HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes.

abstract：:Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. Since strong consensus regarding commonly altered MRs in hepatocellular carcinoma (HCC) is lacking, we generated a compendium of HCC datasets from 21 studies and identified a c...

journal_title：Aging

authors： Li Z,Lou Y,Tian G,Wu J,Lu A,Chen J,Xu B,Shi J,Yang J

更新日期：2019-12-18 00:00:00

abstract：:Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis ...

journal_title：Aging

authors： Wang C,Just A,Heiss J,Coull BA,Hou L,Zheng Y,Sparrow D,Vokonas PS,Baccarelli A,Schwartz J

更新日期：2020-06-19 00:00:00

abstract：:Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs. Consecutive patients with IAs who underwent endovascular treatment (...

journal_title：Aging

authors： Zhang B,Lin L,Yuan F,Song G,Chang Q,Wu Z,Miao Z,Mo D,Huo X,Liu A

更新日期：2021-02-01 00:00:00

abstract：:The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy induced in brain cells. In Alzheimer's Disease, T-cells were identified as important...

journal_title：Aging

authors： Fischer M,Ruhnau J,Schulze J,Obst D,Flöel A,Vogelgesang A

更新日期：2020-06-30 00:00:00

abstract：:Cognitive dysfunction caused by chronic cerebral hypoperfusion is a common underlying cause of many cognition-related neurodegenerative diseases. The mechanisms of cognitive dysfunction caused by CCH are not clear. Long non-coding RNA is involved in synaptic plasticity and cognitive function, but whether lncRNA is inv...

journal_title：Aging

authors： Yao ZH,Wang J,Shen BZ,Li YT,Yao XL,Zhang SF,Zhang Y,Hu JC,Xie YC

更新日期：2020-10-11 00:00:00

abstract：:Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...

journal_title：Aging

authors： Yang Y,Jia Y,Sun Q,Dong H,Zhao R

更新日期：2019-03-28 00:00:00

abstract：:Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...

journal_title：Aging

authors： Tian Y,Yang J,Lan M,Zou T

更新日期：2020-12-26 00:00:00

abstract：:Bladder cancer is the most commonly diagnosed malignant tumor in urological system worldwide. The relationship between GSG2 and bladder cancer has not been demonstrated and remains unclear. In this study, it was demonstrated that GSG2 was up-regulated in bladder cancer tissues compared with the normal tissues and its ...

journal_title：Aging

authors： Chen Y,Fu D,Zhao H,Cheng W,Xu F

更新日期：2020-05-21 00:00:00

abstract：:Mounting evidence suggests that noncoding RNAs (ncRNAs) contribute to the pathogenesis of cardiovascular diseases. However, their role in essential hypertension (EH) is still unclear. We therefore identified differentially expressed long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in EH patients from a high-...

journal_title：Aging

authors： Yin L,Yao J,Deng G,Wang X,Cai W,Shen J

更新日期：2020-05-11 00:00:00

abstract：:Bladder cancer (BC) is one of the most commonly diagnosed urologic carcinomas, with high recurrence and death rates. Circular RNAs (circRNAs) are a class of noncoding RNAs which are anomalously expressed in cancers and involved in the progression of cancers. In this study, we found that circSEMA5A was upregulated in B...

journal_title：Aging

authors： Wang L,Li H,Qiao Q,Ge Y,Ma L,Wang Q

更新日期：2020-11-07 00:00:00

abstract：:Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEsche...

journal_title：Aging

authors： Noren Hooten N,Fitzpatrick M,Kompaniez K,Jacob KD,Moore BR,Nagle J,Barnes J,Lohani A,Evans MK

更新日期：2012-10-01 00:00:00

abstract：:Expansion of polyglutamine stretch in the huntingtin (HTT) protein is a major cause of Huntington's disease (HD). The polyglutamine part in HTT interacts with various proteins implicated in epigenetic regulation of genes, suggesting that mutant HTT may disturb the integrity of the epigenetic system. Here, we used a PC...

journal_title：Aging

authors： Park M,Min B,Jeon K,Cho S,Park JS,Kim J,Jeon J,Song J,Kim S,Jeong S,Seo H,Kang YK

更新日期：2017-03-12 00:00:00

abstract：:Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...

journal_title：Aging

authors： Soare A,Weiss EP,Holloszy JO,Fontana L

更新日期：2014-02-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been reported to be involved in many diseases. But there is no report on circRNAs in non-obstructive azoospermia (NOA). The purpose of this paper is to explore the circular RNA expression profile and potential functions of circRNAs in NOA patients. We first preformed circRNA expression pr...

journal_title：Aging

authors： Bo H,Liu Z,Tang R,Gong G,Wang X,Zhang H,Zhu F,Zhou D,Zhu W,Tan Y,Fan L

更新日期：2020-02-06 00:00:00

abstract：:Myocardial infarction is a cardiovascular disease with high mortality. Human umbilical cord mesenchymal stem cells (hUC-MSCs) with strong self-renewal capacity and multipotency, provide the possibility of replacing injured cardiomyocytes. hUC-MSCs were cultured on polyacrylamide hydrogels with stiffnesses correspondin...

journal_title：Aging

authors： Sun Y,Liu J,Xu Z,Lin X,Zhang X,Li L,Li Y

更新日期：2020-12-09 00:00:00

abstract：:Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood. In eukaryotic cells, methionine can be converted to cysteine thr...

