Increased interleukin-6 and C-reactive protein levels after instrumented lumbar spine fusion in older patients.

Abstract:

PURPOSE:Interleukin 6 (IL-6) and the acute phase C-reactive protein (CRP) blood concentrations after lumbar spine fusion may be affected by age. The purpose of this prospective observational study was to assess postoperative serum levels of pro-inflammatory IL-6 and CRP after instrumented lumbar spine fusion surgery. We hypothesized that older patients would have increased levels of IL-6 and CRP after surgery. METHODS:IL-6 and high-sensitive CRP biochemical marker levels were measured before instrumented spinal fusion, and postoperatively at 1 and 3 days, 6 weeks, and 3 months. The 49 patients in this sample were divided into two groups: age ≤ 60 years ( n = 23) and age > 60 years ( n = 26). RESULTS:Acute changes in IL-6 high-sensitivity and CRP from preoperative levels to postoperative day (POD) 1 increased with age. Mean (95% CI) difference between the age-groups in changes of IL-6 at PODs 1 and 3 was 45 pg/ml (10-83, p = 0.014) and 20 pg/ml (5-36, p = 0.021), respectively. Mean (95% CI) difference between groups in changes of CRP at PODs 1 and 3 was 9.6 mg/l (-3.5 to 22.7, p = 0.47) and 24.8 mg/l (-17 to 67, p = 0.33), respectively. Both groups had decreased IL-6 and CRP levels at 6 weeks after surgery compared to the preoperative level. CONCLUSIONS:Elevation of IL-6 and CRP is stronger in patients over 60 years old after instrumented lumbar spinal fusion. The CRP and IL-6 are sensitive markers for acute postoperative inflammation. Even high acute CRP values do not necessarily indicate postoperative infection.

authors

Repo JP,Häkkinen AH,Porkka T,Häkkinen K,Kautiainen H,Kyrölä K,Neva MH

doi

10.1177/2309499019826406

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

2309499019826406

issue

1

eissn

1022-5536

issn

2309-4990

journal_volume

27

pub_type

杂志文章
  • Unreamed interlocking nailing in open fractures of tibia.

    abstract:PURPOSE:To assess the clinical outcome of unreamed intramedullary interlocking nailing in open fractures of tibia, and to evaluate the incidence of complications in these open fractures as a result of the unreamed intramedullary nailing. METHODS:Between June 1999 and May 2000, a total of 60 cases of open tibial shaft ...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949900401200215

    authors: Joshi D,Ahmed A,Krishna L,Lal Y

    更新日期:2004-12-01 00:00:00

  • Inferior dislocation of the hip: a case report and literature review.

    abstract::We report on a 17-year-old man who underwent open reduction and internal fixation for an inferior dislocation of the right hip and displaced fractures of the right femoral head and neck, and antegrade intramedullary nailing for a displaced fracture of the left femoral shaft. In addition, 13 men and 4 women aged 5 to 5...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章,评审

    doi:10.1177/230949901502300128

    authors: Jain S,Haughton BA,Grogan RJ

    更新日期:2015-04-01 00:00:00

  • Review article: Plica syndrome of the knee.

    abstract::Plica syndrome is a pathological condition secondary to inflammation. Plicae around the knee are common and generally asymptomatic. They often are misdiagnosed. The morphology of knee plicae varies; mediopatellar plicae are the most common cause of the plicae syndrome. An intermittent dull pain is the most common symp...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章,评审

    doi:10.1177/230949901101900319

    authors: Al-Hadithy N,Gikas P,Mahapatra AM,Dowd G

    更新日期:2011-12-01 00:00:00

  • Anterior cervical disc replacement for degenerative disc disease.

    abstract:PURPOSE:To review the outcomes of anterior cervical disc replacement using the Prestige LP system for degenerative disc disease. METHODS:Medical records of 12 men and 23 women aged 26 to 66 (mean, 46) years who underwent 48 anterior cervical disc replacements using the Prestige LP system by a single spine surgeon were...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901402200320

    authors: Munigangaiah S,McCabe JP

    更新日期:2014-12-01 00:00:00

  • Diagnosis of periprosthetic joint bacterial infections by culture of sonication fluid from infected implants.

    abstract:PURPOSE:This study compared the results of a culture method using sonication with those yielded by the conventional culture method, for patients with infected total knee arthroplasty (TKA). We also evaluated the usefulness of sonication for the identification of pathogens in infected TKA cases. METHODS:Isolates were c...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/2309499019832417

    authors: Kim HJ,Kim S,Mun JU,Bae KC,Kim J,Kyung HS

    更新日期:2019-01-01 00:00:00

  • Insufficiency fracture of the proximal fibula and then tibia: a case report.

