Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases.

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), which is the most abundant catechin in green tea, has many potential health benefits, including decreased weight gain and/or adipose tissue weight. Suggested mechanisms for body weight reduction by EGCG include: (1) a decrease in calorie intake and (2) activation of AMPK in liver...

journal_title：Frontiers in pharmacology

authors： Li F,Gao C,Yan P,Zhang M,Wang Y,Hu Y,Wu X,Wang X,Sheng J

更新日期：2018-11-22 00:00:00

abstract：:The skin is the first line of defense against pathogen and other environmental pollutant. The body is constantly exposed to reactive oxygen species (ROS) that stimulates inflammatory process in the skin. Many studies have linked ROS to various inflammatory skin diseases. Patients with skin diseases face various challe...

journal_title：Frontiers in pharmacology

authors： Choo WT,Teoh ML,Phang SM,Convey P,Yap WH,Goh BH,Beardall J

更新日期：2020-07-31 00:00:00

abstract：:The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. This enables...

journal_title：Frontiers in pharmacology

authors： Sercombe L,Veerati T,Moheimani F,Wu SY,Sood AK,Hua S

更新日期：2015-12-01 00:00:00

abstract：:Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacological activity involves...

journal_title：Frontiers in pharmacology

authors： Imanishi S,Umezu T,Kobayashi C,Ohta T,Ohyashiki K,Ohyashiki JH

更新日期：2018-10-16 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs. The absence of this channel results in an imbalance of ion concentrations across the cell membrane and results in more a...

journal_title：Frontiers in pharmacology

authors： Bardin P,Sonneville F,Corvol H,Tabary O

更新日期：2018-10-08 00:00:00

abstract：:High-throughput techniques allow for massive screening of drug combinations. To find combinations that exhibit an interaction effect, one filters for promising compound combinations by comparing to a response without interaction. A common principle for no interaction is Loewe Additivity which is based on the assumptio...

journal_title：Frontiers in pharmacology

authors： Lederer S,Dijkstra TMH,Heskes T

更新日期：2018-02-06 00:00:00

abstract：:The number of colorectal cancer (CRC) cases have increased gradually year by year. In fact, CRC is one of the most widely diagnosed cancer in men and women today. This disease is usually diagnosed at a later stage of the development, and by then, the chance of survival has declined significantly. Even though substanti...

journal_title：Frontiers in pharmacology

authors： Hon KW,Abu N,Ab Mutalib NS,Jamal R

更新日期：2017-08-28 00:00:00

abstract：PURPOSE:The importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and communicated to various stakeholders for accountability. Hence ther...

journal_title：Frontiers in pharmacology

authors： Leong J,Walker S,Salek S

更新日期：2015-06-11 00:00:00

abstract：:Background: Comparative efficacy of different pharmacist based interventions on glycemic control of type 2 diabetes patients is unclear. This review aimed to evaluate and compare the efficacy of different pharmacist based interventions on clinical outcomes of type 2 diabetes patients. Methods: A systematic search was ...

journal_title：Frontiers in pharmacology

authors： Bukhsh A,Khan TM,Lee SWH,Lee LH,Chan KG,Goh BH

更新日期：2018-04-10 00:00:00

abstract：:Background: Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying traditional Chinese medicine Rhizoma Rrynariae, has been proved to be effective in treating osteoporosis, bone fractures and defects. However, pharmacological effects of TFRD on type H vessels, angiogenic-osteogenic coupling ...

journal_title：Frontiers in pharmacology

authors： Shen Z,Chen Z,Li Z,Zhang Y,Jiang T,Lin H,Huang M,Chen H,Feng J,Jiang Z

更新日期：2020-11-27 00:00:00

abstract：:Fertility issues are common amongst women with rheumatoid arthritis (RA). Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα), known key players in RA pathogenesis, have been associated with reproductive disorders. This study investigates the role of these cytokines in decreased fertility in women with active ...

journal_title：Frontiers in pharmacology

authors： Bongenaar M,Smeele HTW,Lubberts E,Dolhain RJEM

更新日期：2020-12-10 00:00:00

abstract：:Background: Satisfaction of patients for pharmaceutical services reflects their preferences and expectations, and the realities of care. It is critical to understand the extent of dissatisfaction for pharmaceutical services and its associated factors in order to optimize the required quality of the services provided. ...

