A report from a conference jointly organised by the European Academy of Cancer Sciences and the Pontifical Academy of Sciences, The Vatican, November 16-17, 2018.


:Cancer is a massive challenge with a significant impact on society, healthcare systems, the economy and an increasing number of patients and their families. To help meet this societal challenge, the European Commission has recently proposed a mission-oriented approach to cancer in Horizon Europe, and about 60 participants met at the Vatican to discuss a mission-oriented approach to cancer in Europe, as documented in this report. Painting: Rowe, Ernest Arthur. Courtyard of the Casina Pio IV (ca. 1911-1913).


Mol Oncol


Molecular oncology


European Academy of Cancer Sciences.




Has Abstract


2019-03-01 00:00:00












  • FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome.

    abstract::Estrogen receptor-alpha (ERα)-positive breast cancer is often treated with antihormonal regimens. However, resistance to treatment is common, leading to metastatic disease. ERα activity requires the functional involvement of pioneer factors FOXA1 and GATA3, which enable ERα-chromatin binding and are crucial for ERα-dr...

    journal_title:Molecular oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Schrijver W,Schuurman K,van Rossum A,Droog M,Jeronimo C,Salta S,Henrique R,Wesseling J,Moelans C,Linn SC,van den Heuvel M,van Diest P,Zwart W

    更新日期:2018-11-01 00:00:00

  • Tissue proteomics of the human mammary gland: towards an abridged definition of the molecular phenotypes underlying epithelial normalcy.

    abstract::Our limited understanding of the biological impact of the whole spectrum of early breast lesions together with a lack of accurate molecular-based risk criteria for the diagnosis and assignment of prognostic significance to biopsy findings presents an important problem in the clinical management of patients harboring p...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Moreira JM,Cabezón T,Gromova I,Gromov P,Timmermans-Wielenga V,Machado I,Llombart-Bosch A,Kroman N,Rank F,Celis JE

    更新日期:2010-12-01 00:00:00

  • Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF.

    abstract::The small heat-shock protein of 27 kDa (HSP27) is highly expressed in many cancers and is associated with aggressive tumour behaviour, metastasis, poor prognosis and resistance to chemotherapy. We aimed at assessing the role of HSP27 in modulating responses to target therapies. We selected several oncogene-addicted ca...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Konda JD,Olivero M,Musiani D,Lamba S,Di Renzo MF

    更新日期:2017-06-01 00:00:00

  • Altered purinergic receptor-Ca²⁺ signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells.

    abstract::Hypoxia is a feature of the microenvironment of many cancers and can trigger epithelial-mesenchymal transition (EMT), a process by which cells acquire a more invasive phenotype with enriched survival. A remodeling of adenosine 5'-triphosphate (ATP)-induced Ca(2+) signaling via purinergic receptors is associated with e...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Azimi I,Beilby H,Davis FM,Marcial DL,Kenny PA,Thompson EW,Roberts-Thomson SJ,Monteith GR

    更新日期:2016-01-01 00:00:00

  • Allo-reactive T cells for the treatment of hematological malignancies.

    abstract::Several mechanisms can be responsible for control of hematological tumors by allo-reactive T cells. Following allogeneic stem cell transplantation (alloSCT) donor T cells recognizing genetic disparities presented on recipient cells and not on donor cells are main effectors of tumor control, but also of the detrimental...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Falkenburg JH,Jedema I

    更新日期:2015-12-01 00:00:00

  • Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients.

    abstract::Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylatio...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Ji X,Lin L,Shen S,Dong X,Chen C,Li Y,Zhu Y,Huang H,Chen J,Chen X,Wei L,He J,Duan W,Su L,Jiang Y,Fan J,Guan J,You D,Shafer A,Bjaanæs MM,Karlsson A,Planck M,Staaf J,Helland Å,Esteller M,Wei Y,Zhang R,C

    更新日期:2020-11-01 00:00:00

  • Dual Constant Domain-Fab: A novel strategy to improve half-life and potency of a Met therapeutic antibody.