    abstract::Elderly people with osteoarthritis of the knee and postpartum women are at risk of insufficiency fractures of the proximal fibular or tibia. We report on an 82-year-old woman with valgus osteoarthritis of the knee who developed insufficiency fractures of the right proximal fibula and then the right proximal tibia. She...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901302100126

    authors: Cheung MH,Lee MF,Lui TH

    更新日期:2013-04-01 00:00:00

  • The male osteoporosis risk estimation score and the osteoporosis self-assessment screening tool for Indonesian men.

    abstract:PURPOSE:To evaluate the male osteoporosis risk estimation score (MORES) and the osteoporosis self-assessment screening tool (OST) score as a means of screening for osteoporosis in men. METHODS:Records of 113 Indonesian men aged 50 to 91 (mean, 71) years who underwent evaluation of bone mineral density (T-score) using ...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901202000214

    authors: Fransiska Y,Tiksnadi B,Chaidir R,Ismiarto YD

    更新日期:2012-08-01 00:00:00

  • Two-stage revision anterior cruciate ligament reconstruction: Our experience using allograft bone dowels.

    abstract::The incidence of anterior cruciate ligament reconstruction (ACLR) is continuously increasing. As a result so has the need for revision ACLR, which unfortunately has worse functional outcomes and rate of return to sport. Revision ACLR can be performed as a single stage or in two stages. The latter is recommended in the...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/2309499019857736

    authors: Theodorides AA,Wall OR

    更新日期:2019-05-01 00:00:00

  • Tumoral calcinosis: a case report.

    abstract::An 11-year-old girl presented with a progressive swelling of the right elbow after a contusion. Radiography and magnetic resonance imaging showed a densely calcified lesion with no periosteal reaction or fracture. The underlying bone and muscles had normal signal intensity. A bone scan revealed increased uptake over t...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901101900125

    authors: Leung YY,Lai R

    更新日期:2011-04-01 00:00:00

  • Review article: Paediatric bone and joint infection.

    abstract::Paediatric musculoskeletal infection remains an important cause of morbidity. Methicillin sensitive Staphylococcus aureus is still the most common organism although the incidence of methicillin resistant S. aureus in the community is rising. Osteomyelitis and septic arthritis due to Haemophilus influenzae is decreasin...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949900100900116

    authors: Stott NS

    更新日期:2001-06-01 00:00:00

  • Validation for the reduced Western Ontario and McMaster Universities Osteoarthritis Index function scale.

    abstract:PURPOSE:To assess the criterion validity, repeatability, and the missing value protocol of the reduced Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function scale ('reduced scale'). METHODS:Three separate studies were performed: a cross-over study to compare the full- and reduced-scale scores...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949900801600113

    authors: Whitehouse SL,Crawford RW,Learmonth ID

    更新日期:2008-04-01 00:00:00

  • Local recurrence of parosteal osteosarcoma adjacent to a prosthesis after 20 years: a case report.

    abstract::We describe the treatment of an uncommonly late presentation of a recurrent parosteal osteosarcoma of the distal femur. The osteosarcoma had originally been detected 20 years earlier, and had been treated with wide excision and mega-prosthesis to reconstruct the femur. The tumour recurred in close proximity to the fem...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949900401200225

    authors: Lau TW,Wong JW,Yip DK,Chien EP,Shek TW,Wong LL

    更新日期:2004-12-01 00:00:00

  • Surgeons' knowledge about the costs of orthopaedic implants.

    abstract::PURPOSE. To investigate consultant surgeons' knowledge about the costs of implants for various joint surgeries. METHODS. Questionnaires were distributed to consultant orthopaedic surgeons at 2 hospitals. Respondents were asked to estimate the implant costs of any brand for low-demand and high-demand total hip replacem...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901402200222

    authors: Rohman L,Hadi S,Whitwell G

    更新日期:2014-08-01 00:00:00

  • Volar locking plate osteosynthesis for distal radial fractures.

    abstract:PURPOSE:To review the one-year outcome after volar locking plate fixation for distal radial fractures. METHODS:Records of 22 men and 40 women aged 17 to 86 (mean, 52.5) years who underwent volar locking plate fixation for distal radial fractures were reviewed. According to the Fernandez classification, the distal radi...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901502300313

    authors: Javed S,Shahid R,Thimmiah R,El-deen M

    更新日期:2015-12-01 00:00:00

  • Tubercular osteomyelitis of the clavicle: a report of four cases.

