The Effect of Insomnia on Cortical Excitability in Patients With Generalized Anxiety Disorder.

Abstract:

:The high rate of comorbidity between insomnia and anxiety disorders have been confirmed by previous studies. However, the underlying neurobiological correlates of the relationship between insomnia and anxiety disorders are largely unknown. The aim of the present study was to investigate the effect of insomnia on cortical excitability in patients with generalized anxiety disorder (GAD) by examining the recovery functions of median nerve somatosensory evoked potentials (SEPs) in patients with GAD without insomnia and patients with GAD comorbid with insomnia. We studied the recovery functions of median nerve SEPs in 12 medication-naive patients with GAD without insomnia, 15 medication-naive patients with GAD comorbid with insomnia, and 15 age and sex matched healthy controls. SEPs in response to single stimulus and paired stimuli at interstimulus intervals (ISIs) of 20, 60, 100, and 150 ms were recorded. The recovery function of the P25 component showed significantly reduced suppression in patients with GAD without insomnia as compared to patients with GAD comorbid with insomnia and healthy controls. There were no significant differences in the recovery functions of median nerve SEPs between patients with GAD comorbid with insomnia and healthy controls. The present study suggested that the cortical excitability of right parietal cortex increased in patients with GAD without insomnia, and cortical excitability in patients with GAD comorbid with insomnia was modulated by insomnia. Our findings provide new insights into the underlying neurobiological correlates of the effects of insomnia on GAD, which could ultimately be used to inform clinical intervention.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Huang Z,Zhan S,Chen C,Li N,Ding Y,Hou Y,Wang L,Wang Y

doi

10.3389/fpsyt.2018.00755

subject

Has Abstract

pub_date

2019-01-10 00:00:00

pages

755

issn

1664-0640

journal_volume

9

pub_type

杂志文章
  • Reviewing a Decade of Research Into Suicide and Related Behaviour Using the South London and Maudsley NHS Foundation Trust Clinical Record Interactive Search (CRIS) System.

    abstract::Suicide is a serious public health issue worldwide, yet current clinical methods for assessing a person's risk of taking their own life remain unreliable and new methods for assessing suicide risk are being explored. The widespread adoption of electronic health records (EHRs) has opened up new possibilities for epidem...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2020.553463

    authors: Bittar A,Velupillai S,Downs J,Sedgwick R,Dutta R

    更新日期:2020-11-27 00:00:00

  • Unmet Needs in Children With Attention Deficit Hyperactivity Disorder-Can Transcranial Direct Current Stimulation Fill the Gap? Promises and Ethical Challenges.

    abstract::Attention deficit hyperactivity disorder (ADHD) is a disorder most frequently diagnosed in children and adolescents. Although ADHD can be effectively treated with psychostimulants, a significant proportion of patients discontinue treatment because of adverse events or insufficient improvement of symptoms. In addition,...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00334

    authors: Sierawska A,Prehn-Kristensen A,Moliadze V,Krauel K,Nowak R,Freitag CM,Siniatchkin M,Buyx A

    更新日期:2019-05-16 00:00:00

  • The Autonomic Progress Bar Motivates Treatment Completion for Patients of Stimulant Use Disorder and Cannabis Use Disorder.

    abstract::Background: The intrinsic motivation behind the "need to complete" is more influential than external incentives. We introduced a novel progress-bar tool to motivate the completion of programs designed to treat stimulant and cannabis use disorders. We further examined the effectiveness of the progress bar's scoring app...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00944

    authors: Chen IC,Teng G,Chen CJ,Lan TH,Liu HJ

    更新日期:2020-01-13 00:00:00

  • Type D Personality, Concomitant Depressive and Anxiety Disorders, and Treatment Outcomes in Somatic Symptom and Related Disorders: An Observational Longitudinal Cohort Study.

    abstract::Objective: To establish the prevalence of Type D personality in patients with somatic symptoms and related disorders and to evaluate the association of Type D personality with treatment outcomes. This study explores the effect of Type D personality and its two traits, negative affectivity (NA) and social inhibition (S...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00417

    authors: de Vroege L,de Heer EW,van der Thiel E,van den Broek KC,van Eck van der Sluijs JF,van der Feltz-Cornelis CM

    更新日期:2019-06-19 00:00:00

  • Effect of the Nature of Subsequent Environment on Oxytocin and Cortisol Secretion in Maltreated Children.

