Therapeutic hypercapnia reduces blood-brain barrier damage possibly via protein kinase Cε in rats with lateral fluid percussion injury.

abstract：BACKGROUND:Interleukin-1 beta converting enzyme (ICE, caspase 1) is a cysteine protease that processes immature pro-IL-1β into active mature IL-1β. IL-1β is a pro-inflammatory cytokine that mediates many of the physiological and behavioral responses to inflammation. Genetic deletion of ICE has previously been shown to ...

journal_title：Journal of neuroinflammation

authors： Lawson MA,McCusker RH,Kelley KW

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Neuroinflammatory responses have been recognized as an important aspect in the pathogenesis of Parkinson's disease (PD). Transcriptional regulation plays a critical role in the process of inflammation. Transcription factor myocyte enhancer factor 2D (MEF2D) is identified as a central factor in transmission o...

journal_title：Journal of neuroinflammation

authors： Yang S,Gao L,Lu F,Wang B,Gao F,Zhu G,Cai Z,Lai J,Yang Q

更新日期：2015-02-20 00:00:00

abstract：:BACKGROUND: Twitcher mouse (twi/twi) is an authentic murine model of Krabbe's disease. Accumulation of psychosine, resulting in apoptosis of oligodendrocytes and subsequent demyelination, is a cardinal event to the pathogenesis of this disease. Moreover, recruitment of inflammatory cells plays a significant role in th...

journal_title：Journal of neuroinflammation

authors： Kagitani-Shimono K,Mohri I,Fujitani Y,Suzuki K,Ozono K,Urade Y,Taniike M

更新日期：2005-04-06 00:00:00

abstract：BACKGROUND:The glutamine synthetase (GS), an astrocyte-specific enzyme, is involved in lipopolysaccharide (LPS)-induced inflammation which activates the mitogen-activated protein kinase (MAPK) signaling. Endocannabinoid 2-arachidonyl glycerol (2-AG) has been described to serve as an endogenous mediator of analgesia and...

journal_title：Journal of neuroinflammation

authors： Wang S,Zhang H,Geng B,Xie Q,Li W,Deng Y,Shi W,Pan Y,Kang X,Wang J

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Epilepsy is a common and debilitating consequence of traumatic brain injury (TBI). Seizures contribute to progressive neurodegeneration and poor functional and psychosocial outcomes for TBI survivors, and epilepsy after TBI is often resistant to existing anti-epileptic drugs. The development of post-traumati...

journal_title：Journal of neuroinflammation

authors： Webster KM,Sun M,Crack P,O'Brien TJ,Shultz SR,Semple BD

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Autoantibodies against myelin oligodendrocyte glycoprotein (anti-MOG-Abs) occur in a majority of children with acquired demyelinating syndromes (ADS) and physiopathology is still under investigation. As cynomolgus macaques immunized with rhMOG, all develop an experimental autoimmune encephalomyelitis (EAE), ...

journal_title：Journal of neuroinflammation

authors： Serguera C,Stimmer L,Fovet CM,Horellou P,Contreras V,Tchitchek N,Massonneau J,Leroy C,Perrin A,Flament J,Hantraye P,Demilly J,Marignier R,Chrétien P,Hart B,Boutonnat J,Adam C,Le-Grand R,Deiva K

更新日期：2019-11-30 00:00:00

abstract：BACKGROUND:Atypical antipsychotic agents, such as clozapine, are used to treat schizophrenia and other psychiatric disorders by a mechanism that is believed to involve modulating the immune system. Multiple sclerosis is an immune-mediated neurological disease, and recently, clozapine was shown to reduce disease severit...

journal_title：Journal of neuroinflammation

authors： Robichon K,Patel V,Connor B,La Flamme AC

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:The peripheral immune system is implicated in modulating microglial activation, neurodegeneration and disease progression in amyotrophic lateral sclerosis (ALS). Specifically, there is reduced thymic function and regulatory T cell (Treg) number in ALS patients and mutant superoxide dismutase 1 (SOD1) mice, w...

journal_title：Journal of neuroinflammation

authors： Sheean RK,Weston RH,Perera ND,D'Amico A,Nutt SL,Turner BJ

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:Synucleinopathies comprise a group of neurodegenerative diseases associated with abnormal accumulation of α-synuclein. One of the key factors that contribute to the progression of synucleinopathies is neuroinflammation. However, the role of lymphocytes in synucleinopathies like Parkinson's disease (PD) remai...

