Obesity: A New Adverse Effect of Antibiotics?

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：:Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against to tumor antigens. Some ...

journal_title：Frontiers in pharmacology

authors： Robles-Planells C,Michelson SA,Mena J,Escrig D,Rojas JL,Sanchez-Guerrero G,Hernández R,Barrera-Avalos C,Rojo LE,Sauma D,Kalergis AM,Imarai M,Fernández R,Robles CA,Leiva-Salcedo E,Santander R,Escobar A,Acuña-Castillo C

更新日期：2019-10-22 00:00:00

abstract：:Deregulated activity of the Src tyrosine kinases leads to malignant transformation. Since the FDA approval of the tyrosine kinase inhibitor, imatinib, in 2001 for the treatment of chronic myeloid leukemia (CML), the number of these inhibitors together with Src tyrosine kinase inhibitors (STKIs) has increased notably d...

journal_title：Frontiers in pharmacology

authors： Rivera-Torres J,San José E

更新日期：2019-09-18 00:00:00

abstract：:Calcium-calmodulin/dependent protein kinase II (CaMKII) plays an essential role in LTP induction, but since it has the capacity to remain persistently activated even after the decay of external stimuli it has been proposed that it can also be necessary for LTP maintenance and therefore for memory persistence. It has b...

journal_title：Frontiers in pharmacology

authors： Juárez-Muñoz Y,Ramos-Languren LE,Escobar ML

更新日期：2017-11-14 00:00:00

abstract：:Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. Poly (lactic-co-glycolic acid) (PLGA)-based materials are frequently used in such setups. This review article gives an overview of the properties of previously reported PLGA nanop...

journal_title：Frontiers in pharmacology

authors： Rezvantalab S,Drude NI,Moraveji MK,Güvener N,Koons EK,Shi Y,Lammers T,Kiessling F

更新日期：2018-11-02 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19), an acute onset pneumonia caused by a novel Betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in the Wuhan City of China in December 2019 and evolved into a global pandemic. To date, there are no proven drugs or vaccines against this virus. Hence...

journal_title：Frontiers in pharmacology

authors： Samaddar A,Grover M,Nag VL

更新日期：2020-09-17 00:00:00

abstract：:Opioids are broad spectrum analgesics that are an integral part of the therapeutic armamentarium to combat pain in the clinical practice. Unfortunately, together with analgesia, a number of adverse effects can occur such as nausea, vomiting, constipation, gastrointestinal alterations and cognitive impairments. Naltrex...

journal_title：Frontiers in pharmacology

authors： Micheli L,Di Cesare Mannelli L,Lucarini E,Parisio C,Toti A,Fiorentino B,Rigamonti MA,Calosi L,Ghelardini C

更新日期：2020-09-18 00:00:00

abstract：:Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allodynic activity of two novel sigma receptor antagonists, the S1R-selecti...

journal_title：Frontiers in pharmacology

authors： Cirino TJ,Eans SO,Medina JM,Wilson LL,Mottinelli M,Intagliata S,McCurdy CR,McLaughlin JP

更新日期：2019-06-14 00:00:00

abstract：:The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two...

journal_title：Frontiers in pharmacology

authors： Tai Y,Wang Q,Korner H,Zhang L,Wei W

更新日期：2018-06-26 00:00:00

abstract：:The recent publication of the σ1R crystal structure is an important cornerstone for the derivation of more accurate activity prediction models. We report here a comparative study involving a set of more than 25,000 structures from our internal database that had been screened for σ1R affinity. Using the recently publis...

journal_title：Frontiers in pharmacology

authors： Pascual R,Almansa C,Plata-Salamán C,Vela JM

更新日期：2019-05-31 00:00:00

abstract：:The psoralen-related compound, 4,6,4'-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. We recently demonstrated that TMA, like lumacaftor (VX-809), stab...

journal_title：Frontiers in pharmacology

authors： Laselva O,Marzaro G,Vaccarin C,Lampronti I,Tamanini A,Lippi G,Gambari R,Cabrini G,Bear CE,Chilin A,Dechecchi MC

更新日期：2018-07-04 00:00:00

abstract：PURPOSE:Colostrum has been proposed to treat severe dryness and problematic eye lesions showing a beneficial effect. The aim of the study was to investigate the effect of 2-fucosyl-lactose, a natural sugar present in the human colostrum, in an experimental dry eye. METHODS:Dry eye was induced in adult male New Zealand...

