Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene.


:Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, OAd.DD3.mK5. DD3 is one of the most prostate cancer specific promoters which can transcriptionally control adenoviral replication. mK5 has been proved to be able to inhibit the tumor angiogenesis and inhibit cell proliferation. Our results suggested that targeting PCa with OAd.DD3.mK5 elicited strong antitumor effect.


Open Med (Wars)


Hao J,Xie W,Li H,Li R




Has Abstract


2018-12-24 00:00:00










  • Strength and aerobic training in overweight females in Gdansk, Poland.

    abstract::We compared the effects of 16-week-training on rest metabolic rate, aerobic power, and body fat, and the post-exercise effects upon rest oxygen uptake and respiratory exchange ratio in overweight middle-aged females. Twenty nine overweight women (BMI 29.9 ± 1.2 kg*m-2) participated in training (3 days a week). The sub...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Sawczyn S,Mishchenko V,Moska W,Sawczyn M,Jagiełło M,Kuehne T,Kostrzewa-Nowak D,Nowak R,Cięszczyk P

    更新日期:2015-02-02 00:00:00

  • Development of epidermal growth factor receptor tyrosine kinase inhibitors against EGFR T790M. Mutation in non small-cell lung carcinoma.

    abstract::Individualized therapies targeting epidermal growth factor receptor (EGFR) mutations show promises for the treatment of non small-cell lung carcinoma (NSCLC). However, disease progression almost invariably occurs 1 year after tyrosine kinase inhibitor (TKI) treatment. The most prominent mechanism of acquired resistanc...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章,评审


    authors: Wang Y,Guo Z,Li Y,Zhou Q

    更新日期:2016-03-26 00:00:00

  • Loneliness in the Context of Quality of Life of Nursing Home Residents.

    abstract:Background:Numbers of the elderly have been on a steady increase both in Poland and other countries of the world. As they age, their health declines and they need help with their housekeeping. This, coupled with the transformation of intergenerational into single-generation or nuclear family structures, causes a marked...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Trybusińska D,Saracen A

    更新日期:2019-04-24 00:00:00

  • A Hybrid Neural Network - World Cup Optimization Algorithm for Melanoma Detection.

    abstract::One of the most dangerous cancers in humans is Melanoma. However, early detection of melanoma can help us to cure it completely. This paper presents a new efficient method to detect malignancy in melanoma via images. At first, the extra scales are eliminated by using edge detection and smoothing. Afterwards, the propo...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Razmjooy N,Sheykhahmad FR,Ghadimi N

    更新日期:2018-03-15 00:00:00

  • Pituitary Dysfunction from an Unruptured Ophthalmic Internal Carotid Artery Aneurysm with Improved 2-year Follow-up Results: A Case Report.

    abstract::Internal carotid artery (ICA) supraclinoid segment aneurysms extending into the sellar region and leading to pituitary dysfunction are a rare occurrence. To date, long-term follow up of pituitary function 2 years post-treatment has never been reported. Herein, we present a case of pituitary dysfunction due to an unrup...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Qi M,Ye M,Li M,Zhang P

    更新日期:2018-04-18 00:00:00

  • Meta-analysis of PET/CT Detect Lymph Nodes Metastases of Cervical Cancer.

    abstract:Objective:The aim of this study was to assess the diagnostic value of PET/CT for metastatic lymph nodes in cervical cancer patients. Methods:Searching in the databases including PubMed, Embase, Web of Science, Cochrane Library and Google Scholar about non-invasive modalities for detecting lymph nodes metastases during...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Ruan J,Zhang Y,Ren H

    更新日期:2018-09-22 00:00:00

  • Laparoscopic splenectomy and porto-azygos disconnection: clinical research in the treatment of portal hypertension.

