Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus?


:The expression of human endogenous retroviruses (HERVs) has been associated with Multiple Sclerosis (MS). The MS-related retrovirus (MSRV/HERV-W) has the potential to activate inflammatory immunity, which could promote both susceptibility and progression toward MS. A connection between HERVs and MS is also supported by the observation that people infected with the human immunodeficiency virus (HIV) may have a lower risk of developing MS than the HIV non-infected, healthy population. This may be due to suppression of HERV expression by antiretroviral therapies (ART) used to treat HIV infection. In this pilot study, we compared RNA expression of the envelope gene of MSRV/HERV-W, as well as Toll-like receptors (TLR) 2 and 4, in a small cohort of HIV+ patients with MS patients and healthy controls (HC). An increased expression of MSRV/HERV-Wenv and TLR2 RNA was detected in blood of MS patients compared with HIV patients and HC, while TLR4 was increased in both MS and HIV patients. There was, however, no difference in MSRV/HERV-Wenv, TLR2 and TLR4 expression between ART-treated and -untreated HIV patients. The viral protein Env was expressed mainly by B cells and monocytes, but not by T cells and EBV infection could induce the expression of MSRV/HERV-Wenv in Lymphoblastoid cell lines (LCLs). LCLs were therefore used as an in vitro system to test the efficacy of ART in inhibiting the expression of MSRV/HERV-Wenv. Efavirenz (a non-nucleoside reverse transcriptase inhibitor) alone or different combined drugs could reduce MSRV/HERV-Wenv expression in vitro. Further, experiments are needed to clarify the potential role of ART in protection from MS.


Front Immunol


Frontiers in immunology


Morandi E,Tanasescu R,Tarlinton RE,Constantin-Teodosiu D,Gran B




Has Abstract


2019-01-22 00:00:00








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    journal_title:Frontiers in immunology

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    authors: Bürckert JP,Dubois ARSX,Faison WJ,Farinelle S,Charpentier E,Sinner R,Wienecke-Baldacchino A,Muller CP

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  • Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis.

    abstract::Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collecte...

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    authors: Feng J,Fan S,Sun Y,Zhang Z,Ren H,Li W,Cui L,Peng B,Ren X,Zhang W,Guan H,Wang J

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    pub_type: 杂志文章


    authors: García-González PA,Maggi J,Schinnerling K,Sepúlveda-Gutiérrez A,Soto L,Neira O,Mehdi AM,Nel HJ,Pesce B,Aravena O,Molina MC,Catalán D,Thomas R,Verdugo RA,Aguillón JC

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    authors: Rohlman D,Pham D,Yu Z,Steppan LB,Kerkvliet NI

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    abstract::Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious respiratory impacts. Recently, we have discovered that burning coal generates large quantities of ot...

    journal_title:Frontiers in immunology

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    authors: McDaniel DK,Ringel-Scaia VM,Morrison HA,Coutermarsh-Ott S,Council-Troche M,Angle JW,Perry JB,Davis G,Leng W,Minarchick V,Yang Y,Chen B,Reece SW,Brown DA,Cecere TE,Brown JM,Gowdy KM,Hochella MF Jr,Allen IC

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: García-Cuesta EM,López-Cobo S,Álvarez-Maestro M,Esteso G,Romera-Cárdenas G,Rey M,Cassady-Cain RL,Linares A,Valés-Gómez A,Reyburn HT,Martínez-Piñeiro L,Valés-Gómez M

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    abstract::By uncovering complex dynamics in the expression or localization of transcriptional regulators in single cells that were otherwise hidden at the population level, live cell imaging has transformed our understanding of how cells sense and orchestrate appropriate responses to changes in their internal state or extracell...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Nelson RH,Nelson DE

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    authors: Sato-Kaneko F,Yao S,Lao FS,Shpigelman J,Messer K,Pu M,Shukla NM,Cottam HB,Chan M,Chu PJ,Burkhart D,Schoener R,Matsutani T,Carson DA,Corr M,Hayashi T

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    authors: Garcia-Castillo V,Tomokiyo M,Raya Tonetti F,Islam MA,Takahashi H,Kitazawa H,Villena J

