Safety of fecal microbiota transplantation in Chinese children: A single-center retrospective study.


BACKGROUND:Fecal microbiota transplantation (FMT) is the administration of fecal bacterial liquid from healthy donors to a recipient's digestive tract, which is recommended as a therapeutic method for recurrent Clostridium difficile infection (CDI). Many clinical trials focusing on different diseases are in progress. To date, scarce research and long-term follow-up have been conducted on FMT in children or on the proper guidelines. Our center first performed FMT to treat a 13-month-old boy with severe CDI in 2013. Until February 2018, our center had performed 114 pediatric FMT procedures in 49 subjects. AIM:To investigate the safety of FMT in children. METHODS:A retrospective study was conducted on 49 patients who underwent 114 FMT treatments at our hospital. All FMT processes followed uniform standards. Adverse events (AEs) related to FMT were divided into short-term (48 h post-FMT) and long-term (3 mo). All potential influencing factors for AEs, such as gender, age, time of FMT infusion, route of administration, disease type, immune function state, and donor relative genetic background, were analyzed as independent factors. The significant independent factors and risk ratio with 95% confidence interval (CI) were assessed by multivariate logistic regression analysis. RESULTS:Forty-nine patients (mean age 68.1 mo, range 4 to 193 mo) were recruited. Their average follow-up time after the first FMT was 23.1 mo. The incidence of short-term AEs was 26.32% (30/114). The most common short-term AEs were abdominal pain, diarrhea, fever, and vomiting, which were all self-limited and symptom-free within 48 h. Two severe AEs occurred, and one patient died in the fourth week after FMT. All-cause mortality was 2.04%. As independent factors, age (P = 0.006) and immune state (P = 0.002) had significant effects. Age greater than 72 mo seemed to be correlated with more AEs than age 13 to 36 mo (P = 0.04). In multivariate logistic regression analysis, immune state was an independent risk factor for AE occurrence (P = 0.035), and the risk ratio in immunodeficient patients was 3.105 (95%CI: 1.080-8.923). CONCLUSION:Although FMT was proven to be tolerated in children, we need to be more cautious with immunodeficient patients. The effect on children's long-term health is unpredictable.


World J Clin Cases


Zhang XY,Wang YZ,Li XL,Hu H,Liu HF,Li D,Xiao YM,Zhang T




Has Abstract


2018-12-26 00:00:00










  • Colovesical fistula as the initial manifestation of advanced colon cancer: A case report and review of literature.

    abstract::Colovesical fistulas (CVFs) are rare complications of very advanced cancers of the abdominal or pelvic cavity and often cause diagnostic troubles. CVFs are found more often in males, whereas females usually suffer from rectovaginal or vesicovaginal fistulas. This article presents a case of a female patient who was adm...

    journal_title:World journal of clinical cases



    authors: Skierucha M,Barud W,Baraniak J,Krupski W

    更新日期:2018-10-26 00:00:00

  • Leiomyosarcoma of the stomach: A case report.

    abstract:BACKGROUND:Leiomyosarcoma of the stomach is extremely rare, and only 13 cases have been reported in the literature. Before the advent of KIT immunohistochemistry, gastrointestinal stromal tumors (GISTs) were misdiagnosed as leiomyomas and leiomyosarcomas. Leiomyosarcoma rarely occurs in organs besides the uterus and is...

    journal_title:World journal of clinical cases



    authors: Kang WZ,Xue LY,Tian YT

    更新日期:2019-11-06 00:00:00

  • Impact of perioperative transfusion in patients undergoing resection of colorectal cancer liver metastases: A population-based study.

    abstract:BACKGROUND:Perioperative allogeneic blood transfusion is associated with poorer outcomes. AIM:To identify the factors that were associated with perioperative transfusion and to examine the impact of perioperative transfusion in patients undergoing resection of colorectal cancer (CRC) liver metastases. METHODS:The Uni...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Long B,Xiao ZN,Shang LH,Pan BY,Chai J

