Integrated seroprevalence-based assessment of Wuchereria bancrofti and Onchocerca volvulus in two lymphatic filariasis evaluation units of Mali with the SD Bioline Onchocerciasis/LF IgG4 Rapid Test.


BACKGROUND:Mali has become increasingly interested in the evaluation of transmission of both Wuchereria bancrofti and Onchocerca volvulus as prevalences of both infections move toward their respective elimination targets. The SD Bioline Onchocerciasis/LF IgG4 Rapid Test was used in 2 evaluation units (EU) to assess its performance as an integrated surveillance tool for elimination of lymphatic filariasis (LF) and onchocerciasis. METHODOLOGY/PRINCIPAL FINDINGS:A cross sectional survey with SD Bioline Onchocerciasis/LF IgG4 Rapid Test was piggy-backed onto a transmission assessment survey (TAS) (using the immunochromatographic card test (ICT) Binax Filariasis Now test for filarial adult circulating antigen (CFA) detection) for LF in Mali among 6-7 year old children in 2016 as part of the TAS in two EUs namely Kadiolo-Kolondieba in the region of Sikasso and Bafoulabe -Kita-Oussoubidiagna-Yelimane in the region of Kayes. In the EU of Kadiolo- Kolondieba, of the 1,625 children tested, the overall prevalence of W. bancrofti CFA was 0.62% (10/1,625) [CI = 0.31-1.09]; while that of IgG4 to Wb123 was 0.19% (3/1,600) [CI = 0.04-0.50]. The number of positives tested with the two tests were statistically comparable (p = 0.09). In the EU of Bafoulabe-Kita-Oussoubidiagna-Yelimane, an overall prevalence of W. bancrofti CFA was 0% (0/1,700) and that of Wb123 IgG4 antibody was 0.06% (1/1,700), with no statistically significant difference between the two rates (p = 0.99). In the EU of Kadiolo- Kolondieba, the prevalence of Ov16-specific IgG4 was 0.19% (3/1,600) [CI = 0.04-0.50]. All 3 positives were in the previously O. volvulus-hyperendemic district of Kolondieba. In the EU of Bafoulabe-Kita-Oussoubidiagna-Yelimane, an overall prevalence of Ov16-specific IgG4 was 0.18% (3/1,700) [CI = 0.04-0.47]. These 3 Ov16 IgG4 positives were from previously O.volvulus-mesoendemic district of Kita. CONCLUSIONS/SIGNIFICANCE:The SD Bioline Onchocerciasis/LF IgG4 Rapid test appears to be a good tool for integrated exposure measures of LF and onchocerciasis in co-endemic areas.


PLoS Negl Trop Dis


Dolo H,Coulibaly YI,Dembele B,Guindo B,Coulibaly SY,Dicko I,Doumbia SS,Dembele M,Traore MO,Goita S,Dolo M,Soumaoro L,Coulibaly ME,Diallo AA,Diarra D,Zhang Y,Colebunders R,Nutman TB




Has Abstract


2019-01-30 00:00:00














  • Venezuelan equine encephalitis virus in Iquitos, Peru: urban transmission of a sylvatic strain.

    abstract::Enzootic strains of Venezuelan equine encephalitis virus (VEEV) have been isolated from febrile patients in the Peruvian Amazon Basin at low but consistent levels since the early 1990s. Through a clinic-based febrile surveillance program, we detected an outbreak of VEEV infections in Iquitos, Peru, in the first half o...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Morrison AC,Forshey BM,Notyce D,Astete H,Lopez V,Rocha C,Carrion R,Carey C,Eza D,Montgomery JM,Kochel TJ

    更新日期:2008-01-01 00:00:00

  • Risk of dengue for tourists and teams during the World Cup 2014 in Brazil.

    abstract:BACKGROUND:This year, Brazil will host about 600,000 foreign visitors during the 2014 FIFA World Cup. The concern of possible dengue transmission during this event has been raised given the high transmission rates reported in the past by this country. METHODOLOGY/PRINCIPAL FINDINGS:We used dengue incidence rates repor...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: van Panhuis WG,Hyun S,Blaney K,Marques ET Jr,Coelho GE,Siqueira JB Jr,Tibshirani R,da Silva JB Jr,Rosenfeld R

