Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene.

Abstract:

:Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, OAd.DD3.mK5. DD3 is one of the most prostate cancer specific promoters which can transcriptionally control adenoviral replication. mK5 has been proved to be able to inhibit the tumor angiogenesis and inhibit cell proliferation. Our results suggested that targeting PCa with OAd.DD3.mK5 elicited strong antitumor effect.

journal_name

Open Med (Wars)

authors

Hao J,Xie W,Li H,Li R

doi

10.1515/med-2019-0001

subject

Has Abstract

pub_date

2018-12-24 00:00:00

pages

1-9

issn

2391-5463

pii

med-2019-0001

journal_volume

14

pub_type

杂志文章
  • FPL tendon thickness, tremor and hand functions in Parkinson's disease.

    abstract:INTRODUCTION:In Parkinson's disease (PD), a resting tremor of the thumb may affect the flexor pollicis longus (FPL) and influence hand functions. We investigated the relationship between FPL tendon thickness and hand function in PD patients and compared these characteristics with those in healthy controls. METHODS:The...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2016-0004

    authors: Toktas H,Dundar U,Kusbeci ÖY,Ulasli AM,Toy O,Oruc S

    更新日期:2016-02-19 00:00:00

  • Pharmacokinetics of Vancomycin in Patients with Different Renal Function Levels.

    abstract::There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2018-0068

    authors: Zaric RZ,Milovanovic J,Rosic N,Milovanovic D,Zecevic DR,Folic M,Jankovic S

    更新日期:2018-10-22 00:00:00

  • Endometrial cancer and microsatellite instability status.

    abstract::Microsatellite instability (MSI) is an important factor in the development of various cancers as an identifier of a defective DNA mismatch repair system. The objective of our study was to define the association between microsatellite instability status and traditional clinicopathologic characteristics of endometrioid ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2015-0005

    authors: Kanopiene D,Vidugiriene J,Valuckas KP,Smailyte G,Uleckiene S,Bacher J

    更新日期:2014-11-11 00:00:00

  • Serum AFU, 5'-NT and AFP as Biomarkers for Primary Hepatocellular Carcinoma Diagnosis.

    abstract::To evaluate the clinical value of serum α-L-fucosidase (AFU), 5'-nucleotidase (5'-NT) and alpha fetoprotein (AFP) as biomarkers for primary hepatocellular carcinoma (PHC) diagnosis. METHODS:Thirty six primary hepatocellular carcinoma (PHC) patients and 36 healthy controls were recruited in this study from February 20...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2017-0051

    authors: Junna Z,Gongde C,Jinying X,Xiu Z

    更新日期:2017-10-11 00:00:00

  • MicroRNA-181a-5p Regulates Inflammatory Response of Macrophages in Sepsis.

    abstract::The aim of this study was to evaluate the role of miR-181a-5p in sepsis, and to further explore the molecular mechanism. RAW 264.7 cells were stimulated with 1 μg/ml LPS for 4 hours. Firstly, qRT-PCR and ELISA was adopted to evaluate the expression of miR-181a-5p and p ro-inflammatory cytokines in RAW 264.7 macrophage...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2019-0106

    authors: Huang Z,Xu H

    更新日期:2019-11-20 00:00:00

  • A review of current progress in triple-negative breast cancer therapy.

    abstract::Triple-negative breast cancer (TNBC) is a particularly aggressive subtype known for its extremely high drug resistance, progression, poor prognosis, and lack of clear therapeutic targets. Researchers are aiming to advance TNBC treatment worldwide. In the past 2-3 years, more positive results have emerged in the clinic...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章,评审

    doi:10.1515/med-2020-0138

    authors: Shen M,Pan H,Chen Y,Xu YH,Yang W,Wu Z

    更新日期:2020-11-14 00:00:00

  • Resuscitation Following a Bupivacaine Injection for a Cervical Paravertebral Block.

    abstract:Background:Cardiac arrest related to nerve blockade using a local anaesthetic is a rare event. We report a case of bupivacaine severe cardiovascular toxicity following cervical paravertebral nerve block. Case presentation:A 44-year-old female was admitted to Republican Vilnius University Hospital, with symptoms of sus...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2019-0112

    authors: Vosylius S,Uvarovas V,Svediene S,Satkauskas I

    更新日期:2019-12-17 00:00:00

  • Bevacizumab for non-small cell lung cancer patients with brain metastasis: A meta-analysis.

