Pilot Testing of Peak Alpha Frequency Stability During Repetitive Transcranial Magnetic Stimulation.


:Over half of those diagnosed with post-traumatic stress disorder (PTSD) have comorbid major depressive disorder (MDD), and rates are even higher among military veterans. Transcranial magnetic stimulation (TMS) may be a safe and efficacious treatment for PTSD, both with and without comorbid MDD. Still, the mechanism of action of TMS is not fully understood, and it remains unclear which stimulation techniques (e.g., target regions, pulse strength/frequency, waveform) optimize treatment for these patients. Recent research indicated that a patient's unique individualized alpha frequency (IAF) may be used to guide brain stimulation treatment, and emerging data suggests that stimulation synchronized to the IAF may be efficacious for MDD. However, to our knowledge there are no studies to date that evaluate the stability of IAF over time in patients with comorbid PTSD and MDD. To this end, we used an eight-lead electroencephalography (EEG) system to record IAF before and after a course of TMS. Stimulation parameters were informed by prior studies of TMS for comorbid PTSD and MDD and included 5 Hz TMS to the left dorsolateral prefrontal cortex, at 120% of motor threshold, 3,000-4,000 pulses per session for up to 40 sessions. We tested whether IAF was changed with a course of TMS therapy and evaluated whether IAF predicted clinical outcomes. We observed no significant changes in IAF from baseline to post-treatment, and there was no relationship between IAF and clinical symptom change. These data demonstrate the stability of IAF with TMS and indicate its utility as a trait marker for future brain stimulation studies. This work does not support the use of IAF as predictor of clinical response to TMS as administered.


Front Psychiatry


Frontiers in psychiatry


Petrosino NJ,Zandvakili A,Carpenter LL,Philip NS




Has Abstract


2018-11-20 00:00:00








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    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Sevos J,Grosselin A,Gauthier M,Carmona F,Gay A,Massoubre C

    更新日期:2018-07-23 00:00:00

  • Comorbidity of Obsessive-Compulsive Disorder and Schizotypal Personality Disorder: Clinical Response and Treatment Resistance to Pharmacotherapy in a 3-Year Follow-Up Naturalistic Study.

    abstract::The present study aims to analyze the clinical and socio-demographic characteristics of patients with obsessive-compulsive disorder (OCD) in comorbidity with schizotypal personality disorder (SPD), as well as the response rate to pharmacological treatments. OCD+SPD patients had a younger age at onset, a higher probabi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Perris F,Fabrazzo M,De Santis V,Luciano M,Sampogna G,Fiorillo A,Catapano F

    更新日期:2019-06-17 00:00:00

  • Psychopathological Correlates and Emotion Regulation as Mediators of Approach and Avoidance Motivation in a Chinese Military Sample.

    abstract::Background: Approach and avoidance motivation have been thoroughly studied in common mental disorders, which are prevalent in the military context. Approach/avoidance motivational dispositions underlie emotion responses and are thought to influence emotion dysregulation. However, studies on the mediating role of emoti...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Wang X,Zhang R,Chen X,Liu K,Wang L,Zhang J,Liu X,Feng Z

    更新日期:2019-03-22 00:00:00

  • Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies.

    abstract:BACKGROUND:Schizophreniform syndromes can be divided into primary forms from polygenic causes or secondary forms due to immunological, epileptiform, monogenic, or degenerative causes. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a secondary immunological form associated with incre...

    journal_title:Frontiers in psychiatry



    authors: Endres D,Perlov E,Riering AN,Maier V,Stich O,Dersch R,Venhoff N,Erny D,Mader I,Tebartz van Elst L

    更新日期:2017-04-21 00:00:00

  • Posttraumatic Stress Disorder and Related Disorders among Female Yazidi Refugees following Islamic State of Iraq and Syria Attacks-A Case Series and Mini-Review.

    abstract::Following the severe attacks by the so-called "Islamic State of Iraq and Syria" on the Yazidi population, which started in summer 2014, the state government of Baden-Württemberg, Germany, funded a Special-Quota Project to bring 1,000 very ill or left-behind women and children who were being held hostage to 22 cities a...

    journal_title:Frontiers in psychiatry



    authors: Gerdau I,Kizilhan JI,Noll-Hussong M

    更新日期:2017-12-13 00:00:00

  • Perceived Paternal Involvement, Relationship Satisfaction, Mothers' Mental Health and Parenting Stress: A Multi-Sample Path Analysis.

