Differences in Characteristics of Error-Related Potentials Between Individuals With Spinal Cord Injury and Age- and Sex-Matched Able-Bodied Controls.


:Background: Non-invasive brain-computer interfaces (BCI) represent an emerging technology for enabling persons with impaired or lost grasping and reaching functions due to high spinal cord injury (SCI) to control assistive devices. A major drawback of BCIs is a high rate of false classifications. The robustness and performance of BCIs might be improved using cerebral electrophysiological correlates of error recognition (error-related potentials, ErrPs). As ErrPs have never been systematically examined in subjects with SCI, this study compares the characteristics of ErrPs in individuals with SCI with those of able-bodied control subjects. Methods: ErrPs at FCz and Cz were analyzed in 11 subjects with SCI (9 male, median age 28 y) and in 11 sex- and age-matched controls. Moving a shoulder joystick according to a visual cue, subjects received feedback about the match/mismatch of the performed movement. ErrPs occurring after "error"-feedback were evaluated by comparing means of voltage values within three consecutive time windows after feedback (wP1, wN1, wP2 containing peak voltages P1, N1, P2) using repeated-measurement analysis of variance. Results: In the control group, mean voltage values for the "error" and "correct" feedback condition differed significantly around N1 (FCz: 254 ms, Cz: 252 ms) and P2 (FCz: 347 ms, Cz: 345 ms), but not around P1 (FCz: 181 ms, Cz: 179 ms). ErrPs of the control and the SCI group showed similar morphology, however mean amplitudes of ErrPs were significantly smaller in individuals with SCI compared to controls for wN1 (FCz: control = -1.55 μV, SCI = -0.27 μV, p = 0.02; Cz: control = -1.03 μV, SCI = 0.11 μV, p = 0.04) and wP2 (FCz: control = 2.79 μV, SCI = 1.29 μV, p = 0.011; Cz: control = 2.12 μV, SCI = 0.81 μV, p = 0.003). Mean voltage values in wP1, wN1, and wP2 did not correlate significantly with either chronicity after or level of injury. Conclusion: The morphology of ErrPs in subjects with and without SCI is comparable, however, with reduced mean amplitude in wN1 and wP2 in the SCI group. Further studies should evaluate whether ErrP-classification can be used for online correction of false BCI-commands in individuals with SCI.


Front Neurol


Frontiers in neurology


Keyl P,Schneiders M,Schuld C,Franz S,Hommelsen M,Weidner N,Rupp R




Has Abstract


2019-01-31 00:00:00








  • Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study.

    abstract::This study presents the first implementation of functional ultrasound (fUS) imaging of the spinal cord to monitor local hemodynamic response to epidural electrical spinal cord stimulation (SCS) on two small and large animal models. SCS has been successfully applied to control chronic refractory pain and recently was e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


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    更新日期:2019-03-26 00:00:00

  • Spatial Navigation Is Distinctively Impaired in Persistent Postural Perceptual Dizziness.

    abstract::Objective: To determine whether performance in a virtual spatial navigational task is poorer in persistent postural perceptual dizziness (PPPD) patients than in healthy volunteers and patients suffering other vestibular disorders. Methods: Subjects were asked to perform three virtual Morris water maze spatial navigati...

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    pub_type: 杂志文章


    authors: Breinbauer HA,Contreras MD,Lira JP,Guevara C,Castillo L,Ruëdlinger K,Muñoz D,Delano PH

    更新日期:2020-01-09 00:00:00

  • Cerebrospinal Fluid and Microdialysis Cytokines in Severe Traumatic Brain Injury: A Scoping Systematic Review.

    abstract:OBJECTIVE:To perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumatic brain injury (TBI) patients. METHODS:Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytoki...

