Effect of Betahistine and Metformin on Antipsychotic-Induced Weight Gain: An Analysis of Two Clinical Trials.


:Antipsychotic-induced weight gain is one of the most common adverse effects of antipsychotic treatment. However, there are no well-established interventions for the weight gain yet. In this study, we pooled the data from two clinical trials, which were originally examining the efficacy of betahistine and the efficacy of metformin in treating antipsychotic-induced weight gain and insulin resistance. A total of 67 people with schizophrenia or bipolar disorder treated with antipsychotics were assigned to 36 mg day-1 betahistine (n = 13) or 1,000 mg day-1 metformin (n = 25) or placebo (n = 29) treatment for 12 weeks, with evaluation at baseline and week 12. The primary outcome was the body mass index (BMI). After treatment, metformin group had a mean decrease in BMI of 1.46 ± 0.14 (p < 0.001) and insulin resistance index (IRI) of 4.30 ± 2.02 (p < 0.001). The betahistine group had no significant alteration in BMI or IRI. However, placebo group had a mean increase in BMI of 1.27 ± 0.77 (p < 0.001) and IRI of 0.45 ± 0.86 (p < 0.001). Between the two treatment groups, metformin significantly decreased weight, BMI, fasting glucose, insulin level, and IRI but not waist circumference when compared with betahistine. Moreover, metformin significantly decreased weight, BMI, waist circumference, fasting glucose, insulin level, and IRI when compared with placebo, whereas betahistine significantly decreased body weight, waist circumference, BMI, insulin level, and IRI but not fasting glucose when compared with placebo. In this study, we found that both metformin treatment and betahistine treatment were efficacious in improving antipsychotic-induced weight gain and insulin resistance, and metformin was more efficacious in preventing and revising the weight gain induced by antipsychotics. Clinical Trial Registration: www.ClinicalTrials.gov, NCT00451399(Study 1), NCT00709202(Study 2).


Front Psychiatry


Frontiers in psychiatry


Kang D,Jing Z,Li R,Hei G,Shao T,Li L,Sun M,Yang Y,Wang Y,Wang X,Long Y,Huang X,Wu R




Has Abstract


2018-11-27 00:00:00








  • Cogmed Working Memory Training Presents Unique Implementation Challenges in Adults With ADHD.

    abstract::Cogmed Working Memory Training (CWMT), an online cognitive training program developed for children, is an increasingly popular non-pharmacological intervention for ADHD amongst all ages, despite limited supporting evidence. The initial objective of the present work was to examine the short- and long-term impacts of CW...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Marcelle ET,Ho EJ,Kaplan MS,Adler LA,Castellanos FX,Milham MP

    更新日期:2018-08-28 00:00:00

  • Impaired Facial Emotion Recognition in Individuals at Ultra-High Risk for Psychosis and Associations With Schizotypy and Paranoia Level.

    abstract:Background:Patients with schizophrenia and individuals at ultra-high risk for psychosis (UHR) have been reported to exhibit impaired recognition of facial emotion expressions. This impairment has involved both inaccuracy and negative bias of facial emotion recognition. The present study aimed to investigate whether UHR...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Seo E,Park HY,Park K,Koo SJ,Lee SY,Min JE,Lee E,An SK

    更新日期:2020-06-26 00:00:00

  • Diminished Health Returns of Educational Attainment Among Immigrant Adults in the United States.

    abstract::Objectives: Marginalization-related diminished returns (MDRs) refer to weaker health effects of educational attainment for socially marginalized groups compared to the socially privileged groups. Most of the existing literature on MDRs, however, has focused on marginalization due to race, ethnicity, and sexual orienta...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Assari S,Cobb S,Cuevas AG,Bazargan M

    更新日期:2020-11-27 00:00:00

  • Nonsuicidal Self-Injury: Its Associations With Pathological Internet Use and Psychopathology Among Adolescents.

    abstract:Background/Hypotheses:As risk factors for nonsuicidal self-injury (NSSI), most studies highlight the importance of internalising disorders, while only a few researches show the connection between externalising disorders and NSSI. Although some papers have introduced the idea that increasing prevalence rates of NSSI are...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Mészáros G,Győri D,Horváth LO,Szentiványi D,Balázs J

    更新日期:2020-08-14 00:00:00

  • Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients With Mental Illness.