    abstract::To investigate the safety and efficacy of laparoscopic splenectomy and portaazygous devascularization, we studied laparoscopic splenectomy and porto-azygos devascularization patients within the peri-operative period. Clinical data and curative effect are detailed alongside statistical analysis. The laparoscopic splene...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Fengyong W,Yuanshui S,Zhangbing,Yuewu W,Weihua Z,Jianfeng S,Qi W,Jinming L,Ji X,Zaiyuan Y

    更新日期:2015-12-17 00:00:00

  • Can Keratin Scaffolds be used for Creating Three-dimensional Cell Cultures?

    abstract::Three-dimensional (3D) cell cultures were created with the use of fur keratin associated proteins (F-KAPs) as scaffolds. The procedure of preparation F-KAP involves combinations of chemical activation and enzymatic digestion. The best result in porosity and heterogeneity of F-KAP surface was received during pepsin dig...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Bochynska-Czyz M,Redkiewicz P,Kozlowska H,Matalinska J,Konop M,Kosson P

    更新日期:2020-04-03 00:00:00

  • Is acute appendicitis still misdiagnosed?

    abstract:OBJECTIVE:The optimal diagnostics and treatment of acute appendicitis continues to be a challenge. A false positive diagnosis of appendicitis may lead to an unnecessary operation, which has been appropriately termed negative appendectomy. The aim of our study was to identify the effectiveness of preoperative investigat...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Kryzauskas M,Danys D,Poskus T,Mikalauskas S,Poskus E,Jotautas V,Beisa V,Strupas K

    更新日期:2016-07-22 00:00:00

  • FPL tendon thickness, tremor and hand functions in Parkinson's disease.

    abstract:INTRODUCTION:In Parkinson's disease (PD), a resting tremor of the thumb may affect the flexor pollicis longus (FPL) and influence hand functions. We investigated the relationship between FPL tendon thickness and hand function in PD patients and compared these characteristics with those in healthy controls. METHODS:The...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Toktas H,Dundar U,Kusbeci ÖY,Ulasli AM,Toy O,Oruc S

    更新日期:2016-02-19 00:00:00

  • Clinical significance and potential mechanisms of miR-223-3p and miR-204-5p in squamous cell carcinoma of head and neck: a study based on TCGA and GEO.

    abstract:Objective:To explore the clinical significance and mechanisms of altered miRNAs in squamous cell carcinoma of head and neck (SCCHN) and provide references for SCCHN diagnosis and prognosis. Method:Differential expressed miRNAs (DEMs) in SCCHN were screened through gene expression omnibus (GEO) DataSets and verified by...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Zhao L,Tian C,Xiao E,Du J,Liang J,Chen X,Chi W

    更新日期:2020-08-03 00:00:00

  • Comparison of low-molecular-weight heparins in thromboprophylaxis of major orthopaedic surgery - randomized, prospective pilot study.

    abstract:Aim:To compare the clinical effectiveness of the two most commonly used LMWHs, dalteparin (DALT) and enoxaparin (ENOX), in thromboprophylaxis of elective total hip replacement (THR) or total knee replacement (TKR). Material and methods:To the prospective, randomized study were included 66 adult patients qualified to u...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Biławicz J,Lipa M,Wielgos M

    更新日期:2020-10-12 00:00:00

  • A review of current progress in triple-negative breast cancer therapy.

    abstract::Triple-negative breast cancer (TNBC) is a particularly aggressive subtype known for its extremely high drug resistance, progression, poor prognosis, and lack of clear therapeutic targets. Researchers are aiming to advance TNBC treatment worldwide. In the past 2-3 years, more positive results have emerged in the clinic...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章,评审


    authors: Shen M,Pan H,Chen Y,Xu YH,Yang W,Wu Z

    更新日期:2020-11-14 00:00:00

  • Endometrial cancer and microsatellite instability status.

    abstract::Microsatellite instability (MSI) is an important factor in the development of various cancers as an identifier of a defective DNA mismatch repair system. The objective of our study was to define the association between microsatellite instability status and traditional clinicopathologic characteristics of endometrioid ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Kanopiene D,Vidugiriene J,Valuckas KP,Smailyte G,Uleckiene S,Bacher J

