Abstract:
BACKGROUND:Several studies have reported microRNAs (miRNAs) could regulate the placental development, though the role and mechanism of miRNAs in the development of non-diabetic macrosomia (NDFMS) remains unclear. METHODS:To identify the aberrantly expressed key miRNAs in placenta of NDFMS, we employed a strategy consisting of initial screening with miRNA microarray and further validation with quantitative RT-PCR assay (qRT-PCR). In vitro cellular model and a mouse pregnancy model were used to delineate the functional effects of key miRNA on proliferation, invasion, and migration. FINDINGS:miR-141-3p was identified as the key miRNA with expression level significantly higher in placentas of NDFMS compared with those from normal controls. Overexpressed miR-141-3p in HTR-8/SVneo cells contributed to increased cell proliferation, invasion, and migration. miR-141-3p inhibition in HTR-8/SVneo cells resulted in decreased cell proliferation and invasion. Significantly increased infant birth weight was observed in late pregnancy of C57BL/6J mice treated with miR-141-3p agomir. However, no significant difference was found in early pregnancy of C57BL/6J mice treated with miR-141-3p agomir. INTERPRETATION:miR-141-3p could stimulate placental cell proliferation to participate in the occurrence and development of NDFMS.
journal_name
EBioMedicinejournal_title
EBioMedicineauthors
Guo D,Jiang H,Chen Y,Yang J,Fu Z,Li J,Han X,Wu X,Xia Y,Wang X,Chen L,Tang Q,Wu Wdoi
10.1016/j.ebiom.2018.11.002subject
Has Abstractpub_date
2018-12-01 00:00:00pages
154-161issn
2352-3964pii
S2352-3964(18)30495-Xjournal_volume
38pub_type
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