    abstract::Introduction: Vitamin D inadequacy or deficiency (VDID) has been reported in a high percentage of otherwise healthy individuals. Factors that may contribute to the high prevalence of VDID in people with mental disorders include diet low in vitamin D, poor sunlight exposure, decrease in cutaneous vitamin D synthesis, i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Cuomo A,Maina G,Bolognesi S,Rosso G,Beccarini Crescenzi B,Zanobini F,Goracci A,Facchi E,Favaretto E,Baldini I,Santucci A,Fagiolini A

    更新日期:2019-03-29 00:00:00

  • Aberrant Anterior Thalamic Radiation Structure in Bipolar Disorder: A Diffusion Tensor Tractography Study.

    abstract::Disrupted white matter (WM) integrity in the anterior thalamic radiation (ATR) has been identified in individuals with bipolar disorder (BD). We explored whether structural WM aberration in the ATR could be visually evaluated by diffusion tensor tractography (DTT). The study comprised 114 participants, including 57 pa...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Niida R,Yamagata B,Niida A,Uechi A,Matsuda H,Mimura M

    更新日期:2018-10-24 00:00:00

  • Decision-Making in Suicidal Behavior: The Protective Role of Loss Aversion.

    abstract:Background:Loss aversion is a central and well operationalized trait behavior that describes the tendency for humans to strongly prefer avoiding losses to making equivalent gains. Human decision-making is thus biased toward safer choices. Aim:The aim of this study was to explore the relationship between loss aversion ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Hadlaczky G,Hökby S,Mkrtchian A,Wasserman D,Balazs J,Machín N,Sarchiapone M,Sisask M,Carli V

    更新日期:2018-04-05 00:00:00

  • Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.

    abstract::Proton exchange provides a powerful contrast mechanism for magnetic resonance imaging (MRI). MRI techniques sensitive to proton exchange provide new opportunities to map, with high spatial and temporal resolution, compounds important for brain metabolism and function. Two such techniques, chemical exchange saturation ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Shaffer JJ Jr,Mani M,Schmitz SL,Xu J,Owusu N,Wu D,Magnotta VA,Wemmie JA

    更新日期:2020-09-24 00:00:00

  • A Randomized-Controlled Trial of Mentalization-Based Treatment Compared With Structured Case Management for Borderline Personality Disorder in a Mainstream Public Health Service.

    abstract::Background: Treatment of borderline personality disorder (BPD) in publicly funded mental health services generally use approaches based on medical interventions and generic case management. Specific psychological therapies developed for BPD may be more effective but have rarely been evaluated in routine clinical pract...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Carlyle D,Green R,Inder M,Porter R,Crowe M,Mulder R,Frampton C

    更新日期:2020-11-12 00:00:00

  • Cerebellar Contributions to Major Depression.

    abstract::Extending beyond the motor domain, the cerebellum is involved in various aspects of cognition and affect. Multidisciplinary evidence has demonstrated topographic organization of higher-order cognitive functions within the cerebellum. We here review recent neuroimaging research that indicates cerebellar contributions t...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Depping MS,Schmitgen MM,Kubera KM,Wolf RC

    更新日期:2018-11-29 00:00:00

  • The Therapeutic Community: A Unique Social Psychological Approach to the Treatment of Addictions and Related Disorders.

    abstract::The evolution of the contemporary Therapeutic Community (TC) for addictions over the past 50 years may be characterized as a movement from the marginal to the mainstream of substance abuse treatment and human services. TCs currently serve a wide array of clients and their diverse problems; through advances in research...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: De Leon G,Unterrainer HF

    更新日期:2020-08-06 00:00:00

  • Monitoring Changes in Depression Severity Using Wearable and Mobile Sensors.

    abstract::Background: While preliminary evidence suggests that sensors may be employed to detect presence of low mood it is still unclear whether they can be leveraged for measuring depression symptom severity. This study evaluates the feasibility and performance of assessing depressive symptom severity by using behavioral and ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Pedrelli P,Fedor S,Ghandeharioun A,Howe E,Ionescu DF,Bhathena D,Fisher LB,Cusin C,Nyer M,Yeung A,Sangermano L,Mischoulon D,Alpert JE,Picard RW

    更新日期:2020-12-18 00:00:00

  • Increased Amplitude of Low-Frequency Fluctuation in Right Angular Gyrus and Left Superior Occipital Gyrus Negatively Correlated With Heroin Use.