    更新日期:2019-05-26 00:00:00

  • Retrograde jejunogastric intussusception following Braun's jejunojejunostomy.

    abstract::Jejunogastric intussusception is a rare long term complication of Billroth II gastrectomy. The case reported here is a 50 year old man with history of a Billroth II gastrectomy and Braun's side-to-side jejunojejunal anastomosis who presented with hematemesis. On abdominal examination, there was a mass in the left ilia...

    journal_title:World journal of clinical cases



    authors: Gopal R,Elamurugan TP,Hage S,Muthukumarassamy R,Kate V

    更新日期:2014-01-16 00:00:00

  • Photodynamic therapy for middle-advanced stage upper gastrointestinal carcinomas: A systematic review and meta-analysis.

    abstract:AIM:To determine the therapeutic effect of photodynamic therapy (PDT) for middle-advanced stage upper gastrointestinal carcinomas. METHODS:We searched PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database from inception to Apr...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Chen B,Xiong L,Chen WD,Zhao XH,He J,Zheng YW,Kong FH,Liu X,Zhang ZJ,Miao XY

    更新日期:2018-11-06 00:00:00

  • Expander implantation for correction of high-riding nipple with enlarged nipple-areola complex using revision mastopexy: A case report.

    abstract:BACKGROUND:High-riding nipple is one of the common complications after mastopexty and breast reconstruction. However, to date, a limited number of techniques have concentrated on how to lower the high-riding nipple with enlarged areola. CASE SUMMARY:This is a case report describing a combination of surgical techniques...

    journal_title:World journal of clinical cases



    authors: Qin F,Yu NZ,Yang E,Zeng A,Hao Y,Zhu L,Wang XJ

    更新日期:2020-05-06 00:00:00

  • Allergic fungal rhinosinusitis accompanied by allergic bronchopulmonary aspergillosis: A case report and literature review.

    abstract:BACKGROUND:Concomitant allergic fungal rhinosinusitis (AFRS) and allergic bronchopulmonary aspergillosis (ABPA) are extremely rare, with no more than 20 cases reported in the English literature. CASE SUMMARY:A 52-year-old female patient complained of right-sided nasal obstruction, rhinorrhea, sneezing, epistaxis, and ...

    journal_title:World journal of clinical cases



    authors: Cheng KJ,Zhou ML,Liu YC,Zhou SH

    更新日期:2019-11-26 00:00:00

  • Treatment of afferent loop syndrome using fluoroscopic-guided nasointestinal tube placement: Two case reports.

    abstract:BACKGROUND:Afferent loop syndrome (ALS) is a rare mechanical complication that occurs after reconstruction of the stomach or esophagus to the jejunum, such as Billroth II gastrojejunostomy, Roux-en-Y gastrojejunostomy, or Roux-en-Y esophagoje-junostomy. Traditionally, an operation is the first choice for benign causes....

    journal_title:World journal of clinical cases



    authors: Hu HT,Ma FH,Wu ZM,Qi XH,Zhong YX,Xie YB,Tian YT

    更新日期:2020-11-06 00:00:00

  • Association between resting energy expenditure, psychopathology and HPA-axis in eating disorders.

    abstract:AIM:To investigate the complex relationships between resting energy expenditure (REE), eating psychopathology, and Hypothalamus Pituitary Adrenal axis functioning in patients with eating disorders. METHODS:The study was designed as a cross-sectional survey, and it was planned by the Clinic for Eating Disorders of the ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Castellini G,Castellani W,Lelli L,Sauro CL,Dini C,Lazzeretti L,Bencini L,Mannucci E,Ricca V

    更新日期:2014-07-16 00:00:00

  • Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature.

    abstract:BACKGROUND:Micronodular thymic tumors with lymphoid stroma include micronodular thymoma with lymphoid stroma (MNT) and micronodular thymic carcinoma with lymphoid hyperplasia (MNC), whose micromorphological features are lymphoid stromal hyperplasia and nodular arrangement of tumor epithelial cells. This type of tumor i...

