Abstract:
BACKGROUND:Screening colonoscopy can lower the incidence of colorectal cancer (CRC), yet participation rates are low even in groups at high risk. The goal of this study was to double the rate of participation in screening colonoscopy among persons at familial risk and then to determine the frequency of neoplasia in this risk group. METHODS:In a nationwide, cluster-randomized, multicenter study, first-degree relatives (FDR) of patients with CRC across Germany received written informational materials concerning the familial risk of CRC, along with an invitation to undergo colonoscopy. Participants in the intervention group were additionally counseled by nurses over the telephone. The primary endpoint of the study was colonoscopy uptake within 30 days. RESULTS:The participants' mean age was 50.8 years. The colonoscopy uptake rates were 99/125 (79%) in the intervention group and 97/136 (71%) in the control group (RR = 1.11; 95% confidence interval [0.97; 1.28]). A polypectomy was performed in 72 of 196 asymptomatic persons (37%). In 13 cases (7%), an advanced neoplasia was detected; two of these persons had colon cancer (stages T0 and T1). 42% of the participants expressed barriers against colonoscopy. 22 reported mild side effects; there were no serious side effects. CONCLUSION:Additional counseling by nurses over the telephone does not increase the participation rate. Approaching patients who have CRC is an opportunity to increase the participation of their first-degree relatives in screening colonoscopy. The frequency of neoplasia that was found in this study underscores the need to screen relatives even before they reach the usual age threshold for screening.
journal_name
Dtsch Arztebl Intjournal_title
Deutsches Arzteblatt internationalauthors
Bauer A,Riemann JF,Seufferlein T,Reinshagen M,Hollerbach S,Haug U,Unverzagt S,Boese S,Ritter-Herschbach M,Jahn P,Frese T,Harris M,Landenberger Mdoi
10.3238/arztebl.2018.0715subject
Has Abstractpub_date
2018-10-26 00:00:00pages
715-722issue
43issn
1866-0452pii
arztebl.2018.0715journal_volume
115pub_type
杂志文章,多中心研究,随机对照试验abstract:BACKGROUND:When gunshot and blast injuries affect only a single person, first aid can always be delivered in conformity with the relevant guidelines. In contrast, when there is a dynamic casualty situation affecting many persons, such as after a terrorist attack, treatment may need to be focused on immediately life-thr...
journal_title:Deutsches Arzteblatt international
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abstract:BACKGROUND:Adverse drug events (ADE) are a common cause of hospital admission as well as a common complication of inpatient care. The current reporting systems in Germany are of only limited use for the identification of ADE. The aim of this study is to examine the potential usefulness of ICD-10 coded diagnoses in rout...
journal_title:Deutsches Arzteblatt international
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doi:10.3238/arztebl.2010.0023
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abstract:BACKGROUND:High-altitude travel, for mountain climbing, trekking, or sightseeing, has become very popular. Therefore, the awareness of its dangers has increased, and many prospective travelers seek medical advice before setting forth on their trip. METHODS:We selectively searched the literature for relevant original a...
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doi:10.3238/arztebl.2011.0839
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abstract:INTRODUCTION:The range of indications for vitreoretinal surgery has widened in recent years, and intraocular gas application is frequently performed as part of retinal surgery, with the aim of achieving long-acting tamponade. METHODS:Selective literature review. RESULTS:An intraocular gas bubble containing perfluorop...
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doi:10.3238/arztebl.2011.0856
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abstract:BACKGROUND:Isolated non-compaction cardiomyopathy (NCCM) was first described in 1984. This disorder, a primary genetic cardiomyopathy, is now attracting increased attention. METHOD:The current state of the epidemiology, pathogenesis, pathophysiology, clinical features, diagnosis, treatment, and prognosis of NCCM are d...
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pub_type: 杂志文章,评审
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abstract:BACKGROUND:In endocrine orbitopathy (EO), disfiguring proptosis and diplopia impair patients' quality of life both at home and at work. METHODS:From late 2006 to the beginning of 2008, 250 outpatients in an interdisciplinary thyroid and eye clinic filled out a questionnaire about their quality of life, occupational di...
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The treatment of pregnant women who have illnesses unrelated to pregnancy can cause uncertainty among physicians. METHODS:We searched the PubMed database and specialty guidelines from Germany and abroad (the guidelines of the German Society for Gynecology and Obstetrics, the American Congress of Obstetri ci...
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abstract:BACKGROUND:5% to 8% of 70-year-olds and some 10% of persons over age 80 have atrial fibrillation (AF). METHODS:Selective literature review. RESULTS:New scoring schemes (CHA(2)DS(2)-VASc score, HAS-BLED score) have been introduced to enable more accurate estimation of the risk of stroke and hemorrhage in patients with...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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abstract::[This corrects the article DOI: 10.3238/arztebl.2017.0661.]. ...
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pub_type: 已发布勘误
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pub_type: 杂志文章,评审
doi:10.3238/arztebl.2009.0032
更新日期:2009-01-01 00:00:00
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更新日期:2020-03-13 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2018-01-19 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-05-25 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00