Genome-Wide Screening and Functional Analysis Reveal That the Specific microRNA nlu-miR-173 Regulates Molting by Targeting Ftz-F1 in Nilaparvata lugens.


:Background: Molting is a crucial physiological behavior during arthropod growth. In the past few years, molting as well as chitin biosynthesis triggered by molting, is subject to regulation by miRNAs. However, how many miRNAs are involved in insect molting at the genome-wide level remains unknown. Results: We deeply sequenced four samples obtained from nymphs at the 2nd-3rd and 4th-5th instars, and then identified 61 miRNAs conserved in the Arthropoda and 326 putative novel miRNAs in the brown planthopper Nilaparvata lugens, a fearful pest of rice. A total of 36 mature miRNAs with significant different expression levels at the genome scale during molting, including 19 conserved and 17 putative novel miRNAs were identified. After comparing the expression profiles, we found that most of the targets of 36 miRNAs showing significantly differential expression were involved in energy and hormone pathways. One of the 17 putative novel miRNAs, nlu-miR-173 was chosen for functional study. nlu-miR-173 acts in 20-hydroxyecdysone signaling through its direct target, N. lugens Ftz-F1(NlFtz-F1), a transcription factor. Furthermore, we found that the transcription of nlu-miR-173 was promoted by Broad-Complex (BR-C), suggesting that its involvement in the 20-hydroxyecdysone pathway contributes to proper molting function. Conclusion: We provided a comprehensive resource of miRNAs associated with insect molting and identified a novel miRNA as a potential target for pest control.


Front Physiol


Frontiers in physiology


Chen J,Li TC,Pang R,Yue XZ,Hu J,Zhang WQ




Has Abstract


2018-12-20 00:00:00








  • Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities.

    abstract::The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to the challenging field of virtual design and testing of technologies in a patient-specific environment. Given the recent advances in medical imaging, computational power and mathematical algorithms, patient-specific cardiac models ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Zhong L,Zhang JM,Su B,Tan RS,Allen JC,Kassab GS

    更新日期:2018-06-26 00:00:00

  • Corrigendum: Skeletal Muscle Fiber Size and Gene Expression in the Oldest-Old With Differing Degrees of Mobility.

    abstract::[This corrects the article DOI: 10.3389/fphys.2019.00313.]. ...

    journal_title:Frontiers in physiology

    pub_type: 已发布勘误


    authors: Naro F,Venturelli M,Monaco L,Toniolo L,Muti E,Milanese C,Zhao J,Richardson RS,Schena F,Reggiani C

    更新日期:2020-02-25 00:00:00

  • Neurally Released GABA Acts via GABAC Receptors to Modulate Ca2+ Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum.

    abstract::γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Nevertheless, a role for GABA in enteric synaptic transmission remains elusive. In this study, we characterized the expression and function of GABA in the myenteric plexus of the mouse ileum. A...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Koussoulas K,Swaminathan M,Fung C,Bornstein JC,Foong JPP

    更新日期:2018-02-13 00:00:00

  • Primary Motor Cortex Excitability in Karate Athletes: A Transcranial Magnetic Stimulation Study.

    abstract::Purpose: The mechanisms involved in the coordination of muscle activity are not completely known: to investigate adaptive changes in human motor cortex Transcranial magnetic stimulation (TMS) was often used. The sport models are frequently used to study how the training may affect the corticospinal system excitability...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Monda V,Valenzano A,Moscatelli F,Salerno M,Sessa F,Triggiani AI,Viggiano A,Capranica L,Marsala G,De Luca V,Cipolloni L,Ruberto M,Precenzano F,Carotenuto M,Zammit C,Gelzo M,Monda M,Cibelli G,Messina G,Messina A

    更新日期:2017-09-12 00:00:00

  • The effect of octopamine on the locust stomatogastric nervous system.

    abstract::Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, influencing multiple physiological processes. Among its many roles in insects are the initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory effects of OA on the components of the locust stomatogastric nervous s...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Rand D,Knebel D,Ayali A

    更新日期:2012-07-20 00:00:00

  • Annexin II Light Chain p11 Interacts With ENaC to Increase Functional Activity at the Membrane.

