Gamma/Delta T Cells and Their Role in Protection Against Malaria.

abstract：:Myeloid-derived suppressor cells (MDSC) play a crucial role in regulating the intestinal immune response during colitis. We previously revealed an essential role of MDSC in promoting TH17 cell polarization, which was found to be arginase-1 (Arg-1)-dependent; however, the underlying mechanism remains obscure. Here we r...

journal_title：Frontiers in immunology

authors： Ma Z,Zhen Y,Hu C,Yi H

更新日期：2020-04-22 00:00:00

abstract：:Monoclonal antibodies against the cell surface antigen CD38, e.g., isatuximab, daratumumab, or Mor202, have entered the therapeutic armamentarium in multiple myeloma due to single agent overall response rates of 29 vs. 36 vs. 31%, effectivity in combination regimen, e.g., with lenalidomide or bortezomib plus dexametha...

journal_title：Frontiers in immunology

authors： Seckinger A,Hillengass J,Emde M,Beck S,Kimmich C,Dittrich T,Hundemer M,Jauch A,Hegenbart U,Raab MS,Ho AD,Schönland S,Hose D

更新日期：2018-07-20 00:00:00

abstract：:A recent pandemic caused by a single-stranded RNA virus, COVID-19, initially discovered in China, is now spreading globally. This poses a serious threat that needs to be addressed immediately. Genome analysis of SARS-CoV-2 has revealed its close relation to SARS-coronavirus along with few changes in its spike protein....

journal_title：Frontiers in immunology

authors： Naz A,Shahid F,Butt TT,Awan FM,Ali A,Malik A

更新日期：2020-07-10 00:00:00

abstract：:Infections with respiratory syncytial virus (RSV) occurs repeatedly throughout life because sustained, protective memory responses fail to develop. Why this occurs is not known. During RSV infection the recognition of the virus via the cytosolic RIG-I like receptors and signaling via the adaptor protein MAVS is crucia...

journal_title：Frontiers in immunology

authors： Paulsen M,Varese A,Pinpathomrat N,Kirsebom FCM,Paulsen M,Johansson C

更新日期：2020-10-06 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disease worldwide, both in adults and children. It is characterized by an aberrant lipid storage in hepatocytes, named hepatic steatosis. Simple steatosis remains a benign process in most affected patients, while some of them develop superimp...

journal_title：Frontiers in immunology

authors： Meli R,Mattace Raso G,Calignano A

更新日期：2014-04-23 00:00:00

abstract：:Visceral leishmaniasis (VL)-related mortality and morbidity imposes a great deal of health concern across the globe. The existing anti-leishmanial drug regimen generally fails to eliminate newly emerging resistant isolates of this dreadful parasite. In such circumstances, the development of a prophylactic strategy to ...

journal_title：Frontiers in immunology

authors： Jamal F,Singh MK,Hansa J,Pushpanjali,Ahmad G,Dikhit MR,Umar MS,Bimal S,Das P,Mujeeb AA,Singh SK,Zubair S,Owais M

更新日期：2020-06-02 00:00:00

abstract：:Neuroblastoma (NB) is the most common extracranial solid tumor in children and, in the high-risk group, has a 5-year mortality rate of ~50%. The high mortality rate and significant treatment-related morbidities associated with current standard of care therapies belie the critical need for more tolerable and effective ...

journal_title：Frontiers in immunology

authors： McNerney KO,Karageorgos SA,Hogarty MD,Bassiri H

更新日期：2020-05-08 00:00:00

abstract：:A novel coronavirus, which has been designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first detected in December 2019 in Wuhan China and causes the highly infectious disease referred to as COVID-19. COVID-19 has now spread worldwide to become a global pandemic affecting over 24 million pe...

journal_title：Frontiers in immunology

authors： Sharma O,Sultan AA,Ding H,Triggle CR

更新日期：2020-10-14 00:00:00

abstract：:Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and ...

journal_title：Frontiers in immunology

authors： Oliveira-Nascimento L,Massari P,Wetzler LM

更新日期：2012-04-18 00:00:00

abstract：:Gestational age-dependent immune intolerance at the maternal-fetal interface might be a contributing factor to placental pathology and adverse pregnancy outcomes. Although the intrauterine setting is highly choreographed and considered to be a protective environment for the fetus, unscheduled inflammation might overwh...

