Abstract:
:The liver is one of the most important immunological organs that remains tolerogenic in homeostasis yet promotes rapid responses to pathogens in the presence of a systemic infection. The composition of leucocytes in the liver is highly distinct from that of the blood and other lymphoid organs, particularly with respect to enrichment of innate T cells, i.e., invariant NKT cells (iNKT cells) and Mucosal-Associated Invariant T cells (MAIT cells). In recent years, studies have revealed insights into their biology and potential roles in maintaining the immune-environment in the liver. As the primary liver-resident immune cells, they are emerging as significant players in the human immune system and are associated with an increasing number of clinical diseases. As such, innate T cells are promising targets for modifying host defense and inflammation of various liver diseases, including viral, autoimmune, and those of tumor origin. In this review, we emphasize and discuss some of the recent discoveries and advances in the biology of innate T cells, their recruitment and diversity in the liver, and their role in various liver diseases, postulating on their potential application in immunotherapy.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Huang W,He W,Shi X,He X,Dou L,Gao Ydoi
10.3389/fimmu.2018.02424subject
Has Abstractpub_date
2018-10-30 00:00:00pages
2424issn
1664-3224journal_volume
9pub_type
杂志文章,评审abstract::Post-transplantation cyclophosphamide (PTCy) has been highly successful at preventing severe acute and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). The clinical application of this approach was based on extensive studies in major histocompatibility complex (MHC)-m...
journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2019.02668
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2018.01094
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
doi:10.3389/fimmu.2017.00998
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2018.02252
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pub_type: 杂志文章
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doi:10.3389/fimmu.2019.03066
更新日期:2020-01-23 00:00:00
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更新日期:2018-08-10 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2020.01297
更新日期:2020-07-16 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2019.01640
更新日期:2019-07-19 00:00:00
abstract::[This corrects the article DOI: 10.3389/fimmu.2019.01135.]. ...
journal_title:Frontiers in immunology
pub_type: 已发布勘误
doi:10.3389/fimmu.2019.01755
更新日期:2019-07-24 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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