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    pub_type: 杂志文章


    authors: deMontigny F,Gervais C,Pierce T,Lavigne G

    更新日期:2020-11-02 00:00:00

  • Bounce Forward: A School-Based Prevention Programme for Building Resilience in a Socioeconomically Disadvantaged Context.

    abstract::Socioeconomic status is a strong predictor of normative development and well-being in young people. It is well-known that growing up in a socioeconomically disadvantaged context may lead to negative outcomes, both in childhood and in adulthood. Early intervention and prevention programmes are crucial for building resi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Kara B,Morris R,Brown A,Wigglesworth P,Kania J,Hart A,Mezes B,Cameron J,Eryigit-Madzwamuse S

    更新日期:2021-01-14 00:00:00

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    abstract:BACKGROUND:Identifying objective and accurate markers of cocaine dependence (CD) can innovate its prevention and treatment. Existing evidence suggests that CD is characterized by a wide range of cognitive deficits, most notably by increased impulsivity. Impulsivity is multidimensional and it is unclear which of its var...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Ahn WY,Ramesh D,Moeller FG,Vassileva J

    更新日期:2016-03-10 00:00:00

  • Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.

    abstract::Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia, activated by the neuromodulator adenosine, which interact with dopamine D2 receptors. Although this reciprocal antagonistic interaction is well-established in motor function, the outcome in dopamine-related behaviors remains uncertai...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Coelho JE,Alves P,Canas PM,Valadas JS,Shmidt T,Batalha VL,Ferreira DG,Ribeiro JA,Bader M,Cunha RA,do Couto FS,Lopes LV

    更新日期:2014-06-13 00:00:00

  • High Psychiatric Morbidity and Comorbidity Among Female Prisoners in Hunan, China.

    abstract:Background:High prevalence of mental disorders has been found among female prisoners in Western countries, however, little is known about the epidemiology of mental disorders in such populations in China. This study aims to investigate psychiatric morbidity and comorbidity among sentenced prisoners in a female prison i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Zhong S,Zhu X,Chen Y,Guo H,Luo C,Liang X,Wang F,Chen H,Zhou J,Wang X

    更新日期:2020-04-14 00:00:00

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    abstract::Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, di...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Galvão-Coelho NL,Galvão ACM,da Silva FS,de Sousa MBC

    更新日期:2017-09-21 00:00:00

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    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Liu D,Liu S,Zhu L,Li D,Huang D,Deng H,Guo H,Huang D,Liao Y,Mao Z,Miao Q,Liu W,Xiu M,Zhang X

    更新日期:2020-12-07 00:00:00

  • Methylphenidate Dose-Dependently Affects Aggression and Improves Fear Extinction and Anxiety in BALB/cJ Mice.

    abstract::Overt aggression, increased anxiety, and dysfunctional fear processing are often observed in individuals with conduct disorder (CD) and attention-deficit hyperactivity disorder (ADHD). Methylphenidate (MPH), a psychostimulant increasing dopamine and noradrenaline tone, is effective in reducing aggression in both CD an...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Jager A,Kanters D,Geers F,Buitelaar JK,Kozicz T,Glennon JC

    更新日期:2019-10-25 00:00:00

  • Exploratory Analysis of Behavioral Impulsivity, Pro-inflammatory Cytokines, and Resting-State Frontal EEG Activity Associated With Non-suicidal Self-Injury in Patients With Mood Disorder.

    abstract::Introduction: Non-suicidal self-injury (NSSI) is a rapidly increasing mental health problem that requires more clinical attention. In this study, we aimed to explore the biobehavioral markers of NSSI in participants with mood disorders. Methods: A total of 45 participants with mood disorders (bipolar I, II, and major ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Kim JS,Kang ES,Bahk YC,Jang S,Hong KS,Baek JH

    更新日期:2020-02-26 00:00:00

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    abstract::Transcranial direct current stimulation (tDCS) can enhance cognitive control functions including attention and top-down regulation over negative affect and substance craving in both healthy and clinical populations, including early abstinent (∼1.5 h) smokers. The aim of this study was to assess whether tDCS modulates ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Xu J,Fregni F,Brody AL,Rahman AS

    更新日期:2013-09-20 00:00:00

  • Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.

    abstract::Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single g...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Tordjman S,Somogyi E,Coulon N,Kermarrec S,Cohen D,Bronsard G,Bonnot O,Weismann-Arcache C,Botbol M,Lauth B,Ginchat V,Roubertoux P,Barburoth M,Kovess V,Geoffray MM,Xavier J

    更新日期:2014-08-04 00:00:00

  • Smartphones and Wearables as a Method for Understanding Symptom Mechanisms.

    abstract::While psychological treatments have been shown to be effective in treating psychiatric disorders, the mechanism of their therapeutic effect is less well understood. An improved mechanistic understanding of psychiatric disorders and their treatments would enable refinement of existing interventions, and more targeted i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Griffin B,Saunders KEA

    更新日期:2020-01-17 00:00:00

  • A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.

    abstract::Objective: Selective serotonin reuptake inhibitors like sertraline have been shown in observational studies and anecdotal reports to improve language development in young children with fragile X syndrome (FXS). A previous controlled trial of sertraline in young children with FXS found significant improvement in expres...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Potter LA,Scholze DA,Biag HMB,Schneider A,Chen Y,Nguyen DV,Rajaratnam A,Rivera SM,Dwyer PS,Tassone F,Al Olaby RR,Choudhary NS,Salcedo-Arellano MJ,Hagerman RJ

    更新日期:2019-11-06 00:00:00

  • Primary Sjogren's Syndrome Associated With Treatment-Resistant Obsessive-Compulsive Disorder.

