Neuroimaging Correlates of Suicidality in Decision-Making Circuits in Posttraumatic Stress Disorder.


:In depression, brain and behavioral correlates of decision-making differ between individuals with and without suicidal thoughts and behaviors. Though promising, it remains unknown if these potential biomarkers of suicidality will generalize to other high-risk clinical populations. To preliminarily assess whether brain structure or function tracked suicidality in individuals with posttraumatic stress disorder (PTSD), we measured resting-state functional connectivity and cortical thickness in two functional networks involved in decision-making, a ventral fronto-striatal reward network and a lateral frontal cognitive control network. Neuroimaging data and self-reported suicidality ratings, and suicide-related hospitalization data were obtained from 50 outpatients with PTSD and also from 15 healthy controls, and all were subjected to seed-based resting-state functional connectivity and cortical thickness analyses using a priori seeds from reward and cognitive control networks. First, general linear models (GLM) were used to evaluate whether ROI-to-ROI functional connectivity was predictive of self-reported suicidality after false discovery rate (FDR)-correction for multiple comparisons and covariance of age and depression symptoms. Next, regional cortical thickness statistics were included as predictors of ROI-to-ROI functional connectivity in follow-up GLMs evaluating structure-function relationships. Functional connectivity between reward regions was positively correlated with suicidality (p-FDR ≤ 0.05). Functional connectivity of the lateral pars orbitalis to anterior cingulate/paracingulate control regions also tracked suicidality (p-FDR ≤ 0.05). Furthermore, cortical thickness in anterior cingulate/paracingulate was associated with functional correlates of suicidality in the control network (p-FDR < 0.05). These results provide a preliminary demonstration that biomarkers of suicidality in decision-making networks observed in depression may generalize to PTSD and highlight the promise of these circuits as transdiagnostic biomarkers of suicidality.


Front Psychiatry


Frontiers in psychiatry


Barredo J,Aiken E,van 't Wout-Frank M,Greenberg BD,Carpenter LL,Philip NS




Has Abstract


2019-02-12 00:00:00








  • The Impact of Hypomania on Aerobic Capacity and Cardiopulmonary Functioning-A Case Report.

    abstract::Background: Hypomanic episodes are characterized by increased goal-directed behavior and psychomotor agitation. While the affective, cognitive, and behavioral manifestations of such episodes are well-documented, their physiological influence on aerobic capacity and cardiopulmonary functioning are unknown. Methods: We ...

    journal_title:Frontiers in psychiatry



    authors: Shoval A,Armstrong HF,Vakhrusheva J,Ballon JS,Bartels MN,Kimhy D

    更新日期:2018-12-21 00:00:00

  • Pleasure and addiction.

    abstract::What is the role and value of pleasure in addiction? Foddy and Savulescu (1) have claimed that substance use is just pleasure-oriented behavior. They describe addiction as "strong appetites toward pleasure" and argue that addicts suffer in significant part because of strong social and moral disapproval of lives domina...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Kennett J,Matthews S,Snoek A

    更新日期:2013-09-25 00:00:00

  • Bipolar Mood State Reflected in Functional Connectivity of the Hate Circuit: A Resting-State Functional Magnetic Resonance Imaging Study.

    abstract:Background:Previous studies suggested bipolar disorder caused an aberrant alteration in the insular, putamen, and left superior frontal gyrus, which are the main components of the hate circuit. However, the relationship between the hate circuit and the pathophysiologic substrate underlying different phases of bipolar d...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Fan Z,Yang J,Zeng C,Xi C,Wu G,Guo S,Xue Z,Liu Z,Tao H

    更新日期:2020-10-27 00:00:00

  • Neurobiology of cognitive remediation therapy for schizophrenia: a systematic review.

    abstract::Cognitive impairment is an important aspect of schizophrenia, where cognitive remediation therapy (CRT) is a promising treatment for improving cognitive functioning. While neurobiological dysfunction in schizophrenia has been the target of much research, the neural substrate of cognitive remediation and recovery has n...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Thorsen AL,Johansson K,Løberg EM

    更新日期:2014-08-15 00:00:00

  • Association Between 5-HTTLPR Polymorphism and the Risk of Autism: A Meta-Analysis Based on Case-Control Studies.