journal_title：Aging

authors： Albertini E,Kozieł R,Dürr A,Neuhaus M,Jansen-Dürr P

更新日期：2012-10-01 00:00:00

abstract：:Long intergenic nonprotein-coding RNA 00514 (LINC00514) is upregulated in papillary thyroid cancer and contributes to its aggressiveness. In this study, we thoroughly explored the expression profile, specific functions, and relevant molecular mechanism of LINC00514 in osteosarcoma (OS). Herein, LINC00514 was significa...

journal_title：Aging

authors： Yu D,Xu X,Li S,Zhang K

更新日期：2020-04-23 00:00:00

abstract：:The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...

journal_title：Aging

authors： Zheng HX,Zhao Y,Xu Y,Zhang ZJ,Zhu JJ,Fan YF,Lin N

更新日期：2019-06-19 00:00:00

abstract：:To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g) of enriched BCAA ...

journal_title：Aging

authors： Ko CH,Wu SJ,Wang ST,Chang YF,Chang CS,Kuan TS,Chuang HY,Chang CM,Chou W,Wu CH

更新日期：2020-07-26 00:00:00

abstract：:The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal-epidermal junction, a cell surface-associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perle...

journal_title：Aging

authors： Dos Santos M,Michopoulou A,André-Frei V,Boulesteix S,Guicher C,Dayan G,Whitelock J,Damour O,Rousselle P

更新日期：2016-04-01 00:00:00

abstract：:Age-related hearing loss (ARHL) has been considered as a promising modifiable risk factor for cognitive impairment and dementia. Nonetheless, it is still unclear whether age-related hearing loss associates with neurodegenerative biomarkers of Alzheimer's disease (AD). Participants with ARHL were selected from the esta...

journal_title：Aging

authors： Xu W,Zhang C,Li JQ,Tan CC,Cao XP,Tan L,Yu JT,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2019-05-22 00:00:00

abstract：:PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...

journal_title：Aging

authors： Kunstmann B,Osiewacz HD

更新日期：2009-03-03 00:00:00

abstract：:The study was aimed at evaluation of the role of secondary oxidative stress in the stress-induced premature senescence (SIPS) of human fibroblasts induced by H2O2. Two fibroblast lines were used: lung MRC-5 and ear H8F2p25LM fibroblasts. The lines differed considerably in sensitivity to H2O2 (IC50 of 528 and 33.5 μM, ...

journal_title：Aging

authors： Pieńkowska N,Bartosz G,Pichla M,Grzesik-Pietrasiewicz M,Gruchala M,Sadowska-Bartosz I

更新日期：2020-01-21 00:00:00

abstract：:Aging is associated with the accumulation of DNA damage. High expression of DNA repair genes has been suggested to contribute to prolonged lifespan in several organisms. However, the crucial DNA repair genes contributing to longevity remain unknown. Termite kings have an extraordinary long lifespan compared with that ...

journal_title：Aging

authors： Tasaki E,Mitaka Y,Nozaki T,Kobayashi K,Matsuura K,Iuchi Y

更新日期：2018-10-11 00:00:00

abstract：:Cardiomyocyte apoptosis is a major cause of myocardial ischemia/reperfusion (MI/R) injury, in which the activation of the signal transducer and activator of transcription 1 (STAT1) plays an important role. The E3-ubiquitin ligase TRIM6 has been implicated in regulating STAT1 activity, however, whether it is associated...

journal_title：Aging

authors： Zeng G,Lian C,Yang P,Zheng M,Ren H,Wang H

更新日期：2019-06-06 00:00:00

abstract：:Alternative splicing (AS) changes are considered to be critical in predicting treatment response. Our study aimed to investigate differential splicing patterns and to elucidate the role of splicing factor (SF) as prognostic markers of low-grade glioma (LGG). We downloaded RNA-seq data from a cohort of 516 LGG tumors i...

journal_title：Aging

authors： Liu WR,Li CY,Xu WH,Liu XJ,Tang HD,Huang HN

更新日期：2020-07-13 00:00:00

abstract：:Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...

journal_title：Aging

authors： Nie J,Sui L,Zhang H,Zhang H,Yan K,Yang X,Lu S,Lu K,Liang X

更新日期：2019-10-06 00:00:00

abstract：:Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability. However, the link between a high salt diet (HSD) and the breakdown of tight junctions (TJs) remains unclear. In the present study, we found that high salt d...

journal_title：Aging

authors： Deng Z,Zhou L,Wang Y,Liao S,Huang Y,Shan Y,Tan S,Zeng Q,Peng L,Huang H,Lu Z

更新日期：2020-06-22 00:00:00

abstract：:Atg7, a critical component of autophagy machinery, is essential for counteracting hematopoietic aging. However, the non-autophagic role of Atg7 on hematopoietic cells remains fundamentally unclear. In this study, we found that loss of Atg7, but not Atg5, another autophagy-essential gene, in the hematopoietic system re...

journal_title：Aging

authors： Fang Y,Gu Y,Li L,Zhu L,Qian J,Zhao C,Xu L,Wei W,Du Y,Yuan N,Zhang S,Yuan Y,Xu Y,Jiang C,Wang J

更新日期：2020-11-24 00:00:00

abstract：:Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncan...

journal_title：Aging

authors： Yao Y,Wang X,Zhou D,Li H,Qian H,Zhang J,Jiang L,Wang B,Lin Q,Zhu X

更新日期：2020-07-02 00:00:00