journal_title：Frontiers in pharmacology

authors： Nigussie S,Edessa D

更新日期：2018-10-12 00:00:00

abstract：:Zingiber zerumbet (L) Smith is part of the Zingiberaceae family, one of the largest families of the plant kingdom. Z. zerumbet is a perennial, aromatic and tuberose plant that grows in humid locations where its center of distribution is located in the South-East Asia region. This plant has been traditionally used in f...

journal_title：Frontiers in pharmacology

authors： Tan JW,Israf DA,Tham CL

更新日期：2018-06-20 00:00:00

abstract：:Lung cancer is one of main causes of cancer mortality and 83% of lung cancer cases are classified as non-small cell lung cancer (NSCLC). Patients with NSCLC usually have a poor prognosis and one of the leading causes is drug resistance. With the progress of drug therapy, the emergence and development of drug resistanc...

journal_title：Frontiers in pharmacology

authors： Sun R,Wang R,Chang S,Li K,Sun R,Wang M,Li Z

更新日期：2019-12-18 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00512.]. ...

journal_title：Frontiers in pharmacology

authors： Jiang YH,Jiang LY,Wang YC,Ma DF,Li X

更新日期：2020-05-29 00:00:00

abstract：:Flavonoids is an intensively studied group of natural compounds with antioxidant, antineoplastic, antihyperglycemic, cardioprotective, and neuroprotective properties. The present study intends to investigate the geroprotective action of three selected flavonoids (naringin, luteolin, chrysin) in two model organisms, Ca...

journal_title：Frontiers in pharmacology

authors： Lashmanova E,Zemskaya N,Proshkina E,Kudryavtseva A,Volosnikova M,Marusich E,Leonov S,Zhavoronkov A,Moskalev A

更新日期：2017-12-07 00:00:00

abstract：:Background: From October 2018, adalimumab biosimilars could enter the European market. However, in some countries, such as Netherlands, high discounts reported for the originator product may have influenced biosimilar entry. Objectives: The aim of this paper is to provide a European overview of (list) prices of origin...

journal_title：Frontiers in pharmacology

authors： Moorkens E,Godman B,Huys I,Hoxha I,Malaj A,Keuerleber S,Stockinger S,Mörtenhuber S,Dimitrova M,Tachkov K,Vončina L,Palčevski VV,Achniotou G,Slabý J,Popelková L,Kohoutová K,Bartels D,Laius O,Martikainen JE,Selke GW,

更新日期：2021-01-08 00:00:00

abstract：:Limited data are available on the adherence to opioid therapy and the influence of different patient groups on adherence. This study examined the patterns of adherence in opioid naïve and opioid existing patients with varying age and gender. This retrospective cohort study was conducted using the prescription database...

journal_title：Frontiers in pharmacology

authors： Zin CS,Taufek NH,Ahmad MM

更新日期：2019-10-29 00:00:00

abstract：:Stability of traditional Chinese medicine injection (TCMI) is an important issue related with its clinical application. TCMI is composed of multi-components, therefore, when evaluating TCMI stability, several marker compounds cannot represent global components or biological activities of TCMI. Till now, when evaluatin...

journal_title：Frontiers in pharmacology

authors： Li JP,Liu Y,Guo JM,Shang EX,Zhu ZH,Zhu KY,Tang YP,Zhao BC,Tang ZS,Duan JA

更新日期：2017-11-15 00:00:00

abstract：:Black peppercorns (Piper nigrum L.) elicit a pungent and tingling oral impression. Their pungency is partially explained by the agonist activity of some of their active principles, especially piperine, on TRP channels. However, we recently showed that piperine, as well as other pungent compounds, also possess a marked...

journal_title：Frontiers in pharmacology

authors： Beltrán LR,Dawid C,Beltrán M,Levermann J,Titt S,Thomas S,Pürschel V,Satalik M,Gisselmann G,Hofmann T,Hatt H

更新日期：2017-06-26 00:00:00

abstract：:Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement factor H (CFH) gene; ...

journal_title：Frontiers in pharmacology

authors： Stravalaci M,Davi F,Parente R,Gobbi M,Bottazzi B,Mantovani A,Day AJ,Clark SJ,Romano MR,Inforzato A

