Advances in Resting State Neuroimaging of Mild Cognitive Impairment.


:The rapidly increasing number of patients with Alzheimer's disease (AD) worldwide has become a major public concern. Mild cognitive impairment (MCI), characterized with accelerated memory decline than normal aging, is a stage between cognitively unimpaired and dementia. Identification of MCI in the Alzheimer's continuum from normal aging, is important for early diagnosis and improved intervention of AD. The imaging technique has been extensively used for diagnose and understanding the mechanisms of MCI. Firstly, we review the recent progresses in the research framework of MCI depending on the clinical and/or biomarker findings. Secondly, we cover studies that use of rs-fMRI (resting state functional magnetic resonance imaging) for the brain activities and functional connectivity between normal aging and MCI. Other methodologies and multi-modal studies for investigating the mechanism and early diagnosis of MCI are also discussed. Finally, we discuss how genetic and environmental factors such as education could interact with in MCI. Overall, MCI is a heterogeneous state and employing resting state neuroimaging with other AD biomarker approaches will be able to target in the more precise population and AD-related pathology process.


Front Psychiatry


Frontiers in psychiatry


Lin L,Xing G,Han Y




Has Abstract


2018-12-06 00:00:00








  • Language Patterns Discriminate Mild Depression From Normal Sadness and Euthymic State.

    abstract:Objectives:Deviations from typical word use have been previously reported in clinical depression, but language patterns of mild depression (MD), as distinct from normal sadness (NS) and euthymic state, are unknown. In this study, we aimed to apply the linguistic approach as an additional diagnostic key for understandin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Smirnova D,Cumming P,Sloeva E,Kuvshinova N,Romanov D,Nosachev G

    更新日期:2018-04-10 00:00:00

  • Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.

    abstract::Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single g...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Tordjman S,Somogyi E,Coulon N,Kermarrec S,Cohen D,Bronsard G,Bonnot O,Weismann-Arcache C,Botbol M,Lauth B,Ginchat V,Roubertoux P,Barburoth M,Kovess V,Geoffray MM,Xavier J

    更新日期:2014-08-04 00:00:00

  • Offense-Related Issues in Forensic Psychiatric Treatment: A Thematic Analysis.

    abstract::Characteristics unique to forensic psychiatric treatment include coming to terms with the offenses committed, the long duration of treatment and the assessment of the risk of repeat offending. This study describes the views of both patients and staff on the significance of the patient's offense as a part of forensic p...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Askola R,Soininen P,Seppänen A

    更新日期:2020-01-08 00:00:00

  • Lifestyle Interventions and Prevention of Suicide.

    abstract::Over the past years, there has been a growing interest in the association between lifestyle psychosocial interventions, severe mental illness, and suicide risk. Patients with severe mental disorders have higher mortality rates, poor health states, and higher suicide risk compared to the general population. Lifestyle b...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Berardelli I,Corigliano V,Hawkins M,Comparelli A,Erbuto D,Pompili M

    更新日期:2018-11-06 00:00:00

  • Repeated Exposure to the "Spice" Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats.

    abstract::Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive "spice" products that activates cannabinoid receptors. Preclinical evidence suggests that exposure to synthetic cannabinoids increases 5-HT2A/2C receptor function in the brain, an effect which might contribute to psyc...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Elmore JS,Baumann MH

    更新日期:2018-02-27 00:00:00

  • Psychosocial Predictors of Postpartum Posttraumatic Stress Disorder in Women With a Traumatic Childbirth Experience.

    abstract::Objective: To analyze the predictive value of antepartum vulnerability factors, such as social support, coping, history of psychiatric disease, and fear of childbirth, and intrapartum events on the development of symptoms of postpartum posttraumatic stress disorder (PP-PTSD) in women with a traumatic childbirth experi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: van Heumen MA,Hollander MH,van Pampus MG,van Dillen J,Stramrood CAI

    更新日期:2018-07-31 00:00:00

  • Semantic Memory Organization in Japanese Patients With Schizophrenia Examined With Category Fluency.