    abstract::This study evaluates the efficacy and safety of bevacizumab (BEV) in the treatment of non-small cell lung cancer (NSCLC) patients with brain metastases (BM) by performing meta-analyses of response and survival indices. Seventeen studies were included. BEV treatment was associated with a lower new BM incidence (hazard ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2020-0192

    authors: Liang P,Wang YD,Wei ZM,Deng QJ,Xu T,Liu J,Luo N,Hou J

    更新日期:2020-07-01 00:00:00

  • Erratum to "Suffering from Cerebral Small Vessel Disease with and without Metabolic Syndrome".

    abstract::[This corrects the article on p. 479 in vol. 14, PMID: 31231684.]. ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 已发布勘误

    doi:10.1515/med-2021-0006

    authors: Tb M,G T,A G,D A

    更新日期:2020-11-27 00:00:00

  • Diagnostic Value of Recombinant Heparin-binding Hemagglutinin Adhesin Protein in Spinal Tuberculosis.

    abstract:Background and aim:To explore the diagnostic value of recombinant heparin-binding hemagglutinin adhesin (HBHA) protein antigen in spinal tuberculosis. Materials and methods:Forty patients with spinal tuberculosis were included in the experimental group and 40 healthy people were included in the control group. Serum Ig...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2020-0017

    authors: Pu F,Feng J,Niu F,Xia P

    更新日期:2020-02-28 00:00:00

  • The diagnosis and pathological value of combined detection of HE4 and CA125 for patients with ovarian cancer.

    abstract:OBJECTIVE:To evaluate the value of individual and combined measurement of human epididymis protein 4 (HE4) and cancer antigen 125 (CA-125) in the diagnosis of ovarian cancer. METHODS:A clinical case-control study was performed in which the levels of serum HE4 and CA-125 of subjects with malignant, borderline, benign o...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2016-0024

    authors: Zheng LE,Qu JY,He F

    更新日期:2016-05-06 00:00:00

  • Urgent arterial embolization of ruptured renal angiomyolipoma.

    abstract::The most undesired complication of renal angiomyolipoma (AML) is bleeding. Because of tumor rupture, the bleeding can spread to the retroperitoneal field and can be severe enough to be life threatening. We report a case of retroperitoneal hemorrhage caused by a ruptured AML that was successfully treated with transarte...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type:

    doi:10.1515/med-2015-0035

    authors: Kervancioglu S,Yilmaz F

    更新日期:2015-04-02 00:00:00

  • Garengeot's hernia: two case reports with CT diagnosis and literature review.

    abstract::Garengeot's hernia (GH) is defined as the presence of the appendix inside a femoral hernia. It occurs in 0.9% of femoral hernias and is usually an incidental finding during surgery. Its treatment is controversial and the aim of this article is to review the diagnostic methods and surgical considerations. We report two...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章,评审

    doi:10.1515/med-2016-0065

    authors: Garcia-Amador C,De la Plaza R,Arteaga V,Lopez-Marcano A,Ramia J

    更新日期:2016-10-07 00:00:00

  • Electromyography as an intraoperative test to assess the quality of nerve anastomosis - experimental study on rats.

    abstract:Background:Many factors contribute to successful nerve reconstruction. The correct technique of anastomosis is one of the key elements that determine the final result of a surgery. The aim of this study is to examine how useful an electromyography (EMG) can be as an objective intraoperative anastomosis assessment metho...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2020-0143

    authors: Czapla N,Bargiel P,Petriczko J,Kotrych D,Krajewski P,Prowans P

    更新日期:2020-06-13 00:00:00

  • Abnormal right hepatic artery injury resulting in right hepatic atrophy: diagnosed by laparoscopic cholecystectomy.

    abstract::An intact hepatic artery is the gateway to successful hepato-biliary surgery. Introduction of laproscopic cholecystectomy (LC) has stimulated a renewed interest in the anatomy of hepatic artery. In this case report we have highlighted importance of variations of right hepatic artery in terms of origin and course We pr...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2015-0090

    authors: Martino V,Ferrarese A,Bindi M,Marola S,Gentile V,Rivelli M,Ferrara Y,Enrico S,Berti S,Solej M