    abstract::The epithelial Na+ channel (ENaC) provides for Na+ absorption in various types of epithelia including the kidney, lung, and colon where ENaC is localized to the apical membrane to enable Na+ entry into the cell. The degree of Na+ entry via ENaC largely depends on the number of active channels localized to the cell mem...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Cheung TT,Ismail NAS,Moir R,Arora N,McDonald FJ,Condliffe SB

    更新日期:2019-02-08 00:00:00

  • Urea transporter physiology studied in knockout mice.

    abstract::In mammals, there are two types of urea transporters; urea transporter (UT)-A and UT-B. The UT-A transporters are mainly expressed in kidney epithelial cells while UT-B demonstrates a broader distribution in kidney, heart, brain, testis, urinary tract, and other tissues. Over the past few years, multiple urea transpor...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Li X,Chen G,Yang B

    更新日期:2012-06-26 00:00:00

  • The Variation Tendency of Polyamines Forms and Components of Polyamine Metabolism in Zoysiagrass (Zoysia japonica Steud.) to Salt Stress with Exogenous Spermidine Application.

    abstract::To understand dynamic changes in polyamines (PAs) forms and components of polyamine metabolism in zoysiagrass (Zoysia japonica Steud.) response to salt stress with exogenous spermidine (Spd) application, two Chinese zoysia cultivars, z081 and z057, were exposed to sodium chloride stress for 2, 4, 6, and 8 days. The z0...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Li S,Cui L,Zhang Y,Wang Y,Mao P

    更新日期:2017-04-06 00:00:00

  • Identification of Halloween Genes and RNA Interference-Mediated Functional Characterization of a Halloween Gene shadow in Plutella xylostella.

    abstract::Ecdysteroids play an essential role in controlling insect development and reproduction. Their pathway is regulated by a group of enzymes called Halloween gene proteins. The relationship between the Halloween genes and ecdysteroid synthesis has yet to be clearly understood in diamondback moth, Plutella xylostella (L.),...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Peng L,Wang L,Zou MM,Vasseur L,Chu LN,Qin YD,Zhai YL,You MS

    更新日期:2019-08-28 00:00:00

  • Short-Term Dosage Regimen for Stimulation-Induced Long-Lasting Desynchronization.

    abstract::In this paper, we computationally generate hypotheses for dose-finding studies in the context of desynchronizing neuromodulation techniques. Abnormally strong neuronal synchronization is a hallmark of several brain disorders. Coordinated Reset (CR) stimulation is a spatio-temporally patterned stimulation technique tha...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Manos T,Zeitler M,Tass PA

    更新日期:2018-04-12 00:00:00

  • Novel Strategies for Endothelial Preservation in Lung Transplant Ischemia-Reperfusion Injury.

    abstract::Lung ischemia reperfusion (IR) injury inevitably occurs during lung transplantation. The pulmonary endothelium is the primary target of IR injury that potentially results in severe pulmonary dysfunction. Over the last decades, various molecules, receptors, and signaling pathways were identified in order to develop tre...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Jungraithmayr W

    更新日期:2020-12-18 00:00:00

  • Designing Dietary Recommendations Using System Level Interactomics Analysis and Network-Based Inference.

    abstract::Background: A range of computational methods that rely on the analysis of genome-wide expression datasets have been developed and successfully used for drug repositioning. The success of these methods is based on the hypothesis that introducing a factor (in this case, a drug molecule) that could reverse the disease ge...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Zheng T,Ni Y,Li J,Chow BKC,Panagiotou G

    更新日期:2017-09-28 00:00:00

  • Power Equation for Predicting the Risk of Central Nervous System Oxygen Toxicity at Rest.

    abstract::Patients undergoing hyperbaric oxygen therapy and divers engaged in underwater activity are at risk of central nervous system oxygen toxicity. An algorithm for predicting CNS oxygen toxicity in active underwater diving has been published previously, but not for humans at rest. Using a procedure similar to that employe...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Aviner B,Arieli R,Yalov A

    更新日期:2020-08-17 00:00:00

  • Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins.

    abstract::Na(+)/Ca(2+) exchanger (NCX) proteins extrude Ca(2+) from the cell to maintain cellular homeostasis. Since NCX proteins contribute to numerous physiological and pathophysiological events, their pharmacological targeting has been desired for a long time. This intervention remains challenging owing to our poor understan...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Giladi M,Tal I,Khananshvili D