    更新日期:2014-07-31 00:00:00

  • Identification of strain-specific B-cell epitopes in Trypanosoma cruzi using genome-scale epitope prediction and high-throughput immunoscreening with peptide arrays.

    abstract:BACKGROUND:The factors influencing variation in the clinical forms of Chagas disease have not been elucidated; however, it is likely that the genetics of both the host and the parasite are involved. Several studies have attempted to correlate the T. cruzi strains involved in infection with the clinical forms of the dis...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Mendes TA,Reis Cunha JL,de Almeida Lourdes R,Rodrigues Luiz GF,Lemos LD,dos Santos AR,da Câmara AC,Galvão LM,Bern C,Gilman RH,Fujiwara RT,Gazzinelli RT,Bartholomeu DC

    更新日期:2013-10-31 00:00:00

  • Transmission assessment surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation.

    abstract:BACKGROUND:Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,多中心研究


    authors: Chu BK,Deming M,Biritwum NK,Bougma WR,Dorkenoo AM,El-Setouhy M,Fischer PU,Gass K,Gonzalez de Peña M,Mercado-Hernandez L,Kyelem D,Lammie PJ,Flueckiger RM,Mwingira UJ,Noordin R,Offei Owusu I,Ottesen EA,Pavluck A,Pilotte

    更新日期:2013-12-05 00:00:00

  • Prescription of concomitant medications in patients treated with Nifurtimox Eflornithine Combination Therapy (NECT) for T.b. gambiense second stage sleeping sickness in the Democratic Republic of the Congo.

    abstract:BACKGROUND:Nifurtimox eflornithine combination therapy (NECT) to treat human African trypanosomiasis (HAT), commonly called sleeping sickness, was added to the World Health Organisation's (WHO) Essential Medicines List in 2009 and to the Paediatric List in 2012. NECT was further tested and documented in a phase IIIb cl...

    journal_title:PLoS neglected tropical diseases

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Kuemmerle A,Schmid C,Kande V,Mutombo W,Ilunga M,Lumpungu I,Mutanda S,Nganzobo P,Ngolo D,Kisala M,Valverde Mordt O

    更新日期:2020-01-27 00:00:00

  • Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients.

    abstract:UNLABELLED:CELADEN was a randomized placebo-controlled trial of 50 patients with confirmed dengue fever to evaluate the efficacy and safety of celgosivir (A study registered at, number NCT01619969). Celgosivir was given as a 400 mg loading dose and 200 mg bid (twice a day) over 5 days. Replication co...

    journal_title:PLoS neglected tropical diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sung C,Wei Y,Watanabe S,Lee HS,Khoo YM,Fan L,Rathore AP,Chan KW,Choy MM,Kamaraj US,Sessions OM,Aw P,de Sessions PF,Lee B,Connolly JE,Hibberd ML,Vijaykrishna D,Wijaya L,Ooi EE,Low JG,Vasudevan SG

    更新日期:2016-08-10 00:00:00

  • A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital.

    abstract:BACKGROUND:Salmonella serovars Typhi (S. Typhi) and Paratyphi A (S. Paratyphi A), the causative agents of enteric fever, have been routinely isolated organisms from the blood of febrile patients in the Kathmandu Valley since the early 1990s. Susceptibility against commonly used antimicrobials for treating enteric fever...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Zellweger RM,Basnyat B,Shrestha P,Prajapati KG,Dongol S,Sharma PK,Koirala S,Darton TC,Dolecek C,Thompson CN,Thwaites GE,Baker SG,Karkey A

    更新日期:2017-11-27 00:00:00

  • Mosquito vector diversity across habitats in central Thailand endemic for dengue and other arthropod-borne diseases.