    更新日期:2015-12-17 00:00:00

  • Antibody Response to Live Attenuated Vaccines in Adults in Japan.

    abstract::The purpose of this study was to examine the efficacy rendered with a single dose of live attenuated measles, rubella, mumps, and varicella containing vaccine. We inoculated healthcare workers (HCWs) with a single dose of vaccine to a disease lacking in antibody titer for those not meeting the criteria of our hospital...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2016-0085

    authors: Ogawa T,Uchiyama-Nakamura F,Sugata-Tsubaki A,Yamada Y,Uno K,Kasahara K,Maeda K,Konishi M,Mikasa K

    更新日期:2016-11-26 00:00:00

  • Long non-coding RNA FOXD2-AS1 promotes cell proliferation, metastasis and EMT in glioma by sponging miR-506-5p.

    abstract::Long non-coding RNA forkhead box D2 adjacent opposite strand RNA 1 (FOXD2-AS1) has emerged as a potential oncogene in several tumors. However, its biological function and potential regulatory mechanism in glioma have not been fully investigated to date. In the present study, RT-qPCR was conducted to detect the levels ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2020-0175

    authors: Zhao J,Zeng XB,Zhang HY,Xiang JW,Liu YS

    更新日期:2020-09-30 00:00:00

  • Relationship of HS CRP and Sacroiliac Joint Inflammation in Undifferentiated Spondyloarthritis.

    abstract:Objective:Elevation of serum high sensitivity C-reactive protein (hs-CRP) level has been demonstrated as a risk factor for varying diseases, as well as a biomarker for predicting recovery after operation of lumber disc herniation. Our objective was to investigate the relationship between serum hs-CRP and sacroiliac (SI...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2018-0018

    authors: Liu TJ,Chang CC,Chen LC,Chu HY,Hsu CS,Chang ST

    更新日期:2018-05-19 00:00:00

  • Optimization of the Convolutional Neural Networks for Automatic Detection of Skin Cancer.

    abstract::Convolutional neural networks (CNNs) are a branch of deep learning which have been turned into one of the popular methods in different applications, especially medical imaging. One of the significant applications in this category is to help specialists make an early detection of skin cancer in dermoscopy and can reduc...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2020-0006

    authors: Zhang L,Gao HJ,Zhang J,Badami B

    更新日期:2020-01-13 00:00:00

  • Plastination: ethical and medico-legal considerations.

    abstract::The international plastination phenomenon has proved to be immensely popular with audiences world-wide. Never before has the human body been exposed to public gaze in such an accessible manner. The exhibitions have perplexed many, included anatomists, some of whom find the display of human bodies unethical. The object...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2016-0095

    authors: Bin P,Conti A,Buccelli C,Addeo G,Capasso E,Piras M

    更新日期:2016-12-16 00:00:00

  • Brainstem Anaesthesia after Retrobulbar Block.

    abstract::Regional anaesthesia techniques in ophthalmology are usually utilized for day case surgery. During various procedures, profound akinesia of the eye and anaesthesia of the surgical site are required, both of which are achieved with retrobulbar block. Due to the anatomy of the eye, life-threatening complications are pos...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2019-0025

    authors: Kostadinov I,Hostnik A,Cvenkel B,Potočnik I

    更新日期:2019-03-02 00:00:00

  • Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates.

    abstract::Not fully maturated immune system in preterm neonates may contribute to the increased susceptibility to infection. The levels of some cytokines can be useful in the prediction and diagnosis of sepsis in premature neonates. In the present study, we evaluated the potential predictive role of IFN-γ and IL-5 in cord and v...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2021-0206

    authors: Vucic J,Vucic M,Stankovic T,Stamenkovic H,Stankovic S,Zlatanovic D

    更新日期:2021-01-11 00:00:00

  • CXCL13 concentration in latent syphilis patients with treatment failure.

