The Impact of Hypomania on Aerobic Capacity and Cardiopulmonary Functioning-A Case Report.

Abstract:

:Background: Hypomanic episodes are characterized by increased goal-directed behavior and psychomotor agitation. While the affective, cognitive, and behavioral manifestations of such episodes are well-documented, their physiological influence on aerobic capacity and cardiopulmonary functioning are unknown. Methods: We describe a case report of an individual with schizophrenia who experienced a hypomanic episode while serving as a control participant (wait list) in a single-blind, randomized clinical trial examining the impact of aerobic exercise (AE) on neurocognition in people schizophrenia. As part of the trial, participants completed two scheduled clinical assessments and cardiopulmonary exercise tests (VO2max) at baseline and 12 weeks later at end of study. All participants received standard psychiatric care during the trial. Following a baseline assessment in which he displayed no evidence of mood lability, the subject returned on Week-12 for his scheduled follow-up assessment displaying symptoms of hypomania. He was able to complete the follow-up assessment, as well as third assessment 2 weeks later (Week-14) when his hypomanic symptoms ebbed. Results: While not engaging in AE, the subject's aerobic capacity, as indexed by VO2max, increased by 33% from baseline to Week-12. In comparison, participants engaged in the aerobic exercise training increased their aerobic capacity on average by 18%. In contrast, participants in the control group displayed a small decline (-0.5%) in their VO2max scores. Moreover, the subject's aerobic capacity increased even further by Week-14 (49% increase from baseline), despite the ebbing of his hypomania symptoms at that time. These changes were accompanied by increases in markers of aerobic fitness including peak heart rate, respiratory exchange rate, peak minute ventilation, watts, and peak systolic blood pressure. Resting systolic and diastolic blood pressure, and peak diastolic blood pressure remained unchanged. Conclusions: Our findings suggest that hypomania produce substantial increase in aerobic capacity and that such elevations may remain sustained following the ebbing of hypomanic symptoms. Such elevations may be attributed to increased mobility and goal-directed behavior associated with hypomania, as individuals in hypomanic states may ambulate more frequently, for longer duration, and/or at higher intensity. Our results provide a first and unique view into the impact of hypomania on aerobic capacity and cardiopulmonary functioning.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Shoval A,Armstrong HF,Vakhrusheva J,Ballon JS,Bartels MN,Kimhy D

doi

10.3389/fpsyt.2018.00729

subject

Has Abstract

pub_date

2018-12-21 00:00:00

pages

729

issn

1664-0640

journal_volume

9

pub_type

  • Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome.

    abstract::Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.543049

    authors: Lou YT,Li XL,Wang Y,Ji GJ,Zang YF,Wang J,Feng JH

    更新日期:2020-12-17 00:00:00

  • Neurophysiologic Characterization of Resting State Connectivity Abnormalities in Schizophrenia Patients.

    abstract::Background: Patients with schizophrenia show abnormal spontaneous oscillatory activity in scalp-level electroencephalographic (EEG) responses across multiple frequency bands. While oscillations play an essential role in the transmission of information across neural networks, few studies have assessed the frequency-spe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.608154

    authors: Koshiyama D,Miyakoshi M,Tanaka-Koshiyama K,Joshi YB,Molina JL,Sprock J,Braff DL,Light GA

    更新日期:2020-11-27 00:00:00

  • Pupillometric assessment of sleepiness in narcolepsy.

    abstract:PURPOSE:Excessive daytime sleepiness is highly prevalent in the general population, is the hallmark of narcolepsy, and is linked to significant morbidity. Clinical assessment of sleepiness remains challenging and the common objective multiple sleep latency test (MSLT) and subjective Epworth sleepiness scale (ESS) metho...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2011.00035

    authors: Prasad B,Choi YK,Weaver TE,Carley DW

    更新日期:2011-06-07 00:00:00

  • Development of the WHO Caregiver Skills Training Program for Developmental Disorders or Delays.