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    journal_title:Frontiers in psychiatry



    authors: Ong LTC,Galambos G,Brown DA

    更新日期:2017-07-11 00:00:00

  • A Medicinal Herb Scutellaria lateriflora Inhibits PrP Replication in vitro and Delays the Onset of Prion Disease in Mice.

    abstract::Transmissible spongiform encephalopathies (TSE) are characterized by the misfolding of the host encoded prion protein (PrP(C)) into a pathogenic isoform (PrP(Sc)) which leads to the accumulation of β-sheet-rich fibrils and subsequent loss of neurons and synaptic functions. Although many compounds have been identified ...

    journal_title:Frontiers in psychiatry

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    authors: Eiden M,Leidel F,Strohmeier B,Fast C,Groschup MH

    更新日期:2012-02-17 00:00:00

  • Cortical Thickness in Alcohol Dependent Patients With Apathy.

    abstract:Objectives:Many studies reported structural brain changes in patients with alcohol dependence (PADs). However, no studies identified structural correlates of apathy that might aggravate alcohol misuse. Here, we explored regional differences in cortical thickness in PADs relative to healthy controls (HCs), and examined ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Yang K,Yang Q,Niu Y,Fan F,Chen S,Luo X,Tan S,Wang Z,Tong J,Yang F,Le TM,Li CR,Tan Y

    更新日期:2020-05-05 00:00:00

  • Efficacy of the Whole-Body Cryotherapy as Add-on Therapy to Pharmacological Treatment of Depression-A Randomized Controlled Trial.

    abstract:Introduction:Accumulating evidence indicates the effectiveness of cryogenic temperature interventions in rheumatoid arthritis, ankylosing spondylitis, fibromyalgia, multiple sclerosis, and chronic low back pain. The application of whole-body cryotherapy (WBC) in psychiatric aspects of medicine was also noted. Neverthel...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Rymaszewska J,Lion KM,Pawlik-Sobecka L,Pawłowski T,Szcześniak D,Trypka E,Rymaszewska JE,Zabłocka A,Stanczykiewicz B

    更新日期:2020-06-09 00:00:00

  • Predictors of Remission of Early-Onset Poststroke Depression and the Interaction Between Depression and Cognition During Follow-Up.

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    journal_title:Frontiers in psychiatry

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    authors: Huang J,Zhou FC,Guan B,Zhang N,Wang A,Yu P,Zhou L,Wang CY,Wang C

    更新日期:2019-01-08 00:00:00

  • IPS in Supported Housing: Fidelity and Employment Outcomes Over a 4 Year Period.

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    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Roeg D,de Winter L,Bergmans C,Couwenbergh C,McPherson P,Killaspy H,van Weeghel J

    更新日期:2021-01-14 00:00:00

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    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Hjetland GJ,Nordhus IH,Pallesen S,Cummings J,Tractenberg RE,Thun E,Kolberg E,Flo E

    更新日期:2020-03-13 00:00:00

  • Increasing Risks of Suicide Attempt and Suicidal Drug Overdose After Head Trauma in Patients With Sleep-Disordered Breathing: A Population-Based Study.

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    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Harnod D,Lin CL,Harnod T,Kao CH

    更新日期:2020-12-09 00:00:00

  • The Effect of COVID-19 on Mental Health and Wellbeing in a Representative Sample of Australian Adults.

    abstract::There is minimal knowledge about the impact of large-scale epidemics on community mental health, particularly during the acute phase. This gap in knowledge means we are critically ill-equipped to support communities as they face the unprecedented COVID-19 pandemic. This study aimed to provide data urgently needed to i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Dawel A,Shou Y,Smithson M,Cherbuin N,Banfield M,Calear AL,Farrer LM,Gray D,Gulliver A,Housen T,McCallum SM,Morse AR,Murray K,Newman E,Rodney Harris RM,Batterham PJ

    更新日期:2020-10-06 00:00:00

  • Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics.

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    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Euteneuer F,Dannehl K,Del Rey A,Engler H,Schedlowski M,Rief W

    更新日期:2017-11-23 00:00:00

  • Mental Health Symptoms and Work-Related Stressors in Hospital Midwives and NICU Nurses: A Mixed Methods Study.

    abstract::Hospital midwives and neonatal intensive care (NICU) nurses frequently encounter work-related stressors and are therefore vulnerable to developing mental health problems, such as secondary traumatic stress, burnout, anxiety, and depression. However, so far, the exact nature of these work-related stressors (traumatic v...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Favrod C,Jan du Chêne L,Martin Soelch C,Garthus-Niegel S,Tolsa JF,Legault F,Briet V,Horsch A

    更新日期:2018-08-20 00:00:00

  • Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A Network Meta-Analysis.

    abstract::Background: Attenuated positive psychotic symptoms represent the defining features of the clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available treatment for reducing attenuated positive psychotic symptoms remains undetermined. This network meta-analysis (NMA) investigates the consiste...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Davies C,Radua J,Cipriani A,Stahl D,Provenzani U,McGuire P,Fusar-Poli P

    更新日期:2018-06-12 00:00:00