    journal_title:World journal of clinical cases



    authors: Wang B,Li K,Song QK,Wang XH,Yang L,Zhang HL,Zhong DR

    更新日期:2019-12-06 00:00:00

  • Leveraging machine learning techniques for predicting pancreatic neuroendocrine tumor grades using biochemical and tumor markers.

    abstract:BACKGROUND:The incidence of pancreatic neuroendocrine tumors (PNETs) is now increasing rapidly. The tumor grade of PNETs significantly affects the treatment strategy and prognosis. However, there is still no effective way to non-invasively classify PNET grades. Machine learning (ML) algorithms have shown potential in i...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Zhou RQ,Ji HC,Liu Q,Zhu CY,Liu R

    更新日期:2019-07-06 00:00:00

  • Dysbetalipoproteinemia: Two cases report and a diagnostic algorithm.

    abstract::Dysbetalipoproteinemia is a rare familial dyslipidemia characterized by approximately equally elevated serum cholesterol and triglyceride levels due to accumulated remnant lipoproteins in apolipoprotein E2/E2 homozygotes. It is associated with an increased risk for premature cardiovascular disease. Thus, making a diag...

    journal_title:World journal of clinical cases



    authors: Kei A,Miltiadous G,Bairaktari E,Hadjivassiliou M,Cariolou M,Elisaf M

    更新日期:2015-04-16 00:00:00

  • Passage of nasogastric tube through tracheo-esophageal fistula into stomach: A rare event.

    abstract::Esophageal atresia with tracheo-oesophageal fistula (TEF) occurs in 1 in 3500 live births. Anorectal malformation is found to be associated with 14% of TEF. Esophageal atresia with TEF is a congenital anomaly which classically presents as excessive frothing from the mouth and respiratory distress. Rarely gastric posit...

    journal_title:World journal of clinical cases



    authors: Kamble RS,Gupta R,Gupta A,Kothari P,Dikshit KV,Kesan K,Mudkhedkar K

    更新日期:2014-07-16 00:00:00

  • Highlighting the importance of early diagnosis in progressive multi-organ involvement of IgG4-related disease: A case report and review of literature.

    abstract::IgG4-related disease (IgG4-RD) is an increasingly recognized pathological entity that tends to involve multiple organs with an elevated level of serum IgG4, which is easily misdiagnosed owing to sharing common clinical features with a variety of other diseases. Here, we report an interesting IgG4-RD case of a woman wi...

    journal_title:World journal of clinical cases



    authors: Xue J,Wang XM,Li Y,Zhu L,Liu XM,Chen J,Chi SH

    更新日期:2018-11-06 00:00:00

  • Usefulness of ultrasonography to assess the response to steroidal therapy for the rare case of type 2b immunoglobulin G4-related sclerosing cholangitis without pancreatitis: A case report.

    abstract:BACKGROUND:A type 2b immunoglobulin G4 (IgG4)-related sclerosing cholangitis (SC) without autoimmune pancreatitis is a rare condition with IgG4-SC. While the variety of the imaging modalities have tested its usefulness in diagnosing the IgG4-SC, however, the usage of ultrasonography for the assessment of the response t...

    journal_title:World journal of clinical cases



    authors: Tanaka Y,Kamimura K,Nakamura R,Ohkoshi-Yamada M,Koseki Y,Mizusawa T,Ikarashi S,Hayashi K,Sato H,Sakamaki A,Yokoyama J,Terai S

    更新日期:2020-11-26 00:00:00

  • Dydrogesterone treatment for menstrual-cycle regularization in abnormal uterine bleeding - ovulation dysfunction patients.

    abstract:BACKGROUND:Dydrogesterone has shown significant efficacy in treatment of irregular menstrual cycle due to abnormal uterine bleeding - ovulation dysfunction (AUB-O), but there were few relevant studies. This observational study was designed to evaluate the effectiveness of dydrogesterone for the treatment of Chinese pat...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Wang L,Guan HY,Xia HX,Chen XY,Zhang W