    更新日期:2014-11-11 00:00:00

  • Acute chemoradiotherapy toxicity in cervical cancer patients.

    abstract::During radiotherapy treatment for cervical cancer, up to 84% of patients exhibit some form of acute radiation toxicity (ART). The primary aim of this clinical study is to determine the impact of angiotensin-converting enzyme (ACE) inhibitors, β-blockers and other risk factors such as the patient's anatomical character...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Radojevic MZ,Tomasevic A,Karapandzic VP,Milosavljevic N,Jankovic S,Folic M

    更新日期:2020-09-02 00:00:00

  • Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates.

    abstract::Not fully maturated immune system in preterm neonates may contribute to the increased susceptibility to infection. The levels of some cytokines can be useful in the prediction and diagnosis of sepsis in premature neonates. In the present study, we evaluated the potential predictive role of IFN-γ and IL-5 in cord and v...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Vucic J,Vucic M,Stankovic T,Stamenkovic H,Stankovic S,Zlatanovic D

    更新日期:2021-01-11 00:00:00

  • Galen Vein Aneurysm- Challenge for Treatment.

    abstract::The term vein of Galen aneurysm is related to a group of different vascular anomalies, with one common distinction being the dilatation of the vein of Galen. It represents a rear vascular anomaly, whose incidence is yet unknown, although some authors suggest numbers around 1:25000 deliveries. It accounts for only 1% o...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Crnogorac S,Bozaric AV

    更新日期:2017-12-05 00:00:00

  • Analysis of Ticagrelor's Cardio-protective Effects on Patients with ST-segment Elevation Acute Coronary Syndrome Accompanied with Diabetes.

    abstract:Background:To analyze the cardio-protective effects of ticagrelor in patients with acute coronary syndrome with S-T segment elevation. Methods:The sample was 200 patients who had been diagnosed with acute coronary syndrome accompanied by diabetes Mellitus type II. Only patients having ST segment elevation before the t...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Li DT,Li SB,Zheng JY,Tang HH,Qiu YG,Xue N,Cao Y

    更新日期:2019-02-20 00:00:00

  • MicroRNA-181a-5p Regulates Inflammatory Response of Macrophages in Sepsis.

    abstract::The aim of this study was to evaluate the role of miR-181a-5p in sepsis, and to further explore the molecular mechanism. RAW 264.7 cells were stimulated with 1 μg/ml LPS for 4 hours. Firstly, qRT-PCR and ELISA was adopted to evaluate the expression of miR-181a-5p and p ro-inflammatory cytokines in RAW 264.7 macrophage...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Huang Z,Xu H

    更新日期:2019-11-20 00:00:00

  • Genetic Testing and Professional Responsibility: The Italian Experience.

    abstract::Responsibility means responding to the damaging consequences of technical work and in this binding perspective the general principles of guilt in genetic diagnostics and related activities are not different from any other medical performance. Performing a genetic test however, especially when it has predictive charact...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Bin P,Conti A,Capasso E,Fedeli P,Ceccarelli P,Policino F,Casella C,Delbon P

    更新日期:2018-08-24 00:00:00

  • The Mechanism of Mitral Regurgitant Jets Identified by 3-Dimensional Transesophageal Echocardiography.

    abstract::This study is a case report, which presents a case of severe mitral regurgitation in a 77-year-old man. Two-dimensional transesophageal echocardiography (TEE), regurgitant jets directed anteriorly in early systole and centrally to laterally in late systole were seen, while three-dimensional TEE showed a flail posterio...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Iida R,Aono M,Choy J

    更新日期:2018-08-11 00:00:00

  • Pharmacokinetics of Vancomycin in Patients with Different Renal Function Levels.

    abstract::There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Zaric RZ,Milovanovic J,Rosic N,Milovanovic D,Zecevic DR,Folic M,Jankovic S

