当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism.

Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism.

Abstract：

BACKGROUND:Intake of ω-3 PUFAs have been demonstrated to have positive effects on pregnancy outcome, whose receptor, GPR120, regulates several cellular functions including differentiation, metabolism and immune reaction. However, whether GPR120 is involved in decidualization and pregnancy remains unknown. METHODS:Decidua tissue from women with normal pregnancy and spontaneous abortion were collected to determine the expression profile of GPR120. Abortion mouse models and artificially induced deciduoma in mice were established to evaluate the effect of GPR120 on pregnancy outcome and in vivo decidualization. HESCs and primary DSCs were used to explore the roles of GPR120 in decidualization and mechanisms involved. FINDINGS:We found that GPR120 functioned to promote decidualization by upregulating glucose uptake and pentose-phosphate pathway (PPP) of human endometrial stromal cells. Firstly, the expression of GPR120 in decidua of spontaneous abortion was downregulated compared to normal decidua. Lack of GPR120 predisposed mice to LPS or RU486 induced abortion. Decidualization was augmented by GPR120 via improving GLUT1-mediated glucose uptake and G6PD- mediated PPP. FOXO1 was upregulated by GPR120 via activation of ERK1/2 and AMPK signaling and increased the expression of GLUT1. Furthermore, the expression of chemokines and cytokines in decidual stromal cells was enhanced by GPR120. Lastly, GPR120 agonist ameliorated LPS-induced abortion in the mice. INTERPRETATION:GPR120 plays significant roles in decidualization and the maintenance of pregnancy, which might be a potential target for diagnosis and treatment of spontaneous abortion. FUND: Ministry of Science and Technology of China, National Natural Science Foundation of China, the Program of Science and Technology Commission of Shanghai Municipality.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Huang J,Xue M,Zhang J,Yu H,Gu Y,Du M,Ye W,Wan B,Jin M,Zhang Y

doi

10.1016/j.ebiom.2018.12.019

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

540-551

issn

2352-3964

pii

S2352-3964(18)30596-6

journal_volume

39

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment.

    abstract：BACKGROUND:Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. METHODS:Patient-derived GBM cells were engineered by CRISPR/Cas9-assisted knock-in of an inducib...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.03.064

    authors： Tejero R,Huang Y,Katsyv I,Kluge M,Lin JY,Tome-Garcia J,Daviaud N,Wang Y,Zhang B,Tsankova NM,Friedel CC,Zou H,Friedel RH

    更新日期：2019-04-01 00:00:00

  • Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug.

    abstract：:The last major advance in the treatment of glioblastoma multiforme (GBM) was the introduction of temozolomide in 1999. Treatment with temozolomide following surgical debulking extends survival rate compared to radiotherapy and debulking alone. However, virtually all glioblastoma patients experience disease progression...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.08.013

    authors： Sharpe MA,Livingston AD,Gist TL,Ghosh P,Han J,Baskin DS

    更新日期：2015-08-08 00:00:00

  • Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury.

    abstract：:Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown. Here we identify two enzymes that regulate the balance of LPA1 ubiquitinati...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.07.020

    authors： Zhao J,Wei J,Dong S,Bowser RK,Zhang L,Jacko AM,Zhao Y

    更新日期：2016-08-01 00:00:00

  • Evaluation of antiviral - passive - active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice.

    abstract：BACKGROUND:Chronic Hepatitis B (CHB) remains a major problem for global public health. Viral persistence and immune defects are the two major reasons for CHB, and it was hypothesized that based on a transient clearance of serum viral DNA and HBsAg "window stage", active immunization against hepatitis B virus (HBV) migh...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.043

    authors： Shi B,Wu Y,Wang C,Li X,Yu F,Wang B,Yang Z,Li J,Liang M,Wen Y,Ying T,Yuan Z

    更新日期：2019-11-01 00:00:00

  • Proteins mimicking epitope of HIV-1 virus neutralizing antibody induce virus-neutralizing sera in mice.