    abstract::The kinase receptor encoded by the Met oncogene is a sensible target for cancer therapy. The chimeric monovalent Fab fragment of the DN30 monoclonal antibody (MvDN30) has an odd mechanism of action, based on cell surface removal of Met via activation of specific plasma membrane proteases. However, the short half-life ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Cignetto S,Modica C,Chiriaco C,Fontani L,Milla P,Michieli P,Comoglio PM,Vigna E

    更新日期:2016-06-01 00:00:00

  • Expression patterns of bone morphogenetic protein antagonists in colorectal cancer desmoplastic invasion fronts.

    abstract::Bone morphogenetic proteins (BMPs) are a group of growth factors with dual functions in cancer development and progression. Recently, certain tumor-promoting roles have been identified for selected antagonists/inhibitors (BMPIs) of this developmental pathway. A recent focus on the implication of BMP in colorectal canc...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Karagiannis GS,Treacy A,Messenger D,Grin A,Kirsch R,Riddell RH,Diamandis EP

    更新日期:2014-10-01 00:00:00

  • Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma.

    abstract::Periampullary adenocarcinomas can be of two histological subtypes, intestinal or pancreatobiliary. The latter is more frequent and aggressive, and characterized by a prominent desmoplastic stroma, which is tightly related to the biology of the cancer, including its poor response to chemotherapy. Whereas miRNAs are kno...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Sandhu V,Bowitz Lothe IM,Labori KJ,Skrede ML,Hamfjord J,Dalsgaard AM,Buanes T,Dube G,Kale MM,Sawant S,Kulkarni-Kale U,Børresen-Dale AL,Lingjærde OC,Kure EH

    更新日期:2016-02-01 00:00:00

  • Detection of circulating tumor cells in colorectal cancer patients using the GILUPI CellCollector: results from a prospective, single-center study.

    abstract::The GILUPI CellCollector (CC) is a novel in vivo circulating tumor cell (CTC) detection device reported to overcome the limitations of small blood sample volumes. The aim of this prospective, blinded study was to evaluate the clinical application of the CC and to compare its performance to the CellSearch (CS) system i...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Dizdar L,Fluegen G,van Dalum G,Honisch E,Neves RP,Niederacher D,Neubauer H,Fehm T,Rehders A,Krieg A,Knoefel WT,Stoecklein NH

    更新日期:2019-07-01 00:00:00

  • CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas.

    abstract::The elevated expression and activation of human telomerase reverse transcriptase (hTERT) is associated with the unlimited proliferation of cancer cells. However, the excise mechanism of hTERT regulation during carcinogenesis is not well understood. In this study, we discovered cleavage and polyadenylation specific fac...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Chen W,Qin L,Wang S,Li M,Shi D,Tian Y,Wang J,Fu L,Li Z,Guo W,Yu W,Yuan Y,Kang T,Huang W,Deng W

    更新日期:2014-05-01 00:00:00

  • FOXM1D Potentiates PKM2-mediated tumor glycolysis and angiogenesis.

    abstract::Tumor growth, especially in the late stage, requires adequate nutrients and rich vasculature, in which PKM2 plays a convergent role. It has been reported that PKM2, together with FOXM1D, is upregulated in late stage colorectal cancer and associated with metastasis; however, their underlying mechanism for promoting tum...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Zhang W,Zhang X,Huang S,Chen J,Ding P,Wang Q,Li L,Lv X,Li L,Zhang P,Zhou D,Wen W,Wang Y,Lei QY,Wu J,Hu W

    更新日期:2020-12-13 00:00:00

  • The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma.

    abstract::Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS-ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS chaperone domain-containing endochondral bone protein chondromodulin I (CHM1) in ES pathogenes...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: von Heyking K,Calzada-Wack J,Göllner S,Neff F,Schmidt O,Hensel T,Schirmer D,Fasan A,Esposito I,Müller-Tidow C,Sorensen PH,Burdach S,Richter GHS

    更新日期:2017-09-01 00:00:00

  • Revisiting epithelial-mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness.

    abstract::Epithelial-mesenchymal transition (EMT) is an important process in embryonic development, fibrosis, and cancer metastasis. During cancer progression, the activation of EMT permits cancer cells to acquire migratory, invasive, and stem-like properties. A growing body of evidence supports the critical link between EMT an...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Liao TT,Yang MH