    abstract::Globally, 52.9 million children under the age of 5 experience a developmental disability, such as sensory impairment, intellectual disability, and autism spectrum disorders. Of these 95% live in low-and-middle-income countries. Most of these children lack access to care. In light of the growing evidence that caregiver...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00769

    authors: Salomone E,Pacione L,Shire S,Brown FL,Reichow B,Servili C

    更新日期:2019-11-11 00:00:00

  • A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.

    abstract::Objective: Selective serotonin reuptake inhibitors like sertraline have been shown in observational studies and anecdotal reports to improve language development in young children with fragile X syndrome (FXS). A previous controlled trial of sertraline in young children with FXS found significant improvement in expres...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00810

    authors: Potter LA,Scholze DA,Biag HMB,Schneider A,Chen Y,Nguyen DV,Rajaratnam A,Rivera SM,Dwyer PS,Tassone F,Al Olaby RR,Choudhary NS,Salcedo-Arellano MJ,Hagerman RJ

    更新日期:2019-11-06 00:00:00

  • An Intervention to Increase Situational Awareness and the Culture of Mutual Care (Foco) and Its Effects During COVID-19 Pandemic: A Randomized Controlled Trial and Qualitative Analysis.

    abstract::Situational awareness is especially important to decision-making in health care. Comprehending the situation is crucial for anticipating any change in the environment and delivering optimal care. The objective of this study was to evaluate the effects of a training to increase situational awareness and mutual care des...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.570786

    authors: Kozasa EH,Lacerda SS,Polissici MA,Coelho RDS,Farias GDS,Chaves P,Leão ER

    更新日期:2020-11-26 00:00:00

  • Adenosine-to-Inosine RNA Editing Within Corticolimbic Brain Regions Is Regulated in Response to Chronic Social Defeat Stress in Mice.

    abstract::Adenosine-to-inosine (A-to-I) RNA editing is a co-/posttranscriptional modification of double-stranded RNA, catalyzed by the adenosine deaminase acting on RNA (ADAR) family of enzymes, which results in recognition of inosine as guanosine by translational and splicing machinery causing potential recoding events in amin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00277

    authors: Dick ALW,Khermesh K,Paul E,Stamp F,Levanon EY,Chen A

    更新日期:2019-04-26 00:00:00

  • Consumer Perspectives of Safewards Impact in Acute Inpatient Mental Health Wards in Victoria, Australia.

    abstract::Background: Inpatient mental health wards are reported by many consumers to be custodial, unsafe, and lacking in therapeutic relationships. These consumer experiences are concerning, given international policy directives requiring recovery-oriented practice. Safewards is both a model and a suite of interventions desig...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00461

    authors: Fletcher J,Buchanan-Hagen S,Brophy L,Kinner SA,Hamilton B

    更新日期:2019-07-09 00:00:00

  • Patterns in Psychiatrists' Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire Survey.

    abstract:Background:Accumulating evidence has shown that valproate has the greatest teratogenic potential for increasing the risk of major congenital malformations, such as neural tube defects, cleft palate, and neurodevelopmental disability. Although valproate is a pharmacological option for acute mania and is used as a stabil...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00250

    authors: Tachibana M,Hashimoto T,Tanaka M,Watanabe H,Sato Y,Takeuchi T,Terao T,Kimura S,Koyama A,Ebisawa S,Shizu Y,Nagase T,Hirakawa J,Hatta K,Nakazato M,Iyo M

    更新日期:2020-04-15 00:00:00

  • Increased Nucleus Accumbens Connectivity in Resting-State Patients With Drug-Naive, First-Episode Somatization Disorder.

    abstract::The nucleus accumbens (NAc) plays an important role in the reward circuit, and abnormal regional activities of the reward circuit have been reported in various psychiatric disorders including somatization disorder (SD). However, few researches are designed to analyze the NAc connectivity in SD. This study was designed...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00585

    authors: Ou Y,Su Q,Liu F,Ding Y,Chen J,Zhang Z,Zhao J,Guo W

    更新日期:2019-08-16 00:00:00

  • Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors.