    abstract:Background:Disorganization of semantic memory in patients with schizophrenia has been studied by referring to their category fluency performance. Recently, data-mining techniques such as singular value decomposition (SVD) analysis have been reported to be effective in elucidating the latent semantic memory structure in...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Sumiyoshi C,Fujino H,Sumiyoshi T,Yasuda Y,Yamamori H,Fujimoto M,Hashimoto R

    更新日期:2018-03-21 00:00:00

  • Pilot Testing of Peak Alpha Frequency Stability During Repetitive Transcranial Magnetic Stimulation.

    abstract::Over half of those diagnosed with post-traumatic stress disorder (PTSD) have comorbid major depressive disorder (MDD), and rates are even higher among military veterans. Transcranial magnetic stimulation (TMS) may be a safe and efficacious treatment for PTSD, both with and without comorbid MDD. Still, the mechanism of...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Petrosino NJ,Zandvakili A,Carpenter LL,Philip NS

    更新日期:2018-11-20 00:00:00

  • State-Dependent and Trait-Like Characteristics of Dysfunctional Attitudes in Patients With Major Depressive Disorder.

    abstract:Background:Studies have shown that patients with major depressive disorder (MDD) exhibit elevated dysfunctional attitudes (DAs). However, it remains controversial whether the DAs are state-dependent or trait-like features of MDD. Methods:This study recruited 172 patients and 159 healthy controls (HCs) at baseline. DAs...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Liu B,Sun J,Qin X,Wang M,Lu X,Dong Q,Zhang L,Liu J,Ju Y,Wan P,Guo H,Zhao F,Zhang Y,Li L

    更新日期:2020-07-10 00:00:00

  • Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Stressed Withdrawn Mice.

    abstract::This study compares the impact of repeated injections of baclofen (an agonist of GABAB receptors) or diazepam (a benzodiazepine having an agonist action on GABAA receptors) given during the alcohol-withdrawal period on the stress-induced restoration of alcohol-seeking behavior and hypothalamic-pituitary-adrenal (HPA) ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Rabat Y,Henkous N,Corio M,Nogues X,Beracochea D

    更新日期:2019-04-16 00:00:00

  • Psychometric Properties of Three Simplified Chinese Online-Related Addictive Behavior Instruments Among Mainland Chinese Primary School Students.

    abstract:Background/Objective:There are inadequate screening instruments for assessing specific internet-related addictions among mainland Chinese primary school students. Therefore, the present study validated the psychometric properties of three simplified Chinese online-related addictive behavior instruments among mainland C...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Chen IH,Ahorsu DK,Pakpour AH,Griffiths MD,Lin CY,Chen CY

    更新日期:2020-09-03 00:00:00

  • Nonsuicidal Self-Injury: Its Associations With Pathological Internet Use and Psychopathology Among Adolescents.

    abstract:Background/Hypotheses:As risk factors for nonsuicidal self-injury (NSSI), most studies highlight the importance of internalising disorders, while only a few researches show the connection between externalising disorders and NSSI. Although some papers have introduced the idea that increasing prevalence rates of NSSI are...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Mészáros G,Győri D,Horváth LO,Szentiványi D,Balázs J

    更新日期:2020-08-14 00:00:00

  • Low Density Lipoprotein Receptor-Related Protein and Apolipoprotein E Expression is Altered in Schizophrenia.

    abstract::Our recent microarray study reported altered mRNA expression of several low density lipoprotein receptor-related proteins (LRP) associated with the first 4 years following diagnosis with schizophrenia. Whilst this finding is novel, apolipoprotein E (APOE), which mediates its activity through LRPs, has been reported by...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Gibbons AS,Thomas EA,Scarr E,Dean B

    更新日期:2010-07-08 00:00:00

  • Parameter-Based Evaluation of Attentional Impairments in Schizophrenia and Their Modulation by Prefrontal Transcranial Direct Current Stimulation.

    abstract:Background:Attentional dysfunctions constitute core cognitive symptoms in schizophrenia, but the precise underlying neurocognitive mechanisms remain to be elucidated. Methods:In this randomized, double-blind, sham-controlled study, we applied, for the first time, a theoretically grounded modeling approach based on Bun...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Gögler N,Papazova I,Oviedo-Salcedo T,Filipova N,Strube W,Funk J,Müller HJ,Finke K,Hasan A