    abstract：BACKGROUND:The development of an effective vaccine preventing HIV-1 infection is hindered by the enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutralizing antibody. Functional studies of rare elite neutralizers led to t...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.07.015

    authors： Kosztyu P,Kuchar M,Cerny J,Barkocziova L,Maly M,Petrokova H,Czernekova L,Liskova V,Raskova Kafkova L,Knotigova P,Masek J,Turanek J,Maly P,Raska M

    更新日期：2019-09-01 00:00:00

  • A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis.

    abstract：BACKGROUND:Tumor necrosis factor-like weak inducer of apoptosis (Tnfsf12; TWEAK) and its receptor Fibroblast growth factor-inducible 14 (Tnfrsf12a; Fn14) participate in the inflammatory response associated with vascular remodeling. However, the functional effect of TWEAK on vascular smooth muscle cells (VSMCs) is not c...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.07.072

    authors： Méndez-Barbero N,Gutierrez-Muñoz C,Madrigal-Matute J,Mínguez P,Egido J,Michel JB,Martín-Ventura JL,Esteban V,Blanco-Colio LM

    更新日期：2019-08-01 00:00:00

  • Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks.

    abstract：:Ageing is a leading risk factor for many debilitating diseases. While age-related diseases have been the subject of over a century of intense investigation, until recently, physiological ageing was considered unavoidable. Pharmacological and genetic studies have since shown that ageing is a malleable process and that ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2016.11.020

    authors： Mallikarjun V,Swift J

    更新日期：2016-12-01 00:00:00

  • High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation.

    abstract：BACKGROUND:Urea, the end product of protein metabolism, has been considered to have negligible toxicity for a long time. Our previous study showed a depression phenotype in urea transporter (UT) B knockout mice, which suggests that abnormal urea metabolism may cause depression. The purpose of this study was to determin...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.09.049

    authors： Wang H,Huang B,Wang W,Li J,Chen Y,Flynn T,Zhao M,Zhou Z,Lin X,Zhang Y,Xu M,Li K,Tian K,Yuan D,Zhou P,Hu L,Zhong D,Zhu S,Li J,Chen D,Wang K,Liang J,He Q,Sun J,Shi J,Yan L,Sands JM,Xie Z,Lian X,Xu

    更新日期：2019-10-01 00:00:00

  • Programming and Regulation of Metabolic Homeostasis by HDAC11.

    abstract：:Histone deacetylases (HDACs) are enzymes that regulate protein functions by catalyzing the removal of acetyl and acyl groups from lysine residues. They play pivotal roles in governing cell behaviors and are indispensable in numerous biological processes. HDAC11, the last identified and sole member of class IV HDACs, w...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.06.025

    authors： Sun L,Marin de Evsikova C,Bian K,Achille A,Telles E,Pei H,Seto E

    更新日期：2018-07-01 00:00:00

  • Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection.

    abstract：BACKGROUND:Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103129

    authors： Novelli S,Lécuroux C,Goujard C,Reynes J,Villemant A,Blum L,Essat A,Avettand-Fenoël V,Launay O,Molina JM,Bourgeois C,Meyer L

    更新日期：2020-12-01 00:00:00

  • Improving B-mode ultrasound diagnostic performance for focal liver lesions using deep learning: A multicentre study.

    abstract：BACKGROUND:The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network of US (DCNN-US) for aiding radiologists in classification of malignant from benign FLLs. MATERIALS AND METHODS:This study was conducted in 13 hosp...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102777

    authors： Yang Q,Wei J,Hao X,Kong D,Yu X,Jiang T,Xi J,Cai W,Luo Y,Jing X,Yang Y,Cheng Z,Wu J,Zhang H,Liao J,Zhou P,Song Y,Zhang Y,Han Z,Cheng W,Tang L,Liu F,Dou J,Zheng R,Yu J,Tian J,Liang P

