Impact of Traumatic Brain Injury on Neurogenesis.


:New neurons are generated in the hippocampal dentate gyrus from early development through adulthood. Progenitor cells and immature granule cells in the subgranular zone are responsive to changes in their environment; and indeed, a large body of research indicates that neuronal interactions and the dentate gyrus milieu regulates granule cell proliferation, maturation, and integration. Following traumatic brain injury (TBI), these interactions are dramatically altered. In addition to cell losses from injury and neurotransmitter dysfunction, patients often show electroencephalographic evidence of cortical spreading depolarizations and seizure activity after TBI. Furthermore, treatment for TBI often involves interventions that alter hippocampal function such as sedative medications, neuromodulating agents, and anti-epileptic drugs. Here, we review hippocampal changes after TBI and how they impact the coordinated process of granule cell adult neurogenesis. We also discuss clinical TBI treatments that have the potential to alter neurogenesis. A thorough understanding of the impact that TBI has on neurogenesis will ultimately be needed to begin to design novel therapeutics to promote recovery.


Front Neurosci


Ngwenya LB,Danzer SC




Has Abstract


2019-01-09 00:00:00










  • Adolescent Vulnerability to Heightened Emotional Reactivity and Anxiety After Brief Exposure to an Obesogenic Diet.

    abstract:Background:Emerging evidence demonstrates that diet-induced obesity disrupts corticolimbic circuits underlying emotional regulation. Studies directed at understanding how obesity alters brain and behavior are easily confounded by a myriad of complications related to obesity. This study investigated the early neurobiolo...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Vega-Torres JD,Azadian M,Rios-Orsini RA,Reyes-Rivera AL,Ontiveros-Angel P,Figueroa JD

    更新日期:2020-06-30 00:00:00

  • Identification of neural cells activated by mating stimulus in the periaqueductal gray in female rats.

    abstract::Induction of lordosis as typical female sexual behavior in rodents is dependent on a mount stimulus from males and blood levels of estrogen. Periaqueductal gray (PAG) efferent neurons have been suggested to be important for lordosis behavior; however, the neurochemical basis remains to be understood. In this study, we...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Yamada S,Kawata M

    更新日期:2014-12-18 00:00:00

  • Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes.

    abstract::Defects in the endoplasmic reticulum (ER) membrane shaping and interaction with other organelles seem to be a crucial mechanism underlying Hereditary Spastic Paraplegia (HSP) neurodegeneration. REEP1, a transmembrane protein belonging to TB2/HVA22 family, is implicated in SPG31, an autosomal dominant form of HSP, and ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Napoli B,Gumeni S,Forgiarini A,Fantin M,De Filippis C,Panzeri E,Vantaggiato C,Orso G

    更新日期:2019-11-19 00:00:00

  • Left Shifting of Language Related Activity Induced by Bihemispheric tDCS in Postacute Aphasia Following Stroke.

    abstract::Both anodal transcranial direct current stimulation (tDCS) of the left IFG and cathodal stimulation of the right IFG were shown to improve rehabilitation of stroke patients with Broca's aphasia. The study aimed at assessing the impact of a bihemispheric IFG stimulation compared to sham on postacute non-fluent aphasia....

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Feil S,Eisenhut P,Strakeljahn F,Müller S,Nauer C,Bansi J,Weber S,Liebs A,Lefaucheur JP,Kesselring J,Gonzenbach R,Mylius V

    更新日期:2019-04-26 00:00:00

  • Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus.

    abstract::Women with epilepsy commonly have premature onset of menopause. The decrease in estrogen levels is associated with increased occurrence of neurodegenerative processes and cognitive decline. Previously, we found that estradiol (E2) replacement in ovariectomized (OVX) female rats significantly reduced the seizure-relate...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Iacobas DA,Iacobas S,Nebieridze N,Velíšek L,Velíšková J