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    pub_type: 杂志文章,评审


    authors: Zeiler FA,Thelin EP,Czosnyka M,Hutchinson PJ,Menon DK,Helmy A

    更新日期:2017-07-10 00:00:00

  • Clinical Characteristics and Long-Term Outcome of Headaches Associated With Moyamoya Disease in the Chinese Population-A Cohort Study.

    abstract::Background: Headache associated with Moyamoya disease (HAMD) in the Chinese population is not well-described. The long-term outcome of surgical revascularization and natural course of HAMD has not been disclosed either. Methods: A headache screening questionnaire in China based on the ICHD2 and a face-to-face intervie...

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    pub_type: 杂志文章


    authors: Gao B,Kang K,Zhang J,Zhang D,Zhao X

    更新日期:2020-11-26 00:00:00

  • Mandibular Movements As Accurate Reporters of Respiratory Effort during Sleep: Validation against Diaphragmatic Electromyography.

    abstract:CONTEXT:Mandibular movements (MM) are considered as reliable reporters of respiratory effort (RE) during sleep and sleep disordered breathing (SDB), but MM accuracy has never been validated against the gold standard diaphragmatic electromyography (EMG-d). OBJECTIVES:To assess the degree of agreement between MM and EMG...

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    pub_type: 杂志文章


    authors: Martinot JB,Le-Dong NN,Cuthbert V,Denison S,Silkoff PE,Guénard H,Gozal D,Pepin JL,Borel JC

    更新日期:2017-07-21 00:00:00

  • Urgent Measures for the Containment of the Coronavirus (Covid-19) Epidemic in the Neurorehabilitation/Rehabilitation Departments in the Phase of Maximum Expansion of the Epidemic.

    abstract::COVID-19 has rapidly become a pandemic emergency, distressing health systems in each affected country. COVID-19 determines the need for healthcare in a large number of people in an extremely short time and, like a tsunami wave, overruns emergency, infectious diseases, and pneumology departments as well as intensive ca...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Bartolo M,Intiso D,Lentino C,Sandrini G,Paolucci S,Zampolini M,Board of the Italian Society of Neurological Rehabilitation (SIRN).

    更新日期:2020-04-30 00:00:00

  • Lower Functional Connectivity in Vestibular-Limbic Networks in Individuals With Subclinical Agoraphobia.

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    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Indovina I,Conti A,Lacquaniti F,Staab JP,Passamonti L,Toschi N

    更新日期:2019-08-13 00:00:00

  • A Prospective Analysis of Lesion-Symptom Relationships in Acute Vestibular and Ocular Motor Stroke.

    abstract::Background: Diagnosing stroke as a cause of acute vertigo, dizziness, or double vision remains a challenge, because symptom characteristics can be variable. The purpose of this study was to prospectively investigate lesion-symptom relationships in patients with acute vestibular or ocular motor stroke. Methods: Three h...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zwergal A,Möhwald K,Salazar López E,Hadzhikolev H,Brandt T,Jahn K,Dieterich M

    更新日期:2020-08-06 00:00:00

  • The antibody genetics of multiple sclerosis: comparing next-generation sequencing to sanger sequencing.

    abstract::We previously identified a distinct mutation pattern in the antibody genes of B cells isolated from cerebrospinal fluid (CSF) that can identify patients who have relapsing-remitting multiple sclerosis (RRMS) and patients with clinically isolated syndromes who will convert to RRMS. This antibody gene signature (AGS) wa...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Rounds WH,Ligocki AJ,Levin MK,Greenberg BM,Bigwood DW,Eastman EM,Cowell LG,Monson NL

    更新日期:2014-09-16 00:00:00

  • A Cross-Study Analysis for Reproducible Sub-classification of Traumatic Brain Injury.

    abstract::Objective: To identify reproducible sub-classes of traumatic brain injury (TBI) that correlate with patient outcomes. Methods: Two TBI datasets from the Federal Interagency Traumatic Brain Injury Research (FITBIR) Informatics System were utilized, Transforming Research and Clinical Knowledge in Traumatic Brain Injury ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Si B,Dumkrieger G,Wu T,Zafonte R,Dodick DW,Schwedt TJ,Li J