journal_title：Frontiers in immunology

authors： Kamity R,Sharma S,Hanna N

更新日期：2019-04-05 00:00:00

abstract：:Recent clinical observations indicate that bacterial vaccines induce cross-protection against infections produced by different microorganisms. MV130, a polyvalent bacterial sublingual preparation designed to prevent recurrent respiratory infectious diseases, reduces the infection rate in patients with recurrent respir...

journal_title：Frontiers in immunology

authors： Vázquez A,Fernández-Sevilla LM,Jiménez E,Pérez-Cabrera D,Yañez R,Subiza JL,Varas A,Valencia J,Vicente A

更新日期：2020-11-19 00:00:00

abstract：:Antibodies have proven their high value in antitumor therapy over the last two decades. They are currently being used as the first-choice to treat some of the most frequent metastatic cancers, like HER2+ breast cancers or colorectal cancers, currently treated with trastuzumab (Herceptin) and bevacizumab (Avastin), res...

journal_title：Frontiers in immunology

authors： Corraliza-Gorjón I,Somovilla-Crespo B,Santamaria S,Garcia-Sanz JA,Kremer L

更新日期：2017-12-21 00:00:00

abstract：Objectives:Granulocyte monocyte colony-stimulating factor (GM-CSF) is currently considered a crucial inflammatory mediator and a novel therapeutic target in rheumatoid arthritis (RA), despite the fact that its precise cellular sources remain uncertain. We studied the expression of GM-CSF in peripheral lymphocytes from ...

journal_title：Frontiers in immunology

authors： Makris A,Adamidi S,Koutsianas C,Tsalapaki C,Hadziyannis E,Vassilopoulos D

更新日期：2018-01-10 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are the major producers of type I and type III interferons (IFNs) that play essential roles in host antiviral immunity. MicroRNAs (miRs) are small, noncoding RNAs that can modulate many immune processes. Although molecular regulation of type I IFN production by pDCs has been studied...

journal_title：Frontiers in immunology

authors： Liu F,Liu C,Hu X,Shang Y,Wu L

更新日期：2017-08-21 00:00:00

abstract：:The immune system is composed of two subsystems-the innate immune system and the adaptive immune system. The innate immune system is the first to respond to pathogens and does not retain memory of previous responses. Innate immune responses are evolutionarily older than adaptive responses and elements of innate immuni...

journal_title：Frontiers in immunology

authors： Smith NC,Rise ML,Christian SL

更新日期：2019-10-10 00:00:00

abstract：:The liver is one of the most important immunological organs that remains tolerogenic in homeostasis yet promotes rapid responses to pathogens in the presence of a systemic infection. The composition of leucocytes in the liver is highly distinct from that of the blood and other lymphoid organs, particularly with respec...

journal_title：Frontiers in immunology

authors： Huang W,He W,Shi X,He X,Dou L,Gao Y

更新日期：2018-10-30 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TILs), found in patients with advanced pancreatic ductal adenocarcinoma (PDAC), are shown to correlate with overall survival (OS) rate. Although majority of TILs consist of CD8+/CD4+ T cells, the presence of NK cells and their role in the pathogenesis of PDAC remains elusive. We perform...

journal_title：Frontiers in immunology

authors： Lim SA,Kim J,Jeon S,Shin MH,Kwon J,Kim TJ,Im K,Han Y,Kwon W,Kim SW,Yee C,Kim SJ,Jang JY,Lee KM

更新日期：2019-04-09 00:00:00

abstract：:Tumors must evade the immune system to survive and metastasize, although the mechanisms that lead to tumor immunoediting and their evasion of immune surveillance are far from clear. The first line of defense against metastatic invasion is the innate immune system that provides immediate defense through humoral immunit...

journal_title：Frontiers in immunology

authors： Benito-Martin A,Di Giannatale A,Ceder S,Peinado H

更新日期：2015-02-24 00:00:00

abstract：:The COVID-19 pandemic demonstrates the ongoing threat of pandemics caused by novel, previously unrecognized, or mutated pathogens with high transmissibility. Currently, vaccine development is too slow for vaccines to be used in the control of emerging pandemics. RNA-based vaccines might be suitable to meet this challe...

journal_title：Frontiers in immunology

authors： Sandbrink JB,Shattock RJ

更新日期：2020-12-22 00:00:00

abstract：:Neutrophil granulocytes are the most numerous type of leukocyte in humans bearing an enormous, yet largely unexplored therapeutic potential. Scientists have very recently increased their efforts to study and understand these cells which contribute to various types of inflammatory diseases and cancer. The mechanisms th...