    更新日期:2018-06-20 00:00:00

  • Isoflurane Post-conditioning Ameliorates Cerebral Ischemia/Reperfusion Injury by Enhancing Angiogenesis Through Activating the Shh/Gli Signaling Pathway in Rats.

    abstract::Background: Stroke is the second leading cause of death worldwide. Angiogenesis facilitates the formation of microvascular networks and promotes recovery after stroke. The Shh/Gli signaling pathway is implicated in angiogenesis and cerebral ischemia-reperfusion (I/R) injury. This study aimed at investigating the influ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Peng L,Yin J,Ge M,Wang S,Xie L,Li Y,Si JQ,Ma K

    更新日期:2019-04-09 00:00:00

  • Iowa gambling task: there is more to consider than long-term outcome. Using a linear equation model to disentangle the impact of outcome and frequency of gains and losses.

    abstract::The Iowa Gambling Task (IGT) has been widely used to assess differences in decision-making under uncertainty. Recently, several studies have shown that healthy subjects do not meet the basic predictions of the task (i.e., prefer options with positive long-term outcome), hence questioning its basic assumptions. Since c...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Horstmann A,Villringer A,Neumann J

    更新日期:2012-05-14 00:00:00

  • Reduction in Parasympathetic Tone During Sleep in Children With Habitual Snoring.

    abstract::Introduction: Changes in the autonomic nervous system due to Obstructive Sleep Apnea (OSA) during the life span have been described. Some pediatric studies have shown cardiovascular effects in children who do not fit the criteria for OSA; namely children with mild sleep disordered breathing. Objective: We investigated...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Lopes MC,Spruyt K,Azevedo-Soster L,Rosa A,Guilleminault C

    更新日期:2019-01-10 00:00:00

  • Pathophysiological Changes of Physical Barriers of Peripheral Nerves After Injury.

    abstract::Peripheral nerves are composed of complex layered anatomical structures, including epineurium, perineurium, and endoneurium. Perineurium and endoneurium contain many physical barriers, including the blood-nerve barrier at endoneurial vessels and the perineurial barrier. These physical barriers help to eliminate flux p...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Liu Q,Wang X,Yi S

    更新日期:2018-08-23 00:00:00

  • White Matter Tract Segmentation as Multiple Linear Assignment Problems.

    abstract::Diffusion magnetic resonance imaging (dMRI) allows to reconstruct the main pathways of axons within the white matter of the brain as a set of polylines, called streamlines. The set of streamlines of the whole brain is called the tractogram. Organizing tractograms into anatomically meaningful structures, called tracts,...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Sharmin N,Olivetti E,Avesani P

    更新日期:2018-02-06 00:00:00

  • Corrigendum: Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats.

    abstract::[This corrects the article on p. 589 in vol. 10, PMID: 28066172.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 已发布勘误


    authors: Wang H,Li X,Shan L,Zhu J,Chen R,Li Y,Yuan W,Yang L,Huang J

    更新日期:2017-02-13 00:00:00

  • Rethinking Therapeutic Strategies for Anorexia Nervosa: Insights From Psychedelic Medicine and Animal Models.

    abstract::Anorexia nervosa (AN) has the highest mortality rate of any psychiatric disease, yet available pharmacological treatments are largely ineffective due, in part, to an inadequate understanding of the neurobiological drivers that underpin the condition. The recent resurgence of research into the clinical applications of ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Foldi CJ,Liknaitzky P,Williams M,Oldfield BJ

    更新日期:2020-02-04 00:00:00

  • When and How to Interpret Null Results in NIBS: A Taxonomy Based on Prior Expectations and Experimental Design.

    abstract::Experiments often challenge the null hypothesis that an intervention, for instance application of non-invasive brain stimulation (NIBS), has no effect on an outcome measure. In conventional statistics, a positive result rejects that hypothesis, but a null result is meaningless. Informally, however, researchers often d...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: de Graaf TA,Sack AT

    更新日期:2018-12-11 00:00:00

  • The behavioral relevance of multisensory neural response interactions.