    更新日期:2018-08-13 00:00:00

  • Role of Decompressive Craniectomy in the Management of Cerebral Venous Sinus Thrombosis.

    abstract::Cerebral venous sinus thrombosis (CVST) is a relatively uncommon cause of stroke more often affecting women and younger individuals. Blockage of the venous outflow rapidly causes edema and space-occupying venous infarctions and it seems intuitive that decompressive craniectomy (DC) can effectively reduce intracranial ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Avanali R,Gopalakrishnan MS,Devi BI,Bhat DI,Shukla DP,Shanbhag NC

    更新日期:2019-05-15 00:00:00

  • Distinctive Patterns of Seizure-Related White Matter Alterations in Right and Left Temporal Lobe Epilepsy.

    abstract::Background: We hypothesized that right and left temporal lobe epilepsy (RTLE and LTLE, respectively) have distinctive spatial patterns of white matter (WM) changes that can be differentiated and interpreted with the use of multiple diffusion parameters. We compared the global microstructure of fiber bundles with regar...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Buksakowska I,Szabó N,Martinkovič L,Faragó P,Király A,Vrána J,Kincses ZT,Meluzín J,Šulc V,Kynčl M,Roček M,Tichý M,Charvát F,Hořínek D,Marusič P

    更新日期:2019-10-01 00:00:00

  • Access to Expert Stroke Care with Telemedicine: REACH MUSC.

    abstract::Stroke is a leading cause of death and disability, and recombinant tissue plasminogen activator (rtPA) can significantly reduce the long-term impact of acute ischemic stroke (AIS) if given within 3 h of symptom onset. South Carolina is located in the "stroke belt" and has a high rate of stroke and stroke mortality. Ma...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Kazley AS,Wilkerson RC,Jauch E,Adams RJ

    更新日期:2012-03-21 00:00:00

  • Post-cueing deficits with maintained cueing benefits in patients with Parkinson's disease dementia.

    abstract::In Parkinson's disease (PD), internal cueing mechanisms are impaired leading to symptoms like hypokinesia. However, external cues can improve movement execution by using cortical resources. These cortical processes can be affected by cognitive decline in dementia. It is still unclear how dementia in PD influences exte...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gräber S,Liepelt-Scarfone I,Csoti I,Maetzler W,Sultan F,Berg D

    更新日期:2014-11-17 00:00:00

  • Vestibular Dysfunction in Wernicke's Encephalopathy: Predominant Impairment of the Horizontal Semicircular Canals.

    abstract:Background:Wernicke's encephalopathy (WE), a metabolic disorder due to thiamine deficiency, manifests with various neurological symptoms and signs. It has been known as a cause of vestibular dysfunction. Preliminary reports have proposed predominant involvement of the horizontal semicircular canals (HSCs). Objective:T...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Lee SH,Kim SH,Kim JM,Tarnutzer AA

    更新日期:2018-03-12 00:00:00

  • A Persistent Primitive Hypoglossal Artery As the Sole Supply to the Brain Associated with a Basilar Bifurcation Aneurysm.

    abstract::The persistent primitive hypoglossal artery (PPHA) is the second most common persistent carotid-vertebrobasilar anastomosis, with an incidence of 0.027-0.26%. PPHAs change the hemodynamics of the carotid and vertebrobasilar system and may be associated with intracranial vascular anomalies, but basilar bifurcation aneu...

    journal_title:Frontiers in neurology



    authors: Wang M,Gu J,Lan P,Wan S,Zhou Y,Zheng X,Zhan R

    更新日期:2017-04-26 00:00:00

  • Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease.

