional deficits that increase their risk of falling. However, psychological aspects such as loss of confidence in undertaking activities could also contribute to this risk. We examined correlations between balance confidence and fall risk among in...

journal_title：Frontiers in endocrinology

authors： Riandini T,Khoo EYH,Tai BC,Tavintharan S,Phua MSLA,Chandran K,Hwang SW,Venkataraman K

更新日期：2020-10-23 00:00:00

abstract：:Several studies have shown that a woman's vaginal or axillary odors convey information on her attractivity. Yet, whether such scents induce psychoneuroendocrinological changes in perceivers is still controversial. We studied if smelling axillary and vulvar odors collected in the periovulatory and late luteal phases of...

journal_title：Frontiers in endocrinology

authors： Cerda-Molina AL,Hernández-López L,de la O CE,Chavira-Ramírez R,Mondragón-Ceballos R

更新日期：2013-10-28 00:00:00

abstract：Objective:To analyze association between different perioperative glycemic control strategies and postoperative outcomes in patients with diabetes undergoing cardiac surgery. Methods:MEDLINE, Cochrane Library, Web of Science, EMBASE, Wanfang Data, China National Knowledge Infrastructure (CNKI) and China Biology Medicin...

journal_title：Frontiers in endocrinology

authors： Jin X,Wang J,Ma Y,Li X,An P,Wang J,Mao W,Mu Y,Chen Y,Chen K

更新日期：2020-12-17 00:00:00

abstract：:The G-protein coupled parathyroid hormone 2 receptor (PTH2R) is concentrated in endocrine and limbic regions in the forebrain. Its endogenous ligand, tuberoinfundibular peptide of 39 residues (TIP39), is synthesized in only two brain regions, within the posterior thalamus and the lateral pons. TIP39-expressing neurons...

journal_title：Frontiers in endocrinology

authors： Dobolyi A,Dimitrov E,Palkovits M,Usdin TB

更新日期：2012-10-08 00:00:00

abstract：:Estetrol (E4) is a natural human estrogen present at high concentrations during pregnancy. Due to its high oral bioavailability and long plasma half-life, E4 is particularly suitable for therapeutic applications. E4 acts as a selective estrogen receptor (ER) modulator, exerting estrogenic actions on the endometrium or...

journal_title：Frontiers in endocrinology

authors： Giretti MS,Montt Guevara MM,Cecchi E,Mannella P,Palla G,Spina S,Bernacchi G,Di Bello S,Genazzani AR,Genazzani AD,Simoncini T

更新日期：2014-05-26 00:00:00

abstract：:The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced levels of drug transporters, enhanced DNA-damage repair mechanisms, ...

journal_title：Frontiers in endocrinology

authors： Veschi V,Verona F,Thiele CJ

更新日期：2019-11-19 00:00:00

abstract：:Type 2 diabetes prevalence is increasing dramatically worldwide. Metabolic surgery is the most effective treatment for selected patients with diabetes and/or obesity. When compared to intensive medical therapy and lifestyle intervention, metabolic surgery has shown superiority in achieving glycemic improvement, reduci...

journal_title：Frontiers in endocrinology

authors： Pérez-Pevida B,Escalada J,Miras AD,Frühbeck G

更新日期：2019-09-19 00:00:00

abstract：:Pituitary adenomas are common neoplasms. Their classification is based upon size, invasion of adjacent structures, sporadic or familial cases, biochemical activity, clinical manifestations, morphological characteristics, response to treatment and recurrence. Although they are considered benign tumors, some of them are...

journal_title：Frontiers in endocrinology

authors： Syro LV,Rotondo F,Ramirez A,Di Ieva A,Sav MA,Restrepo LM,Serna CA,Kovacs K

更新日期：2015-06-12 00:00:00

abstract：:Failure of uterine vascular transformation is associated with pregnancy complications including Intra Uterine Growth Restriction (IUGR). The decidua and its immune cell populations play a key role in the earliest stages of this process. Here we investigate the hypothesis that abnormal decidualization and failure of ma...

journal_title：Frontiers in endocrinology

authors： Dunk C,Kwan M,Hazan A,Walker S,Wright JK,Harris LK,Jones RL,Keating S,Kingdom JCP,Whittle W,Maxwell C,Lye SJ

更新日期：2019-03-20 00:00:00

abstract：:JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1-3 and TYK2. JAKs serve as the cytoplasmic signaling components of cytokine receptors and are activated through cytokine-mediated trans-phosphorylation, which leads to receptor phosphorylation and recruitmen...

journal_title：Frontiers in endocrinology

authors： Hubbard SR

更新日期：2018-01-05 00:00:00

abstract：:The world-wide obesity epidemic constitutes a severe threat to human health and wellbeing and poses a major challenge to health-care systems. Current therapeutic approaches, relying mainly on reduced energy intake and/or increased exercise energy expenditure, are generally of limited effectiveness. Previously believed...