更新日期：2020-11-26 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease that is primarily characterized by synovial inflammation. In this study, we found that a traditional Chinese decoction, Juanbi-Tang (JBT), JBT attenuated the symptoms of collagen-induced arthritis (CIA) mice and in tumor necrosis factor transgenic (TNF-Tg) mice...

journal_title：Frontiers in pharmacology

authors： Wang T,Jia Q,Chen T,Yin H,Tian X,Lin X,Liu Y,Zhao Y,Wang Y,Shi Q,Huang C,Xu H,Liang Q

更新日期：2020-02-14 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma multiforme (GBM). This tumor is characterized by extensive areas of hypox...

journal_title：Frontiers in pharmacology

authors： Maugeri G,D'Amico AG,Reitano R,Magro G,Cavallaro S,Salomone S,D'Agata V

更新日期：2016-05-31 00:00:00

abstract：:Background: The research into bioactive natural products of medicinal plants has a long tradition, but ethnopharmacology as a well-defined field of research has a relatively short history, only dating back 50 years. Aims: With the fast development of this field and its global importance especially in the fast developi...

journal_title：Frontiers in pharmacology

authors： Yeung AWK,Heinrich M,Atanasov AG

更新日期：2018-03-15 00:00:00

abstract：Objective:Drawing a growth curve of multidrug-resistant Pseudomonas aeruginosa (MDR-PA) provides a foundation for susceptibility testing. By observing in vitro antibacterial activity and ultrastructure cthanges on MDR-PA of the effective components in the drug-containing serum of rats after the administration of Fuzhen...

journal_title：Frontiers in pharmacology

authors： Xu H,Liu C,Li M,Wang C,Liu G,Wang H,Ma J,Li L,Chen M,Cheng M,Yao X,Lin Y,Zhao S,Wang Y,Wang M

更新日期：2020-02-12 00:00:00

abstract：:Over the past several decades, natural products with poly-pharmacological profiles have demonstrated promise as novel therapeutics for various complex diseases, including cancer. Berberine (PubChem CID: 2353), a soliloquies quaternary alkaloid, has been validated to exert powerful effects in many cancers. However, the...

journal_title：Frontiers in pharmacology

authors： Guo P,Cai C,Wu X,Fan X,Huang W,Zhou J,Wu Q,Huang Y,Zhao W,Zhang F,Wang Q,Zhang Y,Fang J

更新日期：2019-08-06 00:00:00

abstract：:The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles a...

journal_title：Frontiers in pharmacology

authors： Coricovac DE,Moacă EA,Pinzaru I,Cîtu C,Soica C,Mihali CV,Păcurariu C,Tutelyan VA,Tsatsakis A,Dehelean CA

更新日期：2017-03-28 00:00:00

abstract：:We explored the therapeutic effects of Dendrobium officinale polysaccharide (DOP) on CCl4-induced liver fibrosis with respect to the intestinal hepatic axis using a rat model. Histopathological staining results showed that DOP alleviated extensive fibrous tissue proliferation in interstitium and lessened intestinal mu...

journal_title：Frontiers in pharmacology

authors： Wang K,Yang X,Wu Z,Wang H,Li Q,Mei H,You R,Zhang Y

更新日期：2020-03-12 00:00:00

abstract：PURPOSE:Hydrogen is a proven novel antioxidant that selectively reduces hydroxyl radicals. In this study, we investigated the effects of hydrogen-rich saline solution on the prevention of renal injury induced by ischemia/reperfusion (I/R) and on renal function recovery. METHODS:A rat model of renal I/R injury was indu...

journal_title：Frontiers in pharmacology

authors： Li J,Hong Z,Liu H,Zhou J,Cui L,Yuan S,Chu X,Yu P

更新日期：2016-04-22 00:00:00

abstract：:Irregular histone modification and aberrant lncRNAs expression are closely related to the occurrence of tumors including acute myeloid leukemia (AML). However, the effects and specific underlying molecular mechanism of histone deacetylase inhibitors on lncRNA expression in AML cells are unclear. Here, we reported the ...

journal_title：Frontiers in pharmacology

authors： Lin L,Que Y,Lu P,Li H,Xiao M,Zhu X,Li D

更新日期：2020-10-19 00:00:00