    更新日期:2016-02-09 00:00:00

  • The Whitish Inner Mantle of the Giant Clam, Tridacna squamosa, Expresses an Apical Plasma Membrane Ca2+-ATPase (PMCA) Which Displays Light-Dependent Gene and Protein Expressions.

    abstract::Giant clams live in symbiosis with extracellular zooxanthellae and display high rates of growth and shell formation (calcification) in light. Light-enhanced calcification requires an increase in the supply of Ca2+ to, and simultaneously an augmented removal of H+ from, the extrapallial fluid where shell formation occu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Ip YK,Hiong KC,Goh EJK,Boo MV,Choo CYL,Ching B,Wong WP,Chew SF

    更新日期:2017-10-10 00:00:00

  • Exercise, Obesity and CNS Control of Metabolic Homeostasis: A Review.

    abstract::This review details the manner in which the central nervous system regulates metabolic homeostasis in normal weight and obese rodents and humans. It includes a review of the homeostatic contributions of neurons located in the hypothalamus, the midbrain and limbic structures, the pons and the medullary area postrema, n...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Smith JK

    更新日期:2018-05-17 00:00:00

  • Relationship Between Distance Run Per Week, Omega-3 Index, and Arachidonic Acid (AA)/Eicosapentaenoic Acid (EPA) Ratio: An Observational Retrospective Study in Non-elite Runners.

    abstract::Background: Tissue availability of polyunsaturated fatty acids (PUFA) depends on several factors, including dietary intake, physical exercise, genetic variation, and metabolic turnover. However, there is limited evidence whether running training activity per se may influence indices associated with PUFA metabolism suc...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Davinelli S,Corbi G,Righetti S,Casiraghi E,Chiappero F,Martegani S,Pina R,De Vivo I,Simopoulos AP,Scapagnini G

    更新日期:2019-04-26 00:00:00

  • Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.

    abstract::The senescence of vascular smooth muscle cells (VSMCs) has been implicated as a causal pro-inflammatory mechanism for cardiovascular disease development and progression of atherosclerosis, the instigator of ischemic heart disease. Contemporary limitations related to studying this cellular population and senescence-rel...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Stojanović SD,Fuchs M,Kunz M,Xiao K,Just A,Pich A,Bauersachs J,Fiedler J,Sedding D,Thum T

    更新日期:2020-05-25 00:00:00

  • Oral Supplementation with Baker's Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise.

    abstract::Exercise and physical labor in extreme environmental conditions causes transient decreases in immune cell and cytokine concentrations, likely increasing the susceptibility to opportunistic infection. Baker's yeast beta glucan (BYBG) has been previously demonstrated to be an effective countermeasure in athletes, but it...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: McFarlin BK,Venable AS,Carpenter KC,Henning AL,Ogenstad S

    更新日期:2017-10-20 00:00:00

  • Corrigendum: Two Consecutive Days of Extreme Conditioning Program Training Affects Pro and Anti-inflammatory Cytokines and Osteoprotegerin without Impairments in Muscle Power.

    abstract::[This corrects the article DOI: 10.3389/fphys.2016.00260.]. ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,已发布勘误


    authors: Tibana RA,de Almeida LM,Frade de Sousa NM,Nascimento DDC,Neto IVS,de Almeida JA,de Souza VC,Lopes MFTPL,Nobrega OT,Vieira DCL,Navalta JW,Prestes J

    更新日期:2018-07-16 00:00:00

  • A Chemosensory Protein BtabCSP11 Mediates Reproduction in Bemisia tabaci.

    abstract::The olfactory system serves a vital role in the evolution and survival of insects, being involved in behaviors such as host seeking, foraging, mating, and oviposition. Odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) are involved in the olfactory recognition process. In this study, BtabCSP11, a CSP11 g...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Zeng Y,Merchant A,Wu Q,Wang S,Kong L,Zhou X,Xie W,Zhang Y

    更新日期:2020-06-30 00:00:00

  • Cloning and Analysis of Gene Expression of Two Toll Receptors in Freshwater Pearl Mussel Hyriopsis cumingii.