    abstract::Childhood maltreatment (CM), including abuse and neglect, is a crucial factor that distorts child development. CM is associated with alterations in numerous brain regions, and may be associated with hormonal dysregulation. This study aimed to investigate differences in secretion patterns of cortisol (CT) and oxytocin ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2015.00173

    authors: Mizushima SG,Fujisawa TX,Takiguchi S,Kumazaki H,Tanaka S,Tomoda A

    更新日期:2015-12-11 00:00:00

  • Efficacy of the Whole-Body Cryotherapy as Add-on Therapy to Pharmacological Treatment of Depression-A Randomized Controlled Trial.

    abstract:Introduction:Accumulating evidence indicates the effectiveness of cryogenic temperature interventions in rheumatoid arthritis, ankylosing spondylitis, fibromyalgia, multiple sclerosis, and chronic low back pain. The application of whole-body cryotherapy (WBC) in psychiatric aspects of medicine was also noted. Neverthel...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00522

    authors: Rymaszewska J,Lion KM,Pawlik-Sobecka L,Pawłowski T,Szcześniak D,Trypka E,Rymaszewska JE,Zabłocka A,Stanczykiewicz B

    更新日期:2020-06-09 00:00:00

  • The Attribution of Mental Health Problems to Jinn: An Explorative Study in a Transcultural Psychiatric Outpatient Clinic.

    abstract:Background:Among Muslim patients, a common cultural concept of distress is the notion that jinn may be the cause of mental health problems, especially in the presence of hallucinations. Objective:This study examines the frequency with which this attribution style is manifest in a specific psychiatric outpatient popula...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00089

    authors: Lim A,Hoek HW,Ghane S,Deen M,Blom JD

    更新日期:2018-03-28 00:00:00

  • Co-design of eHealth Interventions With Children and Young People.

    abstract::Co-design, defined as collective creativity across the entire design process, can lead to the development of interventions that are more engaging, satisfying, and useful to potential users. However, using this methodology within the research arena requires a shift from traditional practice. Co-design of eHealth interv...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00481

    authors: Thabrew H,Fleming T,Hetrick S,Merry S

    更新日期:2018-10-18 00:00:00

  • Interpersonal Psychotherapy vs. Treatment as Usual for Major Depression Related to Work Stress: A Pilot Randomized Controlled Study.

    abstract::Background: Depressive disorders are among the leading causes of sick leave and long-term work incapacity in most modern countries. Work related stress is described by patients as the most common context of depression. It is vital to know what types of treatments are effective in improving work related problems and oc...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2020.00193

    authors: Schramm E,Mack S,Thiel N,Jenkner C,Elsaesser M,Fangmeier T

    更新日期:2020-03-18 00:00:00

  • Levels of Social Sharing and Clinical Implications for Severe Social Withdrawal in Patients with Personality Disorders.

    abstract::Social sharing capacities have attracted attention from a number of fields of social cognition and have been variously defined and analyzed in numerous studies. Social sharing consists in the subjective awareness that aspects of the self's experience are held in common with other individuals. The definition of social ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00263

    authors: Colle L,Pellecchia G,Moroni F,Carcione A,Nicolò G,Semerari A,Procacci M

    更新日期:2017-12-04 00:00:00

  • Determinants of Community Integration Among Formerly Homeless Veterans Who Received Supportive Housing.

    abstract::Community integration is recognized as a meaningful goal that is highly relevant to the long-term success of supportive housing programs. Research to date highlights concerns that some individuals in permanent supportive housing remain socially isolated and have limited success in other domains of community integratio...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00472

    authors: Chinchilla M,Gabrielian S,Hellemann G,Glasmeier A,Green M

    更新日期:2019-06-26 00:00:00

  • Reliving, Replaying Lived Experiences Through Auditory Verbal Hallucinations: Implications on Theories and Management.

    abstract::Objective: This study aims to understand the impact of negative life experience (NLE) in auditory hallucinations (AHs) and explain the heterogeneity in phenomenology of auditory verbal hallucinations (AVHs). Method: In depth interviews were conducted with 21 individuals (7 males and 14 females) experiencing AHs and ac...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00528

    authors: Vallath S,Luhrmann T,Bunders J,Ravikant L,Gopikumar V

    更新日期:2018-10-30 00:00:00

  • Anti-Suicide Function of Nonsuicidal Self-Injury in Female Inpatient Adolescents.