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    authors: Antonialli R,Sulczewski FB,Amorim KNDS,Almeida BDS,Ferreira NS,Yamamoto MM,Soares IS,Ferreira LCS,Rosa DS,Boscardin SB

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    authors: D'Angelo C,Reale M,Costantini E,Di Nicola M,Porfilio I,de Andrés C,Fernández-Paredes L,Sánchez-Ramón S,Pasquali L

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


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    authors: Corvillo F,Aparicio V,López-Lera A,Garrido S,Araújo-Vilar D,de Miguel MP,López-Trascasa M

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    journal_title:Frontiers in immunology

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    authors: Onder L,Scandella E,Chai Q,Firner S,Mayer CT,Sparwasser T,Thiel V,Rülicke T,Ludewig B

    更新日期:2011-10-12 00:00:00

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    abstract::Toll-like receptors (TLR) triggering of B cells are known to promote B cell expansion, differentiation of B cells into antibody-producing and memory cells, but the TLR responses of porcine B cells is poorly characterized. Therefore, this study investigated the response pattern of porcine B cell subsets to a large coll...

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    authors: Braun RO,Python S,Summerfield A

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    pub_type: 杂志文章,评审


    authors: Vlaicu SI,Tatomir A,Rus V,Rus H

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    journal_title:Frontiers in immunology

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    authors: Liu J,Mustafa S,Barratt DT,Hutchinson MR

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    pub_type: 杂志文章,评审


    authors: Randall-Demllo S,Chieppa M,Eri R

    更新日期:2013-09-30 00:00:00

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    abstract::Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Upon binding to CD38-expressing MM cells, isatuximab is thought to induce tumor cell killing via fragment crystallizable (...

    journal_title:Frontiers in immunology

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    authors: Zhu C,Song Z,Wang A,Srinivasan S,Yang G,Greco R,Theilhaber J,Shehu E,Wu L,Yang ZY,Passe-Coutrin W,Fournier A,Tai YT,Anderson KC,Wiederschain D,Bahjat K,Adrián FJ,Chiron M

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    journal_title:Frontiers in immunology

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    authors: Higuchi BS,Rodrigues N,Gonzaga MI,Paiolo JCC,Stefanutto N,Omori WP,Pinheiro DG,Brisotti JL,Matheucci E Jr,Mariano VS,de Oliveira GLV

    更新日期:2018-07-25 00:00:00

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Jiao P,Song Y,Huang J,Xiang C,Cui J,Wu S,Qu N,Wang N,Ouyang G,Liao M

    更新日期:2018-04-13 00:00:00

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Smith AJ,Miller SM,Buhl C,Child R,Whitacre M,Schoener R,Ettenger G,Burkhart D,Ryter K,Evans JT

    更新日期:2019-02-28 00:00:00

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Sherlock LG,Sjostrom K,Sian L,Delaney C,Tipple TE,Krebs NF,Nozik-Grayck E,Wright CJ

    更新日期:2020-11-05 00:00:00

  • The Injury-Related Activation of Hedgehog Signaling Pathway Modulates the Repair-Associated Inflammation in Liver Fibrosis.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Shen X,Peng Y,Li H

    更新日期:2017-11-06 00:00:00

  • Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zhang Q,Wang L,Jiang J,Lin S,Luo A,Zhao P,Tan W,Zhang M

    更新日期:2020-08-18 00:00:00

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Stijlemans B,Caljon G,Van Den Abbeele J,Van Ginderachter JA,Magez S,De Trez C

    更新日期:2016-06-24 00:00:00

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Chen Y,Ye Z,Chen L,Qin T,Seidler U,Tian D,Xiao F

    更新日期:2020-09-23 00:00:00

  • Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires.

    abstract::Memory B cells that are generated during an infection or following vaccination act as sentinels to guard against future infections. Upon repeat antigen exposure memory B cells differentiate into new antibody-secreting plasma cells to provide rapid and sustained protection. Some pathogens evade or suppress the humoral ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Shah HB,Smith K,Wren JD,Webb CF,Ballard JD,Bourn RL,James JA,Lang ML

    更新日期:2019-01-15 00:00:00