    abstract::Background: Recently, many case-control studies have reported the association between 5-HTTLPR polymorphism and autism risk. However, the results are inconclusive and conflicting. To investigate the genetic association of 5-HTTLPR polymorphism and autism risk, we conducted a comprehensive meta-analysis based on previo...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Wang H,Yin F,Gao J,Fan X

    更新日期:2019-02-13 00:00:00

  • The Modified Yale Food Addiction Scale 2.0: Validation Among Non-Clinical and Clinical French-Speaking Samples and Comparison With the Full Yale Food Addiction Scale 2.0.

    abstract:Objectives:The modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) was designed to assess food addiction using a shorter version than the YFAS 2.0. We lack data about the psychometric properties of the mYFAS 2.0 in patients with obesity, as well as studies comparing the psychometric properties of the mYFAS 2.0 versus th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Brunault P,Berthoz S,Gearhardt AN,Gierski F,Kaladjian A,Bertin E,Tchernof A,Biertho L,de Luca A,Hankard R,Courtois R,Ballon N,Benzerouk F,Bégin C

    更新日期:2020-09-08 00:00:00

  • Perceived Paternal Involvement, Relationship Satisfaction, Mothers' Mental Health and Parenting Stress: A Multi-Sample Path Analysis.

    abstract::Research has demonstrated the short- and long-term impacts of maternal mental health and well-being on children's emotional and behavioral outcomes. It is thus important to better understand the antecedents of maternal depression and stress. The aim of this study was to determine whether the contribution of perceived ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: deMontigny F,Gervais C,Pierce T,Lavigne G

    更新日期:2020-11-02 00:00:00

  • Efficacy, Safety, and Tolerability of Theta-Burst Stimulation in Mixed Depression: Design, Rationale, and Objectives of a Randomized, Double-Blinded, Sham-Controlled Trial.

    abstract:Introduction:Mixed-specifier mood disorders are probably a different subgroup in terms of response to treatment, socio-demographic parameters, course, and family history. Here we describe the rationale and design of a clinical trial aimed to test the efficacy, safety, and tolerability of a non-pharmacological treatment...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Tavares DF,Dos Santos CGR,Valiengo LDCL,Klein I,Borrione L,Forte PM,Brunoni AR,Moreno RA

    更新日期:2020-05-15 00:00:00

  • Determinants of Mental Illness Among Humanitarian Migrants: Longitudinal Analysis of Findings From the First Three Waves of a Large Cohort Study.

    abstract::Background: As refugee numbers grow worldwide, understanding prevalence and determinants of mental illness in this population becomes increasingly important. Methods: We used longitudinal data to examine the initial years of resettlement in Australian refugees with a focus on ethnic-like social support. Three annual w...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Cooper S,Enticott JC,Shawyer F,Meadows G

    更新日期:2019-08-02 00:00:00

  • Exploring Mental Health Status and Syndrome Patterns Among Young Refugee Children in Germany.

    abstract::Refugee children share a large number of pre-, peri-, and post-migration risk factors, which make them vulnerable for developing mental health concerns. Within the last few years, a large number of families with young children have sought refuge in Germany. However, children's mental health status in Germany is mostly...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Buchmüller T,Lembcke H,Busch J,Kumsta R,Leyendecker B

    更新日期:2018-05-25 00:00:00

  • Effects of Trazodone on Sleep Quality and Cognitive Function in Arteriosclerotic Cerebral Small Vessel Disease Comorbid With Chronic Insomnia.

    abstract:Background:Chronic insomnia is common in patients with arteriosclerotic cerebral small vessel disease (CSVD) and aggravates the cognitive impairment caused by CSVD. Low-dose trazodone is effective in treating insomnia, but it is unclear whether it can also improve cognitive function in CSVD patients. This study was per...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Wang J,Liu S,Zhao C,Han H,Chen X,Tao J,Lu Z

    更新日期:2020-06-30 00:00:00

  • The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.

    abstract::Pathological impulsivity is encountered in a broad range of psychiatric conditions and is thought to be a risk factor for aggression directed against oneself or others. Recently, a strong association was found between impulsivity and obesity which may explain the high prevalence of metabolic disorders in individuals w...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Sfera A,Osorio C,Inderias LA,Parker V,Price AI,Cummings M

    更新日期:2017-02-13 00:00:00

  • The Therapeutic Community: A Unique Social Psychological Approach to the Treatment of Addictions and Related Disorders.