    abstract:Background:There have been numerous studies investigating the relationship between nonsuicidal self-injury (NSSI) and suicidality. On the one side, NSSI is an important risk factor for suicidality, including suicidal thoughts and behaviors. On the other side, it has been suggested that one function of NSSI might be as ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00490

    authors: Kraus L,Schmid M,In-Albon T

    更新日期:2020-06-03 00:00:00

  • Depression Preceding Diagnosis of Bipolar Disorder.

    abstract::This paper focuses on depression that precedes an onset of manifest bipolar disorder as early stage bipolar disorder. First, we review how to pragmatically identify the clinical characteristics of patients presenting with an episode of depression who subsequently go on to develop episodes of mania or hypomania. The ex...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2020.00500

    authors: O'Donovan C,Alda M

    更新日期:2020-06-11 00:00:00

  • Pharmacological modulation of the short-lasting effects of antagonistic direct current-stimulation over the human motor cortex.

    abstract::Combined administration of transcranial direct current-stimulation (tDCS) with either pergolide (PER) or d-cycloserine (d-CYC) can prolong the excitability-diminishing effects of cathodal, or the excitability enhancing effect of anodal stimulation for up to 24 h poststimulation. However, it remains unclear whether the...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2012.00067

    authors: Chaieb L,Antal A,Terney D,Paulus W

    更新日期:2012-07-05 00:00:00

  • The Efficacy of Fecal Microbiota Transplantation for Children With Tourette Syndrome: A Preliminary Study.

    abstract::Therapies for Tourette syndrome (TS) are insufficient, and novel therapies are needed. Fecal microbiota transplantation (FMT) has been a potential therapy for several neurological diseases. Here, we report a preliminary study to investigate the effects of FMT on patients with TS. Five patients with TS received a singl...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2020.554441

    authors: Zhao HJ,Luo X,Shi YC,Li JF,Pan F,Ren RR,Peng LH,Shi XY,Yang G,Wang J,Hu LY,Zou LP,Yang YS

    更新日期:2020-12-23 00:00:00

  • Personality and Psychological Factors of Problematic Internet Gamers Seeking Hospital Treatment.

    abstract::Introduction: Previous studies on internet gaming disorder (IGD) have reported an association between personality traits and impulsive or problematic use of the internet or internet games, but the results obtained were inconsistent. Our study's hypothesis was that personality traits are associated with the individual'...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00583

    authors: Seong W,Hong JS,Kim S,Kim SM,Han DH

    更新日期:2019-08-28 00:00:00

  • Neuroinflammation in Bipolar Depression.

    abstract::Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders. Pathological mechanisms are still vastly unclear, and current treatments with conventional medications are often unsatisfactory in maintaining symptoms control and an adequate quality of life. Consequently, current research is focus...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2020.00071

    authors: Benedetti F,Aggio V,Pratesi ML,Greco G,Furlan R

    更新日期:2020-02-26 00:00:00

  • Impact of Cognitive Remediation Therapy on Neurocognitive Processing in Anorexia Nervosa.

    abstract:Background:Anorexia nervosa (AN) is characterized by severe malnutrition as well as inefficiencies in neurocognitive functioning, which are believed to contribute to the maintenance of disordered eating. The aim of this study was to examine the impact of individual cognitive remediation therapy (CRT) on neurocognition ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00096

    authors: Leppanen J,Adamson J,Tchanturia K

    更新日期:2018-03-20 00:00:00

  • Novel Psychoactive Substances-Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs.

    abstract::A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects. These drugs change the mental state and/or the behavioral performance of an individual and can be instrumentalized for various purposes. After the emergen...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2017.00152

    authors: Hassan Z,Bosch OG,Singh D,Narayanan S,Kasinather BV,Seifritz E,Kornhuber J,Quednow BB,Müller CP

    更新日期:2017-08-18 00:00:00

  • A Review of Impaired Neuroplasticity in Schizophrenia Investigated with Non-invasive Brain Stimulation.

    abstract:BACKGROUND:Several lines of evidence implicate dysfunctional neuronal plasticity in the pathophysiology of schizophrenia (SCZ). Aberrant glutamatergic and gamma amino--butyric acid neurotransmission are thought to underlie core cognitive deficits and negative symptoms of SCZ. Non-invasive brain stimulation (NIBS) allow...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2016.00045

    authors: Bhandari A,Voineskos D,Daskalakis ZJ,Rajji TK,Blumberger DM

    更新日期:2016-03-29 00:00:00

  • Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors.