journal_title：Frontiers in pharmacology

authors： Bucolo C,Musumeci M,Salomone S,Romano GL,Leggio GM,Gagliano C,Reibaldi M,Avitabile T,Uva MG,Musumeci S,Drago F

更新日期：2015-11-18 00:00:00

abstract：:Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

journal_title：Frontiers in pharmacology

authors： Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

更新日期：2018-01-24 00:00:00

abstract：:Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2'-O-methyl RNA (2'-OMe-RNA) and phosphoryl guanidine ol...

journal_title：Frontiers in pharmacology

authors： Novopashina D,Vorobyeva M,Nazarov A,Davydova A,Danilin N,Koroleva L,Matveev A,Bardasheva A,Tikunova N,Kupryushkin M,Pyshnyi D,Altman S,Venyaminova A

更新日期：2019-07-19 00:00:00

abstract：:Traditional Chinese medicine is one of the complementary and alternative therapies to improve the prognosis of coronary heart disease (CHD). Taohong Siwu Decoction (THSWD), a classical traditional Chinese medication that promotes blood circulation, is clinically beneficial in CHD. However, the underlying mechanism of ...

journal_title：Frontiers in pharmacology

authors： Tao T,He T,Mao H,Wu X,Liu X

更新日期：2020-05-08 00:00:00

abstract：:Oncogenic activation of the KRAS gene via point mutations occurs in 20-30% of patients with non-small cell lung cancer (NSCLC). The RAS-RAF-ERK and RAS-PI3K-AKT pathways are the major hyper-activated downstream pathways in RAS mutation, which promotes the unlimited lifecycle of cancer cells and their metastasis in hum...

journal_title：Frontiers in pharmacology

authors： Lai H,Wang Y,Duan F,Li Y,Jiang Z,Luo L,Liu L,Leung ELH,Yao X

更新日期：2018-08-22 00:00:00

abstract：:Synthetic cannabinoid receptor agonists (SCRAs) are the largest class of new psychoactive substances (NPS). New examples are detected constantly, and some are associated with a series of adverse effects, including seizures. CUMYL-4CN-BINACA (1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide) is structural...

journal_title：Frontiers in pharmacology

authors： Kevin RC,Anderson L,McGregor IS,Boyd R,Manning JJ,Glass M,Connor M,Banister SD

更新日期：2019-05-29 00:00:00

abstract：:Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment. CYP3A4 genetic polymorphisms are believed to be one of the important causes, leading to inter-individual variability in drug metabolism. Quinine is ...

journal_title：Frontiers in pharmacology

authors： Zhou XY,Hu XX,Wang CC,Lu XR,Chen Z,Liu Q,Hu GX,Cai JP

更新日期：2019-05-31 00:00:00

abstract：:Gastric cancer is a common digestive tract tumor and the second most prevalent cancer. The prognosis of advanced gastric cancer is poor. Conversion therapy can reduce tumor burden, downgrade tumor, and increase the possibility of complete resection, thus prolonging the survival time of patients with gastric cancer. In...

journal_title：Frontiers in pharmacology

authors： Jiang D,Xu Y,Chen Y,Jiang J,Wang M,Yang M,Chen Z,Yang L

更新日期：2020-07-14 00:00:00

abstract：:Inborn cardiac diseases are among the most frequent congenital anomalies and are the main cause of death in infants within the first year of age in industrialized countries when not adequately treated. They can be divided into simple and complex cardiac malformations. The former ones, for instance atrial and ventricul...

journal_title：Frontiers in pharmacology

authors： Salameh A,Blanke K,Daehnert I

更新日期：2013-06-03 00:00:00

abstract：:Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinical and hospital settings. Fisetin (FST) is a phenolic compound derived from natural products such as fruit and vegetables. Our research investigated the protective mechanisms of FST in APAP-induced hepatic injury in vitro and...

journal_title：Frontiers in pharmacology

authors： Zhang J,Zhao L,Hu C,Wang T,Lu J,Wu C,Chen L,Jin M,Hu H,Ji G,Cao Q,Jiang Y