    abstract::Impulse control disorder (ICD) is a major non-motor complication of Parkinson's disease (PD) with often devastating consequences for patients' quality of life. In this study, we aimed to characterize the phenotype of impulsivity in PD and its neuroanatomical correlates. Methods: Thirty-seven PD patients (15 patients w...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Hlavatá P,Linhartová P,Šumec R,Filip P,Světlák M,Baláž M,Kašpárek T,Bareš M

    更新日期:2020-01-10 00:00:00

  • Presynaptic Mechanisms of l-DOPA-Induced Dyskinesia: The Findings, the Debate, and the Therapeutic Implications.

    abstract::The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's disease (PD) for over 40 years. However, the response to this treatment changes with disease progression, and most patients develop dyskinesias (abnormal involuntary movements) and motor fluctuations within a few years of l-DOPA t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Cenci MA

    更新日期:2014-12-15 00:00:00

  • Blast TBI Models, Neuropathology, and Implications for Seizure Risk.

    abstract::Traumatic brain injury (TBI) due to explosive blast exposure is a leading combat casualty. It is also implicated as a key contributor to war related mental health diseases. A clinically important consequence of all types of TBI is a high risk for development of seizures and epilepsy. Seizures have been reported in pat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Kovacs SK,Leonessa F,Ling GS

    更新日期:2014-04-09 00:00:00

  • Stroke Lesion Segmentation in FLAIR MRI Datasets Using Customized Markov Random Fields.

    abstract::Robust and reliable stroke lesion segmentation is a crucial step toward employing lesion volume as an independent endpoint for randomized trials. The aim of this work was to develop and evaluate a novel method to segment sub-acute ischemic stroke lesions from fluid-attenuated inversion recovery (FLAIR) magnetic resona...

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    pub_type: 杂志文章


    authors: Subbanna NK,Rajashekar D,Cheng B,Thomalla G,Fiehler J,Arbel T,Forkert ND

    更新日期:2019-05-24 00:00:00

  • Dipeptidyl Peptidase-4 Inhibitors for the Potential Treatment of Brain Disorders; A Mini-Review With Special Focus on Linagliptin and Stroke.

    abstract::Cerebral stroke is a leading cause of death and persistent disability of elderly in the world. Although stroke prevention by targeting several risk factors such as diabetes and hypertension has decreased the stroke incidence, the total number of strokes is increasing due to the population aging and new preventive ther...

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    pub_type: 杂志文章,评审


    authors: Darsalia V,Johansen OE,Lietzau G,Nyström T,Klein T,Patrone C

    更新日期:2019-05-08 00:00:00

  • Atypical Autoimmune Encephalitis With Neuropil Antibodies Against a Yet Unknown Epitope.

    abstract::Autoimmune encephalitis often causes acute psychiatric symptoms and epileptic seizures. However, it is becoming increasingly clear that depending on the target antigen both symptoms and disease severity may vary. Furthermore, the identification and characterization of antibody subtypes are highly relevant for personal...

    journal_title:Frontiers in neurology



    authors: Edwin Thanarajah S,Prüss H,Warnke C,Barbe MT,Schroeter M,Fink GR,Onur OA

    更新日期:2019-03-05 00:00:00

  • Relationship Between Sleep Apnea and Coronary Artery Calcium in Patients With Ischemic Stroke.

    abstract::Study Objectives: Coronary artery disease is considered to be the major cause of death amongst patients with ischemic stroke. The coronary artery calcium (CAC) score is related not only to sleep-disordered breathing, but also with future risk of cardiovascular mortality. We investigated the association between the sev...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cho KH,Lee DH,Kim KM,Choi YH,Nam HS,Heo JH,Heo K,Kim YD

    更新日期:2019-07-31 00:00:00

  • Somatosensory Influence on Platform-Induced Translational Vestibulo-Ocular Reflex in Vertical Direction in Humans.

    abstract::The vestibulo-ocular reflex (VOR) consists of two components, the rotational VOR (rVOR) elicited by semicircular canal signals and the translational VOR (tVOR) elicited by otolith signals. Given the relevant role of the vertical tVOR in human walking, this study aimed at measuring the time delay of eye movements in re...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Kutz DF,Kolb FP,Glasauer S,Straka H

