Abstract：
BACKGROUND:We present a closed-loop system able to control the frequency of slow oscillations (SO) spontaneously generated by the cortical network in vitro. The frequency of SO can be controlled by direct current (DC) electric fields within a certain range. Here we set out to design a system that would be able to autonomously bring the emergent oscillatory activity to a target frequency determined by the experimenter. METHODS:The cortical activity was recorded through an electrode and was analyzed online. Once a target frequency was set, the frequency of the slow oscillation was steered through the injection of DC of variable intensity that generated electric fields of proportional amplitudes in the brain slice. To achieve such closed-loop control, we designed a custom programmable stimulator ensuring low noise and accurate tuning over low current levels. For data recording and analysis, we relied on commercial acquisition and software tools. RESULTS:The result is a flexible and reliable system that ensures control over SO frequency in vitro. The system guarantees artifact removal, minimal gaps in data acquisition and robustness in spite of slice heterogeneity. CONCLUSIONS:Our tool opens new possibilities for the investigation of dynamics of cortical slow oscillations-an activity pattern that is associated with cognitive processes such as memory consolidation, and that is altered in several neurological conditions-and also for potential applications of this technology.
journal_name
J Neuroeng Rehabiljournal_title
Journal of neuroengineering and rehabilitationauthors
D'Andola M,Giulioni M,Dante V,Del Giudice P,Sanchez-Vives MVdoi
10.1186/s12984-018-0470-zsubject
Has Abstractpub_date
2019-01-09 00:00:00pages
7issue
1issn
1743-0003pii
10.1186/s12984-018-0470-zjournal_volume
16pub_type
杂志文章abstract：BACKGROUND:Functional electrical stimulation (FES) has been used to improve function in individuals with hemiparesis following stroke. An ideal functional electrical stimulation (FES) system needs an accurate mathematical model capable of designing subject and task-specific stimulation patterns. Such a model was previo...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-5-7
更新日期：2008-02-27 00:00:00
abstract：:Even though feedback is considered to play an important role in learning how to operate a brain-computer interface (BCI), to date no significant influence of feedback design on BCI-performance has been reported in literature. In this work, we adapt a standard motor-imagery BCI-paradigm to study how BCI-performance is ...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-7-34
更新日期：2010-07-27 00:00:00
abstract：BACKGROUND:Quantitative evaluation of position control ability in stroke patients is needed. Here we report a demonstration of position control ability assessment and test-retest reliability during squat-stand activity on a new system in hemiparetic patients and controls. METHODS:Sixty-two healthy adults and thirty-fo...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-10-37
更新日期：2013-04-15 00:00:00
abstract：BACKGROUND:There is a paucity of information regarding visuospatial (VS) and visuomotor (VM) task performance in patients with chronic right fronto-parietal lobe stroke, as the majority of knowledge to date in this realm has been gleaned from acute stroke patients. The goal of this paper is to determine how VS and VM p...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-10-20
更新日期：2013-02-13 00:00:00
abstract：:Unfortunately, the original version of this article [1] contained an error. Equation 6 was included incorrectly: in the original equation variable slinks3 was missing.The correct Equation 6 can be found below: ...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 已发布勘误
doi：10.1186/s12984-015-0106-5
更新日期：2015-12-04 00:00:00
abstract：BACKGROUND:People with severe disabilities, e.g., due to neurodegenerative disease, depend on technology that allows for accurate wheelchair control. For those who cannot operate a wheelchair with a joystick, brain-computer interfaces (BCI) may offer a valuable option. Technology depending on visual or auditory input m...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-11-7
更新日期：2014-01-16 00:00:00
abstract：BACKGROUND:Intention tremor and dysmetria are leading causes of upper extremity disability in Multiple Sclerosis (MS). The development of effective therapies to reduce tremor and dysmetria is hampered by insufficient understanding of how the distributed, multi-focal lesions associated with MS impact sensorimotor contro...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-11-170
更新日期：2014-12-19 00:00:00
