MiR-409-3p Inhibits Cell Proliferation and Invasion of Osteosarcoma by Targeting Zinc-Finger E-Box-Binding Homeobox-1.

abstract：:The clinical practice of selective serotonin reuptake inhibitor (SSRI) augmentation relies heavily on trial-and-error. Unfortunately, the drug combinations prescribed today fail to provide relief for many depressed patients. In order to identify potentially more effective treatments, we developed a computational model...

journal_title：Frontiers in pharmacology

authors： Camacho MB,Vijitbenjaronk WD,Anastasio TJ

更新日期：2019-10-25 00:00:00

abstract：Introduction:Diabetes is a metabolic disease with a high incidence and serious harm to human health. Islet β-cell function defects can occur in the late stage of type 1 diabetes and type 2 diabetes. Studies have shown that stem cell is a promising new approach in bioengineering regenerative medicine. In the study of st...

journal_title：Frontiers in pharmacology

authors： Xu B,Fan D,Zhao Y,Li J,Wang Z,Wang J,Wang X,Guan Z,Niu B

更新日期：2020-01-24 00:00:00

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：:Proteolytic enzymes are crucial for a variety of biological processes in organisms ranging from lower (virus, bacteria, and parasite) to the higher organisms (mammals). Proteases cleave proteins into smaller fragments by catalyzing peptide bonds hydrolysis. Proteases are classified according to their catalytic site, a...

journal_title：Frontiers in pharmacology

authors： Verma S,Dixit R,Pandey KC

更新日期：2016-04-25 00:00:00

abstract：:Canonical Wnt signaling pathway, also known as Wnt/β-catenin signaling pathway, is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues in...

journal_title：Frontiers in pharmacology

authors： Aminuddin A,Ng PY

更新日期：2016-08-12 00:00:00

abstract：:We aimed to ascertain the mechanism underlying the effects of acteoside (ACT) from Ligustrum robustum (Roxb.) Blume (Oleaceae) on lipid metabolism and synthesis. ACT, a water-soluble phenylpropanoid glycoside, is the most abundant and major active component of L. robustum; the leaves of L. robustum, known as kudingcha...

journal_title：Frontiers in pharmacology

authors： Sun L,Yu F,Yi F,Xu L,Jiang B,Le L,Xiao P

更新日期：2019-05-24 00:00:00

abstract：:We explored the therapeutic effects of Dendrobium officinale polysaccharide (DOP) on CCl4-induced liver fibrosis with respect to the intestinal hepatic axis using a rat model. Histopathological staining results showed that DOP alleviated extensive fibrous tissue proliferation in interstitium and lessened intestinal mu...

journal_title：Frontiers in pharmacology

authors： Wang K,Yang X,Wu Z,Wang H,Li Q,Mei H,You R,Zhang Y

更新日期：2020-03-12 00:00:00

abstract：:Purpose: The present study compared the risk of ischemic stroke in atrial fibrillation (AF) patients receiving digoxin and amiodarone. Methods: A retrospective cohort study was conducted using the longitudinal population-based database of Taiwan's National Health Insurance program. Patients with AF who received amioda...

journal_title：Frontiers in pharmacology

authors： Lai KC,Chen SJ,Lin CS,Yang FC,Lin CL,Hsu CW,Huang WC,Kao CH

更新日期：2018-05-07 00:00:00

abstract：RATIONALE:Alzheimer's disease (AD) is a debilitating disease with complex pathophysiology. Amyloid beta (Aβ) (1-42) is a reliable model of AD that recapitulates many aspects of human AD. OBJECTIVE:The intent of the present study was to investigate the neuroprotective potential of Coenzyme Q10 (CoQ10) and its modulatio...

journal_title：Frontiers in pharmacology

authors： Singh A,Kumar A

更新日期：2015-11-09 00:00:00

abstract：:Mainstay chemotherapy for malaria is often faced with the problem of instability and poor bio-distribution thus resulting in impaired pharmacokinetics. Nanomedicine has been acclaimed for its success in drug delivery and improved efficacy. The aim of the study was to assess the antiplasmodial efficacy and safety of cu...