    更新日期:2020-08-06 00:00:00

  • Clinical outcomes for Conduits and Scaffolds in peripheral nerve repair.

    abstract::The gold standard of peripheral nerve repair is nerve autograft when tensionless repair is not possible. Use of nerve autograft has several shortcomings, however. These include limited availability of donor tissue, sacrifice of a functional nerve, and possible neuroma formation. In order to address these deficiencies,...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: Gerth DJ,Tashiro J,Thaller SR

    更新日期:2015-02-16 00:00:00

  • Predictive value of serum cystatin C for risk of mortality in severe and critically ill patients with COVID-19.

    abstract:BACKGROUND:The outbreak of coronavirus disease 2019 (COVID-19) has rapidly evolved into a global pandemic. COVID-19 is clinically categorized into mild, moderate, severe, and critical illness. Acute kidney injury is an independent risk factor for poor prognosis in patients with. Serum cystatin C (sCys C) is considered ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Li Y,Yang S,Peng D,Zhu HM,Li BY,Yang X,Sun XL,Zhang M

    更新日期:2020-10-26 00:00:00

  • Jejunal cavernous lymphangioma manifested as gastrointestinal bleeding with hypogammaglobulinemia in adult: A case report and literature review.

    abstract:BACKGROUND:Lymphangioma is a benign lesion that rarely involves the gastrointestinal tract, especially in adults. Small bowel lymphangioma is a rare cause of gastrointestinal bleeding. Here, we report a case of an adult diagnosed with jejunal lymphangioma presenting with melena, anemia and hypogammaglobulinemia. We als...

    journal_title:World journal of clinical cases



    authors: Tan B,Zhang SY,Wang YN,Li Y,Shi XH,Qian JM

    更新日期:2020-01-06 00:00:00

  • Tattooing: A potential novel risk factor for iliopsoas abscess.

    abstract::Iliopsoas abscess (IPA) is an uncommon infection. The clinical presentation is usually insidious. Most patients present with nonspecific symptoms, leading to difficulty in prompt and accurate diagnosis. Delay in diagnosis can lead to complications, such as sepsis and death. Tattooing has become more popular over the r...

    journal_title:World journal of clinical cases



    authors: Gulati S,Jain A,Sattari M

    更新日期:2014-09-16 00:00:00

  • A large basal cell adenoma extending to the ipsilateral skull base and mastoid in the right parotid gland: A case report.

    abstract:BACKGROUND:Basal cell adenoma (BCA) is a rare benign tumour that has unique histological characteristics and primarily arises in the parotid glands. According to published reports, nearby tissue destruction by BCA seems impossible. CASE SUMMARY:We presented a case of a 54-year-old woman with a mass in the deep lobe of...

    journal_title:World journal of clinical cases



    authors: Du LY,Weng XH,Shen ZY,Cheng B

    更新日期:2019-06-06 00:00:00

  • Adult-onset mitochondrial encephalopathy in association with the MT-ND3 T10158C mutation exhibits unique characteristics: A case report.

    abstract:BACKGROUND:Mitochondrial diseases are a heterogenous group of multisystemic disorders caused by genetic mutations affecting mitochondrial oxidation function. Brain involvement is commonly found in most cases but rarely as the unique clinical manifestation. Since the knowledge of its clinical manifestation combined with...

    journal_title:World journal of clinical cases



    authors: Fu XL,Zhou XX,Shi Z,Zheng WC

    更新日期:2019-05-06 00:00:00

  • Diagnosis and management of glandular papilloma of lung: A case report.

    abstract:BACKGROUND:Solitary respiratory papilloma is a rare epithelial tumor that can be categorized into multiple subtypes depending on tumor location, histological presentation and number. The glandular type is the rarest, with only 30 cases available within the field. Hence, information on its identification and treatment i...

    journal_title:World journal of clinical cases



    authors: Wu CW,Chen A,Huang TW

    更新日期:2020-03-26 00:00:00

  • Severe isolated sciatic neuropathy due to a modified lotus position.