    abstract::Cocaine addiction is a widespread psychiatric condition still waiting for approved efficacious medications. Previous studies suggested that simultaneous activation of nociceptin opioid (NOP) and mu opioid (MOP) receptors could be a successful strategy to treat cocaine addiction, but the paucity of molecules co-activat...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00234

    authors: Shen Q,Deng Y,Ciccocioppo R,Cannella N

    更新日期:2017-11-13 00:00:00

  • COVID-19 Outbreak Can Change the Job Burnout in Health Care Professionals.

    abstract::Background: The outbreak of COVID-19 in China was a sudden bio-disaster, which may bring a negative impact on the job burnout of health care professionals (HCPs). Objective: We aim to find out the association factors, especially those closely related to this outbreak, of job burnout in Chinese HCPs. Method: The cross-...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.563781

    authors: Liu X,Chen J,Wang D,Li X,Wang E,Jin Y,Ma Y,Yu C,Luo C,Zhang L,Liu C,Zhou Y,Yang L,Song J,Bai T,Hou X

    更新日期:2020-12-08 00:00:00

  • Advances in Resting State Neuroimaging of Mild Cognitive Impairment.

    abstract::The rapidly increasing number of patients with Alzheimer's disease (AD) worldwide has become a major public concern. Mild cognitive impairment (MCI), characterized with accelerated memory decline than normal aging, is a stage between cognitively unimpaired and dementia. Identification of MCI in the Alzheimer's continu...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00671

    authors: Lin L,Xing G,Han Y

    更新日期:2018-12-06 00:00:00

  • Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies.

    abstract::Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and maj...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00767

    authors: Li CT,Yang KC,Lin WC

    更新日期:2019-01-24 00:00:00

  • Increased Serum C3 and Decreased UA in Patients of Bipolar Disorder in Chinese Han Population.

    abstract::The aim of this study is to explore the changes and clinical significance of serum C3, C4, hypersensitive C-reactive protein (hsCRP) and uric acid (UA) in patients of bipolar disorder (BD). In this case-control study, we recruited 141 BD patients from The Second Xiangya Hospital, Central South University, and 151 age ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00381

    authors: Yang X,Tao H,Xiao L,Li C,Tang Y,Liu Y

    更新日期:2018-08-21 00:00:00

  • Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics.

    abstract::Depression has been associated with peripheral inflammatory processes and alterations in cellular immunity. Growing evidence suggests that immunological alterations may neither be necessary nor sufficient to induce depression in general, but seem to be associated with specific features. Using baseline data from the Ou...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00250

    authors: Euteneuer F,Dannehl K,Del Rey A,Engler H,Schedlowski M,Rief W

    更新日期:2017-11-23 00:00:00

  • Cinemotion, a Program of Cognitive Remediation to Improve the Recognition and Expression of Facial Emotions in Schizophrenia: A Pilot Study.

    abstract::Objective: Patients with schizophrenia exhibit impaired social cognition, especially in the recognition and expression of facial emotions, aspects of communication profoundly interlinked in an embodied approach of cognition. Nevertheless, many training programs have been developed that focus on either of these deficit...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00312

    authors: Sevos J,Grosselin A,Gauthier M,Carmona F,Gay A,Massoubre C

    更新日期:2018-07-23 00:00:00

  • Monetary Incentives Increase Metacognitive Confidence in Source Memory Performance in Patients With Schizophrenia.

    abstract:Background:Contemporary psychiatric research focuses its attention on the patient's dysfunction of metacognition in relation to the basic cognitive processes of mental activity. The current study investigated dysfunctional metacognition in relation to self-monitoring of memory in patients diagnosed with schizophrenia. ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00725

    authors: Szczepanowski R,Cichoń E,Pasieczna AH,Gawęda Ł,Rosińczuk J

    更新日期:2020-07-29 00:00:00

  • Neural Correlates of Duration Discrimination in Young Adults with Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder and Their Comorbid Presentation.

    abstract::Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share neurocognitive deficits. One such shared impairment is in duration discrimination. However, no studies using functional magnetic resonance imaging (fMRI) have investigated whether these duration discrimination d...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00569

    authors: Lukito SD,O'Daly OG,Lythgoe DJ,Whitwell S,Debnam A,Murphy CM,Ashwood K,Stoencheva V,Simonoff E,Rubia K

    更新日期:2018-11-14 00:00:00