    abstract::Recent years have seen the greatest ecological disturbances of our times, with global human expansion, species and habitat loss, climate change, and the emergence of new and previously-known infectious diseases. Biodiversity loss affects infectious disease risk by disrupting normal relationships between hosts and path...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Thongsripong P,Green A,Kittayapong P,Kapan D,Wilcox B,Bennett S

    更新日期:2013-10-31 00:00:00

  • Correction: Schistosoma species detection by environmental DNA assays in African freshwaters.

    abstract::[This corrects the article DOI: 10.1371/journal.pntd.0008129.]. ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 已发布勘误


    authors: Alzaylaee H,Collins RA,Rinaldi G,Shechonge A,Ngatunga B,Morgan ER,Genner MJ

    更新日期:2020-09-01 00:00:00

  • Monitoring toxicity associated with parenteral sodium stibogluconate in the day-case management of returned travellers with New World cutaneous leishmaniasis [corrected].

    abstract:BACKGROUND:Patients with New World cutaneous leishmaniasis (NWCL) caused by Leishmania Viannia are treated with parenteral sodium stibogluconate (SbV) to reduce the risk of development of mucocutanous leishmaniasis. Our centre manages patients with NWCL on an outpatient-basis. This study was conducted to assess the saf...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Wise ES,Armstrong MS,Watson J,Lockwood DN

    更新日期:2012-01-01 00:00:00

  • Pediatric visceral leishmaniasis in Albania: a retrospective analysis of 1,210 consecutive hospitalized patients (1995-2009).

    abstract:BACKGROUND:Little information is available about infantile visceral leishmaniasis (VL) in Albania as regards incidence, diagnosis and management of the disease. METHODOLOGY/PRINCIPAL FINDINGS:Demographic data, clinical and laboratory features and therapeutic findings were considered in children admitted to University ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Petrela R,Kuneshka L,Foto E,Zavalani F,Gradoni L

    更新日期:2010-09-07 00:00:00

  • Multiplex real-time PCR diagnostic of relapsing fevers in Africa.

    abstract:BACKGROUND:In Africa, relapsing fever borreliae are neglected arthropod-borne pathogens causing mild to deadly septicemia and miscarriage. The closely related Borrelia crocidurae, Borrelia duttonii, Borrelia recurrentis and Borrelia hispanica are rarely diagnosed at the species level, hampering refined epidemiological ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Elbir H,Henry M,Diatta G,Mediannikov O,Sokhna C,Tall A,Socolovschi C,Cutler SJ,Bilcha KD,Ali J,Campelo D,Barker SC,Raoult D,Drancourt M

    更新日期:2013-01-01 00:00:00

  • An integrated linkage, chromosome, and genome map for the yellow fever mosquito Aedes aegypti.

    abstract:BACKGROUND:Aedes aegypti, the yellow fever mosquito, is an efficient vector of arboviruses and a convenient model system for laboratory research. Extensive linkage mapping of morphological and molecular markers localized a number of quantitative trait loci (QTLs) related to the mosquito's ability to transmit various pa...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Timoshevskiy VA,Severson DW,Debruyn BS,Black WC,Sharakhov IV,Sharakhova MV

    更新日期:2013-01-01 00:00:00

  • Validation of a new test for Schistosoma haematobium based on detection of Dra1 DNA fragments in urine: evaluation through latent class analysis.

    abstract:BACKGROUND:Diagnosis of urogenital schistosomiasis in chronically infected adults is challenging but important, especially because long term infection of the bladder and urinary tract can have dire consequences. We evaluated three tests for viable infection: detection of parasite specific DNA Dra1 fragments, haematuria...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Ibironke O,Koukounari A,Asaolu S,Moustaki I,Shiff C

    更新日期:2012-01-01 00:00:00

  • Head and neck mycetoma: the mycetoma research centre experience.

    abstract::Mycetoma is a unique neglected tropical disease which is endemic in what is known as the "mycetoma belt". The disease has many devastating impacts on patients and communities in endemic area and is characterised by massive deformity, destruction and disability. Mycetoma is commonly seen in the foot and hand and less f...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Fahal A,Mahgoub el S,El Hassan AM,Jacoub AO,Hassan D