abstract：BACKGROUND:Advances such as targeted muscle reinnervation and pattern recognition control may provide improved control of upper limb myoelectric prostheses, but evaluating user function remains challenging. Virtual environments are cost-effective and immersive tools that are increasingly used to provide practice and ev...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 临床试验,杂志文章
doi：10.1186/s12984-018-0402-y
更新日期：2018-09-05 00:00:00
abstract：:Physical interactions between patients and therapists during rehabilitation have served as motivation for the design of rehabilitation robots, yet we lack a fundamental understanding of the principles governing such human-human interactions (HHI). Here we review the literature and pose important open questions regardi...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章,评审
doi：10.1186/1743-0003-11-142
更新日期：2014-10-06 00:00:00
abstract：:The general objective of the "Rehabilitation Medicine Summit: Building Research Capacity" was to advance and promote research in medical rehabilitation by making recommendations to expand research capacity. The five elements of research capacity that guided the discussions were: 1) researchers; 2) research culture, en...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-3-1
更新日期：2006-01-03 00:00:00
abstract：BACKGROUND:Previous reports of the mechanics and energetics of post-stroke hemiparetic walking have either not combined estimates of mechanical and metabolic energy or computed external mechanical work based on the limited combined limbs method. Here we present a comparison of the mechanics and energetics of hemipareti...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/s12984-015-0012-x
更新日期：2015-02-27 00:00:00
abstract：BACKGROUND:Although several studies have investigated the outcomes after distal hamstring lengthening (DHL), no study has undertaken an approach that included all or most of the important factors that could influence the results. This study was performed to evaluate the outcomes after DHL and analyze the factors that i...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/s12984-017-0296-0
更新日期：2017-08-14 00:00:00
abstract：:The original use of biofeedback to train single muscle activity in static positions or movement unrelated to function did not correlate well to motor function improvements in patients with central nervous system injuries. The concept of task-oriented repetitive training suggests that biofeedback therapy should be deli...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-3-11
更新日期：2006-06-21 00:00:00
abstract：BACKGROUND:Cerebellar symptoms are extremely disabling and are common in Multiple Sclerosis (MS) subjects. In this feasibility study, we developed and tested a robot therapy protocol, aimed at the rehabilitation of incoordination in MS subjects. METHODS:Eight subjects with clinically defined MS performed planar reachi...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章,随机对照试验
doi：10.1186/1743-0003-7-37
更新日期：2010-07-29 00:00:00
abstract：BACKGROUND:The importance to restore the hand function following an injury/disease of the nervous system led to the development of novel rehabilitation interventions. Surface electromyography can be used to create a user-driven control of a rehabilitation robot, in which the subject needs to engage actively, by using s...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/s12984-016-0172-3
更新日期：2016-08-04 00:00:00
abstract：:Peripheral nerves possess the capacity of self-regeneration after traumatic injury but the extent of regeneration is often poor and may benefit from exogenous factors that enhance growth. The use of cellular systems is a rational approach for delivering neurotrophic factors at the nerve lesion site, and in the present...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-7-7
更新日期：2010-02-11 00:00:00
abstract：BACKGROUND:Add-on robot-mediated therapy has proven to be more effective than conventional therapy alone in post-stroke gait rehabilitation. Such robot-mediated interventions routinely use also visual biofeedback tools. A better understanding of biofeedback content effects when used for robotic locomotor training may i...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12984-019-0558-0
更新日期：2019-07-23 00:00:00
abstract：BACKGROUND:Gait disorders of Parkinson's disease (PD) are characterized by the breakdown of the temporal organization of stride duration variability that was tightly associated to dynamic instability in PD. Activating the upper body during walking, Nordic Walking (NW) may be used as an external cueing to improve spatio...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12984-017-0226-1
更新日期：2017-02-21 00:00:00
abstract：BACKGROUND:Forearm surface electromyography (EMG) has been in use since the Sixties to feed-forward control active hand prostheses in a more and more refined way. Recent research shows that it can be used to control even a dexterous polyarticulate hand prosthesis such as Touch Bionics's i-LIMB, as well as a multifinger...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-6-41