    abstract::Toll receptors are involved in innate immunity of invertebrates. In this study, we identify and characterize two Toll genes (named HcToll4 and HcToll5) from triangle sail mussel Hyriopsis cumingii. HcToll4 has complete cDNA sequence of 3,162 bp and encodes a protein of 909 amino acids. HcToll5 cDNA is 4,501 bp in leng...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Huang Y,Han K,Ren Q

    更新日期:2018-03-05 00:00:00

  • Myocardial Blood Flow and Metabolic Rate of Oxygen Measurement in the Right and Left Ventricles at Rest and During Exercise Using 15O-Labeled Compounds and PET.

    abstract::Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Kudomi N,Kalliokoski KK,Oikonen VJ,Han C,Kemppainen J,Sipilä HT,Knuuti J,Heinonen IHA

    更新日期:2019-06-19 00:00:00

  • Comparison of Baroreflex Sensitivity and Cardiac Autonomic Function Between Adolescent Athlete and Non-athlete Boys - A Cross-Sectional Study.

    abstract::Introduction: It is well known that regular physical activity improves cardiovascular health, and higher baroreflex sensitivity and heart rate variability are associated with cardiovascular health. Adolescence is the age when an individual's behavior is easily modified; early intervention at this stage in terms of phy...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Subramanian SK,Sharma VK,Arunachalam V,Rajendran R,Gaur A

    更新日期:2019-08-22 00:00:00

  • In Vivo Calcium Imaging of Cardiomyocytes in the Beating Mouse Heart With Multiphoton Microscopy.

    abstract::Background: Understanding the microscopic dynamics of the beating heart has been challenging due to the technical nature of imaging with micrometer resolution while the heart moves. The development of multiphoton microscopy has made in vivo, cell-resolved measurements of calcium dynamics and vascular function possible...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Jones JS,Small DM,Nishimura N

    更新日期:2018-07-31 00:00:00

  • Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female Drosophila.

    abstract::Mild normobaric hypoxia (NH) and modest exercise have multiple beneficial effects on health, but the changes in physiological function induced by NH and/or exercise remain unclear. The purpose of this investigation was to examine the specific effects of NH and/or exercise on cardiac function and myocardial structure a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Li QF,Wang H,Zheng L,Yang F,Li HZ,Li JX,Cheng D,Lu K,Liu Y

    更新日期:2020-01-21 00:00:00

  • The Role of Krüppel-like Factor 4 in Renal Fibrosis.

    abstract::Chronic kidney disease (CKD) caused by renal fibrosis is an important public health concern. It is therefore necessary to understand the molecular pathogenesis of renal fibrosis in order to develop novel therapeutic strategies. KLF4 is the most extensively studied factor among the various members of the Krüppel-like f...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Ke B,Zhang A,Wu X,Fang X

    更新日期:2015-11-12 00:00:00

  • Osteoconductive Microarchitecture of Bone Substitutes for Bone Regeneration Revisited.

    abstract::In the last three decades, all efforts in bone tissue engineering were driven by the dogma that the ideal pore size in bone substitutes lies between 0.3 and 0.5 mm in diameter. Newly developed additive manufacturing methodologies for ceramics facilitate the total control over pore size, pore distribution, bottleneck s...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Ghayor C,Weber FE

    更新日期:2018-07-19 00:00:00

  • Cancer Metabolism: A Modeling Perspective.

    abstract::Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant on constant supply of nutrients and energy. In addition to the widely studied dysregulated glucose metabolism to fuel tumor cell growth, accumulating evidences suggest that utiliz...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Ghaffari P,Mardinoglu A,Nielsen J

    更新日期:2015-12-16 00:00:00

  • Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis.

    abstract::Lactic acid and short chain fatty acids (SCFAs) produced by vaginal microbiota have reported antimicrobial and immune modulatory activities indicating their potential as biomarkers of disease and/or disease susceptibility. In asymptomatic women of reproductive-age the vaginal microbiota is comprised of lactic acid-pro...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Aldunate M,Srbinovski D,Hearps AC,Latham CF,Ramsland PA,Gugasyan R,Cone RA,Tachedjian G

    更新日期:2015-06-02 00:00:00