    abstract::Cocaine addiction is a widespread psychiatric condition still waiting for approved efficacious medications. Previous studies suggested that simultaneous activation of nociceptin opioid (NOP) and mu opioid (MOP) receptors could be a successful strategy to treat cocaine addiction, but the paucity of molecules co-activat...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00234

    authors: Shen Q,Deng Y,Ciccocioppo R,Cannella N

    更新日期:2017-11-13 00:00:00

  • Use of Technology to Promote Child Behavioral Health in the Context of Pediatric Care: A Scoping Review and Applications to Low- and Middle-Income Countries.

    abstract::Background: The burden of mental, neurological, and substance (MNS) disorders is greater in low- and middle-income countries (LMICs). The rapid growth of digital health (i.e., eHealth) approaches offer new solutions for transforming pediatric mental health services and have the potential to address multiple resource a...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2019.00806

    authors: Huang KY,Lee D,Nakigudde J,Cheng S,Gouley KK,Mann D,Schoenthaler A,Chokshi S,Kisakye EN,Tusiime C,Mendelsohn A

    更新日期:2019-11-13 00:00:00

  • Ranking the Harm of Psychoactive Drugs Including Prescription Analgesics to Users and Others-A Perspective of German Addiction Medicine Experts.

    abstract::Background: Over the past 15 years, comparative assessments of psychoactive substance harms to both users and others have been compiled by addiction experts. None of these rankings however have included synthetic cannabinoids or non-opioid prescription analgesics (NOAs, e.g., gabapentinoids) despite evidence of increa...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.592199

    authors: Bonnet U,Specka M,Soyka M,Alberti T,Bender S,Grigoleit T,Hermle L,Hilger J,Hillemacher T,Kuhlmann T,Kuhn J,Luckhaus C,Lüdecke C,Reimer J,Schneider U,Schroeder W,Stuppe M,Wiesbeck GA,Wodarz N,McAnally H,Scherbaum N

    更新日期:2020-10-26 00:00:00

  • Functional Connectivity of Cognitive Brain Networks in Schizophrenia during a Working Memory Task.

    abstract::Task-based connectivity studies facilitate the understanding of how the brain functions during cognition, which is commonly impaired in schizophrenia (SZ). Our aim was to investigate functional connectivity during a working memory task in SZ. We hypothesized that the task-negative (default mode) network and the cognit...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00294

    authors: Godwin D,Ji A,Kandala S,Mamah D

    更新日期:2017-12-22 00:00:00

  • Measuring Psychological Change and Predicting Recidivism Following the Swedish One-to-One Program.

    abstract::The One-to-One program aims to reduce criminal recidivism among prisoners shortly awaiting release, and among probationers. Of 1,484 program participants in Sweden, 776 contained adequate data for analysis. Pre- and post-program scores were available for the Alternative Thinking Test, Levenson's Locus of Control Scale...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00811

    authors: Berman AH,Gajecki M,Morien P,Priestley P

    更新日期:2019-11-29 00:00:00

  • A Closer Look at the Effects of Repeated Cocaine Exposure on Adaptive Decision-Making under Conditions That Promote Goal-Directed Control.

    abstract::It has been proposed that compulsive drug seeking reflects an underlying dysregulation in adaptive behavior that favors habitual (automatic and inflexible) over goal-directed (deliberative and highly flexible) action selection. Rodent studies have established that repeated exposure to cocaine or amphetamine facilitate...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2016.00044

    authors: Halbout B,Liu AT,Ostlund SB

    更新日期:2016-03-21 00:00:00

  • Functional Correlates of Resting-State Connectivity in the Default Mode Network of Heroin Users on Methadone Treatment and Medication-Free Therapeutic Community Program.