    abstract::We aimed to investigate the CXCL13 concentration of the serum and cerebral spinal fluid (CSF) in human immunodeficiency virus (HIV)-negative latent syphilis patients with treatment failure and explore the change in CXCL13 after treatment. Sixty-eight latent syphilis patients with treatment failure (failure group), 68 ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2020-0204

    authors: Zhang Y,Wang J,Wei Y,Liu H,Wu C,Qu B,Yan Y

    更新日期:2020-07-10 00:00:00

  • Expression and clinical significance of LXRα and SREBP-1c in placentas of preeclampsia.

    abstract:OBJECTIVE:To evaluate the expression and correlations of liver X receptor alpha (LXRa) and its target gene sterol regulatory element-binding protein-1c (SREBP-1c) in placentas of preeclampsia (PE) and their significance in PE. METHODS:Pregnancies were divided into two groups, 60 cases (29 cases of mild and 31 cases of...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章,评审

    doi:10.1515/med-2016-0057

    authors: Jianhua L,Xueqin M,Jifen H

    更新日期:2016-08-13 00:00:00

  • Research on the treatment of Pseudomonas aeruginosa pneumonia in children by macrolide antibiotics.

    abstract::To observe a therapeutic effect of macrolide antibiotics in children with Pseudomonas aeruginosa pneumonia. Fifty-four cases of children with Pseudomonas aeruginosa pneumonia were randomly divided into an observation group (n=30) and a control group (n=24). The observation group was treated with macrolide antibiotics ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2015-0082

    authors: Huang XQ,Deng L,Lu G,He CH,Wu PQ,Xie ZW,Ashraf MA

    更新日期:2015-12-17 00:00:00

  • A confusing case report of pulmonary langerhans cell histiocytosis and literature review.

    abstract::Pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare disease. From the insidious onset and nonspecific manifestations, it is difficult to diagnose PLCH. To help improve the diagnosis and therapy options of adult PLCH, we present this case report and literature review about a confusing case of PLCH. In this report,...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2016-0034

    authors: Li Y,Zhen W,Costable U,Jun X,Zhe R,YuPing M

    更新日期:2016-06-15 00:00:00

  • Color Doppler Ultrasound in Uterine Arterial Embolization.

    abstract:Objective:To observe and analyze the effect of color doppler ultrasonography (CDU) in uterine arterial embolization (UAE). Methods:160 cases of patients with uterine fibroid were selected in this study. CDU were performed on all patients before UAE as well as 5-9 days and 3-6 months after UAE, so as to observe the sha...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2017-0069

    authors: Jinhe R

    更新日期:2017-12-29 00:00:00

  • Differences of plasma IL-1 and TNF-α in healthy Chinese Population.

    abstract::Pleiotropic proinflammatory cytokines, interleukin- 1 (IL-1) and tumor necrosis factor-α (TNF-α), involved in the regulations of various immune responses, inflammatory processes and hematopoiesis. In the present study, the expression levels of IL-1 and TNF-α were detected by enzyme-linked immunosorbent assay (ELISA). ...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2015-0044

    authors: Yuan J,Wang L,Lin Y,Chen J,Hu J

    更新日期:2015-06-09 00:00:00

  • Pituitary Dysfunction from an Unruptured Ophthalmic Internal Carotid Artery Aneurysm with Improved 2-year Follow-up Results: A Case Report.

    abstract::Internal carotid artery (ICA) supraclinoid segment aneurysms extending into the sellar region and leading to pituitary dysfunction are a rare occurrence. To date, long-term follow up of pituitary function 2 years post-treatment has never been reported. Herein, we present a case of pituitary dysfunction due to an unrup...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2018-0021

    authors: Qi M,Ye M,Li M,Zhang P

    更新日期:2018-04-18 00:00:00

  • LncRNA LINC00152 Promotes Laryngeal Cancer Progression by Sponging MiR-613.

    abstract:Background:Long noncoding RNA (lncRNA) LINC00152 (CYTOR) has been reported to be upregulated and to serve as a diagnostic biomarker in multiple types of cancers, including laryngeal squamous cell cancer (LSCC). However, the functional role and molecular mechanisms of LINC00152 in LSCC progression need to be further inv...

    journal_title:Open medicine (Warsaw, Poland)

    pub_type: 杂志文章

    doi:10.1515/med-2020-0035

    authors: Zheng X,Dong S,Sun L,Xu J,Liu J,Hao R

    更新日期:2020-03-26 00:00:00