    更新日期：2020-06-01 00:00:00

  • Immunolocalization and Distribution of Rubella Antigen in Fatal Congenital Rubella Syndrome.

    abstract：BACKGROUND:An estimated 100,000 cases of congenital rubella syndrome (CRS) occur worldwide each year. The reported mortality rate for infants with CRS is up to 33%. The cellular mechanisms responsible for the multiple congenital defects in CRS are presently unknown. Here we identify cell types positive for rubella viru...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.11.050

    authors： Lazar M,Perelygina L,Martines R,Greer P,Paddock CD,Peltecu G,Lupulescu E,Icenogle J,Zaki SR

    更新日期：2015-11-27 00:00:00

  • Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania.

    abstract：BACKGROUND:The contribution of hepcidin as a regulator of iron metabolism & erythropoiesis on the severity of anemia in sickle cell disease (SCD) remains poorly characterized, especially in Sub-Saharan African populations. The aims of the study were to determine if hepcidin is associated with severity of steady-state a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.07.024

    authors： Lee N,Makani J,Tluway F,Makubi A,Armitage AE,Pasricha SR,Drakesmith H,Prentice AM,Cox SE

    更新日期：2018-08-01 00:00:00

  • Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1.

    abstract：BACKGROUND:A newly developed drug trastuzumab emtansine (T-DM1) has improved the survival of breast cancer (BC) patients. Despite an impressive initial clinical response, a subgroup of patient develop resistance and present therapeutic challenges. The underlying resistance mechanisms are not fully investigated. We repo...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.061

    authors： Islam SS,Uddin M,Noman ASM,Akter H,Dity NJ,Basiruzzman M,Uddin F,Ahsan J,Annoor S,Alaiya AA,Al-Alwan M,Yeger H,Farhat WA

    更新日期：2019-05-01 00:00:00

  • Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial.

    abstract：BACKGROUND:In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24Gag vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART) received six immunizations over 18weeks, followed by analytical treatment interruption (ATI) between weeks 28 and 52. Cell-mediated immune responses...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.09.028

    authors： Huang Y,Pantaleo G,Tapia G,Sanchez B,Zhang L,Trondsen M,Hovden AO,Pollard R,Rockstroh J,Ökvist M,Sommerfelt MA

    更新日期：2017-10-01 00:00:00

  • EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure.

    abstract：BACKGROUND:Recurrent implantation failure (RIF) remains a critical and challenging problem in assisted reproductive technology mainly due to impaired decidualization. The endocytic and transcytotic activity in the endometrium are crucial for decidualization. The most representative endocytic gene is the C-terminal Eps1...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.018

    authors： Zhou Q,Yan G,Ding L,Liu J,Yu X,Kong S,Zhang M,Wang Z,Liu Y,Jiang Y,Kong N,Sun J,Sun H

    更新日期：2019-12-01 00:00:00

  • Three kinds of corneal host cells contribute differently to corneal neovascularization.

    abstract：BACKGROUND:Corneal neovascularization (angiogenesis and lymphangiogenesis) compromises corneal transparency and transplant survival, however, the molecular mechanisms of corneal host epithelial and stromal cells in neovascularization have not yet been fully elucidated. Furthermore, the contribution and mechanism of cor...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.026

    authors： Yu H,Sun L,Cui J,Li Y,Yan Y,Wei X,Wang C,Song F,Jiang W,Liu Y,Ge H,Qian H,Li X,Tang X,Liu P

    更新日期：2019-06-01 00:00:00

  • Urinary TERT promoter mutations as non-invasive biomarkers for the comprehensive detection of urothelial cancer.