    abstract::The treatment of heroin addiction is a complex process involving changes in addictive behavior and brain functioning. The goal of this study was to explore the brain default mode network (DMN) functional connectivity using resting-state functional magnetic resonance imaging (rs-fMRI) and decision-making performance ba...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00381

    authors: Kuo LW,Lin PS,Lin SY,Liu MF,Jan H,Lee HC,Wang SC

    更新日期:2019-06-06 00:00:00

  • The Gut Microbiome in Anorexia Nervosa: Friend or Foe?

    abstract::The human gut microbiome is emerging as a key modulator of homeostasis, with far-reaching implications for various multifactorial diseases, including anorexia nervosa (AN). Despite significant morbidity and mortality, the underlying mechanisms of this eating disorder are poorly understood, but the classical view defin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2020.611677

    authors: Ghenciulescu A,Park RJ,Burnet PWJ

    更新日期:2021-01-12 00:00:00

  • Parental Recognition of Bullying and Associated Factors Among Children After the Fukushima Nuclear Disaster: A 3-Year Follow-Up Study From the Fukushima Health Management Survey.

    abstract::This study examined parental recognition of bullying victimization and associated factors among evacuated children after the 2011 Fukushima Daiichi Nuclear Power Plant accident, using a 3-year follow-up data (wave 1: January 2012; wave 2: January 2013; wave 3: February 2014). The sample included the caregivers of 2,61...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00283

    authors: Oe M,Maeda M,Ohira T,Itagaki S,Harigane M,Suzuki Y,Yabe H,Yasumura S,Kamiya K,Ohto H

    更新日期:2019-05-03 00:00:00

  • Using structural neuroimaging to make quantitative predictions of symptom progression in individuals at ultra-high risk for psychosis.

    abstract::Neuroimaging holds the promise that it may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups, which do not permit accurate inferences at the level of the individual. We examined the potent...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00187

    authors: Tognin S,Pettersson-Yeo W,Valli I,Hutton C,Woolley J,Allen P,McGuire P,Mechelli A

    更新日期:2014-01-29 00:00:00

  • Increasing Risks of Suicide Attempt and Suicidal Drug Overdose After Head Trauma in Patients With Sleep-Disordered Breathing: A Population-Based Study.

    abstract::Objective: To determine the risks of suicide attempt (SA) and suicidal drug overdose (SDO) after head trauma in patients with sleep-disordered breathing (SDB) by using the National Health Insurance Research Database of Taiwan. Methods: We analyzed the data of patients aged ≥20 years who were diagnosed with SDB between...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.533784

    authors: Harnod D,Lin CL,Harnod T,Kao CH

    更新日期:2020-12-09 00:00:00

  • Exploratory Analysis of Behavioral Impulsivity, Pro-inflammatory Cytokines, and Resting-State Frontal EEG Activity Associated With Non-suicidal Self-Injury in Patients With Mood Disorder.

    abstract::Introduction: Non-suicidal self-injury (NSSI) is a rapidly increasing mental health problem that requires more clinical attention. In this study, we aimed to explore the biobehavioral markers of NSSI in participants with mood disorders. Methods: A total of 45 participants with mood disorders (bipolar I, II, and major ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00124

    authors: Kim JS,Kang ES,Bahk YC,Jang S,Hong KS,Baek JH

    更新日期:2020-02-26 00:00:00

  • Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Stressed Withdrawn Mice.

    abstract::This study compares the impact of repeated injections of baclofen (an agonist of GABAB receptors) or diazepam (a benzodiazepine having an agonist action on GABAA receptors) given during the alcohol-withdrawal period on the stress-induced restoration of alcohol-seeking behavior and hypothalamic-pituitary-adrenal (HPA) ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00238

    authors: Rabat Y,Henkous N,Corio M,Nogues X,Beracochea D

    更新日期:2019-04-16 00:00:00

  • Mirror neurons, birdsong, and human language: a hypothesis.