journal_title：Frontiers in immunology

authors： Bartneck M,Wang J

更新日期：2019-09-20 00:00:00

abstract：:Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understanding of Treg cell biology provided us with molecular mechanisms-both transcriptional and epi...

journal_title：Frontiers in immunology

authors： Korn T,Muschaweckh A

更新日期：2019-11-14 00:00:00

abstract：BACKGROUND:Graft-vs-host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the beneficial graft vs leukemia (GVL) of the allogeneic response. Previou...

journal_title：Frontiers in immunology

authors： Burlion A,Brunel S,Petit NY,Olive D,Marodon G

更新日期：2017-06-30 00:00:00

abstract：:The lymphatic vasculature plays a crucial role in regulating the inflammatory response by influencing drainage of extravasated fluid, inflammatory mediators, and leukocytes. Lymphatic vessels undergo pronounced enlargement in inflamed tissue and display increased leakiness, indicating reduced functionality. Interferin...

journal_title：Frontiers in immunology

authors： Schwager S,Detmar M

更新日期：2019-02-26 00:00:00

abstract：:The Pediatric Acute Liver Failure (PALF) study is a multicenter, observational cohort study of infants and children diagnosed with this complex clinical syndrome. Outcomes in PALF reflect interactions among the child's clinical condition, response to supportive care, disease severity, potential for recovery, and, if n...

journal_title：Frontiers in immunology

authors： Vodovotz Y,Barclay D,Yin J,Squires RH,Zamora R

更新日期：2021-01-15 00:00:00

abstract：:A process is a function of time; in immunometabolism, this is reflected by the stepwise adaptation of metabolism to sustain the bio-energetic demand of an immune-response in its various states and shades. This perspective article starts by presenting an early attempt to investigate the physiology of inflammation, in o...

journal_title：Frontiers in immunology

authors： Nagy C,Haschemi A

更新日期：2015-04-08 00:00:00

abstract：:Neisseria gonorrhoeae is a significant health problem worldwide due to multi-drug resistance issues and absence of an effective vaccine. Patients infected with N. gonorrhoeae have not shown a better immune response in successive infections. This might be explained by the fact that N. gonorrhoeae possesses several mech...

journal_title：Frontiers in immunology

authors： Escobar A,Rodas PI,Acuña-Castillo C

更新日期：2018-12-21 00:00:00

abstract：:In this study, we identified and characterized the potential of a high ratio of bicarbonate to CO2 and a moderately alkaline pH to render neutrophils prone to undergo neutrophil extracellular trap (NET) formation. Both experimental settings increased the rate of spontaneous NET release and potentiated the NET-inducing...

journal_title：Frontiers in immunology

authors： Maueröder C,Mahajan A,Paulus S,Gößwein S,Hahn J,Kienhöfer D,Biermann MH,Tripal P,Friedrich RP,Munoz LE,Neurath MF,Becker C,Schett GA,Herrmann M,Leppkes M

更新日期：2016-12-09 00:00:00

abstract：:Background: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition, there has been an increasing number of patients with wild-type FOXP3 gene and, in some cases, mutations in other immune regulatory genes. Objectiv...

journal_title：Frontiers in immunology

authors： Gambineri E,Ciullini Mannurita S,Hagin D,Vignoli M,Anover-Sombke S,DeBoer S,Segundo GRS,Allenspach EJ,Favre C,Ochs HD,Torgerson TR

更新日期：2018-11-01 00:00:00

abstract：:While T cell-based immunotherapies are steadily improving, there are still many patients who progress, despite T cell-infiltrated tumors. Emerging evidence suggests that T cells themselves may provoke immune escape of cancer cells. Here, we describe a well-controlled co-culture system for studying the dynamic T cell -...

journal_title：Frontiers in immunology

authors： Neubert NJ,Soneson C,Barras D,Baumgaertner P,Rimoldi D,Delorenzi M,Fuertes Marraco SA,Speiser DE

更新日期：2016-08-30 00:00:00

abstract：:Enamel matrix derivatives (EMDs)-based periodontal tissue regenerative therapy is known to promote healing with minimal inflammatory response after periodontal surgery, i. e., it promotes wound healing with reduced pain and swelling. It has also been reported that macrophages stimulated with amelogenin, a major compon...

journal_title：Frontiers in immunology

authors： Yotsumoto K,Sanui T,Tanaka U,Yamato H,Alshargabi R,Shinjo T,Nakao Y,Watanabe Y,Hayashi C,Taketomi T,Fukuda T,Nishimura F

更新日期：2020-04-21 00:00:00