journal_title：Frontiers in pharmacology

authors： Oyeyemi O,Morenkeji O,Afolayan F,Dauda K,Busari Z,Meena J,Panda A

更新日期：2018-05-30 00:00:00

abstract：:Nanoparticle-based antibiotic constructs have become a popular area of investigation in the biomedical sciences. Much of this work has pertained to human diseases, largely in the cancer therapy arena. However, considerable research has also been devoted to the nanochemistry for controlling infectious diseases. Among t...

journal_title：Frontiers in pharmacology

authors： Labruère R,Sona AJ,Turos E

更新日期：2019-10-04 00:00:00

abstract：:Since the introduction of antibiotics, they have been used freely, with their prescription occurring almost always when they were not necessary. The other major form of contact between humans and antibiotics, now unintentionally, is with the large amount of these drugs in the environment and in our food. The relations...

journal_title：Frontiers in pharmacology

authors： Del Fiol FS,Balcão VM,Barberato-Fillho S,Lopes LC,Bergamaschi CC

更新日期：2018-12-03 00:00:00

abstract：:The growing interest in testosterone's effects on men's social behaviors, in particular aggressive, risk-taking, or status maintenance behaviors, is accompanied by a paucity of dose-dependent pharmacokinetic data. Examining the neurophysiological effects of transdermal testosterone typically includes a 4h delay before...

journal_title：Frontiers in pharmacology

authors： Puiu AA,Radke S,Votinov M,Habel U,Herpertz-Dahlmann B,Turetsky B,Konrad K

更新日期：2019-11-21 00:00:00

abstract：:The root of Aconitum kusnezoffii (Caowu in Chinese, CW) is not only commonly used as a traditional Chinese medicine (TCM), but also served as a tonic in China. Due to its high toxicity, clinical poisoning cases induced by CW have frequently been reported. However, the mechanism is still unclear. In this study, Aconitu...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Bian X,Yang J,Wu H,Wu JL,Li N

更新日期：2019-03-22 00:00:00

abstract：:Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon. The excitatory neurotransmitter glutamate and its receptors have been closely ...

journal_title：Frontiers in pharmacology

authors： Ménard C,Quirion R

更新日期：2012-10-12 00:00:00

abstract：:Over 1 million cases of scorpion stings are estimated every year, whereas current treatment is limited to antivenom serum combined with supportive therapy. Tityus serrulatus scorpion venom (TsV) is composed of diverse molecules, including toxins that induce a catecholamine storm and mediate classical symptoms of scorp...

journal_title：Frontiers in pharmacology

authors： Zoccal KF,Gardinassi LG,Bordon KCF,Arantes EC,Marleau S,Ong H,Faccioli LH

更新日期：2019-03-01 00:00:00

abstract：:Background: Doxorubicin (Dox) can induce endotheliotoxicity and damage the vascular endothelium (VE). The most principle mechanism might be excess reactive oxygen species (ROS) generation. Nevertheless, the characteristics of ROS generation, downstream mechanisms, and target organelles in Dox-induced endotheliotoxicit...

journal_title：Frontiers in pharmacology

authors： He H,Wang L,Qiao Y,Zhou Q,Li H,Chen S,Yin D,Huang Q,He M

更新日期：2020-01-10 00:00:00

abstract：:One of the most difficult challenges in clinical hepatology is the diagnosis of a drug-induced liver injury (DILI). The timing of the events, exclusion of alternative causes, and taking into account the clinical context should be systematically assessed and scored in a transparent manner. RUCAM (Roussel Uclaf Causalit...

journal_title：Frontiers in pharmacology

authors： Teschke R

更新日期：2019-07-23 00:00:00

abstract：:There are many types of biomarkers; the two common ones are biomarkers of exposure and biomarkers of effect. The utility of a biomarker for estimating exposures or predicting risks depends on the strength of the correlation between biomarker concentrations and exposure/effects. In the current study, a combined exposur...

journal_title：Frontiers in pharmacology

authors： Phillips MB,Yoon M,Young B,Tan YM

更新日期：2014-11-18 00:00:00

abstract：:ORY-1001, an inhibitor of covalent lysine (K)-specific demethylase 1A (KDM1A), has been used as a therapy for the treatment of acute leukemia. However, the underlying mechanisms of anticancer are still not fully elucidated. Here, we report that KDM1A is highly expressed in lung cancers, where it appears to drive aggre...