    abstract::Abnormal amplitude of low-frequency fluctuation has been implicated in heroin addiction. However, previous studies lacked consistency and didn't consider the impact of confounding factors such as methadone and alcohol. Fifty-one heroin-dependent (HD) individuals and 40 healthy controls underwent resting-state function...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Luo J,Yang R,Yang W,Duan C,Deng Y,Zhang J,Chen J,Liu J

    更新日期:2020-07-03 00:00:00

  • 25 Hz Magnetic Seizure Therapy Is Feasible but Not Optimal for Chinese Patients With Schizophrenia: A Case Series.

    abstract::Magnetic seizure therapy (MST) is a potential alternative to electroconvulsive therapy (ECT), but there is currently a lack of reports about MST in Chinese patients with schizophrenia. Our objective was to investigate the feasibility and acceptability of add-on MST in the treatment of patients with schizophrenia. Eigh...

    journal_title:Frontiers in psychiatry



    authors: Jiang J,Li Q,Sheng J,Yang F,Cao X,Zhang T,Jia Y,Wang J,Li C

    更新日期:2018-05-29 00:00:00

  • IPS in Supported Housing: Fidelity and Employment Outcomes Over a 4 Year Period.

    abstract::Background: People with severe mental illness have difficulties finding and maintaining competitive employment. This is particularly so for those living in supported housing who, by definition, have significant day-to-day support needs: in the Netherlands only 3 to 5% of people with serious mental health problems who ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Roeg D,de Winter L,Bergmans C,Couwenbergh C,McPherson P,Killaspy H,van Weeghel J

    更新日期:2021-01-14 00:00:00

  • Effect of Psychological-Behavioral Intervention on the Depression and Anxiety of COVID-19 Patients.

    abstract::The COVID-19 epidemic has caused increasing public panic and mental health stress. In this study, we explore the prevalence and factors linked to anxiety and depression in hospitalized patients with COVID-19. A total of 144 patients diagnosed with COVID-19 underwent depression and anxiety assessment by using the Hospi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Kong X,Kong F,Zheng K,Tang M,Chen Y,Zhou J,Li Y,Diao L,Wu S,Jiao P,Su T,Dong Y

    更新日期:2020-11-20 00:00:00

  • Mechanisms of auditory verbal hallucination in schizophrenia.

    abstract::Recent work on the mechanisms underlying auditory verbal hallucination (AVH) has been heavily informed by self-monitoring accounts that postulate defects in an internal monitoring mechanism as the basis of AVH. A more neglected alternative is an account focusing on defects in auditory processing, namely a spontaneous ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Cho R,Wu W

    更新日期:2013-11-27 00:00:00

  • Primary and Secondary Diagnoses of Gambling Disorder and Psychiatric Comorbidity in the Swedish Health Care System-A Nationwide Register Study.

    abstract::Background: Psychiatric comorbidity is common in gambling disorder, a condition with low rates of treatment seeking. There is a paucity of documented nationwide data on gambling disorder and its co-occurring psychiatric comorbidities in the health care system. Methods: This is a nationwide register-based study of all ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Håkansson A,Karlsson A,Widinghoff C

    更新日期:2018-09-07 00:00:00

  • Predictors of Remission of Early-Onset Poststroke Depression and the Interaction Between Depression and Cognition During Follow-Up.

    abstract::Objectives: This study aimed to examine the rate of remission in individuals experiencing early-onset poststroke depression (PSD) in China and to identify predictors of remission during a 3-month follow-up. This study also explored the interaction between cognitive impairment and depression. Methods: A total of 820 pa...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Huang J,Zhou FC,Guan B,Zhang N,Wang A,Yu P,Zhou L,Wang CY,Wang C

    更新日期:2019-01-08 00:00:00

  • The Influence of Depression on the Psychometric Properties of the Maslach Burnout Inventory-Human Services Survey: A Cross-Sectional Study With Nursing Assistants.

    abstract::Background: The Maslach Burnout Inventory-Human Services Survey (MBI-HSS) is the most commonly used instrument to assess burnout. Although various factors have been reported to influence its validity, the influence of major depressive disorder (MDD) has not been previously considered. We developed this study to invest...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Trigo TR,de Freitas CCS,Wang YP,Ribeiro FG,de Lucia MCS,Siqueira JO,Iosifescu DV,Hallak JEC,Fraguas R

    更新日期:2018-12-18 00:00:00

  • An Integrative Program to Reduce Stigma in Primary Healthcare Workers Toward People With Diagnosis of Severe Mental Disorders: A Protocol for a Randomized Controlled Trial.