journal_title：Frontiers in endocrinology

authors： Betz MJ,Enerbäck S

更新日期：2011-11-29 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune diseases and mainly include Graves' disease (GD) and Hashimoto's thyroiditis (HT). CD14 is an important component of the immune system as a receptor for gram-negative lipopolysaccharide (LPS). The genetic polymorphisms of CD14 have been confirme...

journal_title：Frontiers in endocrinology

authors： Jia X,Wang B,Yao Q,Li Q,Zhang J

更新日期：2019-01-16 00:00:00

abstract：:Diabetes is a worldwide public health concern as it is associated with various complications. One of the major complications of diabetes is diabetic foot syndrome that results in catastrophic events such as ulceration and amputation. Therefore, the main four strategies of diabetic foot care involve risk prediction, pr...

journal_title：Frontiers in endocrinology

authors： Balasubramanian G,Vas P,Chockalingam N,Naemi R

更新日期：2020-05-22 00:00:00

abstract：:The past two decades have witnessed many advances in the prevention, treatment, and control of diabetes mellitus (DM) and its complications. Increased screening has led to a greater recognition of type 2 diabetes mellitus (type 2 DM) and prediabetes; however, Hispanics/Latinos, the largest minority group in the US, ha...

journal_title：Frontiers in endocrinology

authors： Avilés-Santa ML,Colón-Ramos U,Lindberg NM,Mattei J,Pasquel FJ,Pérez CM

更新日期：2017-11-10 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2019.00276.]. ...

journal_title：Frontiers in endocrinology

authors： Thambirajah AA,Koide EM,Imbery JJ,Helbing CC

更新日期：2019-06-26 00:00:00

abstract：Objectives:Based on data from the China National Health Survey, we aimed to examine the association between body height and cardiometabolic disease (CMD) in a large adult population from Shaanxi province, and further to test whether this association was hinged upon other population characteristics. Methods:This popula...

journal_title：Frontiers in endocrinology

authors： Yuan Y,Zhou B,Wang S,Ma J,Dong F,Yang M,Zhang Z,Niu W

更新日期：2020-12-21 00:00:00

abstract：:O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 30 years ago, great ...

journal_title：Frontiers in endocrinology

authors： Cox NJ,Luo PM,Smith TJ,Bisnett BJ,Soderblom EJ,Boyce M

更新日期：2018-10-15 00:00:00

abstract：:In rodents, insufficient thyroid hormone (TH) gestationally has adverse effects on cerebral cortex development. Comparable studies of humans examining how TH insufficiency affects cortical morphology are limited to children with congenital hypothyroidism or offspring of hypothyroxinemic women; effects on cortex of chi...

journal_title：Frontiers in endocrinology

authors： Lischinsky JE,Skocic J,Clairman H,Rovet J

更新日期：2016-02-25 00:00:00

abstract：:Older women with type 2 diabetes mellitus (DM) have higher bone mineral density (BMD) but also have higher rates of fracture compared to those without DM. Limited evidence suggests that DM may also be associated with more rapid bone loss. To determine if bone loss rates differ by DM status in older women, we analyzed ...

journal_title：Frontiers in endocrinology

authors： Schwartz AV,Ewing SK,Porzig AM,McCulloch CE,Resnick HE,Hillier TA,Ensrud KE,Black DM,Nevitt MC,Cummings SR,Sellmeyer DE

更新日期：2013-05-30 00:00:00

abstract：:Introduction: Although pre-treatment with a GnRH agonist can reduce the size of adenomyosis lesions, the supra-physiological hormone level induced by controlled ovarian hyperstimulation (COH) may negate the usefulness of the GnRH agonist in patients with adenomyosis lesions, leading to continued poor outcomes in fresh...

journal_title：Frontiers in endocrinology

authors： Chen M,Luo L,Wang Q,Gao J,Chen Y,Zhang Y,Zhou C

更新日期：2020-05-29 00:00:00

abstract：:Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervou...

journal_title：Frontiers in endocrinology

authors： Gonçalves RA,Wijesekara N,Fraser PE,De Felice FG

更新日期：2020-03-12 00:00:00

abstract：:A well-functioning hematopoietic system requires a certain robustness and flexibility to maintain appropriate quantities of functional mature blood cells, such as red blood cells and platelets. This review focuses on the cytokine receptor that plays a significant role in thrombopoiesis: the receptor for thrombopoietin...

journal_title：Frontiers in endocrinology

authors： Varghese LN,Defour JP,Pecquet C,Constantinescu SN

更新日期：2017-03-31 00:00:00