更新日期：2020-02-28 00:00:00

abstract：:Objective: Calcium dobesilate (CaD), an effective drug for the treatment of diabetic microvascular complications, especially diabetic retinopathy, is widely used in the clinic. Interestingly, several studies have indicated that CaD is therapeutic for diabetic kidney disease (DKD). Recently, evidence has indicated that...

journal_title：Frontiers in pharmacology

authors： Wang Y,Lu YH,Tang C,Xue M,Li XY,Chang YP,Cheng Y,Li T,Yu XC,Sun B,Li CJ,Chen LM

更新日期：2019-08-09 00:00:00

abstract：:Chijabyukpi-tang (CBT) is an oriental herbal formula consisting of three herbs (Gardeniae Fructus (Gardenia jasminoides J.Ellis.), Phellodendri Cortex (Phellodendron amurense Rupr.), Glycyrrhizae Radix (Glycyrrhiza uralensis Fisch. ex DC.) at the ratio of 2: 2: 1. CBT has traditionally been used to treat eczema with i...

journal_title：Frontiers in pharmacology

authors： Lee JH,Lim JY,Jo EH,Noh HM,Park S,Park MC,Kim DK

更新日期：2020-07-07 00:00:00

abstract：:Scoring functions play an important role in structure-based virtual screening. It has been widely accepted that target-specific scoring functions (TSSFs) may achieve better performance compared with universal scoring functions in actual drug research and development processes. A method that can effectively construct T...

journal_title：Frontiers in pharmacology

authors： Wang D,Cui C,Ding X,Xiong Z,Zheng M,Luo X,Jiang H,Chen K

更新日期：2019-08-22 00:00:00

abstract：:Infections with the pathogenic bacterium Clostridioides (C.) difficile are coming more into focus, in particular in hospitalized patients after antibiotic treatment. C. difficile produces the exotoxins TcdA and TcdB. Since some years, hypervirulent strains are described, which produce in addition the binary actin ADP-...

journal_title：Frontiers in pharmacology

authors： Korbmacher M,Fischer S,Landenberger M,Papatheodorou P,Aktories K,Barth H

更新日期：2020-08-12 00:00:00

abstract：:Background and Objective: Idiopathic central precocious puberty (ICPP) is characterized by early pubertal changes, the acceleration of growth velocity, and rapid bone maturation that often results in reduced adult height. Gonadotrophin-releasing hormone agonist (GnRHa) is currently considered to be an effective therap...

journal_title：Frontiers in pharmacology

authors： Yu HK,Liu X,Chen JK,Wang S,Quan XY

更新日期：2019-02-11 00:00:00

abstract：:Background: Up to date, the efficacy and safety of warfarin treatment in atrial fibrillation patients receiving hemodialysis remain controversial. So we performed this meta-analysis to try to offer recommendations regarding warfarin management in this population. Methods: We searched Pubmed, Embase, and Cochrane libra...

journal_title：Frontiers in pharmacology

authors： Lei H,Yu LT,Wang WN,Zhang SG

更新日期：2018-11-06 00:00:00

abstract：:Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular le...

journal_title：Frontiers in pharmacology

authors： Kistamás K,Veress R,Horváth B,Bányász T,Nánási PP,Eisner DA

更新日期：2020-02-25 00:00:00

abstract：:Choroid plexus carcinomas (CPCs) are rare, aggressive pediatric brain tumors with no established curative therapy for relapsed disease, and poor survival rates. TP53 Mutation or dysfunction correlates with poor or no survival outcome in CPCs. Here, we report the case of a 4 month-old female who presented with dissemin...

journal_title：Frontiers in pharmacology

authors： Cornelius A,Foley J,Bond J,Nagulapally AB,Steinbrecher J,Hendricks WPD,Rich M,Yendrembam S,Bergendahl G,Trent JM,Sholler GS

更新日期：2017-09-25 00:00:00

abstract：:Disruptions in iron homeostasis are linked to a broad spectrum of chronic conditions including cardiovascular, malignant, metabolic, and neurodegenerative disease. Evidence supporting this contention derives from a variety of analytical approaches, ranging from molecular to population-based studies. This review focuse...

journal_title：Frontiers in pharmacology

authors： Basuli D,Stevens RG,Torti FM,Torti SV

更新日期：2014-05-20 00:00:00