A report from a conference jointly organised by the European Academy of Cancer Sciences and the Pontifical Academy of Sciences, The Vatican, November 16-17, 2018.

Abstract:

:Cancer is a massive challenge with a significant impact on society, healthcare systems, the economy and an increasing number of patients and their families. To help meet this societal challenge, the European Commission has recently proposed a mission-oriented approach to cancer in Horizon Europe, and about 60 participants met at the Vatican to discuss a mission-oriented approach to cancer in Europe, as documented in this report. Painting: Rowe, Ernest Arthur. Courtyard of the Casina Pio IV (ca. 1911-1913).

journal_name

Mol Oncol

journal_title

Molecular oncology

authors

European Academy of Cancer Sciences.

doi

10.1002/1878-0261.12436

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

511-516

issue

3

eissn

1574-7891

issn

1878-0261

journal_volume

13

pub_type

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    更新日期:2016-11-01 00:00:00

  • Synergistic activity of everolimus and 5-aza-2'-deoxycytidine in medullary thyroid carcinoma cell lines.

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    doi:10.1002/1878-0261.12070

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    更新日期:2017-08-01 00:00:00

  • Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer.

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    更新日期:2015-03-01 00:00:00

  • Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors.

    abstract::Although mutations in the phosphoinositide 3-kinase catalytic subunit (PIK3CA) are common in breast cancer, PI3K inhibitors alone have shown modest efficacy. We sought to identify additional pathways altered in PIK3CA-mutant tumors that might be targeted in combination with PI3K inhibitors. We generated two transgenic...

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    更新日期:2017-05-01 00:00:00

  • miR-200c and phospho-AKT as prognostic factors and mediators of osteosarcoma progression and lung metastasis.

    abstract::Lung metastasis is the major cause of death in osteosarcoma patients. However, molecular mechanisms underlying this metastasis remain poorly understood. To identify key molecules related with pulmonary metastasis of pediatric osteosarcomas, we analyzed high-throughput miRNA expression in a cohort of 11 primary tumors ...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2016.04.004

    authors: Berlanga P,Muñoz L,Piqueras M,Sirerol JA,Sánchez-Izquierdo MD,Hervás D,Hernández M,Llavador M,Machado I,Llombart-Bosch A,Cañete A,Castel V,Font de Mora J

    更新日期:2016-08-01 00:00:00

  • Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses.

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    doi:10.1002/1878-0261.12521

    authors: Tavassoly I,Hu Y,Zhao S,Mariottini C,Boran A,Chen Y,Li L,Tolentino RE,Jayaraman G,Goldfarb J,Gallo J,Iyengar R

    更新日期:2019-08-01 00:00:00

  • Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma.

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    更新日期:2015-01-01 00:00:00

  • Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle.

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    更新日期:2013-12-01 00:00:00

  • Genomic profiling of newly diagnosed glioblastoma patients and its potential for clinical utility - a prospective, translational study.

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    更新日期:2020-09-04 00:00:00

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    更新日期:2016-02-01 00:00:00

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    更新日期:2013-04-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1016/j.molonc.2009.05.005

    authors: Vaccari T,Bilder D

    更新日期:2009-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1002/1878-0261.12536

    authors: Mazzu YZ,Yoshikawa Y,Nandakumar S,Chakraborty G,Armenia J,Jehane LE,Lee GM,Kantoff PW

    更新日期:2019-09-01 00:00:00

  • PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells.

    abstract::Triple negative breast cancer (TNBC) is a very aggressive subgroup of breast carcinoma, still lacking specific markers for an effective targeted therapy and with a poorer prognosis compared to other breast cancer subtypes. In this study we investigated the possibility that TNBC cells contribute to the establishment of...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2014.03.015

    authors: Plantamura I,Casalini P,Dugnani E,Sasso M,D'Ippolito E,Tortoreto M,Cacciatore M,Guarnotta C,Ghirelli C,Barajon I,Bianchi F,Triulzi T,Agresti R,Balsari A,Campiglio M,Tripodo C,Iorio MV,Tagliabue E

    更新日期:2014-07-01 00:00:00

  • Targeting HER2 in patient-derived xenograft ovarian cancer models sensitizes tumors to chemotherapy.

    abstract::Ovarian cancer is the most lethal gynecologic malignancy. About 75% of ovarian cancer patients relapse and/or develop chemo-resistant disease after initial response to standard-of-care treatment with platinum-based therapies. HER2 amplifications and overexpression in ovarian cancer are reported to vary, and responses ...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12414

    authors: Harris FR,Zhang P,Yang L,Hou X,Leventakos K,Weroha SJ,Vasmatzis G,Kovtun IV

    更新日期:2019-02-01 00:00:00

  • Prioritization of candidate cancer drugs based on a drug functional similarity network constructed by integrating pathway activities and drug activities.

    abstract::Due to the speed, efficiency, relative risk, and lower costs compared to traditional drug discovery, the prioritization of candidate drugs for repurposing against cancers of interest has attracted the attention of experts in recent years. Herein, we present a powerful computational approach, termed prioritization of c...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12564

    authors: Di J,Zheng B,Kong Q,Jiang Y,Liu S,Yang Y,Han X,Sheng Y,Zhang Y,Cheng L,Han J

    更新日期:2019-10-01 00:00:00

  • Stromal SPOCK1 supports invasive pancreatic cancer growth.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is marked by an abundant stromal deposition. This stroma is suspected to harbor both tumor-promoting and tumor-suppressing properties. This is underscored by the disappointing results of stroma targeting in clinical studies. Given the complexity of tumor-stroma interaction in PD...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12073

    authors: Veenstra VL,Damhofer H,Waasdorp C,Steins A,Kocher HM,Medema JP,van Laarhoven HW,Bijlsma MF

    更新日期:2017-08-01 00:00:00