    abstract::The evolution of the contemporary Therapeutic Community (TC) for addictions over the past 50 years may be characterized as a movement from the marginal to the mainstream of substance abuse treatment and human services. TCs currently serve a wide array of clients and their diverse problems; through advances in research...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: De Leon G,Unterrainer HF

    更新日期:2020-08-06 00:00:00

  • Cognitive Intervention Targeting Autobiographical Memory Impairment in Patients With Schizophrenia Using a Wearable Camera: A Proof-of-Concept Study.

    abstract::Autobiographical memory (AM) impairment in schizophrenia affects the richness of detail in personal memories and is one of the major predictors of patients' social functioning. Despite the empirical evidence attributing these difficulties to a defective encoding process, cognitive remediation interventions targeting A...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Dassing R,Allé MC,Cerbai M,Obrecht A,Meyer N,Vidailhet P,Danion JM,Mengin AC,Berna F

    更新日期:2020-05-08 00:00:00

  • Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder.

    abstract::Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies. Although the etiology and pathophysiology of MDD are not clear until these days, it is acknowledged that they are almost certain...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Shao X,Zhu G

    更新日期:2020-05-13 00:00:00

  • Validating the Cognitive Scale for Down Syndrome (CS-DS) to Detect Longitudinal Cognitive Decline in Adults With Down Syndrome.

    abstract::Down syndrome (DS) is associated with intellectual disability and an ultra-high risk of developing dementia. Informant ratings are invaluable to assess abilities and related changes in adults with DS, particularly for those with more severe intellectual disabilities and/or cognitive decline. We previously developed th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Startin CM,Lowe B,Hamburg S,Hithersay R,Strydom A,LonDownS Consortium.

    更新日期:2019-04-16 00:00:00

  • Burnout Syndrome and Logotherapy: Logotherapy as Useful Conceptual Framework for Explanation and Prevention of Burnout.

    abstract::Burnout syndrome is a state of total exhaustion related to work conditions and stress from work. Recent findings suggest that logotherapy and the concepts of existential meaning and life fulfilment could provide a useful framework for explaining and potentially preventing burnout. This review article summarizes and re...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Riethof N,Bob P

    更新日期:2019-06-14 00:00:00

  • No Laughing Matter: Presence, Consumption Trends, Drug Awareness, and Perceptions of "Hippy Crack" (Nitrous Oxide) among Young Adults in England.

    abstract::In clinical settings, nitrous oxide gas is a safe anesthetic used during childbirth, in dentistry, and to relieve anxiety in emergencies. Colloquially known as "hippy crack"' or "laughing gas," it is increasingly taken recreationally for its euphoric and relaxing effects and hallucinogenic properties. Using a self-rep...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Ehirim EM,Naughton DP,Petróczi A

    更新日期:2018-01-22 00:00:00

  • Psychometric Properties of the Bermond-Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population.

    abstract:Introduction:The Bermond-Vorst Alexithymia Questionnaire (BVAQ) has been validated in student samples and small clinical samples, but not in the general population; thus, representative general-population norms are lacking. Aim:We examined the factor structure of the BVAQ in Longitudinal Internet Studies for the Socia...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: de Vroege L,Emons WHM,Sijtsma K,van der Feltz-Cornelis CM

    更新日期:2018-04-23 00:00:00

  • Altered Gray-Matter Volumes Associated With Betel Quid Dependence.

    abstract::Betel quid (BQ) is one of the most commonly consumed psychoactive substances. It has been suggested to be associated with various health issues, especially oral cancer. Evidence also points to possible decreased cognitive functions after long-term BQ chewing, such as attention and inhibition control. The present study...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Yuan F,Kong L,Zhu X,Jiang C,Fang C,Liao W

    更新日期:2017-08-03 00:00:00

  • Adolescents' Emotion Regulation Strategies Questionnaire: Initial Validation and Prospective Associations With Nonsuicidal Self-Injury and Other Mental Health Problems in Adolescence and Young Adulthood in a Swedish Youth Cohort.

    abstract::Although there is extensive research indicating the vital role of functional emotion regulation (ER) in healthy psychological development, such research has neglected examination of adolescents. One potential reason for this neglect is the lack of valid ER instruments developed specifically for adolescents. Further, t...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Zhou Y,Daukantaitė D,Lundh LG,Wångby-Lundh M,Ryde A

    更新日期:2020-05-28 00:00:00

  • Parameter-Based Evaluation of Attentional Impairments in Schizophrenia and Their Modulation by Prefrontal Transcranial Direct Current Stimulation.