    abstract::We report the clinicoradiological features of tuberculosis in the clavicle in 4 patients. The patients' ages ranged from 9 months to 29 years. All patients were managed with antitubercular drug therapy for one year and one underwent surgical debridement and curettage as well. Clinicians should be aware of the varied p...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949900901700128

    authors: Aggarwal AN,Dhammi IK,Singh AP,Kumar S,Goyal MK

    更新日期:2009-04-01 00:00:00

  • First metatarsophalangeal joint fusion using a Fyxis plate.

    abstract:PURPOSE:To report the outcome of fusion of the first metatarsophalangeal joint (MTPJ) using the Fyxis plate and compression screws. METHODS:Medical records of 12 men and 39 women (54 feet) aged 28 to 74 (mean, 58) years who underwent primary fusion of the first MTPJ using the Fyxis plate and compression screws for hal...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901402200110

    authors: Marudanayagam A,Appan SV

    更新日期:2014-04-01 00:00:00

  • Preoperative ropivacaine with or without tramadol for femoral nerve block in total knee arthroplasty.

    abstract:PURPOSE:To compare the analgesic effect of preoperative ropivacaine with or without tramadol for femoral nerve block in total knee arthroplasty (TKA). METHODS:14 men and 46 women aged 59 to 80 years who were American Society of Anesthesiologists (ASA) grade I or II and were scheduled for TKA were randomised to receive...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1602400213

    authors: Tang Q,Li X,Yu L,Hao Y,Lu G

    更新日期:2016-08-01 00:00:00

  • Percutaneous release of trigger finger.

    abstract:PURPOSE:To evaluate the condition of the tendons and neurovascular bundles after percutaneous release for trigger finger of the middle, ring, and little fingers. METHODS:30 women and 13 men aged 20 to 55 (mean, 40) years underwent percutaneous release of the A1 pulley using a 18-gauge needle for 43 trigger fingers of ...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901502300227

    authors: Diab RA

    更新日期:2015-08-01 00:00:00

  • The use of fluoroscopic guided percutaneous pedicle screws in the upper thoracic spine (T1-T6): Is it safe?

    abstract:PURPOSE:This study analysed the accuracy and safety of the fluoroscopic guided percutaneous screws in the upper thoracic vertebrae (T1-T6). METHODS:Computed tomography scans from 74 patients were retrospectively evaluated between January 2008 and December 2012. Pedicle perforations were classified by two types of grad...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/2309499017722438

    authors: Kwan MK,Chiu CK,Chan CYW,Zamani R,Hansen-Algenstaedt N

    更新日期:2017-05-01 00:00:00

  • Midterm results of the cylindrical fully porous-coated uncemented femoral stem in revision patients with Paprosky I-IIIA femoral defects.

    abstract:INTRODUCTION:The aim of this study was to analyze the survival of the Echelon® femoral stems in revision hip surgeries in patients with Paprosky I-IIIA femoral defects. PATIENTS AND METHODS:Sixty-six patients (70 hips) who underwent revision hip surgery with at least 3 years of follow-up data were included in the stud...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/2309499018783906

    authors: Ahmet S,İsmet KÖ,Mehmet E,Eren Y,Remzi T,Önder Y

    更新日期:2018-05-01 00:00:00

  • In vivo three-dimensional scapular kinematic alterations after reverse total shoulder arthroplasty.

    abstract:BACKGROUND:In vivo three-dimensional (3D) kinematics of the scapula after reverse total shoulder arthroplasty (rTSA) have been sparsely investigated. The aim of this study was to analyze static and dynamic kinematic alterations of the scapula after rTSA in vivo with the use of computer-aided 3D reconstruction program. ...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/2309499020921979

    authors: Kim E,Jang T,Park HJ,Ikemoto S,Murase T,Sugamoto K,Hong SW

    更新日期:2020-01-01 00:00:00

  • Posterior 360-degree stabilisation of the upper thoracic spine: a technical note.

    abstract:PURPOSE:To describe a technique involving posterior 360-degree stabilisation of the upper thoracic spine: spinal cord decompression, posterior vertebral body replacement, and then posterior instrumentation and intercostal posterolateral vertebral stabilisation. METHODS:Three men and 4 women aged 41 to 77 (mean, 58) ye...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949900701500214

    authors: Timbihurira G,Nakajima H,Kobayashi S,Sato R,Yayama T,Uchida K,Horiuchi Y,Baba H

    更新日期:2007-08-01 00:00:00

  • Surgical treatment of tumours and metastases of the spine by minimally invasive cavity-coblation method.