journal_title：Journal of neuroinflammation

authors： Sommer A,Fadler T,Dorfmeister E,Hoffmann AC,Xiang W,Winner B,Prots I

更新日期：2016-06-30 00:00:00

abstract：BACKGROUND:In the healthy central nervous system (CNS), microglia are found in a homeostatic state and peripheral macrophages are absent from the brain. Microglia play key roles in maintaining CNS homeostasis and acting as first responders to infection and inflammation, and peripheral macrophages infiltrate the CNS dur...

journal_title：Journal of neuroinflammation

authors： DePaula-Silva AB,Gorbea C,Doty DJ,Libbey JE,Sanchez JMS,Hanak TJ,Cazalla D,Fujinami RS

更新日期：2019-07-20 00:00:00

abstract：BACKGROUND:Obesity can lead to cognitive dysfunction including poor performance in memory tasks. However, poor memory is not seen in all obese humans and takes several months to develop in animal models, indicating the adult brain is relatively resistant to obesity's cognitive effects. We have seen that, in the rat, ov...

journal_title：Journal of neuroinflammation

authors： De Luca SN,Ziko I,Sominsky L,Nguyen JC,Dinan T,Miller AA,Jenkins TA,Spencer SJ

更新日期：2016-05-18 00:00:00

abstract：BACKGROUND:Some children with autism spectrum disorders (ASD) are characterized by fluctuating behavioral symptoms following immune insults, persistent gastrointestinal (GI) symptoms, and a lack of response to the first-line intervention measures. These children have been categorized as the ASD-inflammatory subtype (AS...

journal_title：Journal of neuroinflammation

authors： Jyonouchi H,Geng L,Davidow AL

更新日期：2014-10-27 00:00:00

abstract：BACKGROUND:Mice with pilocarpine-induced temporal lobe epilepsy (TLE) are characterized by intense hippocampal neuroinflammation, a prominent pathological hallmark of TLE that is known to contribute to neuronal hyperexcitability. Recent studies indicate that Adam10, a member of a disintegrin and metalloproteinase domai...

journal_title：Journal of neuroinflammation

authors： Zhu X,Li X,Zhu M,Xu K,Yang L,Han B,Huang R,Zhang A,Yao H

更新日期：2018-08-04 00:00:00

abstract：BACKGROUND:Meningothelial cells (MECs) are the cellular components of the meninges. As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and the cerebrospinal fluid (CSF), and are also part of the immune response of the CNS. METHODS:Human,...

journal_title：Journal of neuroinflammation

authors： Li J,Fang L,Meyer P,Killer HE,Flammer J,Neutzner A

更新日期：2014-02-24 00:00:00

abstract：BACKGROUND:β-Amyloid (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis. Neurons are major sources of Aβ in the brain. However, astrocytes outnumber neurons by at least five-fold. Thus, even a small level of astrocytic Aβ production could make a significant contribution to Aβ burden in AD. Moreover, act...

journal_title：Journal of neuroinflammation

authors： Zhao J,O'Connor T,Vassar R

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood. OBJECTIVE:We explored the central nervous system consequences of subchronic exposure to diesel exhaust (DE) and addr...

journal_title：Journal of neuroinflammation

authors： Levesque S,Surace MJ,McDonald J,Block ML

更新日期：2011-08-24 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against secondary brain injury. Evidence from stroke and inflammatory disease models suggests that adenosine s...

journal_title：Journal of neuroinflammation

authors： Farr SA,Cuzzocrea S,Esposito E,Campolo M,Niehoff ML,Doyle TM,Salvemini D

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Leukocytes are believed to be involved in delayed cell death following traumatic brain injury (TBI). However, data demonstrating that blood-borne inflammatory cells are present in the injured brain prior to the onset of secondary brain damage have been inconclusive. We therefore investigated both the interac...

journal_title：Journal of neuroinflammation

authors： Schwarzmaier SM,Zimmermann R,McGarry NB,Trabold R,Kim SW,Plesnila N

更新日期：2013-02-28 00:00:00

abstract：BACKGROUND:Obesity and its associated disorders are becoming a major health issue in many countries. The resulting low-grade inflammation not only affects the periphery but also the central nervous system. We set out to study, in a time-dependent manner, the effects of a high-fat diet on different regions of the centra...

journal_title：Journal of neuroinflammation

authors： Guillemot-Legris O,Masquelier J,Everard A,Cani PD,Alhouayek M,Muccioli GG