journal_title：Frontiers in pharmacology

authors： Lu Z,Guo Y,Zhang X,Li J,Li L,Zhang S,Shan C

更新日期：2018-12-04 00:00:00

abstract：:The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy. In cardiomyocyte hypertrophy induced by β-adrenergic receptor agonist isoprenaline (ISO), PRMT5 expression was decreased while HoxA9 was upregulated. Silencing of...

journal_title：Frontiers in pharmacology

authors： Cai S,Liu R,Wang P,Li J,Xie T,Wang M,Cao Y,Li Z,Liu P

更新日期：2020-12-10 00:00:00

abstract：:Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regardin...

journal_title：Frontiers in pharmacology

authors： van Schaik RHN,Müller DJ,Serretti A,Ingelman-Sundberg M

更新日期：2020-09-11 00:00:00

abstract：:Pickering emulsion, a kind of emulsion stabilized only by solid particles locating at oil-water interface, has been discovered a century ago, while being extensively studied in recent decades. Substituting solid particles for traditional surfactants, Pickering emulsions are more stable against coalescence and can obta...

journal_title：Frontiers in pharmacology

authors： Yang Y,Fang Z,Chen X,Zhang W,Xie Y,Chen Y,Liu Z,Yuan W

更新日期：2017-05-23 00:00:00

abstract：:Lipid emulsions (LEs), an integral component in parenteral nutrition (PN) feeding, have shifted from the primary aim of delivering non-protein calories and essential fatty acids to defined therapeutic outcomes such as reducing inflammation, and improving metabolic and clinical outcomes. Use of LEs in PN for surgical a...

journal_title：Frontiers in pharmacology

authors： Sadu Singh BK,Narayanan SS,Khor BH,Sahathevan S,Abdul Gafor AH,Fiaccadori E,Sundram K,Karupaiah T

更新日期：2020-04-29 00:00:00

abstract：BACKGROUND:The dried root of Paeonia lactiflora Pall. (PLP) is a classical Chinese herbal medicine that has been used to treat hepatic disease for 1000s of years. Our previous work suggested that PLP can be used to treat hepatitis with severe cholestasis. This study explored the mechanism by which PLP affects ANIT-indu...

journal_title：Frontiers in pharmacology

authors： Ma X,Chi YH,Niu M,Zhu Y,Zhao YL,Chen Z,Wang JB,Zhang CE,Li JY,Wang LF,Gong M,Wei SZ,Chen C,Zhang L,Wu MQ,Xiao XH

更新日期：2016-02-04 00:00:00

abstract：:Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement factor H (CFH) gene; ...

journal_title：Frontiers in pharmacology

authors： Stravalaci M,Davi F,Parente R,Gobbi M,Bottazzi B,Mantovani A,Day AJ,Clark SJ,Romano MR,Inforzato A

更新日期：2020-11-26 00:00:00

abstract：:Lipopolysaccharide (LPS) can induce bone loss by stimulating bone resorption. Natural compounds have great potential for the treatment of osteolytic bone diseases. Magnesium lithospermate B (MLB) plays an important role in protecting against oxidative damage and also has potential anti-inflammatory pharmacological pro...

journal_title：Frontiers in pharmacology

authors： Wang J,Wu X,Duan Y

更新日期：2018-02-06 00:00:00

abstract：:Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary edema (PE) is a fatal complication of EV71 infection. Among inotr...

journal_title：Frontiers in pharmacology

authors： Wang SM

更新日期：2016-03-29 00:00:00

abstract：:Background: Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process activated by lung transplantation and acute lung injury. The p38 mitogen-activated protein kinase (MAPK) is involved in breakdown of the endothelial barrier during LIRI, but the mechanism is still unclear. Therefore, we investi...

journal_title：Frontiers in pharmacology

authors： Wang T,Liu C,Pan LH,Liu Z,Li CL,Lin JY,He Y,Xiao JY,Wu S,Qin Y,Li Z,Lin F

更新日期：2020-12-11 00:00:00

abstract：:Digoxin is widely used to treat heart failure. Epidemiological studies suggested it might be used as an anticancer drug or sensitizing agent for cancer therapy. Adriamycin is a well-known anticancer drug, but often causes cardiotoxicity which limits its use. We recently investigated the anticancer effects of digoxin a...

journal_title：Frontiers in pharmacology

authors： Wang Y,Ma Q,Zhang S,Liu H,Zhao B,Du B,Wang W,Lin P,Zhang Z,Zhong Y,Kong D

更新日期：2020-02-28 00:00:00