    abstract::Tumours and metastases of the spine are extremely stressful for patients, especially for elderly multimorbid patients. The modern cavity/coblation method offers a very good therapeutic alternative for such patients. The goal of this article was to evaluate and present the characteristics, significance, opportunities, ...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/2309499016684505

    authors: Dabravolski D,Eßer J,Lahm A,Merk H

    更新日期:2017-01-01 00:00:00

  • Early results of posterior-stabilised NexGen Legacy total knee arthroplasty.

    abstract:OBJECTIVE:To retrospectively assess the early results of the NexGen Legacy posterior-stabilised total knee prosthesis, which is a newer version of the Insall-Burstein II posterior-stabilised implant. METHODS:48 consecutive elderly patients had 60 NexGen Legacy posterior-stabilised total knees. The mean follow-up durat...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949900301100109

    authors: Ip D,Wu WC,Tsang WL

    更新日期:2003-06-01 00:00:00

  • Prosthesis design and stress profile after hip resurfacing: a finite element analysis.

    abstract:PURPOSE:To evaluate the effect of prosthesis design on stress profile in the proximal femur after hip resurfacing. METHODS:The von Mises stress profile of the native femur was simulated and compared with that of resurfaced femurs using various prosthetic materials (titanium, cobalt-chrome, ceramic), stem lengths (norm...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949900801600312

    authors: Heijink A,Zobitz ME,Nuyts R,Morrey BF,An KN

    更新日期:2008-12-01 00:00:00

  • Tophaceous pseudogout in the knee joint mimicking a soft-tissue tumour: a case report.

    abstract::Tophaceous pseudogout in the knee joint is rare. We report an 82-year-old man who presented with a one-year history of pain and swelling of the right knee joint. Treatment with non-steroidal anti-inflammatory drugs and aspiration of the joint effusion had not been effective. The mass continued to enlarge, and the pati...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901001800127

    authors: Kato H,Nishimoto K,Yoshikawa T,Kusuzaki K,Sudo A

    更新日期:2010-04-01 00:00:00

  • Clinical, radiological, and histological outcomes after the fibrin-matrix autologous chondrocyte implantation for chondral lesions of the knee in patients more than 50 years old: A prospective case series with minimum 2-year follow-up.

    abstract:BACKGROUND:The purpose of this study was to evaluate clinical and radiological outcomes and to analyze the histological findings of repaired cartilage in patients more than 50 years old with underwent fibrin-matrix autologous chondrocyte implantation (ACI). METHODS:From January 2013 to February 2014, a prospective stu...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/2309499019893509

    authors: Kim MK,Park JS,Jeon YM,Jeon YS

    更新日期:2020-01-01 00:00:00

  • Review article: Anti-embolism stockings.

    abstract::The National Institute for Health and Clinical Excellence (NICE) guidelines recommend combined mechanical and pharmacological prophylaxis to reduce the risk of venous thromboembolism (VTE) in patients undergoing orthopaedic surgery. There is increasing evidence that anti-embolic stockings (AES) have little effect on r...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章,评审

    doi:10.1177/230949901302100319

    authors: Patel N,Khakha R,Gibbs J

    更新日期:2013-12-01 00:00:00

  • Lumbar spondylolysis: A report of four cases from two generations of a family.

    abstract::Spondylolysis is a major cause of back pain in children and adolescents. The prevalence of spondylolysis depends on the sex, race, and congenital abnormality. These biases suggest hereditary predisposition as an etiology of spondylolysis. However, no conclusive evidence still exists regarding the inheritance for spond...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/2309499017713917

    authors: Yurube T,Kakutani K,Okamoto K,Manabe M,Maeno K,Yoshikawa M,Sha N,Kuroda R,Nishida K

    更新日期:2017-05-01 00:00:00

  • Multiple recurrences and late metastasis of adamantinoma in the tibia: a case report.

    abstract::Adamantinoma is a rare, low-grade, malignant bone tumour. We report on a 46-year-old woman who had early multiple recurrences of adamantinoma of the right tibia and late metastasis to the lung and ribs 13 years after the first surgical treatment. She underwent multiple complete tumour excisions and eventually below-kn...

    journal_title:Journal of orthopaedic surgery (Hong Kong)

    pub_type: 杂志文章

    doi:10.1177/230949901402200330

    authors: Giannoulis DK,Gantsos A,Giotis D,Paschos NK,Vagionas A,Arnaoutoglou CM,Pentheroudakis G,Xenakis TA

    更新日期:2014-12-01 00:00:00