    更新日期:2017-07-01 00:00:00

  • Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

    abstract::The absence of biomarkers to accurately predict anticancer therapy response remains a major obstacle in clinical oncology. We applied a genome-wide loss-of-function screening approach in human haploid cells to characterize genetic vulnerabilities to classical microtubule-targeting agents. Using docetaxel and vinorelbi...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Gerhards NM,Blomen VA,Mutlu M,Nieuwenhuis J,Howald D,Guyader C,Jonkers J,Brummelkamp TR,Rottenberg S

    更新日期:2018-06-01 00:00:00

  • Pharmacologic inhibition of Akt in combination with chemotherapeutic agents effectively induces apoptosis in ovarian and endometrial cancer cell lines.

    abstract::The PI3K/Akt signaling pathway, the most frequently altered signaling system in human cancer, is a crucial inducer of dysregulated proliferation and neoplastic processes; however, few therapeutic strategies using PI3K/Akt inhibitors singly have been shown to be effective. The purpose of this paper was to underline the...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Fabi F,Adam P,Parent S,Tardif L,Cadrin M,Asselin E

    更新日期:2020-12-18 00:00:00

  • The metastasis-associated molecule C4.4A promotes tissue invasion and anchorage independence by associating with the alpha6beta4 integrin.

    abstract::C4.4A is a metastasis-associated molecule that functions appear to rely on associated alph6beta4 integrin. To corroborate the impact of the C4.4A-alpha6beta4 integrin association on metastasis formation, C4.4A was knocked-down in a highly metastatic rat pancreatic adenocarcinoma (ASML, ASML-C4.4Akd). Metastasis format...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Thuma F,Ngora H,Zöller M

    更新日期:2013-10-01 00:00:00

  • SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin β1 signaling pathway in hepatocellular carcinoma.

    abstract::In our previous study, we identified 1241 loci with somatic copy number alterations in human hepatocellular carcinoma (HCC) using Affymetrix SNP 6.0 arrays, and a putative cancer gene SERPINA5 was uncovered in a novel chromosomal region with recurrent copy number loss at 14q31.1-32.13. The SERPINA5 was reported to be ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Jing Y,Jia D,Wong CM,Oi-Lin Ng I,Zhang Z,Liu L,Wang Q,Zhao F,Li J,Yao M,Wu X,He X

    更新日期:2014-03-01 00:00:00

  • Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer.

    abstract::Infiltration of the tumor microenvironment by nerve fibers is an understudied aspect of breast carcinogenesis. In this study, the presence of nerve fibers was investigated in a cohort of 369 primary breast cancers (ductal carcinomas in situ, invasive ductal and lobular carcinomas) by immunohistochemistry for the neuro...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Pundavela J,Roselli S,Faulkner S,Attia J,Scott RJ,Thorne RF,Forbes JF,Bradshaw RA,Walker MM,Jobling P,Hondermarck H

    更新日期:2015-10-01 00:00:00

  • Epigenetic alterations involved in cancer stem cell reprogramming.

    abstract::Current hypotheses suggest that tumors originate from cells that carry out a process of "malignant reprogramming" driven by genetic and epigenetic alterations. Multiples studies reported the existence of stem-cell-like cells that acquire the ability to self-renew and are able to generate the bulk of more differentiate...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Muñoz P,Iliou MS,Esteller M

    更新日期:2012-12-01 00:00:00

  • Integrative analysis of cancer imaging readouts by networks.

    abstract::Cancer is a multifactorial and heterogeneous disease. The corresponding complexity appears at multiple levels: from the molecular and the cellular constitution to the macroscopic phenotype, and at the diagnostic and therapeutic management stages. The overall complexity can be approximated to a certain extent, e.g. cha...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Dominietto M,Tsinoremas N,Capobianco E

    更新日期:2015-01-01 00:00:00

  • Genetically engineered mouse models of pancreatic adenocarcinoma.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of human cancer for which there are no effective therapies. Deep sequencing of PDAC tumors has revealed the presence of a high number of mutations (>50) that affect at least a dozen key signaling pathways. This scenario highlights the urgent need ...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Guerra C,Barbacid M

    更新日期:2013-04-01 00:00:00

  • Essential role of HDAC6 in the regulation of PD-L1 in melanoma.