更新日期：2016-08-26 00:00:00

abstract：:Chronic inflammation has been shown to contribute to the development of a wide variety of disorders by means of a number of proposed mechanisms. Depression and cognitive impairment are two such disorders which may share a closely linked inflammatory etiology. The ability of inflammatory mediators to alter the activity...

journal_title：Journal of neuroinflammation

authors： Allison DJ,Ditor DS

更新日期：2014-09-02 00:00:00

abstract：BACKGROUND:In sepsis syndromes the severity of the inflammation triggers microvascular dysfunction and early organ failure. We studied the effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculatory integrity in an endotoxinemic rat model. METHODS:In both control and endotoxinemic (5 mg/kg li...

journal_title：Journal of neuroinflammation

authors： Mihaylova S,Killian A,Mayer K,Pullamsetti SS,Schermuly R,Rosengarten B

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:There is a need for clinically useful biomarkers of disease activity in clinically isolated syndrome (CIS) and relapsing remitting MS (RRMS). The aim of this study was to assess the correlation between neurofilament light chain (NFL) in cerebrospinal fluid (CSF) and serum and the relationship between NFL and...

journal_title：Journal of neuroinflammation

authors： Håkansson I,Tisell A,Cassel P,Blennow K,Zetterberg H,Lundberg P,Dahle C,Vrethem M,Ernerudh J

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:Betaine (glycine betaine or trimethylglycine) plays important roles as an osmolyte and a methyl donor in animals. While betaine is reported to suppress expression of proinflammatory molecules and reduce oxidative stress in aged rat kidney, the effects of betaine on the central nervous system are not well kno...

journal_title：Journal of neuroinflammation

authors： Miwa M,Tsuboi M,Noguchi Y,Enokishima A,Nabeshima T,Hiramatsu M

更新日期：2011-11-04 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α (TNF-α) is an important inflammatory factor produced by activated macrophages and monocytes and plays an important role in the pathogenesis of diabetic peripheral neuropathy (DPN). To evaluate the effect of TNF-α signaling suppression and the potential of TNF-α in the treatment of DPN...

journal_title：Journal of neuroinflammation

authors： Shi X,Chen Y,Nadeem L,Xu G

更新日期：2013-06-04 00:00:00

abstract：BACKGROUND:The ways in which microglia activate and promote neovascularization (NV) are not fully understood. Recent in vivo evidence supports the theory that calcium is required for the transition of microglia from a surveillance state to an active one. The objectives of this study were to discover novel L-type voltag...

journal_title：Journal of neuroinflammation

authors： Saddala MS,Lennikov A,Mukwaya A,Yang Y,Hill MA,Lagali N,Huang H

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:Activation of microglia is a part of the inflammatory response in neurodegenerative diseases but its role in the pathophysiology of these diseases is still unclear. The osteopetrotic (op/op) mouse lacks colony-stimulating factor-1 (CSF-1) and thus has a deficiency in microglia and macrophages. Prior reports ...

journal_title：Journal of neuroinflammation

authors： Kondo Y,Lemere CA,Seabrook TJ

更新日期：2007-12-20 00:00:00

abstract：BACKGROUND:Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a non-neurotropic virus, dengue infection has been associated recently with a series of neurological syndromes, including encephalitis. In this work, we ev...

journal_title：Journal of neuroinflammation

authors： Amaral DC,Rachid MA,Vilela MC,Campos RD,Ferreira GP,Rodrigues DH,Lacerda-Queiroz N,Miranda AS,Costa VV,Campos MA,Kroon EG,Teixeira MM,Teixeira AL

更新日期：2011-03-09 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the spinal dorsal horn. The cellular and molecular mechanisms by which CCL2 enhances spinal pain transmis...

journal_title：Journal of neuroinflammation

authors： Huang CY,Chen YL,Li AH,Lu JC,Wang HL

更新日期：2014-01-10 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) proteins play critical functions regulating vascular formation and function. Laminin is a major component of the vascular basal lamina, and transgenic mice deficient in astrocyte or pericyte laminin show defective blood-brain barrier (BBB) integrity, indicating an important instruc...

journal_title：Journal of neuroinflammation

authors： Welser JV,Halder SK,Kant R,Boroujerdi A,Milner R

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several cerebrovascular diseases. However, the underlying mechanism was largely unkn...

journal_title：Journal of neuroinflammation

authors： Cheng Z,Wang L,Qu M,Liang H,Li W,Li Y,Deng L,Zhang Z,Yang GY

更新日期：2018-05-03 00:00:00