Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene.

Abstract:

:Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, OAd.DD3.mK5. DD3 is one of the most prostate cancer specific promoters which can transcriptionally control adenoviral replication. mK5 has been proved to be able to inhibit the tumor angiogenesis and inhibit cell proliferation. Our results suggested that targeting PCa with OAd.DD3.mK5 elicited strong antitumor effect.

journal_name

Open Med (Wars)

authors

Hao J,Xie W,Li H,Li R

doi

10.1515/med-2019-0001

subject

Has Abstract

pub_date

2018-12-24 00:00:00

pages

1-9

issn

2391-5463

pii

med-2019-0001

journal_volume

14

pub_type

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