CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration.

abstract：:GNE myopathy is characterized by distal muscle weakness, and caused by recessive mutations in GNE. Its onset is characteristically in young adulthood, although a broad spectrum of onset age is known to exist. A large number of mutations in GNE are pathogenic and this clinical phenotype can be difficult to differentiat...

journal_title：Frontiers in neurology

authors： Soule T,Phan C,White C,Resch L,Lacson A,Martens K,Pfeffer G

更新日期：2018-11-08 00:00:00

abstract：:Poststroke depression (PSD) is the most prevalent psychiatric disorder after stroke, which is independently correlated with negative clinical outcome. The identification of specific biomarkers could help to increase the sensitivity of PSD diagnosis and elucidate its pathophysiological mechanisms. The aim of current st...

journal_title：Frontiers in neurology

authors： Levada OA,Troyan AS

更新日期：2018-07-16 00:00:00

abstract：:Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage inde...

journal_title：Frontiers in neurology

authors： Backner Y,Petrou P,Glick-Shames H,Raz N,Zimmermann H,Jost R,Scheel M,Paul F,Karussis D,Levin N

更新日期：2019-05-03 00:00:00

abstract：:Magnetic resonance elastography (MRE) is a non-invasive imaging technique, using the propagation of mechanical waves as a probe to palpate biological tissues. It consists in three main steps: production of shear waves within the tissue; encoding subsequent tissue displacement in magnetic resonance images; and extracti...

journal_title：Frontiers in neurology

authors： Bigot M,Chauveau F,Beuf O,Lambert SA

更新日期：2018-11-27 00:00:00

abstract：OBJECTIVE:Evaluate medical students' communication and professionalism skills from the perspective of the ambulatory patient and later compare these skills in their first year of residency. METHODS:Students in third year neurology clerkship clinics see patients alone followed by a revisit with an attending neurologist...

journal_title：Frontiers in neurology

authors： Davis LE,King MK,Wayne SJ,Kalishman SG

更新日期：2012-06-20 00:00:00

abstract：:Background: Subthalamic nucleus deep brain stimulation (STN-DBS) has been an established method in improvement of motor disabilities in Parkinson's disease (PD) patients. It has been also claimed to have an impact on balance and gait disorders in PD patients, but the previous results are conflicting. Objective: The ai...

journal_title：Frontiers in neurology

authors： Szlufik S,Kloda M,Friedman A,Potrzebowska I,Gregier K,Mandat T,Przybyszewski A,Dutkiewicz J,Figura M,Habela P,Koziorowski D

更新日期：2018-10-31 00:00:00

abstract：:Purpose: To assess the efficacy and safety of rituximab treatment as second-line immunotherapy in pediatric cases of anti-NMDA receptor (NMDAR) encephalitis. Methods: We retrospectively recruited 8 patients with anti-NMDAR encephalitis who were treated with rituximab as second-line immunotherapy. We evaluated the clin...

journal_title：Frontiers in neurology

authors： Dou X,Li D,Wu Y,Wang Z,Yang L,Ma N,Wang D,Li X

更新日期：2020-12-14 00:00:00

abstract：:Traumatic brain injury (TBI) due to explosive blast exposure is a leading combat casualty. It is also implicated as a key contributor to war related mental health diseases. A clinically important consequence of all types of TBI is a high risk for development of seizures and epilepsy. Seizures have been reported in pat...

journal_title：Frontiers in neurology

authors： Kovacs SK,Leonessa F,Ling GS

更新日期：2014-04-09 00:00:00

abstract：OBJECT:Aneurysmal subarachnoid hemorrhage (aSAH) is a common cause of death or long-term disability. Despite advances in neurocritical care, there is still only a very limited ability to monitor the development of secondary brain injury or to predict neurological outcome after aSAH. Soluble urokinase-type plasminogen a...

journal_title：Frontiers in neurology

authors： Kiiski H,Jalkanen V,Ala-Peijari M,Hämäläinen M,Moilanen E,Peltola J,Tenhunen J

更新日期：2017-04-18 00:00:00

abstract：:Epilepsy is a neurological disorder in which, in many cases, there is poor pharmacological control of seizures. Nevertheless, it may respond beneficially to alternative treatments such as dietary therapy, like the ketogenic diet or caloric restriction. One of the mechanisms of these diets is to produce a hyperpolariza...

journal_title：Frontiers in neurology

authors： Rubio C,Luna R,Rosiles A,Rubio-Osornio M

更新日期：2020-11-05 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is mainly associated with preceding exposure to an infectious agent, although the precise pathogenic mechanisms and causes remain unknown. Increasing evidence indicates an association between trauma-related factors and GBS. Here, we performed a systematic review, summarized the current sc...