    abstract：BACKGROUND:Recurrent mutations in the promoter of the telomerase reverse transcriptase (TERT) gene (C228T and C250T) detected in tumours and cells shed into urine of urothelial cancer (UC) patients are putative biomarkers for UC detection and monitoring. However, the possibility of detecting these mutations in cell-fre...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.004

    authors： Avogbe PH,Manel A,Vian E,Durand G,Forey N,Voegele C,Zvereva M,Hosen MI,Meziani S,De Tilly B,Polo G,Lole O,Francois P,Delhomme TM,Carreira C,Monteiro-Reis S,Henrique R,Abedi-Ardekani B,Byrnes G,Foll M,Weiderpass E

    更新日期：2019-06-01 00:00:00

  • TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia.

    abstract：BACKGROUND:Decidual natural killer (dNK) cells are the predominant lymphocytes accumulated at the maternal-fetal interface. Regulatory mechanism of dNK cells in preeclampsia, a gestational complication characterized by high blood pressure and increased proteinuria occurring after 20 weeks pregnancy, is not completely u...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.015

    authors： Zhang J,Dunk CE,Shynlova O,Caniggia I,Lye SJ

    更新日期：2019-01-01 00:00:00

  • Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.

    abstract：BACKGROUND:In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. METHODS:To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma, we utilized CRISPR-Ca...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102971

    authors： George SL,Lorenzi F,King D,Hartlieb S,Campbell J,Pemberton H,Toprak UH,Barker K,Tall J,da Costa BM,van den Boogaard ML,Dolman MEM,Molenaar JJ,Bryant HE,Westermann F,Lord CJ,Chesler L

    更新日期：2020-09-01 00:00:00

  • Diagnostic Performance of Plasma DNA Methylation Profiles in Lung Cancer, Pulmonary Fibrosis and COPD.

    abstract：:Disease-specific alterations of the cell-free DNA methylation status are frequently found in serum samples and are currently considered to be suitable biomarkers. Candidate markers were identified by bisulfite conversion-based genome-wide methylation screening of lung tissue from lung cancer, fibrotic ILD, and COPD. c...

    journal_title：EBioMedicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ebiom.2015.06.025

    authors： Wielscher M,Vierlinger K,Kegler U,Ziesche R,Gsur A,Weinhäusel A

    更新日期：2015-07-02 00:00:00

  • Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis.

    abstract：:Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune disease, supportive evidence is perhaps circumstantial, often based on animal studies, and is questioned by the perceived failure of CD4-depleting antibodies to control relapsing MS. Therefore, it was interestingly to find that curren...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2017.01.042

    authors： Baker D,Marta M,Pryce G,Giovannoni G,Schmierer K

    更新日期：2017-02-01 00:00:00

  • Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.

    abstract：BACKGROUND:Neurodegenerative diseases are incurable disorders caused by progressive neuronal cell death. Retinitis pigmentosa (RP) is a blinding neurodegenerative disease that results in photoreceptor death and progresses to the loss of the entire retinal network. We previously found that proteomic analysis of the adja...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102636

    authors： Wert KJ,Velez G,Kanchustambham VL,Shankar V,Evans LP,Sengillo JD,Zare RN,Bassuk AG,Tsang SH,Mahajan VB

    更新日期：2020-02-01 00:00:00

  • Large Isoform of Mammalian Relative of DnaJ is a Major Determinant of Human Susceptibility to HIV-1 Infection.

    abstract：:Individual differences in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection have been of interest for decades. We aimed to determine the contribution of large isoform of Mammalian DnaJ (MRJ-L), a HIV-1 Vpr-interacting cellular protein, to this natural variation. Expression of MRJ-L in monocyte-de...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2014.10.002

    authors： Chiang YP,Sheng WH,Shao PL,Chi YH,Chen YM,Huang SW,Shih HM,Chang LY,Lu CY,Chang SC,Hung CC,Huang LM

    更新日期：2014-10-07 00:00:00

  • A novel imaging based Nomogram for predicting post-surgical biochemical recurrence and adverse pathology of prostate cancer from pre-operative bi-parametric MRI.