    更新日期:2015-03-13 00:00:00

  • The Pattern of Adipose Tissue Accumulation during Early Infancy Provides an Environment for the Development of Dengue Hemorrhagic Fever.

    abstract:BACKGROUND:Dengue is the most prevalent arthropod-borne viral illness in humans with half of the world's population at risk. During early infancy, severe dengue can develop after a primary dengue virus infection. There has been a clinical observation that severe dengue during the first year of life is seen only in chub...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Libraty DH,Wang P,Guo Z,Bigcas V,Brion JD,Capeding RZ

    更新日期:2015-12-04 00:00:00

  • Molecular identification and antifungal susceptibility profiles of clinical strains of Fonsecaea spp. isolated from patients with chromoblastomycosis in Rio de Janeiro, Brazil.

    abstract:BACKGROUND:Chromoblastomycosis (CBM) is a difficult-to-treat chronic subcutaneous mycosis. In Brazil, the main agent of this disease is Fonsecaea pedrosoi, which is phenotypically very similar to other Fonsecaea species, differing only genetically. The correct species identification is relevant since different species ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Coelho RA,Brito-Santos F,Figueiredo-Carvalho MHG,Silva JVDS,Gutierrez-Galhardo MC,do Valle ACF,Zancopé-Oliveira RM,Trilles L,Meyer W,Freitas DFS,Almeida-Paes R

    更新日期:2018-07-26 00:00:00

  • Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.

    abstract::Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manif...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,评审


    authors: Mitjà O,Šmajs D,Bassat Q

    更新日期:2013-10-24 00:00:00

  • Chaetomium atrobrunneum causing human eumycetoma: The first report.

    abstract::In this communication, a case of black grain eumycetoma produced by the fungus C. atrobrunneum is reported. The patient was initially misdiagnosed with M. mycetomatis eumycetoma based on the grains' morphological and cytological features. However, further aerobic culture of the black grains generated a melanised fungu...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Mhmoud NA,Santona A,Fiamma M,Siddig EE,Deligios M,Bakhiet SM,Rubino S,Fahal AH

    更新日期:2019-05-30 00:00:00

  • Evaluation of nephroprotective and immunomodulatory activities of antioxidants in combination with cisplatin against murine visceral leishmaniasis.

    abstract:BACKGROUND:Most available drugs against visceral leishmaniasis are toxic, and growing limitations in available chemotherapeutic strategies due to emerging resistant strains and lack of an effective vaccine against visceral leishmaniasis deepens the crisis. Antineoplastic drugs like miltefosine have in the past been eff...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Sharma M,Sehgal R,Kaur S

    更新日期:2012-01-01 00:00:00

  • Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera.

    abstract::Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance. The pathogenesis of several of the most prevalent infections, including cholera and enteroxigenic Escherichia coli, is dom...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Das S,Angsantikul P,Le C,Bao D,Miyamoto Y,Gao W,Zhang L,Eckmann L

    更新日期:2018-02-22 00:00:00

  • An unhealing wound and subcutaneous nodules due to Sporothrix globosa after a cat bite.

    abstract::A 51-year-old man with 3-month unhealing cat bite wound was diagnosed with sporotrichosis, a subacute-to-chronic infection caused by the worldwide endemic, dimorphic fungus Sporothrix globosa. The case would help clinicians to raise awareness of human sporotrichosis due to cat bites, which remains rare and is likely t...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Liu Y,Liu L,Kang M,Zong Z

    更新日期:2020-12-03 00:00:00

  • Phylogeny and niche conservatism in North and Central American triatomine bugs (Hemiptera: Reduviidae: Triatominae), vectors of Chagas' disease.

    abstract::The niche conservatism hypothesis states that related species diverge in niche characteristics at lower rates than expected, given their lineage divergence. Here we analyze whether niche conservatism is a common pattern among vector species (Hemiptera: Reduviidae: Triatominae) of Trypanosoma cruzi that inhabit North a...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Ibarra-Cerdeña CN,Zaldívar-Riverón A,Peterson AT,Sánchez-Cordero V,Ramsey JM