    更新日期:2018-10-22 00:00:00

  • Differences of plasma IL-1 and TNF-α in healthy Chinese Population.

    abstract::Pleiotropic proinflammatory cytokines, interleukin- 1 (IL-1) and tumor necrosis factor-α (TNF-α), involved in the regulations of various immune responses, inflammatory processes and hematopoiesis. In the present study, the expression levels of IL-1 and TNF-α were detected by enzyme-linked immunosorbent assay (ELISA). ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Yuan J,Wang L,Lin Y,Chen J,Hu J

    更新日期:2015-06-09 00:00:00

  • Clinical Features of Infertile Men Carrying a Chromosome 9 Translocation.

    abstract::Previous studies indicated that chromosome 9 translocations are involved in reduced male fertility and increased chance of miscarriage in the female partner. The aim of this study was to review the clinical features and genetic counselling requirements of infertile men carrying chromosome 9 translocations. This study ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Wang R,Yu Y,Wang Q,Jiang Y,Li L,Zhu H,Liu R,Zhang H

    更新日期:2019-11-10 00:00:00

  • Effects of Arginine Vasopressin on Migration and Respiratory Burst Activity in Human Leukocytes.

    abstract::Arginine vasopressin can bind to high-affinity vasopressin V1a receptors in human leukocytes. This study aims to investigate the effects of arginine vasopressin on migration and chemotaxis of neutrophils and oxygen free radical release by human leukocytes. Neutrophils and monocytes were obtained from peripheral blood ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Wiedermann FJ,Watzinger K,Stichlberger M,Joannidis M,Kaehler C,Lederer W

    更新日期:2018-05-09 00:00:00

  • Erratum to "Suffering from Cerebral Small Vessel Disease with and without Metabolic Syndrome".

    abstract::[This corrects the article on p. 479 in vol. 14, PMID: 31231684.]. ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 已发布勘误


    authors: Tb M,G T,A G,D A

    更新日期:2020-11-27 00:00:00

  • Relationship of HS CRP and Sacroiliac Joint Inflammation in Undifferentiated Spondyloarthritis.

    abstract:Objective:Elevation of serum high sensitivity C-reactive protein (hs-CRP) level has been demonstrated as a risk factor for varying diseases, as well as a biomarker for predicting recovery after operation of lumber disc herniation. Our objective was to investigate the relationship between serum hs-CRP and sacroiliac (SI...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Liu TJ,Chang CC,Chen LC,Chu HY,Hsu CS,Chang ST

    更新日期:2018-05-19 00:00:00

  • Optimization of the Convolutional Neural Networks for Automatic Detection of Skin Cancer.

    abstract::Convolutional neural networks (CNNs) are a branch of deep learning which have been turned into one of the popular methods in different applications, especially medical imaging. One of the significant applications in this category is to help specialists make an early detection of skin cancer in dermoscopy and can reduc...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Zhang L,Gao HJ,Zhang J,Badami B

    更新日期:2020-01-13 00:00:00

  • Brainstem Anaesthesia after Retrobulbar Block.

    abstract::Regional anaesthesia techniques in ophthalmology are usually utilized for day case surgery. During various procedures, profound akinesia of the eye and anaesthesia of the surgical site are required, both of which are achieved with retrobulbar block. Due to the anatomy of the eye, life-threatening complications are pos...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章


    authors: Kostadinov I,Hostnik A,Cvenkel B,Potočnik I

    更新日期:2019-03-02 00:00:00

  • Garengeot's hernia: two case reports with CT diagnosis and literature review.

    abstract::Garengeot's hernia (GH) is defined as the presence of the appendix inside a femoral hernia. It occurs in 0.9% of femoral hernias and is usually an incidental finding during surgery. Its treatment is controversial and the aim of this article is to review the diagnostic methods and surgical considerations. We report two...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章,评审


    authors: Garcia-Amador C,De la Plaza R,Arteaga V,Lopez-Marcano A,Ramia J

    更新日期:2016-10-07 00:00:00