    abstract：BACKGROUND:We developed and validated an integrated radiomic-clinicopathologic nomogram (RadClip) for post-surgical biochemical recurrence free survival (bRFS) and adverse pathology (AP) prediction in men with prostate cancer (PCa). RadClip was further compared against extant prognostics tools like CAPRA and Decipher. ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103163

    authors： Li L,Shiradkar R,Leo P,Algohary A,Fu P,Tirumani SH,Mahran A,Buzzy C,Obmann VC,Mansoori B,El-Fahmawi A,Shahait M,Tewari A,Magi-Galluzzi C,Lee D,Lal P,Ponsky L,Klein E,Purysko AS,Madabhushi A

    更新日期：2021-01-01 00:00:00

  • TGF-β-induced transgelin promotes bladder cancer metastasis by regulating epithelial-mesenchymal transition and invadopodia formation.

    abstract：BACKGROUND:Metastatic bladder cancer (BLCA) is a lethal disease with an unmet need for study. Transgelin (TAGLN) is an actin-binding protein that affects the dynamics of the actin cytoskeleton indicating its robust potential as a metastasis initiator. Here, we sought to explore the expression pattern of TAGLN and eluci...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.08.012

    authors： Chen Z,He S,Zhan Y,He A,Fang D,Gong Y,Li X,Zhou L

    更新日期：2019-09-01 00:00:00

  • A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways.

    abstract：BACKGROUND:The rapid spread of SARS-CoV-2, the causative agent of Coronavirus disease 2019 (COVID-19), has been accompanied by the emergence of distinct viral clades, though their clinical significance remains unclear. Here, we aimed to investigate the phylogenetic characteristics of SARS-CoV-2 infections in Chicago, I...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ebiom.2020.103112

    authors： Lorenzo-Redondo R,Nam HH,Roberts SC,Simons LM,Jennings LJ,Qi C,Achenbach CJ,Hauser AR,Ison MG,Hultquist JF,Ozer EA

    更新日期：2020-12-01 00:00:00

  • Serotonin Activates Bacterial Quorum Sensing and Enhances the Virulence of Pseudomonas aeruginosa in the Host.

    abstract：:Bacteria in humans play an important role in health and disease. Considerable emphasis has been placed in understanding the role of bacteria in host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood in the brain and motility in the gut, can also act as a bacterial signaling molec...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.05.037

    authors： Knecht LD,O'Connor G,Mittal R,Liu XZ,Daftarian P,Deo SK,Daunert S

    更新日期：2016-07-01 00:00:00

  • Two years of treatment with the recombinant grass pollen allergy vaccine BM32 induces a continuously increasing allergen-specific IgG4 response.

    abstract：BACKGROUND:BM32, a grass pollen allergy vaccine containing four recombinant fusion proteins consisting of hepatitis B-derived PreS and hypoallergenic peptides from the major timothy grass pollen allergens adsorbed on aluminium hydroxide has been shown to be safe and to improve clinical symptoms of grass pollen allergy ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.006

    authors： Eckl-Dorna J,Weber M,Stanek V,Linhart B,Ristl R,Waltl EE,Villazala-Merino S,Hummel A,Focke-Tejkl M,Froeschel R,Neubauer A,Henning R,Perkmann T,Valenta R,Niederberger V

    更新日期：2019-12-01 00:00:00

  • Childhood growth and neurocognition are associated with distinct sets of metabolites.

    abstract：BACKGROUND:Undernutrition is a serious global problem that contributes to increased child morbidity and mortality, impaired neurocognitive development, and decreased educational and economic attainment. Current interventions are only marginally effective, and identification of associated metabolic pathways can offer ne...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.043

    authors： Moreau GB,Ramakrishnan G,Cook HL,Fox TE,Nayak U,Ma JZ,Colgate ER,Kirkpatrick BD,Haque R,Petri WA Jr

    更新日期：2019-06-01 00:00:00