Regulation of Chromatin Structure During Neural Development.


:The regulation of genome architecture is a key determinant of gene transcription patterns and neural development. Advances in methodologies based on chromatin conformation capture (3C) have shed light on the genome-wide organization of chromatin in developmental processes. Here, we review recent discoveries regarding the regulation of three-dimensional (3D) chromatin conformation, including promoter-enhancer looping, and the dynamics of large chromatin domains such as topologically associated domains (TADs) and A/B compartments. We conclude with perspectives on how these conformational changes govern neural development and may go awry in disease states.


Front Neurosci


Kishi Y,Gotoh Y




Has Abstract


2018-12-11 00:00:00










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    authors: Llorens-Martín M,Rábano A,Ávila J

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    更新日期:2019-03-21 00:00:00

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    pub_type: 杂志文章,评审


    authors: Forostyak S,Sykova E

    更新日期:2017-10-24 00:00:00

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    更新日期:2018-03-16 00:00:00

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    pub_type: 杂志文章


    authors: Zheng T,Du J,Yuan Y,Wu S,Jin Y,Wang Z,Liu D,Shi Q,Wang X,Liu L

    更新日期:2020-03-10 00:00:00

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    pub_type: 杂志文章


    authors: Shine JM,Shine R

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    pub_type: 杂志文章


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    更新日期:2016-09-23 00:00:00