    abstract:Background:Attentional dysfunctions constitute core cognitive symptoms in schizophrenia, but the precise underlying neurocognitive mechanisms remain to be elucidated. Methods:In this randomized, double-blind, sham-controlled study, we applied, for the first time, a theoretically grounded modeling approach based on Bun...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Gögler N,Papazova I,Oviedo-Salcedo T,Filipova N,Strube W,Funk J,Müller HJ,Finke K,Hasan A

    更新日期:2017-11-29 00:00:00

  • The Attribution of Mental Health Problems to Jinn: An Explorative Study in a Transcultural Psychiatric Outpatient Clinic.

    abstract:Background:Among Muslim patients, a common cultural concept of distress is the notion that jinn may be the cause of mental health problems, especially in the presence of hallucinations. Objective:This study examines the frequency with which this attribution style is manifest in a specific psychiatric outpatient popula...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Lim A,Hoek HW,Ghane S,Deen M,Blom JD

    更新日期:2018-03-28 00:00:00

  • Mitragynine Attenuates Morphine Withdrawal Effects in Rats-A Comparison With Methadone and Buprenorphine.

    abstract:Background:Opiate addiction is a major health problem in many countries. A crucial component of the medical treatment is the management of highly aversive opiate withdrawal signs, which may otherwise lead to resumption of drug taking. In a medication-assisted treatment (MAT), methadone and buprenorphine have been imple...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Hassan R,Pike See C,Sreenivasan S,Mansor SM,Müller CP,Hassan Z

    更新日期:2020-05-07 00:00:00

  • Role of the axonal initial segment in psychiatric disorders: function, dysfunction, and intervention.

    abstract::The progress of developing effective interventions against psychiatric disorders has been limited due to a lack of understanding of the underlying cellular and functional mechanisms. Recent research findings focused on exploring novel causes of psychiatric disorders have highlighted the importance of the axonal initia...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Hsu WC,Nilsson CL,Laezza F

    更新日期:2014-08-21 00:00:00

  • Effectiveness of Transitional Interventions in Improving Patient Outcomes and Service Use After Discharge From Psychiatric Inpatient Care: A Systematic Review and Meta-Analysis.

    abstract::Background: The transition from psychiatric hospital to community is often hindered by challenges that influence community adjustment and continuity of care. Transitional interventions with bridging components are provided prior to discharge and continue beyond inpatient care. They provide continuity of care and may b...

    journal_title:Frontiers in psychiatry



    authors: Hegedüs A,Kozel B,Richter D,Behrens J

    更新日期:2020-01-21 00:00:00

  • Neurophysiologic Characterization of Resting State Connectivity Abnormalities in Schizophrenia Patients.

    abstract::Background: Patients with schizophrenia show abnormal spontaneous oscillatory activity in scalp-level electroencephalographic (EEG) responses across multiple frequency bands. While oscillations play an essential role in the transmission of information across neural networks, few studies have assessed the frequency-spe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Koshiyama D,Miyakoshi M,Tanaka-Koshiyama K,Joshi YB,Molina JL,Sprock J,Braff DL,Light GA

    更新日期:2020-11-27 00:00:00

  • Impact of Substance Use Disorder Pharmacotherapy on Executive Function: A Narrative Review.

    abstract::Substance use disorders are chronic, relapsing, and harmful conditions characterized by executive dysfunction. While there are currently no approved pharmacotherapy options for stimulant and cannabis use disorders, there are several evidence-based options available to help reduce symptoms during detoxification and aid...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Butler K,Le Foll B

    更新日期:2019-03-01 00:00:00

  • Classical Conditioning as a Distinct Mechanism of Placebo Effects.

    abstract::Classical conditioning was suggested as a mechanism of placebo effects in the 1950s. It was then challenged by response expectancy theory, which proposed that classical conditioning is just one of the means by which expectancies are acquired and changed. According to that account, placebo effects induced by classical ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Bąbel P

    更新日期:2019-06-25 00:00:00

  • Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder.

    abstract::The most replicated neuroanatomical finding in autism is the tendency toward brain overgrowth, especially in younger children. Research shows that both gray and white matter are enlarged. Proposed mechanisms underlying brain enlargement include abnormal inflammatory and neurotrophic signals that lead to excessive, abe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Sokol DK,Maloney B,Westmark CJ,Lahiri DK

    更新日期:2019-04-10 00:00:00