更新日期：2009-11-17 00:00:00
abstract：BACKGROUND:Current guidelines for rehabilitation of arm and hand function after stroke recommend that motor training focus on realistic tasks that require reaching and manipulation and engage the patient intensively, actively, and adaptively. Here, we investigated the feasibility of a novel robotic task-practice system...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1186/1743-0003-8-42
更新日期：2011-08-03 00:00:00
abstract：BACKGROUND:To go from one place to another, we routinely generate internal representations of surrounding spaces, which can include egocentric (body-centred) and allocentric (world-centred) coordinates, combined into route and survey representations.Recent studies have shown how both egocentric and allocentric represen...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-8-6
更新日期：2011-01-31 00:00:00
abstract：BACKGROUND:Brain activation differs according to lesion location in functional magnetic resonance imaging (fMRI) studies, but lesion location-dependent electroencephalographic (EEG) alterations are unclear. Because of the increasing use of EEG-based brain-computer-interface rehabilitation, we examined lesion location-d...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/s12984-016-0120-2
更新日期：2016-03-02 00:00:00
abstract：BACKGROUND:Assessing arm and hand sensorimotor impairments that are functionally relevant is essential to optimize the impact of neurorehabilitation interventions. Technology-aided assessments should provide a sensitive and objective characterization of upper limb impairments, but often provide arm weight support and n...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/s12984-020-00748-5
更新日期：2020-09-25 00:00:00
abstract：BACKGROUND:Motivation is an important factor in rehabilitation and frequently used as a determinant of rehabilitation outcome. Several factors can influence patient motivation and so improve exercise adherence. This paper presents the design of two robot devices for use in the rehabilitation of upper limb movements, th...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 临床试验,杂志文章
doi：10.1186/1743-0003-4-3
更新日期：2007-02-19 00:00:00
abstract：BACKGROUND:A common goal of persons post-stroke is to regain community ambulation. The plantar flexor muscles play an important role in propulsion generation and swing initiation as previous musculoskeletal simulations have shown. The purpose of this study was to demonstrate that simulation results quantifying changes ...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-10-12
更新日期：2013-01-31 00:00:00
abstract：BACKGROUND:Computer-based cognitive stimulation applications can help the elderly maintain and improve their cognitive skills. In this research paper, our objectives are to verify the usability of PESCO (an open-software application for cognitive evaluation and stimulation) and to determine the concurrent validity of c...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 临床试验,杂志文章
doi：10.1186/1743-0003-11-88
更新日期：2014-05-15 00:00:00
abstract：BACKGROUND:Detecting differences in upper limb use in children with unilateral cerebral palsy (UCP) is challenging and highly dependent on examiner experience. The recent introduction of technologies in the clinical environment, and in particular the use of wearable sensors, can provide quantitative measurement to over...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/s12984-019-0499-7
更新日期：2019-02-22 00:00:00
abstract：BACKGROUND:In clinical gait assessment, the correct interpretation of gait kinematics and kinetics has a decisive impact on the success of the therapeutic programme. Due to the vast amount of information from which primary anomalies should be identified and separated from secondary compensatory changes, as well as the ...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-9-60
更新日期：2012-08-25 00:00:00
abstract：BACKGROUND:Hand synergies have been extensively studied over the last few decades. Objectives of such research are numerous. In neuroscience, the aim is to improve the understanding of motor control and its ability to reduce the control dimensionality. In applied research fields like robotics the aim is to build biomim...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/1743-0003-11-113
更新日期：2014-07-30 00:00:00
abstract：BACKGROUND:The RAPPER II study investigates the feasibility, safety and acceptability of using the REX self-stabilising robotic exoskeleton in people with spinal cord injury (SCI) who are obligatory wheelchair users. Feasibility is assessed by the completion of transfer into the REX device, competency in achieving auto...
journal_title：Journal of neuroengineering and rehabilitation
pub_type： 杂志文章
doi：10.1186/s12984-017-0274-6
更新日期：2017-06-19 00:00:00