    abstract::A 51-year-old man presented to our hospital with progressive pain and weakness in his right leg. Neurological examination revealed atrophy of all muscles of the right leg, unilateral foot drop and paralysis of the anterior tibial and gastrocnemicus muscles. Electromyography confirmed a severe isolated sciatic neuropat...

    journal_title:World journal of clinical cases



    authors: Bosma JW,Wijntjes J,Hilgevoord TA,Veenstra J

    更新日期:2014-02-16 00:00:00

  • Modified procedure for prolapse and hemorrhoids: Lower recurrence, higher satisfaction.

    abstract:BACKGROUND:Hemorrhoidal prolapse is a common benign disease with a high incidence. The treatment procedure for prolapse and hemorrhoids (PPH) remains an operative method used for internal hemorrhoid prolapse. Although it is related to less pos-operative pain, faster recovery and shorter hospital stays, the postoperativ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Chen YY,Cheng YF,Wang QP,Ye B,Huang CJ,Zhou CJ,Cai M,Ye YK,Liu CB

    更新日期:2021-01-06 00:00:00

  • Surgical resection of a large hypopharyngeal hemangioma in an adult using neodymium-doped yttrium aluminum garnet laser: A case report.

    abstract:BACKGROUND:Generally, hemangiomas do not require surgical intervention; however, cases of large hemangiomas, potentially involving the throat and trachea, necessitate surgical therapy. Here, we present a case of hypopharyngeal hemangioma in an adult that was successfully treated with neodymium-doped yttrium aluminum ga...

    journal_title:World journal of clinical cases



    authors: Jin M,Wang CY,Da YX,Zhu W,Jiang H

    更新日期:2020-03-06 00:00:00

  • Pedunculated colonic lipoma prolapsing through the anus.

    abstract::Colorectal lipomas are the second most common benign tumors of the colon. These masses are typically incidental findings with over 94% being asymptomatic. Symptoms-classically abdominal pain, bleeding per rectum and alterations in bowel habits-may arise when lipomas become larger than 2 cm in size. Colonic lipomas are...

    journal_title:World journal of clinical cases



    authors: Ghanem OM,Slater J,Singh P,Heitmiller RF,DiRocco JD

    更新日期:2015-05-16 00:00:00

  • Human herpesvirus-8 positive iatrogenic Kaposi's sarcoma in the setting of refractory ulcerative colitis.

    abstract::Although Kaposi sarcoma (KS) has been more traditionally considered an AIDS-defining illness, it may also be seen in individuals on immunosuppresive therapy. We report a case of a patient who presented to the hospital in the setting of increasingly refractory ulcerative colitis. Computed tomography scan of the abdomen...

    journal_title:World journal of clinical cases



    authors: Duh E,Fine S

    更新日期:2017-12-16 00:00:00

  • Sebaceous lymphadenocarcinoma of the parotid gland: A case report.

    abstract:BACKGROUND:Sebaceous lymphadenoma is a benign tumor that occurs rarely in the salivary glands, most commonly in the parotid glands or periparotid lymph nodes, and even more rarely undergoes malignant transformation into a sebaceous lymphadenocarcinoma. CASE SUMMARY:We report an 82-year-old woman who presented with a p...

    journal_title:World journal of clinical cases



    authors: Hao FY,Wang YL,Li SM,Xue LF

    更新日期:2020-11-26 00:00:00

  • Relationship between homocysteine level and prognosis of elderly patients with acute ischemic stroke treated by thrombolysis with recombinant tissue plasminogen activator.

    abstract:BACKGROUND:Acute ischemic stroke (AIS) is mainly caused by cerebral blood flow disorders, which further leads to ischemic brain necrosis or encephalomalacia. The role of homocysteine (Hcy), an independent risk factor for cardiovascular disease, in the development of atherosclerosis is gradually revealed. However, studi...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Li J,Zhou F,Wu FX

    更新日期:2019-11-26 00:00:00