journal_title：Frontiers in neurology

authors： Huang C,Zhang Y,Deng S,Ren Y,Lu W

更新日期：2020-11-06 00:00:00

abstract：:Periodontitis is an oral inflammatory disease and may contribute to low-grade systemic inflammation. Based on the contribution of periodontitis to systemic inflammation and the potential role of systemic inflammation in neuroinflammation, many epidemiological studies have investigated a possible association between pe...

journal_title：Frontiers in neurology

authors： Nascimento PC,Castro MML,Magno MB,Almeida APCPSC,Fagundes NCF,Maia LC,Lima RR

更新日期：2019-04-24 00:00:00

abstract：:Shame and embarrassment related to Parkinson's disease (PD) are rarely addressed in clinical practice nor studied in neuroscience research, partly because no specific tool exists to detect them in PD. Objective: To develop a self-applied assessment tool of shame and embarrassment specifically related to PD or its trea...

journal_title：Frontiers in neurology

authors： Fleury V,Catalano Chiuvé S,Forjaz MJ,Di Marco M,Messe M,Debove I,Angulo J,Hariz GM,Burkhard PR,Martinez-Martin P,Rodriguez-Blazquez C,Krack P

更新日期：2020-07-31 00:00:00

abstract：Background and purpose:Stroke has been scarcely studied in Latin America (LA). The Mexican Institute of Neurology Stroke Registry was established in 1990 as a prospective computer-based database to register data obtained from patients admitted with stroke. Using this data, we attempted to define the profile of risk fac...

journal_title：Frontiers in neurology

authors： Arauz A,Marquez-Romero JM,Barboza MA,Serrano F,Artigas C,Murillo-Bonilla LM,Cantú-Brito C,Ruiz-Sandoval JL,Barinagarrementeria F

更新日期：2018-04-04 00:00:00

abstract：:Hashimoto's encephalopathy (HE) is a rare, clinically heterogeneous condition associated with positive thyroid autoantibodies. It is increasingly recognized as an important and treatable cause of autoimmune encephalopathy. Thyroid-associated antibodies such as thyroperoxidase (TPO) antibody, thyroglobulin (TG) antibod...

journal_title：Frontiers in neurology

authors： Li J,Li F

更新日期：2019-05-08 00:00:00

abstract：:Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs that mediate many relevant non-image forming functions of the eye, including the pupillary light reflex, through the projections to the olivary pretectal nucleus. In particular, the post-illumination pupil response (PIPR), as evaluated by ...

journal_title：Frontiers in neurology

authors： La Morgia C,Carelli V,Carbonelli M

更新日期：2018-12-07 00:00:00

abstract：Background/objectives:Although the current evidence is insufficient to recommend a special diet for people with multiple sclerosis (MS), dietary advice for people with MS is prolific online and in the media. This study aimed to describe dietary changes made in the year following a first clinical diagnosis of central ne...

journal_title：Frontiers in neurology

authors： Russell RD,Lucas RM,Brennan V,Sherriff JL,Begley A,Ausimmune Investigator Group.,Black LJ

更新日期：2018-03-20 00:00:00

abstract：:The vestibulo-ocular reflex (VOR) consists of two components, the rotational VOR (rVOR) elicited by semicircular canal signals and the translational VOR (tVOR) elicited by otolith signals. Given the relevant role of the vertical tVOR in human walking, this study aimed at measuring the time delay of eye movements in re...

journal_title：Frontiers in neurology

authors： Kutz DF,Kolb FP,Glasauer S,Straka H

更新日期：2020-05-14 00:00:00

abstract：:Gross motor impairments are common after stroke, but efficient and motivating therapies for these impairments are scarce. We present an innovative musical sonification therapy, especially designed to retrain patients' gross motor functions. Sonification should motivate patients and provide additional sensory input inf...

journal_title：Frontiers in neurology

authors： Scholz DS,Rohde S,Nikmaram N,Brückner HP,Großbach M,Rollnik JD,Altenmüller EO

更新日期：2016-06-30 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the presence of cavitating lacunes on brain imaging may have prognostic implications, the modifiable risk factors underlying these frequently observed lesions are not completely understood. We sought to determine if fasting and post-challenge triglycerides associate with cavitating lacun...

journal_title：Frontiers in neurology

authors： Leonards CO,Wang L,Fiebach JB,Endres M,Ebinger M

更新日期：2013-07-10 00:00:00

abstract：:Background and objective: The trajectories of long-term and domain-specific cognitive alterations over a decade after stroke are largely unknown. This study aims to investigate the dynamic alterations of domain-specific cognitive performance among young stroke survivors over 10 years after their first stroke. Methods:...