    abstract::Sensory information can interact to impact perception and behavior. Foods are appreciated according to their appearance, smell, taste and texture. Athletes and dancers combine visual, auditory, and somatosensory information to coordinate their movements. Under laboratory settings, detection and discrimination are like...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Sperdin HF,Cappe C,Murray MM

    更新日期:2010-05-15 00:00:00

  • Spatial Cues Provided by Sound Improve Postural Stabilization: Evidence of a Spatial Auditory Map?

    abstract::It has long been suggested that sound plays a role in the postural control process. Few studies however have explored sound and posture interactions. The present paper focuses on the specific impact of audition on posture, seeking to determine the attributes of sound that may be useful for postural purposes. We invest...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Gandemer L,Parseihian G,Kronland-Martinet R,Bourdin C

    更新日期:2017-06-26 00:00:00

  • A Comparison of Regularization Methods in Forward and Backward Models for Auditory Attention Decoding.

    abstract::The decoding of selective auditory attention from noninvasive electroencephalogram (EEG) data is of interest in brain computer interface and auditory perception research. The current state-of-the-art approaches for decoding the attentional selection of listeners are based on linear mappings between features of sound s...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Wong DDE,Fuglsang SA,Hjortkjær J,Ceolini E,Slaney M,de Cheveigné A

    更新日期:2018-08-07 00:00:00

  • Corrigendum: Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness.

    abstract::[This corrects the article DOI: 10.3389/fnins.2019.01334.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 已发布勘误


    authors: Ooi LQR,Wen MC,Ng SY,Chia NS,Chew IHM,Lee W,Xu Z,Hartono S,Tan EK,Chan LL,Tan LC

    更新日期:2020-05-12 00:00:00

  • Weight Bearing Over-ground Stepping in an Exoskeleton with Non-invasive Spinal Cord Neuromodulation after Motor Complete Paraplegia.

    abstract::We asked whether coordinated voluntary movement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and completely absent of vision (>15 year) using two novel strategies-transcutaneous electrical spinal cord stimulation at selected sites over the spine as well as pharmacolo...

    journal_title:Frontiers in neuroscience



    authors: Gad P,Gerasimenko Y,Zdunowski S,Turner A,Sayenko D,Lu DC,Edgerton VR

    更新日期:2017-06-08 00:00:00

  • Neurophysiological mechanisms involved in auditory perceptual organization.

    abstract::In our complex acoustic environment, we are confronted with a mixture of sounds produced by several simultaneous sources. However, we rarely perceive these sounds as incomprehensible noise. Our brain uses perceptual organization processes to independently follow the emission of each sound source over time. If the acou...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Bidet-Caulet A,Bertrand O

    更新日期:2009-09-15 00:00:00

  • Exosomes and the Prion Protein: More than One Truth.

    abstract::Exosomes are involved in the progression of neurodegenerative diseases. The cellular prion protein (PrPC) is highly expressed on exosomes. In neurodegenerative diseases, PrPC has at least two functions: It is the substrate for the generation of pathological prion protein (PrPSc), a key player in the pathophysiology of...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Hartmann A,Muth C,Dabrowski O,Krasemann S,Glatzel M

    更新日期:2017-04-19 00:00:00

  • Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain.

    abstract:OBJECTIVES:The thickness of the brain's cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Kochunov P,Glahn DC,Nichols TE,Winkler AM,Hong EL,Holcomb HH,Stein JL,Thompson PM,Curran JE,Carless MA,Olvera RL,Johnson MP,Cole SA,Kochunov V,Kent J,Blangero J

    更新日期:2011-10-19 00:00:00

  • A Coordinate-Based Meta-Analysis of Overlaps in Regional Specialization and Functional Connectivity across Subjective Value and Default Mode Networks.

