Regulation of Chromatin Structure During Neural Development.

Abstract:

:The regulation of genome architecture is a key determinant of gene transcription patterns and neural development. Advances in methodologies based on chromatin conformation capture (3C) have shed light on the genome-wide organization of chromatin in developmental processes. Here, we review recent discoveries regarding the regulation of three-dimensional (3D) chromatin conformation, including promoter-enhancer looping, and the dynamics of large chromatin domains such as topologically associated domains (TADs) and A/B compartments. We conclude with perspectives on how these conformational changes govern neural development and may go awry in disease states.

journal_name

Front Neurosci

authors

Kishi Y,Gotoh Y

doi

10.3389/fnins.2018.00874

subject

Has Abstract

pub_date

2018-12-11 00:00:00

pages

874

eissn

1662-4548

issn

1662-453X

journal_volume

12

pub_type

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