journal_title：Frontiers in neurology

authors： Elgh E,Hu X

更新日期：2019-02-12 00:00:00

abstract：:Traumatic brain injury (TBI) can cause seizures and the development of epilepsy. The incidence of seizures varies from 21% in patients with severe brain injuries to 50% in patients with war-related penetrating TBI. In the acute and sub-acute periods following injury, seizures can lead to increased intracranial pressur...

journal_title：Frontiers in neurology

authors： Kirmani BF,Mungall D,Ling G

更新日期：2013-11-01 00:00:00

abstract：:When the diagnosis of myasthenia gravis (MG) has been secured, the aim of management should be prompt symptom control and the induction of remission or minimal manifestations. Symptom control, with acetylcholinesterase inhibitors such as pyridostigmine, is commonly employed. This may be sufficient in mild disease. The...

journal_title：Frontiers in neurology

authors： Farrugia ME,Goodfellow JA

更新日期：2020-07-07 00:00:00

abstract：:Background: Matrix metalloproteinases (MMPs) are pleiotropic enzymes involved in extracellular protein degradation and turnover. MMPs are implicated in the pathogenesis of many neurological diseases, including multiple sclerosis (MS). Objective: To search the level of MMPs in the cerebrospinal fluid (CSF) of MS patien...

journal_title：Frontiers in neurology

authors： Castellazzi M,Ligi D,Contaldi E,Quartana D,Fonderico M,Borgatti L,Bellini T,Trentini A,Granieri E,Fainardi E,Mannello F,Pugliatti M

更新日期：2018-12-18 00:00:00

abstract：:Given the increasing use of regenerative free muscle flaps for various reconstructive procedures and neuroprosthetic applications, there is great interest and value in their enhanced regeneration, revascularization, and reinnervation for improved functional recovery. Here, we implant polyimide-based mircroelectrodes o...

journal_title：Frontiers in neurology

authors： Srinivasan S,Vyas K,McAvoy M,Calvaresi P,Khan OF,Langer R,Anderson DG,Herr H

更新日期：2019-03-22 00:00:00

abstract：:The electrophysiological EEG features such as high frequency oscillations, spikes and functional connectivity are often used for delineation of epileptogenic tissue and study of the normal function of the brain. The epileptogenic activity is also known to be suppressed by cognitive processing. However, differences bet...

journal_title：Frontiers in neurology

authors： Cimbalnik J,Pail M,Klimes P,Travnicek V,Roman R,Vajcner A,Brazdil M

更新日期：2020-10-27 00:00:00

abstract：:In task-specific focal hand dystonia (tspFHD), the temporal dynamics of cortical activity in the motor system and how these processes are related to impairments in sensory and motor function are poorly understood. Here, we use time-frequency reconstructions of magnetoencephalographic (MEG) data to elaborate the tempor...

journal_title：Frontiers in neurology

authors： Hinkley LB,Dolberg R,Honma S,Findlay A,Byl NN,Nagarajan SS

更新日期：2012-11-28 00:00:00

abstract：:Objective: The aims of this study were to compare the characteristics of three motor subtype classifications in patients with de novo Parkinson's disease (PD) and to find the most suitable motor subtype classification for identifying non-motor symptoms (NMSs). Methods: According to previous studies, a total of 256 pat...

journal_title：Frontiers in neurology

authors： Ren J,Hua P,Li Y,Pan C,Yan L,Yu C,Zhang L,Xu P,Zhang M,Liu W

更新日期：2020-12-23 00:00:00

abstract：INTRODUCTION:Limited evidence exists on effective interventions to improve knowledge of preventive medications in patients with chronic diseases, such as stroke. We investigated the effectiveness of a nurse-led intervention, where a component was to improve knowledge of prevention medications, in patients with stroke o...

journal_title：Frontiers in neurology

authors： Olaiya MT,Cadilhac DA,Kim J,Ung D,Nelson MR,Srikanth VK,Bladin CF,Gerraty RP,Fitzgerald SM,Phan TG,Frayne J,Thrift AG

更新日期：2016-11-18 00:00:00

abstract：:Traumatic brain injury (TBI) is understood as an interplay between the initial injury, subsequent secondary injuries, and a complex host response all of which are highly heterogeneous. An understanding of the underlying biology suggests a number of windows where mechanistically inspired interventions could be targeted...

journal_title：Frontiers in neurology

authors： Ercole A,Magnoni S,Vegliante G,Pastorelli R,Surmacki J,Bohndiek SE,Zanier ER

更新日期：2017-08-30 00:00:00