    更新日期:2014-10-30 00:00:00

  • TLR9 activation dampens the early inflammatory response to Paracoccidioides brasiliensis, impacting host survival.

    abstract:BACKGROUND:Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune res...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Menino JF,Saraiva M,Gomes-Alves AG,Lobo-Silva D,Sturme M,Gomes-Rezende J,Saraiva AL,Goldman GH,Cunha C,Carvalho A,Romani L,Pedrosa J,Castro AG,Rodrigues F

    更新日期:2013-07-25 00:00:00

  • Human neutrophil peptide-1 (HNP-1): a new anti-leishmanial drug candidate.

    abstract::The toxicity of available drugs for treatment of leishmaniasis, coupled with emerging drug resistance, make it urgent to find new therapies. Antimicrobial peptides (AMPs) have a strong broad-spectrum antimicrobial activity with distinctive modes of action and are considered as promising therapeutic agents. The defensi...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Dabirian S,Taslimi Y,Zahedifard F,Gholami E,Doustdari F,Motamedirad M,Khatami S,Azadmanesh K,Nylen S,Rafati S

    更新日期:2013-10-17 00:00:00

  • Rapid Enhanced MM3-COPRO ELISA for Detection of Fasciola Coproantigens.

    abstract::ELISA-based methods of detecting Fasciola cathepsins in feces are powerful techniques for diagnosing infections by F. hepatica and F. gigantica. In the last decade, the in-house MM3-COPRO ELISA and its commercial version BIO K 201 (BIO X Diagnostics, Belgium) have been recognized as useful tools for detecting early in...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Martínez-Sernández V,Orbegozo-Medina RA,González-Warleta M,Mezo M,Ubeira FM

    更新日期:2016-07-20 00:00:00

  • Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.

    abstract::In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical. Between these strains, significant differences are found in expression of, and antibody responses to some candidate virulence factors, suggesting...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Giacani L,Chattopadhyay S,Centurion-Lara A,Jeffrey BM,Le HT,Molini BJ,Lukehart SA,Sokurenko EV,Rockey DD

    更新日期:2012-01-01 00:00:00

  • B1 cells protect against Schistosoma japonicum-induced liver inflammation and fibrosis by controlling monocyte infiltration.

    abstract::During Schistosoma infection, lack of B cells results in more severe granulomas, inflammation, and fibrosis in the liver, but the mechanisms underlying this pathology remain unclear. This study was to clarify the mechanisms underpinning the immunomodulation of B cells in mice infected with Schistosoma japonicum (S. ja...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Yong L,Tang Y,Ren C,Liu M,Shen J,Hou X

    更新日期:2019-06-13 00:00:00

  • Turning poop into profit: Cost-effectiveness and soil transmitted helminth infection risk associated with human excreta reuse in Vietnam.

    abstract::Human excreta is a low cost source of nutrients vital to plant growth, but also a source of pathogens transmissible to people and animals. We investigated the cost-savings and infection risk of soil transmitted helminths (STHs) in four scenarios where farmers used either inorganic fertilizer or fresh/composted human e...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,meta分析,评审


    authors: Tran-Thi N,Lowe RJ,Schurer JM,Vu-Van T,MacDonald LE,Pham-Duc P

    更新日期:2017-11-27 00:00:00

  • Differential epidemiology of Salmonella Typhi and Paratyphi A in Kathmandu, Nepal: a matched case control investigation in a highly endemic enteric fever setting.

    abstract:BACKGROUND:Enteric fever, a systemic infection caused by the bacteria Salmonella Typhi and Salmonella Paratyphi A, is endemic in Kathmandu, Nepal. Previous work identified proximity to poor quality water sources as a community-level risk for infection. Here, we sought to examine individual-level risk factors related to...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Karkey A,Thompson CN,Tran Vu Thieu N,Dongol S,Le Thi Phuong T,Voong Vinh P,Arjyal A,Martin LB,Rondini S,Farrar JJ,Dolecek C,Basnyat B,Baker S

    更新日期:2013-08-22 00:00:00