    abstract::Previous research has provided qualitative evidence for overlap in a number of brain regions across the subjective value network (SVN) and the default mode network (DMN). In order to quantitatively assess this overlap, we conducted a series of coordinate-based meta-analyses (CBMA) of results from 466 functional magnet...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Acikalin MY,Gorgolewski KJ,Poldrack RA

    更新日期:2017-01-19 00:00:00

  • Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects.

    abstract::The hippocampus has exhibited navigation-related changes in volume and activity after visual deprivation; however, the resting-state functional connectivity (rsFC) changes of the hippocampus in the blind remains unknown. In this study, we focused on sub-region-specific rsFC changes of the hippocampus and their associa...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Ma G,Yang D,Qin W,Liu Y,Jiang T,Yu C

    更新日期:2017-01-10 00:00:00

  • Single trial prediction of self-paced reaching directions from EEG signals.

    abstract::Early detection of movement intention could possibly minimize the delays in the activation of neuroprosthetic devices. As yet, single trial analysis using non-invasive approaches for understanding such movement preparation remains a challenging task. We studied the feasibility of predicting movement directions in self...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Lew EY,Chavarriaga R,Silvoni S,Millán Jdel R

    更新日期:2014-08-01 00:00:00

  • A Comparative Study of Different EEG Reference Choices for Event-Related Potentials Extracted by Independent Component Analysis.

    abstract::In the event-related potential (ERP) of scalp electroencephalography (EEG) studies, the vertex reference (Cz), linked mastoids or ears (LM), and average reference (AVG) are popular reference methods, and the reference electrode standardization technique (REST) is increasingly applied. Because scalp EEG recordings are ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Dong L,Liu X,Zhao L,Lai Y,Gong D,Liu T,Yao D

    更新日期:2019-10-11 00:00:00

  • Frequency-Following Responses to Complex Tones at Different Frequencies Reflect Different Source Configurations.

    abstract::The neural generators of the frequency-following response (FFR), a neural response widely used to study the human auditory system, remain unclear. There is evidence that the balance between cortical and subcortical contributions to the FFR varies with stimulus frequency. In this study, we tried to clarify whether this...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Zhang X,Gong Q

    更新日期:2019-02-26 00:00:00

  • Protein Quality Control by Molecular Chaperones in Neurodegeneration.

    abstract::Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and their aggregates by protein quality control (PQC), of which molecular chaperones are an essential component. Compared with other cell types, PQC in neurons is particularly challenging because they have a unique cellular struct...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Ciechanover A,Kwon YT

    更新日期:2017-04-06 00:00:00

  • Stochastic Synapses Enable Efficient Brain-Inspired Learning Machines.

    abstract::Recent studies have shown that synaptic unreliability is a robust and sufficient mechanism for inducing the stochasticity observed in cortex. Here, we introduce Synaptic Sampling Machines (S2Ms), a class of neural network models that uses synaptic stochasticity as a means to Monte Carlo sampling and unsupervised learn...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Neftci EO,Pedroni BU,Joshi S,Al-Shedivat M,Cauwenberghs G

    更新日期:2016-06-29 00:00:00

  • Regulation of Chromatin Structure During Neural Development.

    abstract::The regulation of genome architecture is a key determinant of gene transcription patterns and neural development. Advances in methodologies based on chromatin conformation capture (3C) have shed light on the genome-wide organization of chromatin in developmental processes. Here, we review recent discoveries regarding ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Kishi Y,Gotoh Y

    更新日期:2018-12-11 00:00:00

  • Early Detection of Alzheimer's Disease Using Magnetic Resonance Imaging: A Novel Approach Combining Convolutional Neural Networks and Ensemble Learning.

    abstract::Early detection is critical for effective management of Alzheimer's disease (AD) and screening for mild cognitive impairment (MCI) is common practice. Among several deep-learning techniques that have been applied to assessing structural brain changes on magnetic resonance imaging (MRI), convolutional neural network (C...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Pan D,Zeng A,Jia L,Huang Y,Frizzell T,Song X

    更新日期:2020-05-13 00:00:00