    abstract::THE MIRROR SYSTEM HYPOTHESIS AND INVESTIGATIONS OF BIRDSONG ARE REVIEWED IN RELATION TO THE SIGNIFICANCE FOR THE DEVELOPMENT OF HUMAN SYMBOLIC AND LANGUAGE CAPACITY, IN TERMS OF THREE FUNDAMENTAL FORMS OF COGNITIVE REFERENCE: iconic, indexical, and symbolic. Mirror systems are initially iconic but can progress to inde...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2011.00078

    authors: Levy F

    更新日期:2012-01-11 00:00:00

  • Prognostic Utility of Multivariate Morphometry in Schizophrenia.

    abstract::Background: Voxel-based morphometry studies have repeatedly highlighted the presence of distributed gray matter changes in schizophrenia, but to date, it is not clear if clinically useful prognostic information can be gleaned from structural imaging. The suspected association between gray matter volume (GMV) and durat...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00245

    authors: Li M,Li X,Das TK,Deng W,Li Y,Zhao L,Ma X,Wang Y,Yu H,Meng Y,Wang Q,Palaniyappan L,Li T

    更新日期:2019-04-15 00:00:00

  • Attitude Toward Seeking Professional Psychological Help Among Community-Dwelling Population in China.

    abstract:Objective:To explore the attitudes and factors in seeking professional psychological help among a Chinese community-dwelling population in order to promote positive help-seeking behaviors and better utilization of mental health services. Methods:Using system and simple random sampling with Kish selection table methods...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00417

    authors: Chen P,Liu XJ,Wang XQ,Yang BX,Ruan J,Liu Z

    更新日期:2020-05-14 00:00:00

  • Vocational Profile and Correlates of Employment in People With Schizophrenia: The Role of Avolition.

    abstract:Objective:Employment was associated with recovery in individuals with schizophrenia. Our study aimed to delineate the vocational profile and investigate factors associated with likelihood of employment in individuals with schizophrenia. Materials and Methods:276 community dwelling outpatients with schizophrenia were r...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00856

    authors: Ang MS,Rekhi G,Lee J

    更新日期:2020-08-27 00:00:00

  • An Actigraphy-Based Validation Study of the Sleep Disorder Inventory in the Nursing Home.

    abstract::Background: Disrupted sleep is common among nursing home patients with dementia and is associated with increased agitation, depression, and cognitive impairment. Detecting and treating sleep problems in this population are therefore of great importance, albeit challenging. Systematic observation and objective recordin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00173

    authors: Hjetland GJ,Nordhus IH,Pallesen S,Cummings J,Tractenberg RE,Thun E,Kolberg E,Flo E

    更新日期:2020-03-13 00:00:00

  • Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder.

    abstract::Abnormal functional connectivity (FC) within discrete brain networks is involved in the pathophysiology of obsessive-compulsive disorder (OCD) with inconsistent results. In the present study, we investigated the FC patterns of 40 drug-naive patients with OCD and 38 healthy controls (HCs) through an unbiased voxel-wise...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00098

    authors: Cui G,Ou Y,Chen Y,Lv D,Jia C,Zhong Z,Yang R,Wang Y,Meng X,Cui H,Li C,Sun Z,Wang X,Guo W,Li P

    更新日期:2020-03-03 00:00:00

  • The Effect of Insomnia on Cortical Excitability in Patients With Generalized Anxiety Disorder.

    abstract::The high rate of comorbidity between insomnia and anxiety disorders have been confirmed by previous studies. However, the underlying neurobiological correlates of the relationship between insomnia and anxiety disorders are largely unknown. The aim of the present study was to investigate the effect of insomnia on corti...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00755

    authors: Huang Z,Zhan S,Chen C,Li N,Ding Y,Hou Y,Wang L,Wang Y

    更新日期:2019-01-10 00:00:00