Childhood leukaemia and poliomyelitis in relation to military encampments in England and Wales in the period of national military service, 1950-63.

Abstract:

OBJECTIVE:To determine if any excess of childhood leukaemia was associated with the large and increasing numbers of national military servicemen in 1949 and 1950, particularly in rural districts. This would be a further test of the hypothesis that childhood leukaemia can originate in an infection, the transmission of which is facilitated by an increased number of unaccustomed contacts in the community. DESIGN:Rural and urban districts, aggregated by county, were ranked by proportion of servicemen, and five groups containing similar numbers of children were created. In addition, individual local authority districts were ranked and grouped in tenths. Mortality from childhood leukaemia 1950-3 was examined in these groups. Data on infectious diseases were also examined, as well as data on leukaemia in later periods. SETTING:England and Wales. SUBJECTS:Children aged under 15 years. RESULTS:In 1950-3 but not subsequently a significant excess of leukaemia in children under 15 was found in the fifth of county groupings with the highest proportions of servicemen. This was due mainly to a significant excess in children under 2 years (and especially in those under 1 year) in rural districts. It was confirmed among the tenth of local authority districts with the highest proportion of servicemen. These rural areas showed significantly more notifications of, and deaths from, poliomyelitis among children than the rural average. CONCLUSIONS:The findings support the infection hypothesis. That the excess of leukaemia was greatest in children under 1 year suggests transmission of infection among adults and thence to the fetus. The pattern of spread of poliomyelitis may also have been influenced by the presence of large numbers of servicemen.

journal_name

BMJ

authors

Kinlen LJ,Hudson C

doi

10.1136/bmj.303.6814.1357

subject

Has Abstract

pub_date

1991-11-30 00:00:00

pages

1357-62

issue

6814

eissn

0959-8138

issn

1756-1833

journal_volume

303

pub_type

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