    abstract::Histone deacetylases (HDACs), originally described as histone modifiers, have more recently been demonstrated to target a variety of other proteins unrelated to the chromatin environment. In this context, our present work demonstrates that the pharmacological or genetic abrogation of HDAC6 in primary melanoma samples ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: M L,P PV,T K,M P,E S,J P,K V W,C L,F C,S D,M SKS,M M,A K,J PI,A S,E S,J W,E M S,A V

    更新日期:2016-05-01 00:00:00

  • Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis.

    abstract:BACKGROUND:DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells. Lung cancer patients have in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed. ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Bjaanæs MM,Fleischer T,Halvorsen AR,Daunay A,Busato F,Solberg S,Jørgensen L,Kure E,Edvardsen H,Børresen-Dale AL,Brustugun OT,Tost J,Kristensen V,Helland Å

    更新日期:2016-02-01 00:00:00

  • The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma.

    abstract:BACKGROUND:Breast cancer is a heterogeneous disease with different molecular subtypes that have varying responses to therapy. An ongoing challenge in breast cancer research is to distinguish high-risk patients from good prognosis patients. This is particularly difficult in the low-grade, ER-positive luminal A tumors, w...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Montes de Oca R,Gurard-Levin ZA,Berger F,Rehman H,Martel E,Corpet A,de Koning L,Vassias I,Wilson LO,Meseure D,Reyal F,Savignoni A,Asselain B,Sastre-Garau X,Almouzni G

    更新日期:2015-03-01 00:00:00

  • Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

    abstract::Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be 'BRCA1-like' or 'non-BRCA1-like', which refers to resembling a BRCA1-mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approximately one third of ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Schouten PC,Grigoriadis A,Kuilman T,Mirza H,Watkins JA,Cooke SA,van Dyk E,Severson TM,Rueda OM,Hoogstraat M,Verhagen CV,Natrajan R,Chin SF,Lips EH,Kruizinga J,Velds A,Nieuwland M,Kerkhoven RM,Krijgsman O,Vens C,Pe

    更新日期:2015-08-01 00:00:00

  • Genomic imbalances in endometrial adenocarcinomas - comparison of DNA ploidy, karyotyping and comparative genomic hybridization.

    abstract::DNA ploidy analysis is useful for prognostication in cancer patients, but the genomic details underlying ploidy changes are not fully understood. To improve this understanding, we compared DNA ploidy status with karyotypic and comparative genomic hybridization data on 51 endometrial adenocarcinomas. Out of 34 DNA dipl...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Kildal W,Micci F,Risberg B,Abeler VM,Kristensen GB,Heim S,Danielsen HE

    更新日期:2012-02-01 00:00:00

  • Excellent translational research in oncology: A journey towards novel and more effective anti-cancer therapies.

    abstract::Comprehensive Cancer Centres (CCCs) serve as critical drivers for improving cancer survival. In Europe, we have developed an Excellence Designation System (EDS) consisting of criteria to assess "excellence" of CCCs in translational research (bench to bedside and back), with the expectation that many European CCCs will...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Rajan A,Berns A,Ringborg U,Celis J,Ponder B,Caldas C,Livingston D,Bristow RG,Hecht TT,Tursz T,van Luenen H,Bono P,Helander T,Seamon K,Smyth JF,Louvard D,Eggermont A,van Harten WH

    更新日期:2016-05-01 00:00:00

  • Translational cancer research - a coherent cancer research continuum.

    abstract::The main components of the cancer research continuum are basic/preclinical research, early and late clinical research and, after the adoption of an innovation by the healthcare or health organisations, outcomes research. Translational cancer research, defined as a coherent cancer research continuum, is mandatory to ad...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Ringborg U

    更新日期:2019-03-01 00:00:00

  • Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses.

    abstract::The ability to predict responsiveness to drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions that could be experimentally tested to develop transcriptomic signatures for specific drugs. We analyzed lung adenocarcinoma patient data from ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Tavassoly I,Hu Y,Zhao S,Mariottini C,Boran A,Chen Y,Li L,Tolentino RE,Jayaraman G,Goldfarb J,Gallo J,Iyengar R

    更新日期:2019-08-01 00:00:00