    更新日期:2017-11-29 00:00:00

  • Lower Income Levels in Australia Are Strongly Associated With Elevated Psychological Distress: Implications for Healthcare and Other Policy Areas.

    abstract::Background: Australia is a high-income country with increasing income inequality. It is unclear whether Australia's well-developed mental healthcare system is making a difference to population mental health and the Federal Government has targeted outcomes accountability in service funding strategies. In high-income co...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Isaacs AN,Enticott J,Meadows G,Inder B

    更新日期:2018-10-26 00:00:00

  • Empathy in Females With Autism Spectrum Disorder.

    abstract::Objective: Despite the fact that autism spectrum disorder (ASD) is a common psychiatric diagnosis, knowledge about the special behavioral and neurobiological female phenotype is still scarce. The present study aimed to investigate neural correlates of empathy for physical and social pain and to assess the impact of eg...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Stroth S,Paye L,Kamp-Becker I,Wermter AK,Krach S,Paulus FM,Müller-Pinzler L

    更新日期:2019-06-18 00:00:00

  • The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.

    abstract::Pathological impulsivity is encountered in a broad range of psychiatric conditions and is thought to be a risk factor for aggression directed against oneself or others. Recently, a strong association was found between impulsivity and obesity which may explain the high prevalence of metabolic disorders in individuals w...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Sfera A,Osorio C,Inderias LA,Parker V,Price AI,Cummings M

    更新日期:2017-02-13 00:00:00

  • Interleukin-6 in Schizophrenia-Is There a Therapeutic Relevance?

    abstract::Renewing interest in immune aspects of schizophrenia and new findings about the brain-fat axis encourage us to discuss the possible role of interleukin-6 (IL-6) in schizophrenia. Previously, it was suggested that a primary alteration of the innate immune system may be relevant in schizophrenia. Functional dichotomy of...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Borovcanin MM,Jovanovic I,Radosavljevic G,Pantic J,Minic Janicijevic S,Arsenijevic N,Lukic ML

    更新日期:2017-11-06 00:00:00

  • Depressive Symptoms in Late Pregnancy Disrupt Attentional Processing of Negative-Positive Emotion: An Eye-Movement Study.

    abstract::This study investigated biases for negative-positive information in component processes of visual attention (initial shift vs. maintenance of gaze) among women in late pregnancy with or without depressive symptoms. Eye movements were recorded while participants viewed a series of picture pairs depicting negative, posi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Tang W,Bao C,Xu L,Zhu J,Feng W,Zhang W,Lin C,Chen L,Cheng Q,Ding P,Zhou M,Bao Y,Yu X,Zhao K,He J

    更新日期:2019-10-31 00:00:00

  • Reduced intrinsic connectivity of amygdala in adults with major depressive disorder.

    abstract::Imaging studies of major depressive disorder (MDD) have demonstrated enhanced resting-state activity of the amygdala as well as exaggerated reactivity to negative emotional stimuli relative to healthy controls (HCs). However, the abnormalities in the intrinsic connectivity of the amygdala in MDD still remain unclear. ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Ramasubbu R,Konduru N,Cortese F,Bray S,Gaxiola-Valdez I,Goodyear B

    更新日期:2014-02-19 00:00:00

  • The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder.

    abstract::Background: Cognitive impairments in bipolar disorder (BD) such as memory deficits are associated with poor functional outcomes and it has been suggested that the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to individual variability in memory function in BD. The current study investigate...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Hørlyck LD,Macoveanu J,Vinberg M,Kessing LV,Siebner HR,Miskowiak KW

    更新日期:2019-12-06 00:00:00

  • High Psychiatric Morbidity and Comorbidity Among Female Prisoners in Hunan, China.

    abstract:Background:High prevalence of mental disorders has been found among female prisoners in Western countries, however, little is known about the epidemiology of mental disorders in such populations in China. This study aims to investigate psychiatric morbidity and comorbidity among sentenced prisoners in a female prison i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Zhong S,Zhu X,Chen Y,Guo H,Luo C,Liang X,Wang F,Chen H,Zhou J,Wang X