    abstract::Background: People with severe mental disorders (SMDs) have higher disease and death rates than the general population. Stigma (negative attitudes and perceptions) contributes to limited access to health services and a lower quality of medical assistance in this population, and it is manifested as negative attitudes, ...

    journal_title:Frontiers in psychiatry



    authors: Grandón P,Saldivia S,Vaccari P,Ramirez-Vielma R,Victoriano V,Zambrano C,Ortiz C,Cova F

    更新日期:2019-03-07 00:00:00

  • Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons.

    abstract::Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed, animals and humans have fundamental drives to procure (appetitive behaviors) and eventually ingest (consummatory behaviors) substances based on deficits in body fluid (e.g., thirst) and energy balance (e.g., hunger). Consumpti...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Hsu TM,McCutcheon JE,Roitman MF

    更新日期:2018-09-03 00:00:00

  • Dopamine pathology in schizophrenia: analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra.

    abstract:INTRODUCTION:Despite the importance of dopamine neurotransmission in schizophrenia, very few studies have addressed anomalies in the mesencephalic dopaminergic neurons of the substantia nigra/ventral tegmental area (SN/VTA). Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the production of dopamine, and a pos...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Perez-Costas E,Melendez-Ferro M,Rice MW,Conley RR,Roberts RC

    更新日期:2012-04-09 00:00:00

  • Nonsuicidal Self-Injury and Suicide: The Role of Life Events in Clinical and Non-Clinical Populations of Adolescents.

    abstract:Background:Nonsuicidal self-injury (NSSI) is highly prevalent in clinical and non-clinical populations of adolescents. Several studies have supported both the distinction and the strong association between NSSI and suicidal behavior. Although there is a great deal of data on the role of life events in both suicidal beh...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Horváth LO,Győri D,Komáromy D,Mészáros G,Szentiványi D,Balázs J

    更新日期:2020-05-06 00:00:00

  • Development of the WHO Caregiver Skills Training Program for Developmental Disorders or Delays.

    abstract::Globally, 52.9 million children under the age of 5 experience a developmental disability, such as sensory impairment, intellectual disability, and autism spectrum disorders. Of these 95% live in low-and-middle-income countries. Most of these children lack access to care. In light of the growing evidence that caregiver...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Salomone E,Pacione L,Shire S,Brown FL,Reichow B,Servili C

    更新日期:2019-11-11 00:00:00

  • Lower Income Levels in Australia Are Strongly Associated With Elevated Psychological Distress: Implications for Healthcare and Other Policy Areas.

    abstract::Background: Australia is a high-income country with increasing income inequality. It is unclear whether Australia's well-developed mental healthcare system is making a difference to population mental health and the Federal Government has targeted outcomes accountability in service funding strategies. In high-income co...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Isaacs AN,Enticott J,Meadows G,Inder B

    更新日期:2018-10-26 00:00:00

  • Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder.

    abstract::Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be a major cognitive deficit independently caused by depression at acute episodes of MDD. Method: A comprehensive neurocognitive test battery was used to assess the executiv...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Liu J,Dong Q,Lu X,Sun J,Zhang L,Wang M,Wan P,Guo H,Zhao F,Ju Y,Yan D,Li H,Fang H,Guo W,Liao M,Zhang X,Zhang Y,Liu B,Li L

    更新日期:2019-11-12 00:00:00

  • Corrigendum: A Brief Review of Paradigm Shifts in Prevention of Alzheimer's Disease: From Cognitive Reserve to Precision Medicine.

    abstract::[This corrects the article DOI: 10.3389/fpsyt.2019.00786.]. ...

    journal_title:Frontiers in psychiatry

    pub_type: 已发布勘误


    authors: Hahn C,Lee CU

    更新日期:2019-12-17 00:00:00

  • A Narrative Inquiry Into Global Systems Change to Support Families When a Parent Has a Mental Illness.

    abstract::The issues that confront families when a parent experiences mental illness are complex. This often means that multiple service systems must be engaged to meet families' needs, including those related to intergenerational experiences of mental health and illness. A multisystem approach to public mental health care is w...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Isobel S,Allchin B,Goodyear M,Gladstone BM

    更新日期:2019-05-08 00:00:00

  • Modeling Trait Anxiety: From Computational Processes to Personality.

    abstract::Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with ref...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Raymond JG,Steele JD,Seriès P

    更新日期:2017-01-23 00:00:00