    更新日期:2020-05-14 00:00:00

  • Increased Left Putamen Volume Correlates With Pain in Ankylosing Spondylitis Patients.

    abstract::Ankylosing spondylitis (AS) mainly affects the axial skeleton and is an important factor leading to chronic lower back pain in young individuals. However, few studies have explored alterations of brain gray matter volume in AS patients. The purpose of the present study was to describe brain gray matter abnormalities a...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Hua K,Wang P,Lan Z,Li M,Zhao W,Wang T,Li S,Ma X,Li C,Fu S,Yin Y,Liu P,Fang J,Li T,Jiang G

    更新日期:2020-11-30 00:00:00

  • Transplantation of Embryonic Neural Stem Cells and Differentiated Cells in a Controlled Cortical Impact (CCI) Model of Adult Mouse Somatosensory Cortex.

    abstract::Traumatic brain injury (TBI) is a major cause of death worldwide. Depending on the severity of the injury, TBI can reflect a broad range of consequences such as speech impairment, memory disturbances, and premature death. In this study, embryonic neural stem cells (ENSC) were isolated from E14 mouse embryos and cultur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Nasser M,Ballout N,Mantash S,Bejjani F,Najdi F,Ramadan N,Soueid J,Zibara K,Kobeissy F

    更新日期:2018-10-24 00:00:00

  • Cortical-subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep-wake cycle.

    abstract::Subcortical circuits mediating sleep-wake functions have been well characterized in animal models, and corroborated by more recent human studies. Disruptions in these circuits have been identified in hypersomnia disorders (HDs) such as narcolepsy and Kleine-Levin Syndrome, as well as in neurodegenerative disorders exp...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Larson-Prior LJ,Ju YE,Galvin JE

    更新日期:2014-09-11 00:00:00

  • Temporal Lobe Cavernous Malformation Caused Epileptic Amnesic Episodes and Mild Cognitive Impairment.

    abstract::Neuropathological features in Alzheimer's disease (AD) are amyloid β (Aβ) deposits and neurofibrillary changes. AD is characterized by memory impairment and cognitive dysfunction, with some reports associating these impairments with hyperexcitability caused by Aβ in the medial temporal lobe. Epileptic seizures are kno...

    journal_title:Frontiers in neurology



    authors: Hirokawa Y,Fujimoto A,Ichikawa N,Sato K,Tanaka T,Enoki H,Otsuki Y,Okanishi T

    更新日期:2019-06-12 00:00:00

  • Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury.

    abstract::The endothelium is a thin monolayer of specialized cells that lines the luminal wall of blood vessels and constitutes the critical innermost portion of the physical barrier between the blood and the brain termed the blood-brain barrier (BBB). Aberrant changes in the endothelium occur in many neuropathological states, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Lutton EM,Farney SK,Andrews AM,Shuvaev VV,Chuang GY,Muzykantov VR,Ramirez SH

    更新日期:2019-06-06 00:00:00

  • Spinocerebellar Ataxia Type 2 Is Associated with the Extracellular Loss of Superoxide Dismutase but Not Catalase Activity.

    abstract:BACKGROUND:Spinocerebellar ataxia type 2 (SCA2) is an inherited and still incurable neurodegenerative disorder. Evidence suggests that pro-oxidant agents as well as factors involved in antioxidant cellular defenses are part of SCA2 physiopathology. AIM:To assess the influence of superoxide dismutase (SOD3) and catalas...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Almaguer-Gotay D,Almaguer-Mederos LE,Aguilera-Rodríguez R,Rodríguez-Labrada R,Cuello-Almarales D,Estupiñán-Domínguez A,Velázquez-Pérez LC,González-Zaldívar Y,Vázquez-Mojena Y

    更新日期:2017-06-13 00:00:00