    更新日期:2020-04-14 00:00:00

  • COVID-19 Neurological Manifestations and Underlying Mechanisms: A Scoping Review.

    abstract:Background:In the Corona Virus Disease 2019 (COVID-19) pandemic, the primary problem is respiratory-related, but there also is increasing evidence of central nervous system (CNS) involvement. This study aims to summarize the literature on neurological manifestations of COVID-19, underlying mechanisms of CNS involvement...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Wenting A,Gruters A,van Os Y,Verstraeten S,Valentijn S,Ponds R,de Vugt M

    更新日期:2020-08-21 00:00:00

  • Transcranial direct current stimulation reduces negative affect but not cigarette craving in overnight abstinent smokers.

    abstract::Transcranial direct current stimulation (tDCS) can enhance cognitive control functions including attention and top-down regulation over negative affect and substance craving in both healthy and clinical populations, including early abstinent (∼1.5 h) smokers. The aim of this study was to assess whether tDCS modulates ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Xu J,Fregni F,Brody AL,Rahman AS

    更新日期:2013-09-20 00:00:00

  • Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A Network Meta-Analysis.

    abstract::Background: Attenuated positive psychotic symptoms represent the defining features of the clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available treatment for reducing attenuated positive psychotic symptoms remains undetermined. This network meta-analysis (NMA) investigates the consiste...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Davies C,Radua J,Cipriani A,Stahl D,Provenzani U,McGuire P,Fusar-Poli P

    更新日期:2018-06-12 00:00:00

  • Neurological Soft Signs and Psychopathology in Chronic Schizophrenia: A Cross-Sectional Study in Three Age Groups.

    abstract::As established in a wealth of studies subtle motor and sensory neurological abnormalities or neurological soft signs (NSS) are frequently found in patients with schizophrenia at any stage of their illness. However, the potential impact of chronicity and age on NSS was scarcely investigated. Therefore, we assessed NSS ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Herold CJ,Lässer MM,Seidl UW,Hirjak D,Thomann PA,Schröder J

    更新日期:2018-03-26 00:00:00

  • Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention.

    abstract::Alcohol use disorder (AUD) is a devastating public health problem in which both genetic and environmental factors play a role. Growing evidence supports that epigenetic regulation is one major mechanism in neuroadaptation that contributes to development of AUD. Meanwhile, epigenetic patterns can be modified by various...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Chen J,Hutchison KE,Bryan AD,Filbey FM,Calhoun VD,Claus ED,Lin D,Sui J,Du Y,Liu J

    更新日期:2018-11-15 00:00:00

  • Preliminary Reliability and Validity of the DMRS-SR-30, a Novel Self-Report Measure Based on the Defense Mechanisms Rating Scales.

    abstract::Defense mechanisms are psychological factors that influence emotional distress and quality of life. There are a number of measures assessing the construct of defense mechanisms, but only few available instruments reflect the gold-standard theoretical hierarchical organization of defenses. We report on the development ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Di Giuseppe M,Perry JC,Lucchesi M,Michelini M,Vitiello S,Piantanida A,Fabiani M,Maffei S,Conversano C

    更新日期:2020-08-26 00:00:00

  • Rejection Sensitivity Mediates the Relationship Between Social-Interpersonal Stressors and Depressive Symptoms in Military Context.

    abstract:Background:Depression is pervasive in the military context and is likely to elicit lasting negative effects on health. Based on interpersonal models, social-interpersonal stressors are significantly associated with the development and maintenance of depression. However, little is known about the mechanisms by which the...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Wang J,Cheng X,Xu K,Xu H,Wang H,Feng Z

    更新日期:2020-06-18 00:00:00

  • An Actigraphy-Based Validation Study of the Sleep Disorder Inventory in the Nursing Home.

    abstract::Background: Disrupted sleep is common among nursing home patients with dementia and is associated with increased agitation, depression, and cognitive impairment. Detecting and treating sleep problems in this population are therefore of great importance, albeit challenging. Systematic observation and objective recordin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Hjetland GJ,Nordhus IH,Pallesen S,Cummings J,Tractenberg RE,Thun E,Kolberg E,Flo E

    更新日期:2020-03-13 00:00:00